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| 1 | Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion显示文摘OBJECTIVES:Functional magnetic resonance imaging(fMRI) technology was used to study changes to the resting state blood flow in the brains of patients with knee osteoarthritis(KOA) before and after treatment with moxibustion at the acupoint of the left Dubi(ST 35) and to probe the cerebral mechanism underlying the effect of moxibustion.METHODS:The resting state brain function of 30 patients with left KOA was scanned with fMRI before and after treatment with moxibustion.The analytic methods of fractional amplitude of low frequency fluctuation(fALFF) and regional homogeneity(ReHo) were used to observe changes in resting state brain function.RESULTS:The fALFF values of the right cerebrum,extra-nucleus,left cerebellum,left cerebrum and white matter of patients after moxibustion treatment were higher than before treatment,and the fALFF values of the precentral gyrus,frontal lobe and occipital lobe were lower than before treatment(P<0.05,K≥85).The ReHo values of the thalamus,extra-nucleus and parietal lobe of patients were much higher than those before moxibustion treatment,and the ReHo values of the right cerebrum,left cerebrum and frontal lobe were lower than before treatment(P<0.05,K≥85).CONCLUSION:The influence of moxibustion on obvious changes in brain regions basically conforms to the way that pain and warmth is transmitted in the body,and the activation of sensitive systems in the body may be objective evidence of channel transmission.The regulation of brain function by moxibustion is not in a single brain region but rather in a network of many brain regions. | Hongwu Xie Fangming Xu Rixin Chen Tianyou Luo Mingren Chen Weidong Fang Fajin Lü Fei Wu Yune Song Jun Xiong | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 7 |
| 2 | Molecular Characterization of Avian-like H1N1 Swine Influenza A Viruses Isolated in Eastern China, 2011显示文摘Currently, three predominant subtypes of influenza virus are prevalent in pig populations worldwide: H1N1, H3N2, and H1N2. European avian-like H1N1 viruses, which were initially detected in European pig populations in 1979, have been circulating in pigs in eastern China since 2007. In this study, six influenza A viruses were isolated from 60 swine lung samples collected from January to April 2011 in eastern China. Based on whole genome sequencing, molecular characteristics of two isolates were determined. Phylogenetic analysis showed the eight genes of the two isolates were closely related to those of the avian-like H1N1 viruses circulating in pig populations, especially similar to those found in China. Four potential glycosylation sites were observed at positions 13, 26, 198, 277 in the HA1 proteins of the two isolates. Due to the presence of a stop codon at codon 12, the isolates contained truncated PB1-F2 proteins. In this study, the isolates contained 591Q, 627E and 701N in the polymerase subunit PB2, which had been shown to be determinants of virulence and host adaptation. The isolates also had a D rather than E at position 92 of the NS1, a marker of mammalian adaptation. Both isolates contained the GPKV motif at the PDZ ligand domain of the 3' end of the NS1, a characteristic marker of the European avian-like swine viruses since about 1999, which is distinct from those of avian, human and classical swine viruses. The M2 proteins of the isolates have the mutation (S31N), a characteristic marker of the European avian-like swine viruses since about 1987, which may confer resistance to amantadine and rimantadine antivirals. Our findings further emphasize the importance of surveillance on the genetic diversity of influenza A viruses in pigs, and raise more concerns about the occurrence of cross-species transmission events. | Xian Qi Yuning Pan Yuanfang Qin Rongqiang Zu Fengyang Tang Minghao Zhou Hua Wang Yongchun Song | 2012 | Virologica Sinica2012，27，5： | 6 |
| 3 | Transcriptional Characteristics of Xa21-mediated Defense Responses in Rice显示文摘细菌的老家,由 Xanthomonas oryzae pv 引起了。oryzae (Xoo ) ,是米饭的最破坏的细菌的疾病。克隆的米饭基因 Xa21 授与抵抗到许多 Xoo 赛跑。为了识别基因,在 调停Xa21 的免疫包含了,米饭的整个染色体的 oligonucleotide microarray 被用来在 0 点介绍在不兼容的相互作用和嘲笑处理之间的米饭基因的表示, 4 , 8 , 24 , 72 和 120 h 柱子接种( hpi )或在在 4 hpi 的不兼容、兼容的相互作用之间分别地。441 差别的一个总数表示了基因,指定了为 XDG (Xa21 调停了差别表示了基因) ,被识别。基于他们的功能的注解, XDG 被分到 14 个范畴,包括防卫相关,发信号, transcriptional 管理者。大多数防卫相关的基因属于致病相关的基因家庭,它在 72 和 120 hpi 戏剧性地被导致。有趣地,大多数发信号和 transcriptional 管理者基因是在 4 和 8 hpi 的 downregulated,建议细胞的发信号的那条否定规定可以起在调停 Xa21 的防卫反应的一个作用。在 Xa21- 和其它 R 调停基因的防卫系统之间的表示侧面的比较揭示了有趣的普通回答。有支持证据的代表性的 XDG 也被讨论。 | Qiang Gan Hui Bai Xianfeng Zhao Yong Tao Haipan Zeng Yuning Han Wenyuan Song Lihuang Zhu Guozhen Liu | 2011 | Journal of Integrative Plant Biology2011，53，4： | 5 |
| 4 | Phenotypic identification of peanut germplasm for resistance to southern stem rot显示文摘Southern stem rot,caused by Sclerotium rolfsii Sacc.,is a destructive soil fungal disease of peanut in China and other countries.To evaluate resistant germplasm,a total of 256 peanut accessions were investigated on their resistance to southern stem rot in 3 environments by artificial inoculation.Variance analysis indicated that disease index was significantly influenced by environment,genotype and genotypeenvironment interactions.Peanut accessions of var.vulgaris type exhibited higher resistance to southern stem rot.Disease index was significantly negatively correlated with linoleic acid content,while positively correlated with oleic acid content.Six resistant accessions were identified,including Hua 28,Shandongzai,ICG 6326,Quanhua 7,Quanhua 9 and Guihua 836,with their disease indexes under 40 and mortality were less than 30%in the three environments.The identified resistant accessions showed the great potential to be applied in resistant peanut breeding,and would be good genetic resources for enhancing the resistance to southern stem rot. | Pengmin Fan Wanduo Song Yanping Kang Liyun Wan Yong Lei Dongxin Huai Yuning Chen Xin Wang Huifang Jiang Liying Yan Boshou Liao | 2020 | Oil Crop Science2020，5，4： | 3 |
| 5 | Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide显示文摘Cytidine base editor(CBE),which is composed of a cytidine deaminase fused to Cas9 nickase,has been widely used to induce C-to-T conversions in a wide range of organisms.However,the targeting scope of current CBEs is largely restricted to protospacer adjacent motif(PAM)sequences containing G,T,or A bases.In this study,we developed a new base editor termed“nNme2-CBE”with excellent PAM compatibility for cytidine dinucleotide,significantly expanding the genome-targeting scope of CBEs.Using nNme2-CBE,targeted editing efficiencies of 29.0%-55.0%and 17.3%—52.5%were generated in human cells and rabbit embryos,respectively.In contrast to conventional nSp-CBE,the nNme2-CBE is a natural high-fidelity base editing platform with minimal DNA off-targeting detected in vivo.Significantly increased efficiency in GC context and precision were determined by combining nNme2Cas9 with rationally engineered cytidine deaminases.In addition,the Founder rabbits with accurate single-base substitutions at Fgf5 gene loci were successfully generated by using the nNme2-CBE system.These novel nNme2-CBEs with expanded PAM compatibility and high fidelity will expand the base editing toolset for efficient gene modification and therapeutic applications. | Zhiquan Liu Siyu Chen Yingqi Jia Huanhuan Shan Mao Chen Yuning Song Liangxue Lai Zhanjun Li | 2021 | Science China(Life Sciences)2021，64，8： | 2 |
| 6 | Phosphorus fractions and matrix-bound phosphine in coastal surface sediments of the Southwest Yellow Sea显示文摘 | Yuning Hong Jinju Geng Song Qiao Yongzhan Zhang Lili Ding Xiaorong Wang Hongqiang Ren | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 7 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 8 | The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging显示文摘Purpose:To assess the repeatability and reproducibility of swept-source optical coherence tomography(SS-OCT)and Scheimpflug system and evaluate the agreement between the two systems in measuring multiple corneal regions in children.Methods:Pachymetric and keratometric maps for both systems were evaluated.Central,midperipheral and peripheral corneal thickness(CT),keratometry and astigmatism power vectors were recorded.The three outcomes yielded by the same observer were used to assess intraobserver repeatability.The differences in the mean values provided by each observer were used to evaluate interobserver reproducibility.Within-subject standard deviation,test-retest repeatability(TRT)and coefficient of variation(CoV)were used to analyze the intraobserver repeatability and interobserver reproducibility.Paired T-test and Bland-Altman were used to appraise interdevice agreement.Results:Seventy-eight eyes of 78 children were included.The CoV was≤2.12 and 1.10%,respectively,for repeatability and reproducibility.TRT and CoV were lower for central and paracentral CT measurements than for peripheral measurements.The SS-OCT device generated higher precision when acquiring CT data,whereas Scheimpflug system showed higher reliability when measuring corneal keratometry.Although the CT readings measured using SS-OCT were significantly thinner than Scheimpflug device(P<0.001),the central and thinnest CT values were still of high agreement.The interdevice agreement of keratometry measurement was high for the central corneal region and moderate for the paracentral and peripheral areas.Conclusions:The precision of CT measurements by SS-OCT was higher,while the reliability of keratometry measurements by the Scheimpflug system was higher in children.Apart from the measured values in the central corneal region,the thickness and keratometry readings should not be considered interchangeable between the two systems. | Yune Zhao Ding Chen Giacomo Savini Qing Wang Hongfang Zhang Yili Jin Benhao Song Rui Ning Jinhai Huang Chenyang Mei | 2020 | Eye and Vision2020，7，1： | 1 |
| 9 | Integrated genetic linkage map of cultivated peanut by three RIL populations显示文摘High-density and precise genetic linkage map is fundamental to detect quantitative trait locus (QTL) of agronomic and quality related traits in cultivated peanut (Arachis hypogaea L.). In this study, three linkage maps from three RIL (recombinant inbred line)populations were used to construct an integrated map. A total of 2,069 SSR and transposon markers were anchored on the high-density integrated map which covered 2,231.53 cM with 20 linkage groups. Totally, 92 QTLs correlating with pod length (PL), pod width (PW), hundred pods weight (HPW) and plant height (PH) from above RIL populations were mapped on it. Seven intervals were found to harbor QTLs controlling the same traits in different populations,including one for PL, three for PW, two for HPW, and one for PH. Besides, QTLs controlling different traits in different populations were found to be overlapped in four intervals.Interval on A05 contains 17 QTLs for different traits from two RIL populations. New markers were added to these intervals to detect QTLs with narrow confidential intervals.Results obtained in this study may facilitate future genomic researches such as QTL study, fine mapping, positional cloning and marker-assisted selection (MAS) in peanut. | Yanbin Song Huaiyong Luo Li Huang Yuning Chen Weigang Chen Nian Liu Xiaoping Ren Bolun Yu Jianbin Guo Huifang Jiang | 2017 | Oil Crop Science2017，2，3： | 0 |
| 10 | The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging显示文摘Purpose:To assess the repeatability and reproducibility of swept-source optical coherence tomography(SS-OCT)and Scheimpflug system and evaluate the agreement between the two systems in measuring multiple corneal regions in children.Methods:Pachymetric and keratometric maps for both systems were evaluated.Central,midperipheral and peripheral corneal thickness(CT),keratometry and astigmatism power vectors were recorded.The three outcomes yielded by the same observer were used to assess intraobserver repeatability.The differences in the mean values provided by each observer were used to evaluate interobserver reproducibility.Within-subject standard deviation,test-retest repeatability(TRT)and coefficient of variation(CoV)were used to analyze the intraobserver repeatability and interobserver reproducibility.Paired T-test and Bland-Altman were used to appraise interdevice agreement.Results:Seventy-eight eyes of 78 children were included.The CoV was≤2.12 and 1.10%,respectively,for repeatability and reproducibility.TRT and CoV were lower for central and paracentral CT measurements than for peripheral measurements.The SS-OCT device generated higher precision when acquiring CT data,whereas Scheimpflug system showed higher reliability when measuring corneal keratometry.Although the CT readings measured using SS-OCT were significantly thinner than Scheimpflug device(P<0.001),the central and thinnest CT values were still of high agreement.The interdevice agreement of keratometry measurement was high for the central corneal region and moderate for the paracentral and peripheral areas.Conclusions:The precision of CT measurements by SS-OCT was higher,while the reliability of keratometry measurements by the Scheimpflug system was higher in children.Apart from the measured values in the central corneal region,the thickness and keratometry readings should not be considered interchangeable between the two systems. | Yune Zhao Ding Chen Giacomo Savini Qing Wang Hongfang Zhang Yili Jin Benhao Song Rui Ning Jinhai Huang Chenyang Mei | 2022 | Eye and Vision2022，8，5： | 0 |
| 11 | The quantity of OA and activity of cellulase and polygalacturonase are involved in variation of virulence in Sclerotium rolfsii显示文摘In order to understand the pathogenic mechanisms of Sclerotium rolfsii on peanut and to analyze the variation of virulence in S.rolfsii strains,the highly virulent strain(ZY2)and weakly virulent strain(GP3-1)were investigated under both in vivo and in vitro conditions.The results indicated that S.rolfsii directly infected peanut by producing infection cushions.ZY2 formed infection cushions earlier than GP3-1,and ZY2 produced a greater number of infection cushions compare to GP3-1.Both strains could utilize cellulose,xylose,or polygalacturonic acid in the Czapek medium.The activities of cellulase(CL)and polygalacturonase(PG)in the inoculated peanut stems increased significantly at 9 h after inoculation.The activities of CL and PG produced by ZY2 in the inoculated stems were significantly higher than that produced by GP3-1.Both strains could produce oxalic acid(OA),and the content of OA produced by ZY2 in the inoculated stems was higher than that produced by GP3-1.In summary,it suggested that S.rolfsii destroyed peanut cells through physical and biochemical factors by secreting a large amount of OA,CL and PG during the formation of infection cushions.The difference in OA content,activity of CL and PG produced by highly and weakly virulent strains played important roles in variation of virulence. | Dongyang Yu Wanduo Song Qianqian Wang Yanping Kang Yong Lei Zhihui Wang Yuning Chen Dongxin Huai Wang Xin Boshou Liao Liying Yan | 2023 | Oil Crop Science2023，8，2： | 0 |
| 12 | Highly efficient base editing in rabbit by using near-PAMless engineered CRISPR/Cas9 variants显示文摘Dear Editor,Base editors can achieve targeted C-to-T and A-to-G conversion without the generation of DNA double-strand breaks(DSBs)or the requirement of a donor template,showing the potential to generate new mutations or to correct pathogenic mutations(Gaudelli et al.,2018).However,for conventional base editors,efficient base editing requires the presence of an NGG protospacer adjacent motif(PAM)that lies 12–16 nt downstream of the target bases,which generally limits the application of these base editors(Gaudelli et al.,2018). | Zhongtian Zhang Xinyu Wu Jie Yang Xin Liu Ruonan Liu Yuning Song | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 13 | Non-fragile Dynamic Output Feedback H∞Control for a Class of Uncertain Switched Systems with Time-varying Delay显示文摘The problem of non-fragile dynamic output feedback H∞control for a class of uncertain switched systems with time-varying delay is discussed.Firstly,the form of non-fragile dynamic output feedback H∞controller is given.Under the condition that the upper bound of time delay and the upper bound of delay derivative are limited simultaneously,Lyapunov functional and its corresponding switching rules are constructed by using single Lyapunov function method and convex combination technique;Secondly,we use the inequality lemma to scale the derived Lyapunov functional in order to eliminate the time-varying delay term in the inequality,and then introduce the J-function to obtain a nonlinear matrix inequality that satisfies the H∞performance indexγ,we also employ Schur complement lemma to transform the nonlinear matrix inequality into set of linear matrix inequalities consisting of two linear matrix inequalities,a sufficient condition for the existence of a non-fragile dynamic output feedback H∞controller and satisfying the H∞performance indexγis concluded for a class of uncertain switching systems with variable time delay;Finally,a switched system composed of two subsystems is considered and the effectiveness and practicability of the theorem are illustrated by numerical simulation with LMI toolbox. | Yuning Song Yuzhong Liu | 2021 | Journal of Electronic & Information Systems2021，3，1： | 0 |
| 14 | Effect of non-aflatoxigenic strains of Aspergillus flavus on aflatoxin contamination of pre-harvest peanuts in fields in China显示文摘Aflatoxin contamination of peanuts is one of the most concerns in peanut production in China.Applying nonaflatoxigenic Aspergillus flavus strains,based on competitive exclusion,has been proved to be a promising strategy to reduce aflatoxin contamination in pre-harvest peanuts.Two non-aflatoxigenic A.flavus strains collected in China,which have been proved effectively reducing aflatoxin in the laboratory,were mixed with high aflatoxin producer to the soil in peanut growing season.The two non-aflatoxigenic strains significantly(P<0.05)reduced aflatoxin contamination in peanut kernels under both normal and drought stresses in two fields.Compared to control,the total aflatoxin(sum of aflatoxin B1 and B2)was reduced 26.7–99.12%in field 1,and 84.96–99.33%in field 2.The aflatoxin was reduced 84.96–99.33%under drought stress in two fields.The present study indicated the non-aflatoxigenic A.flavus strains could be potential biocontrol agents for reducing aflatoxin contamination under field condition. | Liying Yan Wanduo Song Yuning Chen Yanping Kang Yong Lei Dongxin Huai Zhihui Wang Xin Wang Boshou Liao | 2021 | Oil Crop Science2021，6，2： | 0 |
| 15 | Content determination of saponins and HS-GC/MS analysis of volatile components in Chinese Shizhu Panax of different growth years显示文摘HPLC and headspace-gas chromatography-mass spectrometry(HS-GC-MS)were used to investigate the content of saponins and volatile components in Chinese Shizhu Panax of different growth years.82 components were isolated from Chinese Shizhu Panax,69 components of them were successfully identified.They mainly contained monoterpenes,alkanes and sesquiterpenoids,of which sesquiterpenoids were the main components.The results indicated that the content of saponins in Chinese Shizhu Panax of different growth years was dissimilar and diverse.The content of total saponins can be enriched when properly prolonging the growth years of Chinese Shizhu Panax.However,the content of ginsenosides can reach the level in the fifth year according to Chinese Pharmacopoeia.The volatile components in Chinese Shizhu Panax of different growth years also differ in content,type and proportion of compounds to a certain degree. | Jiangchun Wei Yuning Gao Ting Yan Gaosheng Hu Anhua Wang Yurong Song Qingquan Wang Jingming Jia | 2020 | Asian Journal of Traditional Medicines2020，15，3： | 0 |
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