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| 1 | Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis显示文摘Diabetic osteoporosis(DOP) is the leading complication continuously threatening the bone health of patients with diabetes. A key pathogenic factor in DOP is loss of osteocyte viability. However, the mechanism of osteocyte death remains unclear. Here, we identified ferroptosis, which is iron-dependent programmed cell death, as a critical mechanism of osteocyte death in murine models of DOP. The diabetic microenvironment significantly enhanced osteocyte ferroptosis in vitro, as shown by the substantial lipid peroxidation, iron overload, and aberrant activation of the ferroptosis pathway. RNA sequencing showed that heme oxygenase-1(HO-1) expression was notably upregulated in ferroptotic osteocytes. Further findings revealed that HO-1 was essential for osteocyte ferroptosis in DOP and that its promoter activity was controlled by the interaction between the upstream NRF2 and c-JUN transcription factors. Targeting ferroptosis or HO-1 efficiently rescued osteocyte death in DOP by disrupting the vicious cycle between lipid peroxidation and HO-1 activation, eventually ameliorating trabecular deterioration. Our study provides insight into DOP pathogenesis, and our results provide a mechanism-based strategy for clinical DOP treatment. | Yiqi Yang Yixuan Lin Minqi Wang Kai Yuan Qishan Wang Pei Mu Jingke Du Zhifeng Yu Shengbing Yang Kai Huang Yugang Wang Hanjun Li Tingting Tang | 2022 | Bone Research2022，10，3： | 19 |
| 2 | Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes显示文摘Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan(hydroxypropyltrimethyl ammonium chloride chitosan, HACC), could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes(NT-H). The titanium implant(Ti), nanotubes without polymer loading(NT), and nanotubes loaded with chitosan(NT-C) were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro.The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methicillin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections. | Ying Yang Haiyong Ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang | 2016 | Bone Research2016，4，3： | 9 |
| 3 | Wind Wave Characteristics and Engineering Environment of the South China Sea显示文摘Wave simulation was conducted for the period 1976 to 2005 in the South China Sea(SCS) using the wave model, WAVEWATCH-III. Wave characteristics and engineering environment were studied in the region. The wind input data are from the objective reanalysis wind datasets, which assimilate meteorological data from several sources. Comparisons of significant wave heights between simulation and TOPEX/Poseidon altimeter and buoy data show a good agreement in general. By statistical analysis, the wave characteristics, such as significant wave heights, dominant wave directions, and their seasonal variations, were discussed. The largest significant wave heights are found in winter and the smallest in spring. The annual mean dominant wave direction is northeast(NE) along the southwest(SW)-NE axis, east northeast in the northwest(NW) part of SCS, and north northeast in the southeast(SE) part of SCS. The joint distributions of wave heights and wave periods(directions) were studied. The results show a single peak pattern for joint significant wave heights and periods, and a double peak pattern for joint significant wave heights and mean directions. Furthermore, the main wave extreme parameters and directional extreme values, particularly for the 100-year return period, were also investigated. The main extreme values of significant wave heights are larger in the northern part of SCS than in the southern part, with the maximum value occurring to the southeast of Hainan Island. The direction of large directional extreme Hs values is focus in E in the northern and middle sea areas of SCS, while the direction of those is focus in N in the southeast sea areas of SCS. | WANG Zhifeng ZHOU Liangming DONG Sheng WU Lunyu LI Zhanbin MOU Lin WANG Aifang | 2014 | Journal of Ocean University of China2014，13，6： | 4 |
| 4 | Highly sensitive solar-blind deep ultraviolet photodetector based on graphene/PtSe_(2)/β-Ga_(2)O_(3)2D/3D Schottky junction with ultrafast speed显示文摘There is an emerging need for high-sensitivity solar-blind deep ultraviolet(DUV)photodetectors with an ultra-fast response speed.Although nanoscale devices based on Ga_(2)O_(3)nanostructures have been developed,their practical applications are greatly limited by their slow response speed as well as low specific detectivity.Here,the successful fabrication of two-/three-dimensional(2D/3D)graphene(Gr)/PtSe2/β-Ga_(2)O_(3)Schottky junction devices for high-sensitivity solar-blind DUV photodetectors is demonstrated.Benefitting from the high-quality 2D/3D Schottky junction,the vertically stacked structure,and the superior-quality transparent graphene electrode for effective carrier collection,the photodetector is highly sensitive to DUV light illumination and achieves a high responsivity of 76.2 mA/W,a large on/off current ratio of~105,along with an ultra-high ultraviolet(UV)/visible rejection ratio of 1.8×104.More importantly,it has an ultra-fast response time of 12µs and a remarkable specific detectivity of~1013 Jones.Finally,an excellent DUV imaging capability has been identified based on the Gr/PtSe2/β-Ga_(2)O_(3)Schottky junction photodetector,demonstrating its great potential application in DUV imaging systems. | Di Wu Zhihui Zhao Wei Lu Lukas Rogée Longhui Zeng Pei Lin Zhifeng Shi Yongtao Tian Xinjian Li Yuen Hong Tsang | 2021 | Nano Research2021，14，6： | 4 |
| 5 | Characterization of oil component and solid particle of oily sludge treated by surfactant-assisted ultrasonication显示文摘The ultrasonic technique has been demonstrated to be a promising method for the disposal of hazardous oily sludge.However,the separation of oil from the surfaces of the solid particles is still difficult due to the strong interaction between the oil and solid particle.In this study,three types of surfactants were used to assist the ultrasonic treatment of oily sludge.The oil component,surface composition,and structure of the solid particle were determined.The results showed that different surfactants had different oil removal abilities.In the three surfactant-assisted sonication systems,the oil removal rate increased during the starting reaction period and then decreased with longer sonication time.The results of four components analysis suggested that surfactant easy to be ionized in water posed a better removal effect on resins,while the amphiphilic surfactant preferred saturates,aromatics and asphaltenes.The morphology analysis indicated that particle size was shattered into smaller ones by the ultrasonic process,and the wettability of the solid surface also changed during this treatment.The characterization of the oil component and solid particle during surfactant-assisted ultrasonication treatment will help to better understand the separation of oil from oily sludge and improve the oil recovery efficiency from oily sludge. | Zuhong Lin Fushuai Xu Lili Wang Liyang Hu Lingfu Zhu Jie Tan Zhifeng Li Tingting Zhang | 2021 | Chinese Journal of Chemical Engineering2021，34，6： | 2 |
| 6 | Preparation of Au NPs/ZnO NTs Hybrid Array and Its Photo Catalytic Performance for MO显示文摘X-ray diffraction, scanning electron microscopy and transmission electron microscopy were employed to investigate the microstructure and morphology of Au NPs/ZnO NTs, and their photo-catalytic capability was assessed to a nicety. The results demonstrated that the diameter and the wall thickness of ZnO nanotube were about 200 and 50 nm, respectively. The diameter of Au nanoparticle was about 30 nm. The characterization on the photo-catalytic capability of the Au-ZnO nanotube hybrid indicated that the degradation of methyl orange was 80% within 4 h. Controlled experiments have shown that Au-Zn O nanotube hybrid presents superior photo-catalytic capability to both bare ZnO nanorod and Au-ZnO nanorod hybrid indicated that the degradation procedure of methyl orange. | 曾天 WEI Jin LIU Lin DENG Jiatao ZHENG Gang ZHANG Pei NIU Tongjun JIAO Zhifeng JIN Yong 孙小松 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，3： | 2 |
| 7 | Biodegradation of polycyclic aromatic hydrocarbons in sediments from the Daliao River watershed, China显示文摘The Daliao River, as an important water system in Northeast China, was reported to be heavily polluted by polycyclic aromatic hydrocarbons (PAHs). Aerobic biodegradations of four selected PAHs (naphthalene, phenanthrene, uorene and anthracene) alone or in their mixture in river sediments from the Daliao River water systems were studied in microcosm systems. Eects of additional carbon source, inorganic nitrogen and phosphorus, temperature variation on PAHs degradation were also investigated. Results showed that the degradation of phenanthrene in water alone system was faster than that in water-sediment combined system. Degradation of phenanthrene in sediment was enhanced by adding yeast extract and ammonium, but retarded by adding sodium acetate and not significantly inuenced by adding phosphate. Although PAHs could also be biodegraded in sediment under low temperature (5°C), much lower degradation rate was observed. Sediments from the three main streams of the Daliao River water system (the Hun River, the Taizi River and the Daliao River) demonstrated dierent degradation capacities and patterns to four PAHs. Average removal rates (15 or 19 d) of naphthalene, phenanthrene, uorene and anthracene by sediment were in the range of 0.062-0.087, 0.005-0.066, 0.008- 0.016 and 0-0.059 mg/(L·d), respectively. As a result, naphthalene was most easily degraded compound, anthracene was the hardest one. In multiple PAHs systems, the interactions between PAHs inuenced each PAH biodegradation. | QUAN Xiangchun, TANG Qian, HE Mengchang, YANG Zhifeng, LIN Chunye, GUO Wei State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Beijing Normal University, Beijing 100875, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 2 |
| 8 | Kinetics of methanol steam reforming over COPZr-2 catalyst显示文摘COPZr-2 催化剂,在我们的前期研究被准备,在改革反应的甲醇蒸气显示出好催化性能。在这篇文章,最好的被选择为一个例子学习在这类催化剂上改过的甲醇蒸气的反应动力学。首先,到插头公司的甲醇变换的效果 2 和甲醇变换到甲醇上的插头公司假接触时间 W/F MeOH 被调查。然后,由使用反应线路,直接改过的那甲醇(医生) 和甲醇分解(DE ) 在平行被执行,反应有力量功能类型的运动模型被建立。并且为模型的参数用计算了定义对象函数的加权的最少的广场的一个非线性的回归程序被估计。最后,运动模型通过了关联测试和 F-test。 | Yongfeng Li Weiming Lin Lin Yu Zhifeng Hao Rongjian Mai | 2008 | Journal of Natural Gas Chemistry2008，17，2： | 2 |
| 9 | On-chip solid phase extraction coupled with electrophoresis using modified magnetic microspheres as stationary phase显示文摘A poly(dimethylsiloxane)(PDMS)/glass hybrid microchip for on-line solid phase extraction (SPE) and electrophoresis separation has been developed and evaluated. The SPE microchannel was crossed to the electrophoresis microchannel. All the microfluidic channels were etched on the glass substrate. The magnetic microspheres were coated with hydroxyl-terminated poly-dimethylsiloxane (PDMS-OH) serving as extraction phase,which could be conveniently immobilized into the sample pretreatment channel by magnetic field. The PDMS-OH microspheres were mobilized into and out of the pretreatment channel by injection flow. The 0.1 μmol/L solution of fluorescence isothiocyanate (FITC)-labeled phenylalanine (Phe) was electrically injected into the SPE channel and extracted onto the PDMS-OH microspheres bed. The enriched FITC-labeled Phe was electrically eluted by 9 mmol/L sodium acetate containing 10% acetonitrile and electrically driven into the electrophoresis channel and then separated. The preconcentration factor could reach 87.5 after sufficient extraction. A linear preconcentration curve was obtained with the initial FITC-labeled Phe concentration ranging from 6 nmol/L to 300 nmol/L (R2=0.9922) with 200 s loading time. The detection limit (S/N=3) for the FITC-labeled Phe was 3 nmol/L. | LI Hong LI HaiFang CHEN ZhiFeng LIN JinMing | 2009 | Science China Chemistry2009，52，12： | 2 |
| 10 | Sampling average approximation method for a class of stochastic Nash equilibrium problems显示文摘 | Li Peiyu He Zhifeng Lin Guihua | 2013 | Optimization Methods and Software2013，28，4： | 1 |
| 11 | Temporal and spatial distribution of dissolved oxygen in the Pearl River Estuary and adjacent coastal waters显示文摘 | Y1N KEDONG LIN ZHIFENG KE ZHIYUAN | 2004 | Continental Shelf Research2004，24，： | 1 |
| 12 | G6:A web-based library for graph visualization显示文摘Authoring graph visualization poses great challenges to developers due to its high requirements on both domain knowledge and development skills.Although existing libraries and tools reduce the difficulty of generating graph visualization,there are still many challenges.We work closely with developers and formulate several design goals,then design and implement G6,a web-based library for graph visualization.It combines template-based configuration for high usability and flexible customization for high expressiveness.To enhance development efficiency,G6 proposes a range of optimizations,including state management and interaction modes.We demonstrate its capabilities through an extensive gallery,a quantitative performance evaluation,and an expert interview.G6 was first released in 2017 and has been iterated for 317 versions.It has served as a web-based library for thousands of applications and received 8312 stars on GitHub. | Yanyan Wang Zhanning Bai Zhifeng Lin Xiaoqing Dong Yingchaojie Feng Jiacheng Pan Wei Chen | 2021 | Visual Informatics2021，5，4： | 1 |
| 13 | Microstructure and Mechanical Property of In Situ Synthesized Multiple-Reinforced (TiB + TiC + La2 O3 )/Ti Composites 显示文摘 | Yang Zhifeng Lu Weijie Zhao Lin | 2008 | Journal of AUoys and Compounds2008，455，12： | 1 |
| 14 | Vacuumassisted thermal bonding of plastic capillary electrophoresis microchip imprinted with stainless steel template显示文摘 | CHEN Zhifeng GAO Yunhua LIN Jinming | 2004 | J Chromatogr A2004，1038，12： | 1 |
| 15 | Vacuum- Assisted Thermal Bonding of Plastic Capillary Electrophoresis Microchip Imprinted with Stainless Steel Template显示文摘 | Chen Zhifeng Gao Yunhua Lin Jinming | 2004 | Journal of Chromatography A2004，1038，12： | 1 |
| 16 | Heavy metal contamination in the sediment of the Second Songhua River显示文摘 | Chunye LIN Mengchang HE Baixing YAN Xiangchun QUAN Yuxiang ZHOU Wei GUO Zhifeng YANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 17 | Hibernator: helping disk arrays sleep through the winter 显示文摘 | Zhu Qingbo Chen Zhifeng Tan Lin | 2005 | Operating Systems Review (ACM)2005，39，5： | 1 |
| 18 | Sequence architecture and depositional evolution of the O rdovician carbonate platform margins in the T arim B asin and its response to tectonism and sea‐level change显示文摘 | Changsong Lin Haijun Yang Jingyan Liu Zhifeng Rui Zhenzhong Cai Sitian Li Bingsong Yu | 2011 | Basin Res2011，，： | 1 |
| 19 | Phosphorus sorption and fraction characteristics in the upper, middle and low reach sediments of the Daliao river systems, China 显示文摘 | Lin Chunye Wang Zhigang He Mengchang Li Yanxia Liu Ruimin Yang Zhifeng | 2009 | J Hazard Mater2009，170，1： | 1 |
| 20 | Phosphorus sorption and fraction characteristics in the upper, middle and low reach sediments of the Daliao river systems, China显示文摘 | Chunye Lin Zhigang Wang Mengchang He Yanxia Li Ruimin Liu Zhifeng Yang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
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