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| 1 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 2 | Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells显示文摘Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment. | Xiao Zhang Zhao Guo Jing Liu Gan Tian Kui Chen Shicang Yu Zhanjun Gu | 2017 | Science Bulletin2017，62，14： | 3 |
| 3 | Photocatalytic hydrogenation of nitroarenes using Cu1.94S-Zn0.23Cd0.77S heteronanorods显示文摘 | Zhanjun Yu Zheng Chen Yueguang Chen Qing Peng Rui Lin Yu Wang Rongan Shen Xing Cao Zhongbin Zhuang Yadong Li | 2018 | Nano Research2018，11，7： | 2 |
| 4 | The “bottom-up” synthesis and applications of persistent luminescence nanoparticles显示文摘Persistent luminescence refers to the phenomenon whereby luminescence remains after excitation ceases.In the past few decades,various kinds of persistent luminescent materials have been developed and widely employed in numerous applications,such as security signs,medical diagnostics and photocatalysis.Persistent luminescent materials offer distinctive advantages for biomedical applications,especially for bioimaging,as they can efficiently avoid autofluorescence and tissue-scattered light interference[1]. | Nuo Yu Yang Li Zhanjun Li Gang Han | 2018 | Science China Chemistry2018，61，7： | 1 |
| 5 | Properties and mechanism of ionic liquid/silicone oil based magnetorheological fluids显示文摘A magnetorheological fluid(MRF)is a smart composite suspension composed of nonmagnetic liquid and soft magnetic particles.Carrier fluids can considerably influence the performance of MRFs;therefore,to investigate the effect of carrier fluids on MRFs,an SO/IL-MRF was prepared by mixing an ionic liquid(IL)with silicone oil(SO)in this study.Three types of MRF samples were prepared for experiments(pure SO,pure IL,and SO/IL).According to the experi-mental results,the SO/IL-MRF has better sedimentation stability than those based on pure SO and pure IL.Further,three methods were used to determine the shear yield stresses of the MRFs.The SO/IL-MRF achieved a higher shear yield stress than those of the other two because a network structure is formed between the ionic fragments and the molecular chains of the SO in the SO/IL-MRF.This increases the movement resistance of the particles in the carrier fluid,and it is unlike the mechanism of the IL-enhanced MRF.This work provides new ideas for improving the MRF performance. | Yu Tong Penghui Zhao Xiaoguang Li Ning Ma Xufeng Dong Chenguang Niu Zhanjun Wu Min Qi | 2022 | International Journal of Smart and Nano Materials2022，13，2： | 0 |
| 6 | Boosting oxygen evolution reactivity by modulating electronic structure and honeycomb-like architecture in Ni_(2)P/N,P-codoped carbon hybrids显示文摘Oxygen evolution reaction(OER)as the foremost stumbling block to generate cost-effective clean fuels has received extensive attention in recent years.But,it still maintains the challenge to manipulate the geometric and electronic structure during single reaction process under the same conditions.Herein,we report a simple self-template strategy to generate honeycomb-like Ni_(2)P/N,P-C hybrids with preferred electronic architecture.Experiments coupled with theoretical results revealed that the synthesized catalyst has two characteristics:firstly,the unique honeycomb-like morphology not only enables the fully utilization of catalytic active sites but also optimizes the mass/electron transportation pathway,which favor the diffusion of electrolyte to accessible active sites.Secondly,N,P-C substrate,on the one hand,largely contributes the electronic distribution near Fermi level(E_(F))thus boosting its electrical conductivity.On the other hand,the support effect result in the upshift of d-band center and electropositivity of Ni sites,which attenuates the energy barrier for the adsorption of OH~àand the formation of*OOH.In consequence,the optimized Ni_(2)P/N,P-C catalysts feature high electrocatalytic activity towards OER(a low overpotential of 252 m V to achieve10 m A cm^(-2))and 10 h long-term stability,the outstanding performance is comparable to most of transition metal catalysts.This work gives a innovative tactics for contriving original OER electrocatalysts,inspirng deeper understanding of fabricating catalysts by combining theoretical simulation and experiment design. | Menglei Yuan Yu Sun Yong Yang Jingxian Zhang Sobia Dipazir Tongkun Zhao Shuwei Li Yongbing Xie He Zhao Zhanjun Liu Guangjin Zhang | 2021 | Green Energy & Environment2021，6，6： | 0 |
| 7 | Multiscale structural design of MnO_(2)@GO superoxide dismutase nanozyme for protection against antioxidant damage显示文摘Rational design of metallic active sites and its microenvironment is critical for constructing superoxide dismutase(SOD)nanozymes.Here,we reported a novel SOD nanozyme design,with employing graphene oxide(GO)as the framework,andδ-MnO_(2)as the active sites,to mimic the natural Mn-SOD.This MnO_(2)@GO nanozyme exhibited multiscale laminated structures with honeycomb-like morphology,providing highly specific surface area for·O_(2)−adsorption and confined spaces for subsequent catalytic reactions.Thus,the nanozyme achieved superlative SOD-like catalytic performance with inhibition rate of 95.5%,which is 222.6%and 1605.4%amplification over GO and MnO_(2)nanoparticles,respectively.Additionally,such unique hierarchical structural design endows MnO_(2)@GO with catalytic specificity,which was not present in the individual component(GO or MnO_(2)).This multiscale structural design provides new strategies for developing highly active and specific SOD nanozymes. | Yue Yu Yinuo Zhang Yu Wang Wenxing Chen Zhanjun Guo Ningning Song Minmin Liang | 2023 | Nano Research2023，16，8： | 0 |
| 8 | Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury显示文摘Over the years,electroconductive hydrogels(ECHs)have been extensively applied for stimulating nerve regeneration and restoring locomotor function after peripheral nerve injury(PNI)with diabetes,given their favorable mechanical and electrical properties identical to endogenous nerve tissue.Nevertheless,PNI causes the loss of locomotor function and inflammatory pain,especially in diabetic patients.It has been established that bone marrow stem cells-derived exosomes(BMSCs-Exos)have analgesic,anti-inflammatory and tissue regeneration properties.Herein,we designed an ECH loaded with BMSCs-Exos(ECH-Exos)electroconductive nerve dressing to treat diabetic PNI to achieve functional recovery and pain relief.Given its potent adhesive and self-healing properties,this laminar dressing is convenient for the treatment of damaged nerve fibers by automatically wrapping around them to form a size-matched tube-like structure,avoiding the cumbersome implantation process.Our in vitro studies showed that ECH-Exos could facilitate the attachment and migration of Schwann cells.Meanwhile,Exos in this system could modulate M2 macrophage polarization via the NF-κB pathway,thereby attenuating inflammatory pain in diabetic PNI.Additionally,ECH-Exos enhanced myelinated axonal regeneration via the MEK/ERK pathway in vitro and in vivo,consequently ameliorating muscle denervation atrophy and further promoting functional restoration.Our findings suggest that the ECH-Exos system has huge prospects for nerve regeneration,functional restoration and pain relief in patients with diabetic PNI. | Qinfeng Yang Shenghui Su Shencai Liu Sheng Yang Jing Xu Yixiu Zhong Yusheng Yang Liangjie Tian Zilin Tan Jian Wang Zhiqiang Yu Zhanjun Shi Fangguo Liang | 2023 | Bioactive Materials2023，，8： | 0 |
| 9 | Synthesis of highly ordered AgNPs-coated silica photonic crystal beads for sensitive and reproducible 3D SERS substrates显示文摘3 D highly ordered silver nanoparticles(AgNPs) coated silica photonic crystal beads(Ag/SPCBs) were prepared and exploited as a novel surface enhanced Raman scattering(SERS) substrate.The monodisperse and size-controlled SPCBs were prepared via self-assembly of silica nanoparticles process using a simple microfluidic device.Then the Ag/SPCBs were easily obtained by in situ growth of AgNPs onto the NH_(2)-modified SPCBs.Field emitting scanning electron microscopy(SEM) and energy dispersive X-ray spectrometry(EDX) were used to characterize the Ag/SPCBs.The effect of silica nanoparticle size and AgNO_(3) concentration on the SERS performance of the resultant Ag/SPCBs substrate were discussed in detail.The results indicate that the Ag/SPCBs have highest SERS signals when silica nanoparticle size is250 nm and AgNO_(3) concentration is 0.8 mg/mL.Using malachite green(MG) as model analyte,the Ag/SPCBs substrate displayed a high sensitivity and a wide linear range for MG.The well-designed Ag/SPCBs show high uniformity and excellent reproducibility,and can be used as an effective SERS substrate for sensitive assay application. | Juan Li Wanling Li Yan Rao Feng Shi Suhua Yu Huizhen Yang Lingfeng Min Zhanjun Yang | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 10 | Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells显示文摘CRISPR/Cas9 system is a robust genome editing platform in biotechnology and medicine.However,it generally produces small insertions/deletions(indels,typically 1-3 bp)but rarely induces larger deletions in specific target sites.Here,we report a cytidine deaminase-Cas9 fusion-induced deletion system(C-DEL)and an adenine deaminase-Cas9 fusion-induced deletion system(A-DEL)by combining Cas9 with rat APOBEC1(r A1)and Tad A 8e,respectively.Both C-DEL and A-DEL improve the efficiency of deletions compared with the conventional Cas9 system in human cells.In addition,the C-DEL system generates a considerable fraction of predictable multinucleotide deletions from 5’-deaminated C bases to the Cas9-cleavage site and increases the proportion of larger deletions at the target loci.Taken together,the CDEL and A-DEL systems provide a practical strategy for producing efficient multinucleotide deletions,expanding the CRISPR/Cas9 toolsets for gene modifications in human cells. | Siyu Chen Zhiquan Liu Hao Yu Liangxue Lai Zhanjun Li | 2022 | Journal of Genetics and Genomics2022，49，10： | 0 |
| 11 | Preparation of Sodium Cobalt Tetracarbonyl and Optimization of Process Conditions for Hydroesterification of Ethylene Oxide显示文摘In this paper, sodium cobalt tetracarbonyl(NaCo(CO)_4) was synthesized by using sodium dithionite and zinc powder as the reduction system and cobalt hexahydrate acetate as the precursor in the presence of methanol solvent. Methyl 3-hydroxypropionate was synthesized via hydroesterification of ethylene oxide(EO) catalyzed by NaCo(CO)_4. The influencing factors on the reaction results were discussed, including the different ligands, the molar ratio of solvent and ethylene oxide, the reaction temperature, the reaction time, and the reaction pressure. An optimal catalytic system was obtained by using 3-hydroxypyridine as the ligand under reaction conditions covering a reaction temperature 65 °C, a reaction time of 7 h, a reaction pressure of 6 MPa, and a methanol/EO molar ratio of 3:2. Under the optimal conditions, the conversion of ethylene oxide was equal to 97.86%, while the selectivity and yield of methyl 3-hydroxypropionate reached 88.19% and 86.30%, respectively. Finally, the reaction mechanism of hydroesterification of ethylene oxide catalyzed by NaCo(CO)_4 was proposed. | Wen Liyuan Zhang Zhanjun Chen Xiaoping Wang Shiqin Yu Wenli | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，3： | 0 |
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