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| 1 | Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development显示文摘兼容丑恶纸巾的表面上的花粉萌芽是为植物授精的必要的步。这里,我们报导 Arabidopsis 变异的 bcl1 是由于花粉萌芽的失败不育的男性。我们证明 bcl1 异种等位基因不能被男配偶体播送,没有同型结合的 bcl1 异种被获得。花粉发育阶段的分析显示 bcl1 变化影响花粉萌芽然而并非花粉成熟。分子的分析证明花粉萌芽的失败被 AtBECLIN 1 的混乱引起。AtBECLIN 1 在成熟花粉主要被表示并且与重要相同编码蛋白质到在酵母为 autophagyand vacuolar 蛋白质排序的过程(VPS ) 要求的 Beclin1/Atg6/Vps30。我们也证明 AtBECLIN 1 为正常被要求植物开发,和那与 autophagy, VPS 和 glycosylphosphatidylinositolanchor 系统有关的基因,被 AtBECLIN 1 的缺乏影响。 | Genji Qin Zhiqiang Ma Li Zhang Shufan Xing Xianhui Hou Jie Deng Jingjing Liu Zhangliang Chen Li-Jia Qu Hongya Gu | 2007 | Cell Research2007，17，3： | 17 |
| 2 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 3 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 4 | Counteraction of ABA-Mediated Inhibition of Seed Germination and Seedling Establishment by ABA Signaling Terminator in Arabidopsis显示文摘Seed germination and seedling establishment are important for the reproductive success of plants,but seeds and seedlings typically encounter constantly changing environmental conditions.By inhibiting seed germination and post-germinative growth through the PYR1/PYL/RCAR ABA receptors and PP2C co-receptors,the phytohormone abscisic acid(ABA)prevents premature germination and seedling growth under unfavorable conditions.However,little is known about how the ABA-mediated inhibition of seed germination and seedling establishment is thwarted.Here,we report that ABA Signaling Terminator(ABT),a WD40 protein,efficiently switches off ABA signaling and is critical for seed germination and seedling establishment.ABT is induced by ABA in a PYR1/PYL/RCAR-PP2C-dependent manner.Overexpression of ABT promotes seed germination and seedling greening in the presence of ABA,whereas knockout of ABT has the opposite effect.We found that ABT interacts with the PYR1/PYL/RCAR and PP2C proteins,interferes with the interaction between PYR1/PYL4 and ABI1/ABI2,and hampers the inhibition of ABI1/ABI2 by ABA-bound PYR1/PYL4,thereby terminating ABA signaling.Taken together,our results reveal a core mechanism of ABA signaling termination that is critical for seed germination and seedling establishment in Arabidopsis. | Zhijuan Wang Ziyin Ren Chunhong Cheng Tao Wang Hongtao Ji Yang Zhao Zhiping Deng Liya Zhi Jingjing Lu Xinying Wu Shimin Xu Mengmeng Cao Hongtao Zhao Liu Liu Jiankang Zhu Xia Li | 2020 | Molecular Plant2020，13，9： | 10 |
| 5 | IL-17 sustains the plasma cell response via p38-mediated Bcl-xL RNA stability in lupus pathogenesis显示文摘Recent studies have demonstrated a central role for plasma cells in the development of autoimmune diseases,such as systemic lupus erythematosus(SLE).Currently,both the phenotypic features and functional regulation of autoreactive plasma cells during SLE pathogenesis remain largely unclear.In this study,we first found that a major subset of IL-17 receptor-expressing plasma cells potently produced anti-dsDNA IgG upon IL-17A(IL-17)stimulation in SLE patients and lupus mice.Using a humanized lupus mouse model,we showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total SLE PBMCs.Moreover,long-term BrdU incorporation in lupus mice detected highly enriched long-lived BrdU+subsets among IL-17 receptor-expressing plasma cells.Lupus mice deficient in IL-17 or IL-17 receptor C(IL-17RC)exhibited a diminished plasma cell response and reduced autoantibody production with attenuated renal damage,while the adoptive transfer of Th17 cells triggered the plasma cell response and renal damage in IL-17-deficient lupus mice.In reconstituted chimeric mice,IL-17RC deficiency resulted in severely impaired plasma cell generation but showed no obvious effect on germinal center B cells.Further mechanistic studies revealed that IL-17 significantly promoted plasma cell survival via p38-mediated Bcl-xL transcript stabilization.Together,our findings identified a novel function of IL-17 in enhancing plasma cell survival for autoantibody production in lupus pathogenesis,which may provide new therapeutic strategies for the treatment of SLE. | Kongyang Ma Wenhan Du Fan Xiao Man Han Enyu Huang Na Peng Yuan Tang Chong Deng Lixiong Liu Yulan Chen Jingjing Li Shiwen Yuan Qin Huang Xiaoping Hong Dajun Hu Xiaoyan Cai Quan Jiang Dongzhou Liu Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，7： | 6 |
| 6 | CiteOpinion: Evidence-based Evaluation Tool for Academic Contributions of Research Papers Based on Citing Sentences显示文摘Purpose:To uncover the evaluation information on the academic contribution of research papers cited by peers based on the content cited by citing papers,and to provide an evidencebased tool for evaluating the academic value of cited papers.Design/methodology/approach:CiteOpinion uses a deep learning model to automatically extract citing sentences from representative citing papers;it starts with an analysis on the citing sentences,then it identifies major academic contribution points of the cited paper,positive/negative evaluations from citing authors and the changes in the subjects of subsequent citing authors by means of Recognizing Categories of Moves(problems,methods,conclusions,etc.),and sentiment analysis and topic clustering.Findings:Citing sentences in a citing paper contain substantial evidences useful for academic evaluation.They can also be used to objectively and authentically reveal the nature and degree of contribution of the cited paper reflected by citation,beyond simple citation statistics.Practical implications:The evidence-based evaluation tool CiteOpinion can provide an objective and in-depth academic value evaluation basis for the representative papers of scientific researchers,research teams,and institutions.Originality/value:No other similar practical tool is found in papers retrieved.Research limitations:There are difficulties in acquiring full text of citing papers.There is a need to refine the calculation based on the sentiment scores of citing sentences.Currently,the tool is only used for academic contribution evaluation,while its value in policy studies,technical application,and promotion of science is not yet tested. | Xiaoqiu Le Jingdan Chu Siyi Deng Qihang Jiao Jingjing Pei Liya Zhu Junliang Yao | 2019 | Journal of Data and Information Science2019，4，4： | 6 |
| 7 | The cytotoxicity and protective effects of Astragalus membranaceus extracts and butylated hydroxyanisole on hydroxyl radical-induced apoptosis in fish erythrocytes显示文摘Erythrocytes play an essential role in transporting O_2 and CO_2 for respiration in fish. However,erythrocytes continuously suffer from reactive oxygen species(ROS)-induced oxidative stress and apoptosis. Thus, it is essential to expand our knowledge of how to protect erythrocytes against ROS-induced oxidative stress and apoptosis in fish. In this study, we explored the cytotoxicity and the effects of butylated hydroxyanisole(BHA), ethyl ether extracts, ethyl acetate extracts, acetone extracts(AE), ethanol extracts, and aqueous extracts of Astragalus membranaceus(EAm) on hydroxyl radical(·OH)-induced apoptosis in carp erythrocytes. The rat hepatocytes and carp erythrocytes were incubated with different concentrations of BHA or EAm(0.125 to 1 mg/mL). The toxicity in rat hepatocytes and carp erythrocytes was then measured using a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay and a haemolysis assay,respectively. The carp erythrocytes were treated with BHA or EAm in the presence of 40 μmol/L FeSO4 and20 μmol/L H_2 O_2 at 37℃, except for the control group. Oxidative stress and apoptosis parameters in the carp erythrocytes were then evaluated using the commercial kit. The results indicated that at high concentrations, BHA and EAm could induce toxicity in rat hepatocytes and fish erythrocytes. However, BHA was more toxic than EAm at the same concentrations. Moreover, the toxicity order of BHA and EAm in the fish erythrocytes approximately agreed with that for the rat hepatocytes. Butylated hydroxyanisole and EAm suppressed the ·OH-induced phosphatidylserine exposure and DNA fragmentation(the biomarkers of apoptosis) by decreasing the generation of ROS, inhibiting the oxidation of cellular components, and restoring the activities of antioxidants in carp erythrocytes. Of all of the examined EAm, the AE showed the strongest effects. The effects of AE on superoxide anion, H_2 O_2, met-haemoglobin and reduced glutathione levels, as well as glutathione reductase activity and apoptosis were equivalent to or stronger than those of BHA. These results revealed that the AE of Astragalus membranaceus could be used as a potential natural antioxidant or apoptosis inhibitor in fish erythrocytes. | Huatao Li Xiaoqiu Zhou Min Wu Mengling Deng Chao Wang Jingjing Hou Pengju Mou | 2016 | Animal Nutrition2016，，4： | 5 |
| 8 | Difference of a citrus late-ripening mutant (Citrus sinensis) from its parental line in sugar and acid metabolism at the fruit ripening stage显示文摘‘Fengjiewancheng’(FW) (Citrus sinensis), a bud sport of‘Fengjie 72-1’navel orange (FJ), ripens one month later than its parental line. Differences in sugar and acid content and the transcript level of su-crose- and citric-metabolic enzymes for the two cultivars were investigated during fruit ripening. Re-sults showed that both sugar and acid metabolisms of the mutant were affected by the mutation. In the pulp of FW, sugar content was significantly lower than that in FJ before 227 DAF (days after flowering) and higher at 263 DAF; the mutant’s gene expression of one isoform of citrus sucrose synthase (CitSS1) was delayed, and its gene expression of citrus acid invertase (CitAI) was stronger than that in its pa-rental cultivars at 207 and 263 DAF. In the peel, only the sucrose content in FW was significantly lower than those in FJ at the early periods of fruit ripening (165 and 187 DAF); however the transcripts of the sucrose-cleaving enzymes in the mutant were higher than those in FJ at different ripening points. As regards acid accumulation in the two cultivars, it was observed that in the pulp of the mutant, the malic acid content was significantly lower than that in its parental cultivars from 187 to 263 DAF, and in the peel, remarkably higher during the whole fruit ripening period. The citric acid content in both the pulp and the peel of FW was higher than that in those of FJ during the early ripening period and lower during the late ripening period, which were correspondingly associated in part with the higher transcript level of citrus mitochondrial citrate synthase (CitCS) and with lower or undetectable transcript level of citrus cytosolic aconitase (CitAC). Hence, it could be concluded that the mutation in FW affected sugar and acid metabolism, which might be related with other late-ripening phenotypes. | LIU YongZhong, LIU Qing, XIONG JingJing & DENG XiuXin National Key Laboratory of Crop Genetic Improvement College of Horticulture and Forestry Science, Huazhong Agricultural Uni-versity, Wuhan 430070, China | 2007 | Science China(Life Sciences)2007，50，4： | 5 |
| 9 | High efficiency production of ginsenoside compound K by catalyzing ginsenoside Rb1 using snailase显示文摘The rare ginsenoside Compound K(C-K) is attracting more attention because of its good physiological activity and urgent need. There are many pathways to obtain ginsenoside C-K, including chemical and biological methods. Among these, the conversion of PPD-type ginsenosides by enzymatic hydrolysis is a trend due to its high efficiency and mild conditions. For effectively extracting from the other panaxadiol saponins, the conversion process for ginsenoside C-K was investigated using snailases in this study. The univariate experimental design and response surface methodology were used to determine the optimal hydrolysis conditions for the conversion of ginsenoside Rb1 into ginsenoside C-K by snailases. The optimum conditions were as follows: p H 5.12, temperature 51 °C, ratio of snailase/substrate 0.21, and reaction time 48 h. On the basis of these parameters, the addition of 1.0 mmol·L^(-1) ferric ion was found to significantly improve the enzymolysis of snailases for the first time. With the above conditions, the maximum conversion rate reached 89.7%, suggesting that the process can obviously increase the yield of ginsenoside C-K. The bioassay tests indicated that the ginsenoside C-K showed anti-tumor activity in a series of tumor cell lines. Based on these results, we can conclude that the process of rare ginsenoside CK production by enzymolysis with snailase is feasible, efficient, and suitable for the industrial production and application. | Zhiguang Duan Chenhui Zhu Jingjing Shi Daidi Fan Jianjun Deng Rongzhan Fu Rong Huang Cuiying Fan | 2018 | Chinese Journal of Chemical Engineering2018，26，7： | 5 |
| 10 | Arabidopsis Blue Light Receptor Phototropin 1 Undergoes Blue Light-Induced Activation in Membrane Microdomains显示文摘Phototropin (辐透) 调停了发信号由蓝光(BL ) 开始了在在植物在血浆膜(下午) 优化光合的轻俘获起一个关键作用。然而,响应 BL 在 PM 位于辐透活动的规定下面的机制仍然保持大部分不清楚。在这研究,由单个粒子的追踪和 phot1-GFP 蛋白质的逐步的 photobleaching 分析,我们在黑暗 phot1 表明了那 ? 蛋白质留在一个不活跃的状态并且主要作为单体存在。Dimerization 和 phot1-GFP 的散开率响应 BL 以一种剂量依赖者方式增加了。相反, BL 没影响 kinase 不活跃的 phot1 D806N -GFP?but 确实提高了它的 dimerization,建议那 phot1 dimerization 独立于 phosphorylation。F ? rster 回声精力转移荧光一生成像显微镜学 ? 分析表明在 phot1-GFP 和充满甾醇的类脂化合物环境的一个标记之间的相互作用, AtRem1.3-mCherry,与 BL 处理的增加的时间被提高。然而,这个 BL 依赖的相互作用不在植物共同表示是明显的 phot1 D806N -GFP 和 AtRem1.3-mCherry,显示那 BL 便于功能的 phot1-GFP 的 translocation 进标记 AtRem1.3 的 microdomains 激活调停辐透的发信号。相反地,甾醇弄空稀释了 phot1-GFP 动力学, dimerization,和 phosphorylation。一起拿,这些结果显示膜 microdomains 充当在 PM 组织为激活的 phot1 的合适的功能必要的平台。 | Yiqun Xue Jingjing Xing Yinglang Wan Xueqin Lv Lusheng Fan Yongdeng Zhang Kai Song Li Wang Xiaohua Wang Xin Deng Frantisek Baluska John M. Christie Jinxing Lin | 2018 | Molecular Plant2018，11，6： | 4 |
| 11 | Carboxymethyl chitosan as a polyampholyte mediating intrafibrillar mineralization of collagen via collagen/ACP self-assembly显示文摘The significant role of the polyelectrolytic nature of non-collagenous proteins (NCPs) in regulating the in vivo mineralization of collagen provides important insights for scientists searching for analogues of NCPs to achieve in vitro collagen mineralization. Polyampholyte carboxymethyl chitosan (CMC) has both carboxyl and amino groups, which allows it to act as a cationic or anionic polyelectrolyte below or above its isoelectric point (IP), respectively. In this study, CMC was employed as the analogue of NCPs to stabilize amorphous calcium phosphate (ACP) under acidic conditions (pH < 3.5) via the formation of CMC/ACP nanocomplexes. In the presence of both ACP nanoparticles and acid collagen molecules, ACP nanoparticles could be integrated into collagen fibrils during the process of collagen self-assembly and achieve intrafibrillar mineralization of collagen in vitro (i.e., synchronous self-assembly/mineralization (SSM) of collagen). This mode of mineralization is different from established mechanisms in which mineralization follows the self-assembly (MFS) of collagen. Thus, SSM provides a new strategy for developing materials from mineralized collagen scaffolds. | Mingli Lin Huanhuan Liu Jingjing Deng Ran An Minjuan Shen Yanqiu Li Xu Zhang | 2019 | Journal of Materials Science & Technology2019，35，9： | 4 |
| 12 | A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis显示文摘 | Rui Liu Chunni Zhang Zhibin Hu Gou Li Cheng Wang Cuihua Yang Dingzhi Huang Xi Chen Haiyang Zhang Rui Zhuang Ting Deng Hua Liu Jingjing Yin Sufen Wang Ke Zen Yi Ba Chen-Yu Zhang | 2010 | European Journal of Cancer2010，，5： | 3 |
| 13 | A core-shell structured COYID-19 mRNA vaccine with favorable biodistribution pattern and promising immunity显示文摘Although inoculation of COVID-19 vaccines has rolled out globally,there is still a critical need for safe and effective vaccines to ensure fair and equitable supply for all countries.Here,we report on the development of a highly efficacious mRNA vaccine,SW0123 that is composed of sequence-modified mRNA encoding the full-length SARS-CoV-2 Spike protein packaged in core-shell structured lipopolyplex(LPP)nanoparticles.SWOT 23 is easy to produce using a large-scale microfluidics-based apparatus.The unique core-shell structured nanoparticle facilitates vaccine uptake and demonstrates a high colloidal stability,and a desirable biodistribution pattern with low liver targeting effect upon intramuscular administration.Extensive evaluations in mice and nonhuman primates revealed strong immunogenicity of SW0123,represented by induction of Th1-polarized T cell responses and high levels of antibodies that were capable of neutralizing not only the wild-type SARS-CoV-2,but also a panel of variants including D614G and N501Y variants.In addition,SW0123 conferred effective protection in both mice and non-human primates upon SARS-CoV-2 challenge.Taken together,SW0123 is a promising vaccine candidate that holds prospects for further evaluation in humans. | Ren Yang Yao Deng Baoying Huang Lei Huang Ang Lin Yuhua Li Wenling Wang Jingjing Liu Shuaiyao Lu Zhenzhen Zhan Yufei Wang Ruhan A Wen Wang Peihua Niu Li Zhao Shiqiang Li Xiaopin Ma Luyao Zhang Yujian Zhang Weiguo Yao Xingjie Liang Jincun Zhao Zhongmin Liu Xiaozhong Peng Hangwen Li Wenjie Tan | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 3 |
| 14 | Comparison of lentiviruses pseudotyped with S proteins from coronaviruses and cell tropisms of porcine coronaviruses显示文摘The surface glycoproteins of coronaviruses play an important role in receptor binding and cell entry. Different coronaviruses interact with their specific receptors to enter host cells. Lentiviruses pseudotyped with their spike proteins(S) were compared to analyze the entry efficiency of various coronaviruses. Our results indicated that S proteins from different coronaviruses displayed varied abilities to mediate pseudotyped virus infection. Furthermore, the cell tropisms of porcine epidemic diarrhea virus(PEDV) and transmissible gastroenteritis virus(TGEV) have been characterized by live and pseudotyped viruses. Both live and pseudoviruses could infected VeroCCL-81(monkey kidney), Huh-7(human liver), and PK-15(pig kidney) cells efficiently. CCL94(cat kidney) cells could be infected efficiently by TGEV but not PEDV. Overall, our study provides new insights into the mechanisms of viral entry and forms a basis for antiviral drug screening. | Jingjing Wang Feng Deng Gang Ye Wanyu Dong Anjun Zheng Qigai He Guiqing Peng | 2016 | Virologica Sinica2016，31，1： | 2 |
| 15 | The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules显示文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure. | Nuo Chen Jingjing Deng Shengjie Jiang Xiang-Yu Kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang | 2023 | Nano Research2023，16，1： | 2 |
| 16 | Pre- paration and characterization of the waterborne polyurethane modified with nanosilica显示文摘 | Chen Jingjing Zhu Chuanfang Deng Hongtao | 2009 | Polym Res2009，，16： | 1 |
| 17 | Metaanalysis of methylcobalamin alone and in combination with prostaglandin E1 in the treatment of diabetic peripheral neuropat hy显示文摘 | Deng HouLiang Yin JinJin Zhang JingJing | 2014 | Endocrine2014，46，3： | 1 |
| 18 | Preparation and Characterization of the Waterborne Polyurethane Modified Nanosilica显示文摘 | Chen Jingjing Zhu Chuanfang Deng Hongtao | 2009 | Polymer Research2009，16，： | 1 |
| 19 | Bacterial mukidrug el- flux pumps: Mechanisms, physiology and pharmacological ex- ploitations显示文摘 | Sun Jingjing Deng Ziqing Yan Aixin | 2014 | Biochem Biophys Res Commu2014，14，5： | 1 |
| 20 | Association Between Lipid Profiles and Left Ventricular Hypertrophy:New Evidence from a Retrospective Study显示文摘Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.Methods We conducted a retrospective observational study to investigate the relationship between lipid markers[including triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein(HDL)cholesterol,non-HDL-cholesterol,apolipoprotein A-I,apolipoprotein B,lipoprotein[a],and composite lipid profiles]and left ventricular hypertrophy.A total of 309,400 participants of two populations(one from Beijing and another from nationwide)who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study.7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy.Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the mterventricular septum or left ventricle posterior wall>11 mm.The Logistic regression model was used in the cross-sectional study.Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort.Results In the cross-sectional study for participants in the highest tertile of each lipid marker compared to the respective lowest,triglycerides[odds ratio(OR):1.2S0,95%CI:1.060 to 1.474],HDL-cholesterol(OR:0.780,95%CI:0.662 to 0.918),and lipoprotein(a)(OR:1.311,95%C7:1.115 to 1.541)had an association with left ventricular hypertrophy.In the longitudinal cohort,for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest,triglycerides[hazard ratio(HR):3.277,95%C/:1.720 to 6.244],HDL-cholesterol(HR:0.516,95%C7:0.283 to 0.940),non-HDL-cholesterol(HR:2.309,95%C/:1.296 to 4.112),apolipoprotein B(HR:2.244,95%CI:1.251 to 4.032)showed an association with new-onset left ventricular hypertrophy.In the Cox model with forward stepwise selection,triglycerides were the only lipid markers entered into the final model.Conclusion Lipids levels,especially triglycerides,are associated with left ventricular hypertrophy.Controlling triglycerides level potentiate to be a strategy in harnessing cardiac remodeling but deserve to be furdier investigated. | Xuewei Huang Keqiong Deng Juanjuan Qin Fang Lei Xingyuan Zhang Wenxin Wang Lijin Lin Yuming Zheng Dongai Yao Huiming Lu Feng Liu Lidong Chen Guilan Zhang Yueping Liu Qiongyu Yang Jingjing Cai Zhigang She Hongliang Li | 2022 | Chinese Medical Sciences Journal2022，37，2： | 1 |
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