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| 1 | Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response显示文摘AIM: To evaluate the epithelial-to-mesenchymal transition(EMT) of circulating tumor cells(CTCs) in gastric cancer patients.METHODS: We detected tumor cells for expression of four epithelial(E^+) transcripts(keratins 8, 18, and 19 and epithelial cell adhesion molecule) and two mesenchymal(M^+) transcripts(Vimentin and Twist) by a quantifiable, dual-colorimetric RNA-in situ hybridization assay. Between July 2014 and October 2014, 44 patients with gastric cancer were recruited for CTC evaluation. Blood samples were obtained from selected patients during the treatment course [before surgery, after surgery and at the 6^(th) cycle of XELOX based chemotherapy(about 6 mo postoperatively)].RESULTS: We found the EMT phenomenon in which there were a few biphenotypic E^+/M^+ cells in primary human gastric cancer specimens. Of the 44 patients, the presence of CTCs was reported in 35(79.5%) patients at baseline. Five types of cells including from exclusively E^+ CTCs to intermediate CTCs and exclusively M^+ CTCs were identified(4 patients with M^+ CTCs and 10 patients with M^+ or M^+ > E^+ CTCs). Further, a chemotherapy patient having progressive disease showed a proportional increase of mesenchymal CTCs in the post-treatment blood specimens. We used NCI-N87 cells to analyze the linearity and sensitivity of Can Patrol^(TM) system and the correlation coefficient(R^2) was 0.999.CONCLUSION: The findings suggest that the EMT phenomenon was both in a few cells of primary tumors and abundantly in CTCs from the blood of gastric cancer patients, which might be used to monitor therapy response. | Ting-Ting Li Hao Liu Feng-Ping Li Yan-Feng Hu Ting-Yu Mou Tian Lin Jiang Yu Lei Zheng Guo-Xin Li | 2015 | World Journal of Gastroenterology2015，21，47： | 29 |
| 2 | Appropriate insulin initiation dosage for insulin-naive type 2 diabetes outpatients receiving insulin monotherapy or in combination with metformin and/or pioglitazone显示文摘当与口头的 antidiabetic 药(OAD ) 结合了时,很少研究在适当开始胰岛素剂量上给了建议的背景。这研究是与在这是的胰岛素剂量和相关 factors.Methods 之间的不同联合和关系为胰岛素天真的类型 2diabetes 病人调查适当开始胰岛素剂量一使随机化,开标签,指向学习的对待。目标是两 fasting 血浆葡萄糖(FPG ) 和 2 个小时的 20% 减少早餐以后的血葡萄糖(P2hBG ) 。招募的 147 个胰岛素天真的中国病人是分到 3 个组的 randomiy:组 A,病人们收到了胰岛素 monotherapy;组 B,加 metformin 的收到的胰岛素(0.5 g, tid ) 并且组 C,加 metformin 的收到的胰岛素(0.5 g, tid ) 并且 pioglitazone (15 mg, qd ).Results 两个都,得到 FPG 和 P2hBG 的 20% 减小的时间在三个组之中显示出重要差别。时间在组 C 是最短的。胰岛素剂量需要在三个治疗组完成 20% 的葡萄糖减小(0.40 吗? | LIAO Lin YANG Ming QIU Lu-lu MOU Ya-ru ZHAO Jia-jun DONG Jian-jun | 2010 | Chinese Medical Journal2010，，24： | 11 |
| 3 | Development as adaptation: Framing and measuring urban resilience in Beijing显示文摘As part of their efforts to cope with climate change, many municipal governments have considered the improvement of urban resilience as an important strategy. In this study, we take the megacity of Beijing as an example and conduct a mixed-methods research using both qualitative and quantitative methods to explore linkage between resilience and development. First, based on expert consultation, we develop an analytical framework and propose reference indicators for measuring urban resilience. Second, we conduct an exploratory factor analysis to justify this analytical framework and rank the urban resilience index for 16 districts in Beijing. Results indicate that urban resilience at the district level is distinguished by the characteristics of the district's functional zones. This implies that the development focus of each district influences the driving factors of urban resilience. This article provides evidence that development and adaptation can be complementary. We showcase in Beijing that urban generic resilience is highly dependent on socio-economic development and urbanization, whereas specific resilience to climatic extremes can be attributed to natural endowment and environmental investment. In conclusion, using this study's findings as a guideline, mega-cities are urged to adopt development-oriented adaptation as a strategy of proactive risk planning in the context of rapid urbanization and global climate change in China. | ZHENG Yan XIE Xin-Lu LIN Chen-Zhen WANG Mou HE Xiao-Jia | 2018 | Advances in Climate Change Research2018，9，4： | 11 |
| 4 | Analysis and improvement of missile three-loop autopilots显示文摘The non-minimum phase feature of tail-controlled missile airframes is analyzed.Three selection strategies for desired performance indexes are presented.An acceleration autopilot design methodology based on output feedback and optimization is proposed.Performance and robustness comparisons between the two-loop and classical three-loop topologies are made.Attempts to improve the classical three-loop topology are discussed.Despite the same open-loop structure,the classical three-loop autopilot shows distinct characteristics from a two-loop autopilot with PI compensator.Both the two-loop and three-loop topologies can stabilize a static unstable missile.However, the finite actuator resource is the crucial factor dominating autopilot function. | Lin Defu Fan Junfang Qi Zaikang Mou Yu | 2009 | Journal of Systems Engineering and Electronics2009，20，4： | 10 |
| 5 | GW5-Like, a homolog of GW5, negatively regulates grain width, weight and salt resistance in rice显示文摘Grain size is an important determinant of yield potential in crops. We previously demonstrated that natural mutations in the regulatory sequences of qSW5/GW5 confer grain width diversity in rice. However, the biological function of a GW5 homolog, named GW5-Like(GW5 L), remains unknown. In this study, we report on GW5 L knockout mutants in Kitaake, a japonica cultivar(cv.)considered to have a weak gw5 variant allele that confers shorter and wider grains. GW5 L is evenly expressed in various tissues, and its protein product is localized to the plasma membrane. Biochemical assays verified that GW5 L functions in a similar fashion to GW5. It positively regulates brassinosteroid(BR) signaling through repression of the phosphorylation activity of GSK2. Genetic data show that GW5 L overexpression in either Kitaake or a GW5 knockout line, Kasaorf3(indica cv. Kasalath background), causes more slender, longer grains relative to the wild-type. We also show that GW5 L could confer salt stress resistance through an association with calmodulin protein OsCa M1-1. These findings identify GW5 L as a negative regulator of both grain size and salt stress tolerance, and provide a potential target for breeders to improve grain yield and salt stress resistance in rice. | Peng Tian Jiafan Liu Changling Mou Cuilan Shi Huan Zhang Zhichao Zhao Qibing Lin Jie Wang Jiulin Wang Xin Zhang Xiuping Guo Zhijun Cheng Shanshan Zhu Yulong Ren Cailin Lei Haiyang Wang Jianmin Wan | 2019 | Journal of Integrative Plant Biology2019，61，11： | 9 |
| 6 | Menstrual blood-derived mesenchymal stem cells differentiate into functional hepatocyte-like cells显示文摘Orthotopic liver transplantation(OLT)is the only proven effective treatment for both end-stage and metabolic liver diseases.Hepatocyte transplantation is a promising alternative for OLT,but the lack of available donor livers has hampered its clinical application.Hepatocyte-like cells(HLCs)differentiated from many multi-potential stem cells can help repair damaged liver tissue.Yet almost suitable cells currently identified for human use are difficult to harvest and involve invasive procedures.Recently,a novel mesenchymal stem cell derived from human menstrual blood(MenSC)has been discovered and obtained easily and repeatedly.In this study,we examined whether the MenSCs are able to differentiate into functional HLCs in vitro.After three weeks of incubation in hepatogenic differentiation medium containing hepatocyte growth factor(HGF),fibroblast growth factor-4(FGF-4),and oncostain M(OSM),cuboidal HLCs were observed,and cells also expressed hepatocyte-specific marker genes including albumin(ALB),α-fetoprotein(AFP),cytokeratin 18/19(CK18/19),and cytochrome P450 1A1/3A4(CYP1A1/3A4).Differentiated cells further demonstrated in vitro mature hepatocyte functions such as urea synthesis,glycogen storage,and indocyanine green(ICG)uptake.After intrasplenic transplantation into mice with 2/3 partial hepatectomy,the MenSC-derived HLCs were detected in recipient livers and expressed human ALB protein.We also showed that MenSC-derived HLC transplantation could restore the serum ALB level and significantly suppressed transaminase activity of liver injury animals.In conclusion,MenSCs may serve as an ideal,easily accessible source of material for tissue engineering and cell therapy of liver tissues. | Xiao-zhou MOU Jian LIN Jin-yang CHEN Yi-fei LI Xiao-xing WU Bing-yu XIANG Cai-yun LI Ju-ming MA Charlie XIANG | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，11： | 8 |
| 7 | A Study of the Technique of Western Blot for Diagnosis of Lyme Disease caused by Borrelia afzelii in China显示文摘Objective To study the technique of Western blot for the diagnosis of Lyme disease caused by Borrelia afzelii in China and to establish the standard criteria by operational procedure. Methods FP1, which is the representative strain of B. afzelii in China, was analyzed by SDS‐PAGE, electro transfer and immunoblotting assays. The molecular weights of the protein bands of FP1 were analyzed by Gel‐Pro analysis software. In a study using 451 serum samples (159 patients with Lyme disease and 292 controls), all observed bands were recorded. The accuracy of the WB as a diagnostic test was established by using the ROC curve and Youden index. Results Criteria for a positive diagnosis of Lyme disease were established as at least one band of P83/100, P58, P39, OspB, OspA, P30, P28, OspC, P17, and P14 in the IgG test and at least one band of P83/100, P58, P39, OspA, P30, P28, OspC, P17, and P41 in the IgM test. For IgG criteria, the sensitivity, specificity and Youden index were 69.8%, 98.3%, and 0.681, respectively; for IgM criteria, the sensitivity, specificity and Youden index were 47%, 94.2%, and 0.412, respectively. Conclusion Establishment of WB criteria for B. afzelii is important in validating the diagnostic assays for Lyme disease in China. | LIU Zhi Yun HAO Qin HOU Xue Xia JIANG Yi GENG Zhen WU Yi Mou WAN Kang Lin | 2013 | Biomedical and Environmental Sciences2013，26，3： | 7 |
| 8 | Photo-induced transformations of Hg(Ⅱ) species in the presence of Nitzschia hantzschiana,ferric ion,and humic acid显示文摘Effects of algae Nitzschia hantzschiana, Fe(Ⅲ) ions, humic acid, and pH on the photochemical reduction of Hg(Ⅱ) using the irradiation of metal halide lamps (λ 365 nm, 250 W) were investigated. The photoreduction rate of Hg(Ⅱ) was found to increase with increasing concentrations of algae, Fe(Ⅲ) ions, and humic acid. Alteration of pH value affected the photoreduction of Hg(Ⅱ) in aqueous solution with or without algae. The photoreduction rate of Hg(II) decreased with increasing initial Hg(Ⅱ) concentration in aqueous solution in the presence of algae. The photochemical kinetics of initial Hg(Ⅱ) and algae concentrations on the photoreduction of Hg(Ⅱ) were studied at pH 7.0. The study on the total Hg mass balance in terms of photochemical process revealed that more than 42% of Hg(Ⅱ) from the algal suspension was reduced to volatile metallic Hg under the conditions investigated. | Lin Deng Nansheng Deng Liwei Mou Fangtong Zhu | 2010 | Journal of Environmental Sciences2010，22，1： | 7 |
| 9 | The Anti-allergic Activity of Polyphenol Extracted from Five Marine Algae显示文摘Natural polyphenol has been widely believed to be effective in allergy remission. Currently, most of the natural polyphenol products come from terrestrial sources such as tea, grape seeds among others, and few polyphenols have been developed from algae for their anti-allergic activity. The aim of the study was to screen some commercial seaweed for natural extracts with anti-allergic activity. Five algae including Laminaria japonica, Porphyra sp., Spirulina platensis, Chlorella pyrenoidosa and Scytosiphon sp. were extracted with ethanol, and the extracts were evaluated for total polyphenol contents and anti-allergic activity with the hyaluronidase inhibition assay. Results showed that the total polyphenol contents in the ethanol extracts ranged from 1.67% to 8.47%, while the highest was found in the extract from Scytosiphon sp. Hyaluronidase inhibition assay showed that the extracts from Scytosiphon sp. had the lowest IC50, 0.67 mg m L-1, while Chlorella pyrenoidosa extract had the highest IC50, 15.07 mg m L-1. The anti-allergic activity of Scytosiphon sp. extract was even higher than the typical anti-allergic drug Disodium Cromoglycate(DSCG)(IC50 = 1.13 mg m L-1), and was similar with natural polyphenol from Epigallocatechin gallate(EGCG)(IC50 = 0.56 mg m L-1). These results indicated that the ethanol extract of Scytosiphon sp. contains a high concentration of polyphenol with high anti-allergic activity. Potentially Scytosiphon sp. can be developed to a natural anti-allergic compound for allergy remission. | CHEN Yu LIN Hong LI Zhenxing MOU Quangui | 2015 | Journal of Ocean University of China2015，14，4： | 7 |
| 10 | Structural, magnetic and electronic properties of the iron-chalcogenide AxFe2-ySe2 (A=K, Cs, Rb, and TI, etc.) superconductors显示文摘 | Dai-xiang Mou Lin Zhao Xing-jiang Zhou | 2011 | Frontiers of physics2011，6，4： | 6 |
| 11 | Fouling community characteristics in subtropical coastal waters of the southwestern East China Sea显示文摘A fouling study was conducted in coastal waters southwest of the East China Sea between December 2013 and November 2014. A total of 84 species of fouling organisms belonging to 69 genera, 49 families, and 10 phyla were recorded over the entire year. The community composition was dominated by coastal warm-water species belonging to typical subtropical inner bay communities. The prosperous stage of settlement lasted from April to September, and the adhesion strength of the fouling organisms was the highest in summer. Sessile suspension feeders constituted the main core of settlement for the fouling community. Amphibalanus reticulatus was the most dominant and representative species of fouling organism, and other dominant species included Caprella equilibra, Ectopleura crocea, Anthopleura nigrescens, Stylochus ijimai, Spirobranchus kraussii, Crassostrea angulata, Perna viridis, Jassa falcata, Stenothoe valida, Sphaerozius nitidus, and Biflustra grandicella. The individuals in the fouling community showed a mutual dependence or constraint relationship due to competition for settlement space and food, and they exhibited a particular spatiotemporal distribution in accordance with adaptation to environmental factors. Temperature was the most important environmental factor determining the geographic distribution of fouling organisms. The temperature characteristics of species essentially reflect the differences in the fouling community composition in various climate zones. The species number, settlement stage, and settlement rate of fouling organisms are closely related to water temperature. Local natural environmental conditions(salinity, water currents, light, etc.) as well as human activity(such as aquaculture production) are all important factors affecting the settlement of fouling organisms. | LIN Heshan WANG Jianjun LIU Wei LIU Kun ZHANG Shuyi HE Xuebao HUANG Yaqin LIN Junhui MOU Jianfeng ZHENG Chengxing YAN Tao | 2017 | Acta Oceanologica Sinica2017，36，10： | 6 |
| 12 | Docetaxel-loaded liposomes: preparation, pH sensitivity,Pharmacokinetics, and tissue distribution显示文摘Docetaxel (DTX), as a member of taxoid family, has been widely used in the treatment of cancers. The present study prepared pH-sensitive DTX-loaded liposomes (DTX-Lips) by thin-film dispersion method and various physico-chemical and morphological properties were examined. The pH sensitivity of in vitro DTX release and the in vivo pharmacokinetics and tissue distribution using Kunming mice were also investigated. The mean particle size and zetapotential of DTX liposomes were (277±2) nm and (-32.60±0.26) mV, respectively. Additionally, in vitro drug release study showed that the cumulative release rate was 1.3 times more at pH 5.0 than at pH 7.4, suggesting a pH-dependent releaseability of DTX-Lips. Pharmacokinetic and pharmaceutical studies in comparison with Duopafei showed that the half-timeperiod (t1/2) and area under the curve (AUC) of DTX-Lips in mouse plasma were 1.8 times longer and 2.6 times higher,respectively, and that DTX-Lips selectively accumulated in macrophage-rich organs such as liver and spleen. The seresults together suggest that the DTX-Lips could be a promising formulation for the clinical administration of DTX. | Hong ZHANG Rui-ying LI Xia LU Zhen-zhen MOU Gui-mei LIN | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，12： | 5 |
| 13 | A space power system of free piston Stirling generator based on potassium heat pipe显示文摘The power system of a free piston Stirling generator(FPSG)based on potassium heat pipes has been developed in this paper.Thanks to the advantages of long life,high reliability,and high overall thermal efficiency,the FPSG is a promising candidate for nuclear energy,especially in space exploration.In this paper,the recent progress of FPSG based on nuclear reactor for space use was briefly reviewed.A novel FPSG weighted only 4.2 kg was designed,and one dimensional thermodynamic modeling of the FPSG using Sage software was performed to estimate its performance.The experiment results indicated that this FPSG could provide 142.4 W at a thermal-to-electric efficiency of nearly 17.4%.Besides,the power system integrated with four FPSGs and potassium heat pipes was performed and the single machine failure test was conducted.The results show that this system could provide an electrical power of 300 W at an overall thermal efficiency of 7.3%.Thus,it is concluded that this power system is feasible and will have a great prospect for future applications. | Mingqiang LIN Jian MOU Chunyun CHI Guotong HONG Panhe GE Gu HU | 2020 | Frontiers in Energy2020，14，1： | 5 |
| 14 | Semibatch Emulsifier-free Emulsion Copolymerization of Methyl Methacrylate and n-Butyl Acrylate in the Presence of 2-Hydroxyethyl Methacrylate显示文摘The sendbatch emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and n-butyl acrylate (BA) in the presence of 2-hydroxyethyl methacrylate (HEMA) initiated by K2S2O8 (PSP) was studied. The average palticle diameter increases with an increase of total solids content, HEMA content, PSP content, ionic strength of the system and monomer feed rate, and decreases with the monomer feed ratio from 3/1 (MMA/BA mole.) to 1/3. The stability of this reaction system is improyed by adding HEMA as nonionic comonomer. The high so1ids content (50%) latex with monodisperse particle can be obtained using this process. | Tian Ying GUO Mou Dao SONG Qing Ye ZHOU Bang Hua ZHANG Jian Biao MA Bing Lin HE (The State key Laboratory of Functional Polymer Materials for Adsorption and Separation,Institute of Polymer Chendstry, Nankai University, Tianin, 300071) | 1998 | Chinese Chemical Letters1998，9，7： | 4 |
| 15 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 16 | CORONARY ANGIOGRAPHY WITH DUAL SOURCE COMPUTED TOMOGRAPHY:INITIAL EXPERIENCE显示文摘Objective To explore the scan technique and image quality of coronary angiography with dual source computed tomography(CT) without oral metoprolol preparation.Methods Plain and enhanced dual source CT coronary angiography without oral metoprolol preparation was prospectively performed in 600 patients.Calcium scoring with plain scan images as well as multi-planar reconstruction(MPR),maximum intensity projection(MIP),and volume rendering technique(VRT) reconstruction with enhanced scan images were performed in all cases.The scan technique and post-reconstruction experience was summarized.The image quality was classified as 1 to 4 points,and coronary segments classified according to the American Heart Association standards were evaluated.Results The average calcium score of the 600 cases was 213.6±298.7(0-3 216.5).The average heart rate of the enhanced scan was 82.1±16.2(47-139) bpm.The post-reconstruction methods with which coronary segments could be shown as best as possible consisted of single phase reconstruction method,two or more phases supplemented method,and electrocardiogram editing method.Altogether 8 457 coronary segments were evaluated,among which 97.2% were evaluated as point 1,1.7% point 2,0.5% point 3,and 0.6% point 4.The coronary segments in 261 cases were completely normal,while 360 segments were diagnosed with <50% stenosis and 625 segments with ≥50% stenosis.Conclusions Excellent coronary artery image can be obtained with dual source CT in patients with any heart rate without oral metoprolol preparation.Heart rate is not a major source of the artifact,coronary segments can be well shown with single or multiple-phase reconstruction method. | Zhu-hua Zhang Zheng-yu Jin Shu-yang Zhang Song-bai Lin Dong-jing Li Ling-yan Kong Yi-ning Wang Lan Song Yun Wang Wen-min Zhao Wen-bin Mou Li-ren Zhang Wen-ling Zhu Qi Miao Qi Fang | 2007 | Chinese Medical Sciences Journal2007，22，4： | 4 |
| 17 | Wind Wave Characteristics and Engineering Environment of the South China Sea显示文摘Wave simulation was conducted for the period 1976 to 2005 in the South China Sea(SCS) using the wave model, WAVEWATCH-III. Wave characteristics and engineering environment were studied in the region. The wind input data are from the objective reanalysis wind datasets, which assimilate meteorological data from several sources. Comparisons of significant wave heights between simulation and TOPEX/Poseidon altimeter and buoy data show a good agreement in general. By statistical analysis, the wave characteristics, such as significant wave heights, dominant wave directions, and their seasonal variations, were discussed. The largest significant wave heights are found in winter and the smallest in spring. The annual mean dominant wave direction is northeast(NE) along the southwest(SW)-NE axis, east northeast in the northwest(NW) part of SCS, and north northeast in the southeast(SE) part of SCS. The joint distributions of wave heights and wave periods(directions) were studied. The results show a single peak pattern for joint significant wave heights and periods, and a double peak pattern for joint significant wave heights and mean directions. Furthermore, the main wave extreme parameters and directional extreme values, particularly for the 100-year return period, were also investigated. The main extreme values of significant wave heights are larger in the northern part of SCS than in the southern part, with the maximum value occurring to the southeast of Hainan Island. The direction of large directional extreme Hs values is focus in E in the northern and middle sea areas of SCS, while the direction of those is focus in N in the southeast sea areas of SCS. | WANG Zhifeng ZHOU Liangming DONG Sheng WU Lunyu LI Zhanbin MOU Lin WANG Aifang | 2014 | Journal of Ocean University of China2014，13，6： | 4 |
| 18 | Effect of Hypertonic Versus Isotonic Saline Resuscitation on Heme Oxygenase-1 Expression in Visceral Organs Following Hemorrhagic Shock in Rats显示文摘To compare the early effects of hypertonic and isotonic saline resuscitation on heme oxygenase-1 (HO-1) expression in organs of rats with hemorrhagic shock. Rats were randomly divided into hypertonic saline resuscitation (HTS), normal saline resuscitation (NS) and sham groups. | LU Yuan Qiang GU Lin Hui JIANG Jiu Kun MOU Han Zhou | 2013 | Biomedical and Environmental Sciences2013，26，8： | 4 |
| 19 | An ecological survey of the abundance and diversity of benthic macrofauna in Indonesian multispecific seagrass beds显示文摘Seagrasses are one of the most productive ecosystems in coastal areas and support a wide variety of associated fauna. The tropical Indo-Pacific region is considered to have the highest diversity of seagrass plant species and the largest distribution areas of seagrass, yet the seagrass macrofauna in this region are poorly understood. To help fill this gap in our knowledge, an ecological survey was conducted to describe the abundance and diversity of benthic macrofauna from tropical seagrass beds and to determine between-station variations within a transect and between-site variations in macrofaunal abundance, taxa richness and community structure. Benthic macrofaunal samples associated with seagrass beds were collected with a core sampler on the east coast of North Sulawesi in May 2014 and on the west coast in October 2015. A total of 149 species from 14 higher taxa was collected. The most species-rich groups were polychaetes(56 species, 26% of total individual numbers), decapods(20 species, 9% of total numbers) and amphipods(18 species, 35% of total numbers). Between-station variations within a transect displayed different patterns between the east coast and the west coast. On the east coast, there were marked variations in abundance between stations within a transect for the macrofauna and amphipod assemblages. Both taxa richness and abundance varied with station for the macrofauna and polychaete assemblages on the west coast, resulting from the heterogeneity of the substrate along a transect. One-way ANOSIM together with MDS ordination indicated that macrofaunal community structure in seagrasses differed significantly between the east coast and the west coast, corresponding with the division of seagrasses into two broad categories of habitats, i.e.,mangrove-seagrass-reef continuum and seagrass-reef continuum. Compared with other studies in tropical areas,the abundance and diversity of benthic macrofauna in the present study were moderate. The reason for the two markedly distinct macrofaunal communities might be attributed to multiple factors, including sediment pattern,seagrass structure and temporal changes. | LIN Junhui HUANG Yaqin ARBI Ucu Yanu LIN Heshan AZKAB Muhammad Husni WANG Jianjun HE Xuebao MOU Jianfeng LIU Kun ZHANG Shuyi | 2018 | Acta Oceanologica Sinica2018，37，6： | 3 |
| 20 | Synthesis and Anti-HIV Activity of a Series of 6-Modified 2',3'-Dideoxyguanosine and 2',3'-Didehydro-2',3'- dideoxyguanosine Analogs显示文摘寻找潜在的 2,3-dideoxyguanosine (ddG ) 和 2,3-didehydro-2,3-dideoxyguanosine (D4G ) prodrugs,一系列 6-modified ddG, D4G 类似物在基于房间的试金为他们的 anti-HIV 活动和 cytotoxities 被综合并且评估。所有类似物显示出低 cytotoxicities,他们中的一些显示了良性的 anti-HIV 活动。在 vivo, ddGTP 和 D4TTP 的活跃 triphosphate 形式,被一个新奇、灵巧的“一个壶”也综合方法。由 Taq, Therminater DNA 聚合酶和在 DNA/RNA 海滨合并的 HIV 反向的 transcriptase (RT ) 的 ddGTP 和 D4TTP 的识别被一个非放射性方法调查, Km 是坚定的。 | Lujia Xie Xiantao Yang Delin Pan Yingli Cao Mou Cao Guichun Lin Zhu Guan Ying Guo Lihe Zhang Zhenjun Yang | 2013 | Chinese Journal of Chemistry2013，31，9： | 2 |
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