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| 1 | China National Medical Products Administration approval summary:anlotinib for the treatment of advanced non-small cell lung cancer after two lines of chemotherapy显示文摘Background:On May 8,2018,the China National Medical Products Administration(NMPA)approved anlotinib,an orally administered anti-angiogenesis inhibitor,for the treatment of patients with advanced non-small cell lung can-cer(NSCLC)who have progressed after treatment with two or more lines of prior systemic chemotherapy.Main body of the abstract:China NMPA reviewed and inspected a regional double-blinded,placebo-controlled,Phase III trial comparing the overall survival(OS)of NSCLC patients between the anlotinib and placebo arms.A total of 437 patients were randomized(2:1)to receive either anlotinib(n=294)or placebo(n=143)once daily on a 2-week on and 1-week off schedule.Patients with epidermal growth factor receptor(EGFR)or activating anaplastic lymphoma kinase(ALK)genomic tumor aberrations should have disease progression on NMPA-approved therapy.Anlotinib is the first NMPA-approved drug for patients with advanced NSCLC who have progressed on at least two lines of prior systemic chemotherapies in China.The approval was based on a statistically and clinically significant improvement in median OS with anlotinib(9.46 months)compared with placebo[6.37 months;hazard ratio(HR])=0.70,95%confidence interval(CI)=0.55-0.89;two-sided log-rank P=0.002].The confirmed objective response rate(ORR)was 9.2%in the anlotinib arm and 0.7%in the placebo arm.The median duration of response(DoR)was 4.83 months,with a 95%CI of 3.31-6.97 months.The toxicity profile of anlotinib was consistent with that of known anti-angiogenesis inhibitors.Common adverse drug reactions(ADRs)in anlotinib-treated patients included hypertension(67.4%),hand-foot syndrome(43.9%),hemoptysis(14.0%),thyroid stimulating hormone(TSH)elevation(46.6%),and corrected QT interval(QTc)prolongation(26.2%).Short conclusion:Anlotinib demonstrated a clinically significant OS prolongation as a novel therapeutic option for advanced or metastatic NSCLC following at least two lines of chemotherapy. | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | Cancer Communications2019，39，1： | 35 |
| 2 | Adaptive Sliding Mode Control for Re-entry Attitude of Near Space Hypersonic Vehicle Based on Backstepping Design显示文摘Combining sliding mode control method with radial basis function neural network(RBFNN), this paper proposes a robust adaptive control scheme based on backstepping design for re-entry attitude tracking control of near space hypersonic vehicle(NSHV) in the presence of parameter variations and external disturbances. In the attitude angle loop, a robust adaptive virtual control law is designed by using the adaptive method to estimate the unknown upper bound of the compound uncertainties. In the angular velocity loop, an adaptive sliding mode control law is designed to suppress the effect of parameter variations and external disturbances. The main benefit of the sliding mode control is robustness to parameter variations and external disturbances. To further improve the control performance, RBFNNs are introduced to approximate the compound uncertainties in the attitude angle loop and angular velocity loop, respectively. Based on Lyapunov stability theory, the tracking errors are shown to be asymptotically stable. Simulation results show that the proposed control system attains a satisfied control performance and is robust against parameter variations and external disturbances. | Jingmei Zhang Changyin Sun Ruimin Zhang Chengshan Qian | 2015 | IEEE/CAA Journal of Automatica Sinica2015，2，1： | 30 |
| 3 | Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats显示文摘It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuronal injury in a rat model of vascular dementia. In model rats, hippocampal CA1 neurons were severely damaged, and expression of the autophagy-related proteins beclin-1, cathepsin B and microtubule-associated protein 1 light chain 3 was elevated compared with that in sham-operated animals. These responses were suppressed in animals that received a single intraperitoneal injection of wortmannin, an autophagy inhibitor, prior to model establishment. The present results confirm that autophagy and autophagy-related proteins are involved in the pathological changes of vascular dementia, and that inhibition of autophagy has neuroprotective effects. | Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang | 2014 | Neural Regeneration Research2014，9，13： | 25 |
| 4 | Second-order terminal sliding mode control for hypersonic vehicle in cruising flight with sliding mode disturbance observer显示文摘This paper focuses on the design of nonlinear robust controller and disturbance observer for the longitudinal dynamics of a hypersonic vehicle (HSV) in the presence of parameter uncertainties and external disturbances. First, by combining terminal sliding mode control (TSMC) and second-order sliding mode control (SOSMC) approach, the second-order terminal sliding control (2TSMC) is proposed for the velocity and altitude tracking control of the HSV. The 2TSMC possesses the merits of both TSMC and SOSMC, which can provide fast convergence, continuous control law and high-tracking precision. Then, in order to increase the robustness of the control system and improve the control performance, the sliding mode disturbance observer (SMDO) is presented. The closed-loop stability is analyzed using the Lyapunov technique. Finally, simulation results illustrate the effectiveness of the proposed method, as well as the improved overall performance over the conventional sliding mode control (SMC). | Ruimin ZHANG Changyin SUN Jingmei ZHANG Yingjiang ZHOU | 2013 | 控制理论与应用(英文版)2013，11，2： | 22 |
| 5 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 6 | Insights into epigenetic patterns in mammalian early embryos显示文摘Mammalian fertilization begins with the fusion of two specialized gametes,followed by major epigenetic remodeling leading to the formation of a totipotent embryo.During the development of the pre-implantation embryo,precise reprogramming progress is a prerequisite for avoiding developmental defects or embryonic lethality,but the underlying molecular mechanisms remain elusive.For the past few years,unprecedented breakthroughs have been made in mapping the regulatory network of dynamic epigenomes during mammalian early embryo development,taking advantage of multiple advances and innovations in low-input genome-wide chromatin analysis technologies.The aim of this review is to highlight the most recent progress in understanding the mechanisms of epigenetic remodeling during early embryogenesis in mammals,including DNA methylation,histone modifications,chromatin accessibility and 3D chromatin organization. | Ruimin Xu Chong Li Xiaoyu Liu Shaorong Gao | 2021 | Protein & Cell2021，12，1： | 13 |
| 7 | Effects of long-term warming on the aboveground biomass and species diversity in an alpine meadow on the Qinghai-Tibetan Plateau of China显示文摘Ecosystems in high-altitude regions are more sensitive and respond more rapidly than other ecosystems to global climate warming.The Qinghai-Tibet Plateau(QTP)of China is an ecologically fragile zone that is sensitive to global climate warming.It is of great importance to study the changes in aboveground biomass and species diversity of alpine meadows on the QTP under predicted future climate warming.In this study,we selected an alpine meadow on the QTP as the study object and used infrared radiators as the warming device for a simulation experiment over eight years(2011-2018).We then analyzed the dynamic changes in aboveground biomass and species diversity of the alpine meadow at different time scales,including an early stage of warming(2011-2013)and a late stage of warming(2016-2018),in order to explore the response of alpine meadows to short-term(three years)and long-term warming(eight years).The results showed that the short-term warming increased air temperature by 0.31℃and decreased relative humidity by 2.54%,resulting in the air being warmer and drier.The long-term warming increased air temperature and relative humidity by 0.19℃and 1.47%,respectively,and the air tended to be warmer and wetter.The short-term warming increased soil temperature by 2.44℃and decreased soil moisture by 12.47%,whereas the long-term warming increased soil temperature by 1.76℃and decreased soil moisture by 9.90%.This caused the shallow soil layer to become warmer and drier under both short-term and long-term warming.Furthermore,the degree of soil drought was alleviated with increased warming duration.Under the long-term warming,the importance value and aboveground biomass of plants in different families changed.The importance values of grasses and sedges decreased by 47.56%and 3.67%,respectively,while the importance value of weeds increased by 1.37%.Aboveground biomass of grasses decreased by 36.55%,while those of sedges and weeds increased by 8.09%and 15.24%,respectively.The increase in temperature had a non-significant effect on species diversity.The species diversity indices increased at the early stage of warming and decreased at the late stage of warming,but none of them reached significant levels(P>0.05).Species diversity had no significant correlation with soil temperature and soil moisture under both short-term and long-term warming.Soil temperature and aboveground biomass were positively correlated in the control plots(P=0.014),but negatively correlated under the long-term warming(P=0.013).Therefore,eight years of warming aggravated drought in the shallow soil layer,which is beneficial for the growth of weeds but not for the growth of grasses.Warming changed the structure of alpine meadow communities and had a certain impact on the community species diversity.Our studies have great significance for the protection and effective utilization of alpine vegetation,as well as for the prevention of grassland degradation or desertification in high-altitude regions. | WEN Jing QIN Ruimin ZHANG Shixiong YANG Xiaoyan XU Manhou | 2020 | Journal of Arid Land2020，12，2： | 11 |
| 8 | Runoff reduction due to environmental changes in the Sanchuanhe river basin显示文摘Recently,runoff in many river basins in China has been decreasing.Therefore,the role that climate change and human activities are playing in this decrease is currently of interest.In this study,we evaluated an assessment method that was designed to quantitatively separate the effects of climate change and human activities on runoff in river basins.Specifically,we calibrated the SIMHYD rainfall runoff model using naturally recorded hydro-meteorologic data pertaining to the Sanchuanhe River basin and then determined the effects of climate change and human activities on runoff by comparing the estimated natural runoff that occurred during the period in which humans disturbed the basin to the runoff that occurred during the period prior to disturbance by humans.The results of this study revealed that the SIMHYD rainfall runoff model performs well for estimating monthly discharge.In addition,we found that absolute runoff reductions have increased in response to human activities and climate change,with average reductions of 70.1% and 29.9% in total runoff being caused by human activities and climate change,respectively.Taken together,the results of this study indicate that human activities are the primary cause of runoff reduction in the Sanchuanhe River basin. | Guoqing WANG Jianyun ZHANG Ruimin HE Naiqian JIANG Xin'ai JING | 2008 | International Journal of Sediment Research2008，23，2： | 9 |
| 9 | Historical Transformation of China's Agriculture" Productivity Changes and Other Key Features显示文摘 | Shouying Liu Ruimin Wang Guang Shi | 2018 | China & World Economy2018，26，1： | 9 |
| 10 | 中国国家药品监督管理局批准安罗替尼用于经两种系统化疗后疾病进展的晚期非小细胞肺癌的治疗显示文摘背景2018年5月8日,中国国家药品监督管理局(National Medical Products Administration,NMPA)批准了小分子多靶点抗血管抑制剂盐酸安罗替尼,用于既往经过至少两种系统化疗后疾病进展的晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的治疗。概要中国NMPA审查了一项随机双盲、安慰剂对照的III期临床试验,该临床试验的主要终点为总生存期(overall survival,OS)。试验共纳入437例患者随机分组(2∶1)接受安罗替尼(n=294)或安慰剂(n=143)治疗,每日1次,连服2周,停药1周。表皮生长因子受体(epidermal growth factor receptor,EGFR)基因敏感突变或间变性淋巴瘤激酶(activating anaplasticlymphomakinase,ALK)阳性的患者须经过NMPA已批准的药物治疗后出现疾病进展。安罗替尼为中国NMPA批准的用于治疗既往经过两种及以上系统化疗后疾病进展的晚期NSCLC患者的首个药物。安罗替尼组的中位OS(9.46个月)较安慰剂组[6.37个月;风险比(hazard ratio,HR)=0.70,95%置信区间(confidence Interval,CI):0.55–0.89;双侧log-rank P=0.002]显著延长。安罗替尼组的客观缓解率(objective responserate,ORR)为9.2%,安慰剂组为0.7%。安罗替尼组的中位缓解持续时间(durationofresponse,DoR)为4.83个月,95%CI为3.31–6.97个月。安罗替尼的常见不良反应(adverse drug reactions,ADRs)包括高血压(67.4%)、手足综合征(43.9%)、咳血(14.0%)、促甲状腺激素(thyroid stimulating hormone,TSH)升高(46.6%)、心电图QT间期(corrected QT Interval,QTc)延长(26.2%)。结论安罗替尼显著延长了患者的OS,可作为经二线及以上化疗后晚期或转移性非小细胞肺癌的一种新的治疗方案。 | Ming Zhou Xiaoyuan Chen Hong Zhang Lin Xia Xin Tong Limin Zou Ruimin Hao Jianhong Pan Xiao Zhao Dongmei Chen Yuanyuan Song Yueli Qi Ling Tang Zhifang Liu Rong Gao Yuankai Shi Zhimin Yang | 2019 | 癌症2019，38，12： | 7 |
| 11 | Ternary Organic Solar Cells Based on Two Non-fullerene Acceptors with Complimentary Absorption and Balanced Crystallinity显示文摘Summary of main observation and conclusion The ternary blend structure has been demonstrated as an effective approach to increase the power conversion efficiency of organic solar cells.An effective approach to enhance the power conversion efficiency of ternary solar cells is based on two non-fullerene acceptors with complimentary absorption range and balanced crystallinity.In this work,we have introduced a high crystallinity small-molecule acceptor,named C8IDTT-4CI with appropriate alkyl side chains into a low crystalline blend of conjugated polymer donor PBDT-TPD and fused-ring electron acceptor ITIC-4F.A ternary device based on the blend PBDT-TPD:1TIC-4F:C81DTT-4CI exhibits a best power conversion efficiency of 9.51%with a simultaneous improvement of the short-circuit current density to 18.76 mA-cm^-2 and the fill factor up to 67.53%.The absorption onset for C8IDTT-4CI is located at 900 nm,so that the well complementary light absorption is beneficial to the photocurrent.In addition,the existence of high crystallinity C8IDTT-4CI in the ternary device is found helpful to modulate crystallinity,improve heterojunction morphologies and stacking structure,therefore to realize higher charge mobility and better performance. | Lan Xie Chen Yang Ruimin Zhou Zhen Wang Jianqi Zhang Kun Lu Zhixiang Wei | 2020 | Chinese Journal of Chemistry2020，38，9： | 7 |
| 12 | Location-aided and secure routing protocol for heterogeneous multi-hop wireless networks显示文摘Most of the existing routing protocols for heterogeneous multi-hop wireless networks(HWMNs) use on-demand routing protocols owing to their suitability for dynamic topology environments, but it causes wastes of network resources with large number of data packets being broadcast. Furthermore, some nodes in heterogeneous wireless multi-hop networksmay be malicious or selfish nodes which can easily lead to link attacks. A novel routing protocol called trust-based secure routing protocol with auxiliary of nodes' location information(TSRAL) is proposed for the establishment of a secure routing protocol with a lower overhead for HWMNs which combines the location information and trust value of nodes to select the next forwarding nodes. The destination node selects an optimal path from multiple paths according to the total trust value and the hop number of routes. Simulation results demonstrate that TSRAL can not only reduce the number of hops and data packets being broadcast in the process of routing but also ensure the safety of the route. | Bai Yuan Hao Ruimin An Jie Zhang Huibing | 2016 | The Journal of China Universities of Posts and Telecommunications2016，23，1： | 5 |
| 13 | Adaptive Nonsingular Terminal Sliding Mode Control Design for Near Space Hypersonic Vehicles显示文摘This paper presents an adaptive nonsingular terminal sliding mode approach for the attitude control of near space hypersonic vehicles(NSHV) in the presence of parameter uncertainties and external disturbances. Firstly, a novel nonsingular terminal sliding surface is developed and its finitetime convergence is analyzed. Then, an adaptive nonsingular terminal sliding mode control law is proposed, which is chattering free. In the proposed approach, all parameter uncertainties and external disturbances are lumped into one term, which is estimated by an adaptive uncertainty estimation for eliminating the boundary requirement needed in the conventional control design. Subsequently, stability of the closed-loop system is proven based on Lyapunov theory. Finally, the proposed approach is applied to the attitude control design for NSHV. Simulation results show that the proposed approach attains a satisfactory performance in the presence of parameter uncertainties and external disturbances. | Ruimin Zhang Lu Dong Changyin Sun | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，2： | 4 |
| 14 | Multiple Feature Fusion in Convolutional Neural Networks for Action Recognition显示文摘Action recognition is important for understanding the human behaviors in the video,and the video representation is the basis for action recognition.This paper provides a new video representation based on convolution neural networks(CNN).For capturing human motion information in one CNN,we take both the optical flow maps and gray images as input,and combine multiple convolutional features by max pooling across frames.In another CNN,we input single color frame to capture context information.Finally,we take the top full connected layer vectors as video representation and train the classifiers by linear support vector machine.The experimental results show that the representation which integrates the optical flow maps and gray images obtains more discriminative properties than those which depend on only one element.On the most challenging data sets HMDB51 and UCF101,this video representation obtains competitive performance. | LI Hongyang CHEN Jun HU Ruimin | 2017 | Wuhan University Journal of Natural Sciences2017，22，1： | 4 |
| 15 | Speech wideband extension based on Gaussian mixture model显示文摘减少光谱 highband 信封的失真,功能光谱在特征向量和 highband 信封之间的失真和相互的信息被学习,并且一个扩大 Gaussian 混合模型(GMM ) 带宽延期算法基于研究被建议。与 highband 信封有更大的相互的信息的特征参数被选择组成特征向量,并且 GMM 被采用计算特征向量和 highband 信封的联合概率密度。然后, highband 信封经由从期望最大化(他们) 算法估计的模型参数计算的以后的可能性被估计。试验性的结果证明光谱失真比算法低,例如传统的算法基于 GMM,由 0.3 dB 和框架与的数字光谱在 10 dB 上的失真严厉地减少了超过 50% 。 | ZHANG Yong HU Ruimin | 2009 | Chinese Journal of Acoustics2009，28，4： | 4 |
| 16 | Consumption Structure of Migrant Worker Families in China显示文摘这研究越过在中国城市化区域的四个学生在候鸟的调查上收 12 个城市并且调查城市的候鸟工人家庭和农村消费的结构。结果证明候鸟工人家庭消费的结构被幸存消费统治了。当在他们的农村自已出生的市镇从事明显的消费时,这些家庭趋于节约地住在城市。候鸟工人家庭消费的结构被他们的收入稳定性和财富层次而非他们的当前的收入水平主要塑造。而且,有打算在城市里永久地安定的高教育的层次和那些的候鸟工人家庭是可能的分配实质的开销到地位和快乐消费并且升级他们的城市的消费结构。 | Guangzhong Cao Kai Li Ruimin Wang Tao Liu | 2017 | China & World Economy2017，25，4： | 4 |
| 17 | Fluorination-substitution effect on all-small-molecule organic solar cells显示文摘Due to the strong crystallinity and anisotropy of small molecules, matched molecular photoelectric properties and morphologies between small molecules and non-fullerene acceptors are especially important in all-small-molecule organic solar cells(OSCs).Introducing fluorine atoms has been proved as an effective strategy to achieve a high device performance through tuning molecular energy levels, absorption and assembly properties. Herein, we designed a novel benzodithiophene-based small molecule donor BDTF-CA with deep highest occupied molecular orbital(HOMO) energy level. All-small-molecule OSCs were fabricated by combing non-fullerene acceptor IDIC with different fluorine-atom numbers. Two or four fluorine atoms were introduced to the end-capped acceptor of IDIC, which are named as IDIC-2 F and IDIC-4 F, respectively. With the increase of fluorination from IDIC to IDIC-4 F, the open circuit voltage(Voc) of the devices decreased, while hole and electron mobilities of the active layers increased by one order of magnitude. Contributed to the most balanced Voc, short-circuit current(Jsc) and fill factor(FF), the device based on BDTF-CA/IDIC-2 F achieved the highest power conversion efficiency of 9.11%. | Qiong Wu Dan Deng Jianqi Zhang Wenjun Zou Yang Yang Zhen Wang Huan Li Ruimin Zhou Kun Lu Zhixiang Wei | 2019 | Science China Chemistry2019，62，7： | 3 |
| 18 | Combining chlorination and sulfuration strategies for high-performance all-small-molecule organic solar cells显示文摘Three small-molecule donors based on dithieno [2,3-d:2’,3 ’-d’]-benzo[1,2-b:4,5-b’] dithiophene(DTBDT)unit were designed and synthesized by side chain regulation with chlorinated or/and sulfurated substitutions(namely ZR1,ZR1-Cl,and ZR1-S-Cl respectively),along with a crystalline non-fullerene acceptor IDIC-4 Cl with a chlorinated 1,1-dicyanomethylene-3-indanone(IC) end group.Energy levels,molar extinction coefficients and crystallinities of three donor molecules can be effectively altered by combining chlorination and sulfuration strategies.Especially,the ZR1-S-Cl exhibited the best absorption ability,lowest higher occupied molecular orbital(HOMO) energy level and highest crystallinity among three donors,resulting in the corresponding all-small-molecule organic solar cells to produce a high power conversion efficiency(PCE) of 12.05% with IDIC-4 Cl as an acceptor. | Ruimin Zhou Chen Yang Wenjun Zou Muhammad Abdullah Adil Huan Li Min Lv Ziyun Huang Menglan Lv Jianqi Zhang Kun Lu Zhixiang Wei | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 19 | Facile synthesis of porous nitrogen-doped holey graphene as an efficient metal-free catalyst for the oxygen reduction reaction显示文摘做氮的 graphene 是为氧减小反应(ORR ) 的高贵基于金属的 electrocatalysts 的代替的一个有希望的候选人。进做氮的 graphene 的毛孔和洞的增加由介绍丰富的暴露的边提高 ORR 活动,加速集体转移,并且阻碍 graphene 表的聚集。此处,我们在场为经由脲和镁醋酸盐 tetrahydrate 的热分解产生多孔的有穴的做氮的 graphene (PHNG ) 的直接却有效的策略。由于联合效果在里面 situ 产生了气体和 MgO nanoparticles,综合 PHNG 在弄皱的 graphene 之中展示了不仅众多的 out-of-plane 毛孔在装配 graphene 的表,而且贯穿的 nanoscale (5-15 nm ) 洞。而且,做 PHNG 的配置的氮被 thermal 以后处理在不同温度优化。pyridinic 和第四级的氮的全面内容断然与 ORR 活动相关,这被发现;特别地, pyridinic 氮为 ORR 产生最理想的特征。这个工作为基于 PHNG 的材料的合成揭示新线路并且阐明到 ORR 的各种各样的氮种类的贡献。 | Li Qin Ruimin Ding Huixiang Wang Jianghong Wu Conghui Wang Chenghua Zhang Yao Xu Liancheng Wang Baoliang Lv | 2017 | Nano Research2017，10，1： | 3 |
| 20 | Assessment of effects of best management practices on agricultural non-point source pollution in Xiangxi River watershed显示文摘 | Ruimin Liu Peipei Zhang Xiujuan Wang Yaxin Chen Zhenyao Shen | 2013 | Agricultural Water Management2013，，： | 3 |
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