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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | New yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor for warm-white light-emitting diodes through single-emitting-center conversion显示文摘Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission spectrum.Here,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component.Warm-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion. | Xufan Li John D Budai Feng Liu Jane Y Howe Jiahua Zhang Xiao-Jun Wang Zhanjun Gu Chengjun Sun Richard S Meltzer Zhengwei Pan | 2013 | Light(Science & Applications)2013，2，1： | 11 |
| 3 | Multilocular Cystic Renal Cell Carcinoma:A Series of 8 Cases and Review of the Literature显示文摘OBJECTIVE To study the clinical,pathologic and imaging features of multilocular cystic renal cell carcinoma(MCRCC)and to review the diagnosis and treatment of this subtype of renal cell carcinoma(RCC). METHODS The data from 8 cases(mean age,49.4;5 men and 3 women) who had been treated from 2004 to 2006,were reviewed retrospectively. Radiologic and pathologic documents were evaluated.For treatments,radi- cal nephrectomy was conducted in 4 patients,partial nephrectomy in 2 and laparoscopic nephrectomy in 2. RESULTS Postoperative pathological findings confirmed the diagnosis of MCRCC.The stage of al 8 cases was pT1.For pathologic grade,7 cases were G1 and 1 case was G2.Seven patients available for follow-up had sur- vived tumor-free during the mean time of 8 months. CONCLUSION MCRCC is an uncommon subtype of RCC,it has a lower malignant potential and a better prognosis compared with other types of RCC.Nephron-sparing surgery may be an appropriate treatment options for MCRCC. | Shuo Liu Guang Sun Zhanjun Guo Xiaodong Li | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 9 |
| 4 | Near-infrared light activated persistent luminescence nanoparticles via upconversion显示文摘坚持的光 nanoparticles (PLNP ) 和 upconversion nanoparticles (UCNP ) 是二特殊光成像 nanoprobes。在这研究,有效 upconverted 坚持的光(UCPL ) 被把他们的唯一的特征合为 polymethyl methacrylate 认识到,形成一部电影 PLNP 和 UCNP 创作了。红坚持的光(~ 640 nm ) PLNP (CaS : Eu, Tm, Ce ) 能被 UCNP 的 upconverted 绿色排放激活(-NaYF4:Yb,Er@NaYF4) 由在红外线附近的光(NIR ) 激动。用这策略,两 PLNP 和 UCNP 的唯一的光性质能是最佳地 synergized,因此产生的有效 upconversion,光致发光,和 UCPL 同时。UCPL 系统有潜在的应用在在由简单地监视 biocompatible 的 vivo bioimaging NIR-light-excited 的低力量密度坚持的光。由于它的简洁,我们预计为 UCPL 合成罐头的准备的这个方法容易为很多 biophotonic 和 photonic 应用用另外的可得到的 upconversion 和坚持的黄磷对被调整。 | Zhanjun Li Ling Huang YuanweiZhang Yang Zhao Hong Yang Gang Han | 2017 | Nano Research2017，10，5： | 6 |
| 5 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 6 | An Improved Kalman Filter Positioning Method in NLOS Environment显示文摘In the precision positioning system, NLOS(Non Line of Sight) propagation and clock synchronization error caused by multiple base stations are the main reasons for reducing the reliability of communication and positioning accuracy. So, in the NLOS environment, it has an important role to eliminate the clock synchronization problem in the positioning system. In order to solve this problem, this paper proposes an improved Kalman filter localization method NLOS-K(Non Line of Sight-Kalman filter). First, the maximum likelihood estimation algorithm is used to iterate. Then, the Kalman filter algorithm is implemented and the Kalman gain matrix is redefined. The clock drift is compensated so that the clock between the master and slave base stations remains synchronized. The experimental results show that in the non-lineof-sight environment, compared with other algorithms, the positioning accuracy error of the improved algorithm is about 5 cm, and the accuracy compared with other algorithms is 97%. In addition, the influence of bandwidth and spectral density on the method is analyzed, and the accuracy and stability of positioning are improved as a whole. | Zhanjun Hao Beibei Li Xiaochao Dang | 2019 | China Communications2019，16，12： | 4 |
| 7 | Natural gas consumption forecasting model based on coal-to-gas project in China显示文摘Natural gas is widely used because it is environmentally friendly,particularly in reducing carbon emission and improving the Air Quality Index(AQI)around densely populated cities.China has initiated a coal-to-gas project(CGP)to improve the air quality in northern China.As a subcompany of China National Petroleum Corporation,PetroChina Natural Gas Marketing North Company has been focusing on natural gas resource allocation while considering numerous issues such as ensuring the bottom line of livelihood requirements in winter and the performance of economic indicators for an entire calendar year in the northern part of China.Therefore,the accurate prediction of natural gas consumption is important to PetroChina Natural Gas Marketing North Company.It has become a challenge to forecast natural gas consumption because the natural gas market has changed considerably because of the CGP.Natural gas consumption cannot be forecasted using conventional models.This study analyzes the characteristics of the CGP based on the data obtained from rural individual users and company users.Based on the analysis,the gas consumption in winter is predicted using two different forecasting approaches.The methods presented in this paper provide a basis for formulating effective measures for natural gas scheduling in the northern part of China. | Zhiqiang Wang Yichen Li Zhanjun Feng Kai Wen | 2019 | Global Energy Interconnection2019，2，5： | 4 |
| 8 | Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide显示文摘Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is largely restricted to protospacer adjacent motif(PAM)sequences containing G,T,or A bases.In this study,we developed a new base editor termed“nNme2-CBE”with excellent PAM compatibility for cytidine dinucleotide,significantly expanding the genome-targeting scope of CBEs.Using nNme2-CBE,targeted editing efficiencies of 29.0%-55.0%and 17.3%—52.5%were generated in human cells and rabbit embryos,respectively.In contrast to conventional nSp-CBE,the nNme2-CBE is a natural high-fidelity base editing platform with minimal DNA off-targeting detected in vivo.Significantly increased efficiency in GC context and precision were determined by combining nNme2Cas9 with rationally engineered cytidine deaminases.In addition,the Founder rabbits with accurate single-base substitutions at Fgf5 gene loci were successfully generated by using the nNme2-CBE system.These novel nNme2-CBEs with expanded PAM compatibility and high fidelity will expand the base editing toolset for efficient gene modification and therapeutic applications. | Zhiquan Liu Siyu Chen Yingqi Jia Huanhuan Shan Mao Chen Yuning Song Liangxue Lai Zhanjun Li | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 9 | Microstructures and Phase Transition in Omphacite: Constraints on the P-T Path of Shuanghe Eclogite (Dabie Orogen)显示文摘Omphacite microstructures are important to decipher the metamorphic pressuretemperature(P-T)conditions of eclogite during subduction and exhumation processes.Here we present a systematic microstructural investigation of omphacite using transmission electron microscopy(TEM)in an ultrahigh-pressure(UHP)eclogite sample from Shuanghe,Dabie orogen,China.The omphacite can be divided into two phases:(1)Omp-1,exhibits as the main part of omphacite with P2/n space group containing small amount of dislocations and numerous antiphase domains(APDs).(2)Omp-2,shows as banded subgrains with C2/c space group containing large amount of dislocations.These two phases of omphacite have almost the same crystallography orientation and bounded by dislocation walls.Along these dislocation walls,we found some barroisite and albite microcrystals.The barroisite microcrystals contain large amount of dislocations and show a topological relation with host omphacite.While the albite microcrystals contain small amount of dislocations and does not show topological relation with host.These microstructures could give us the following metamorphic information to constrain the P-T path of eclogite:Firstly,this two omphacite space groups should be evolved from the same precursor C2/c omphacite,which had been underwent strongly plastic deformation during the syn-to late-peak metamorphic stage.Secondly,the precursor C2/c omphacite began to be retrograded and altered by small amount of barroisite microcrystals along its dislocation walls under the P-T condition of 2.2–2.6 GPa and 650–700℃ at the early amphibole eclogite stage.Thirdly,large amount of Na and other elements were exsolved from some precursor C2/c omphacite subgrains and crystallized numerous albite microcrystals at their boundaries,which is the necessary for the space group of C2/c surviving under the lower P-T conditions(1.7–1.9 GPa and 630–690 C)during the middle amphibole eclogite stage.Lastly,the rest of precursor C2/c omphacite subgrains were transformed into P2/n polymorph and formed the APDs structures under the P-T condition of^1.5 GPa and 650–680℃ during the late amphibole eclogite stage. | Zhanjun Xie Xiangwen Liu Zhenmin Jin Zhuoyue Li | 2020 | Journal of Earth Science2020，31，2： | 2 |
| 10 | Photocatalytic hydrogenation of nitroarenes using Cu1.94S-Zn0.23Cd0.77S heteronanorods显示文摘 | Zhanjun Yu Zheng Chen Yueguang Chen Qing Peng Rui Lin Yu Wang Rongan Shen Xing Cao Zhongbin Zhuang Yadong Li | 2018 | Nano Research2018，11，7： | 2 |
| 11 | Ontology-based customer preference modeling for concept generation显示文摘 | CAO Dongxing LI Zhanjun RAMANI K | | Ad- vanced Engineering Informatics0，25，2： | 1 |
| 12 | Bird nest-like zinc oxide nanostructures for sensitive electrochemical glucose biosensor显示文摘In this research,a novel bird nest-like zinc oxide(BN-ZnO)nanostructures were prepared by a simple solvothermal method.A sensitive electrochemical glucose biosensor was for the first time developed based on the immobilization of glucose oxidase(GOx)on nanostructured BN-ZnO modified electrode.The BN-ZnO nanostructure and the resultant biosensor were characterized by scanning electron microscope,X-ray diffraction spectroscopy,Fourier transform infrared spectroscopy,and electrochemical impedance spectroscopy.BN-ZnO nanostructures have large specific surface area and can load large amounts of GOx molecules.Meanwhile,BN-ZnO provides an excellent microenvironment to retain the native bioactivity of enzymes and to promote direct electron transfer between GOx and electrode surface.The proposed biosensor shows a wide linear range of 0.005–1.6 mmol/L,high sensitivity of15.6 mA L mol^(-1)cm^(-2)with a low detection limit of 0.004 mmol/L.The resulting biosensor also shows excellent selectivity,acceptable stability and reproducibility,and can be successfully applied in the detection of glucose in human serum samples at-0.37 V. | Feng Shi Jinming Xu Zhongfang Hu Chuanli Ren Yadong Xue Yongcai Zhang Juan Li Chengyin Wang Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 13 | Soil quality assessment of Albic soils with different productivities for eastern China显示文摘 | Zhanjun Liu Wei Zhou Jianbo Shen Shutian Li Ping He Guoqing Liang | 2014 | Soil & Tillage Research2014，，： | 1 |
| 14 | Experimental and Kinetic Modeling Study of Premixed o- Xylene Flames显示文摘 | Long Zhao Zhanjun Cheng Lili Ye Feng Zhang Lidong Zhang Fei Qi Yuyang Li | 2014 | Proceedings of the Combustion Institute2014，，： | 1 |
| 15 | Soil quality assessment of yellow clayey paddy soils with different productivity显示文摘 | Zhanjun Liu Wei Zhou Jianbo Shen Shutian Li Chao Ai | 2014 | Biology and Fertility of Soils2014，，3： | 1 |
| 16 | Quantitative analysis of temperature,salinity and pH on WSSV proliferation in Chinese shrimp Fenneropenaeus chinensis by real-time PCR显示文摘 | Huan Gao Jie Kong Zhanjun Li | 2011 | Aquaculture2011，312，： | 1 |
| 17 | The “bottom-up” synthesis and applications of persistent luminescence nanoparticles显示文摘Persistent luminescence refers to the phenomenon whereby luminescence remains after excitation ceases.In the past few decades,various kinds of persistent luminescent materials have been developed and widely employed in numerous applications,such as security signs,medical diagnostics and photocatalysis.Persistent luminescent materials offer distinctive advantages for biomedical applications,especially for bioimaging,as they can efficiently avoid autofluorescence and tissue-scattered light interference[1]. | Nuo Yu Yang Li Zhanjun Li Gang Han | 2018 | Science China Chemistry2018，61，7： | 1 |
| 18 | Effect of Addition Sequence during Neutralization and Precipitation on Iron-based Catalysts for High Temperature Shift Reaction显示文摘The preparation of the iron-based catalysts promoted by cobalt with a small amount of copper and aluminum for the high temperature shift reaction(HTS)with different sequences of adding catalyst raw materials during neutralization and precipitation was investigated.XRD,BET and particle size distribution(PSD)were used to characterize the prepared catalysts.It was found that the catalyst crystals were allγ-Fe 2 O3,and the intermediate of the catalyst after aging was Fe3O4.The crystallographic form of the catalyst and its intermediate was not affected by the addition sequence in the neutralization and precipitation process.The results showed that the specific surface area and the particle size of the catalysts depended on the addition sequence to the mother liquor. Cobalt with a small amount of copper and aluminum could increase the specific surface area and decrease the particle size of catalysts. | Li Wei Zhu Jianhua Mou Zhanjun | 2007 | Petroleum Science2007，4，1： | 1 |
| 19 | Ontology-based design information extraction and retrieval显示文摘 | LI Zhanjun RAMANI K | 2007 | Artificial Intelligence for Engineering Design Analysis and Manufacturing2007，21，2： | 1 |
| 20 | Enrichment of arsenic, antimony, thallium and selenium in high-arsenic coal from Xingren County, Guizhou Province显示文摘 | Zhanjun YANG Yuegang TANG Xiao ZHENG Juanjuan LI Weilong HAN Shuting YANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
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