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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | New yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor for warm-white light-emitting diodes through single-emitting-center conversion显示文摘Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission spectrum.Here,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component.Warm-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion. | Xufan Li John D Budai Feng Liu Jane Y Howe Jiahua Zhang Xiao-Jun Wang Zhanjun Gu Chengjun Sun Richard S Meltzer Zhengwei Pan | 2013 | Light(Science & Applications)2013，2，1： | 11 |
| 3 | Simpler criterion on W state for perfect quantumstate splitting and quantum teleportation显示文摘A simpler criterion is presented to judge whether a W state can be taken as quantum channel forperfectly splitting or teleporting an arbitrary single-qubit state. If the W state is usable,the detailed manipulations in the two quantum information processes are amply shown. Moreover,some relevant discussions are made. | ZUO XueQin LIU YiMin ZHANG Wen ZHANG ZhanJun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 10 |
| 4 | Multilocular Cystic Renal Cell Carcinoma:A Series of 8 Cases and Review of the Literature显示文摘OBJECTIVE To study the clinical,pathologic and imaging features of multilocular cystic renal cell carcinoma(MCRCC)and to review the diagnosis and treatment of this subtype of renal cell carcinoma(RCC). METHODS The data from 8 cases(mean age,49.4;5 men and 3 women) who had been treated from 2004 to 2006,were reviewed retrospectively. Radiologic and pathologic documents were evaluated.For treatments,radi- cal nephrectomy was conducted in 4 patients,partial nephrectomy in 2 and laparoscopic nephrectomy in 2. RESULTS Postoperative pathological findings confirmed the diagnosis of MCRCC.The stage of al 8 cases was pT1.For pathologic grade,7 cases were G1 and 1 case was G2.Seven patients available for follow-up had sur- vived tumor-free during the mean time of 8 months. CONCLUSION MCRCC is an uncommon subtype of RCC,it has a lower malignant potential and a better prognosis compared with other types of RCC.Nephron-sparing surgery may be an appropriate treatment options for MCRCC. | Shuo Liu Guang Sun Zhanjun Guo Xiaodong Li | 2007 | Chinese Journal of Clinical Oncology2007，4，2： | 9 |
| 5 | Perfect teleportation of an arbitrary three-qubit state with the highly entangled six-qubit genuine state显示文摘The perfect teleportation of an arbitrary three-qubit state with the highly entangled six-qubit genuine state introduced by Borras et al.(J.Phys.A: Math.Theor.40 (2007) 13407) is studied.Some appropriate measuring bases the sender can take and the corresponding unitary operations the receiver should execute in terms of the sender’s measurement outcome are explicitly given.The flexibility between the measurement difficulty and the reconstruction difficulty is shown.Moreover,discussions and comparisons between our scheme and the recent incomplete scheme (Choudhury et al,J.Phys.A: Math.Theor.42 (2009) 115303) are made. | YIN XiaoFeng 1,LIU YiMin 2,ZHANG ZiYun 1,ZHANG Wen 1 & ZHANG ZhanJun 1 1 Key Laboratory of Optoelectronic Information Acquisition & Manipulation of Ministry of Education of China,School of Physics & Material Science,Anhui University,Hefei 230039,China 2 Department of Physics,Shaoguan University,Shaoguan 512005,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 7 |
| 6 | Partition of arbitrary single-qubit information among n recipients via asymmetric(n+1)-qubit W state显示文摘A symmetric and(n,n)-threshold scheme for a sender to partition his/her arbitrary single-qubit information among n recipients is proposed by using a newly constructed asymmetric(n+1)-qubit W state.Both the scheme in some given scenarios and the new W state are also discussed given. | ZHANG Wen LIU YiMin YIN XiaoFeng ZHANG ZhanJun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，10： | 7 |
| 7 | Analysis of a reduced-ML algorithm in BLAST显示文摘The performance of ML algorithm is much better than other algorithms in the MIMO wireless communication system. However, it is based on the expense of an increase in the complexity. A reduced maximum likelihood (RML) algorithm is proposed in this paper, which derives from the combination of the ML and ZF algorithms. It is shown that the complexity of RML is far lower than that of ML, while in the same performance condition by both theoretic analyses and simulation. | PAN Wen JIANG ZhanJun DU ZhengFeng WANG Yan YOU XiaoHu | 2008 | Science in China(Series F)2008，51，12： | 6 |
| 8 | Near-infrared light activated persistent luminescence nanoparticles via upconversion显示文摘坚持的光 nanoparticles (PLNP ) 和 upconversion nanoparticles (UCNP ) 是二特殊光成像 nanoprobes。在这研究,有效 upconverted 坚持的光(UCPL ) 被把他们的唯一的特征合为 polymethyl methacrylate 认识到,形成一部电影 PLNP 和 UCNP 创作了。红坚持的光(~ 640 nm ) PLNP (CaS : Eu, Tm, Ce ) 能被 UCNP 的 upconverted 绿色排放激活(-NaYF4:Yb,Er@NaYF4) 由在红外线附近的光(NIR ) 激动。用这策略,两 PLNP 和 UCNP 的唯一的光性质能是最佳地 synergized,因此产生的有效 upconversion,光致发光,和 UCPL 同时。UCPL 系统有潜在的应用在在由简单地监视 biocompatible 的 vivo bioimaging NIR-light-excited 的低力量密度坚持的光。由于它的简洁,我们预计为 UCPL 合成罐头的准备的这个方法容易为很多 biophotonic 和 photonic 应用用另外的可得到的 upconversion 和坚持的黄磷对被调整。 | Zhanjun Li Ling Huang YuanweiZhang Yang Zhao Hong Yang Gang Han | 2017 | Nano Research2017，10，5： | 6 |
| 9 | Simpler criterion and flexibility of operation complexity for perfectly teleporting arbitrary n-qubit state with 2n-qubit pure state显示文摘A criterion for whether a pure-state quantum channel consisting of 2n qubits averagely distributed between two nodes can be used for perfectly teleporting an arbitrary n-qubit state via Bell-state measurements is educed.Specifically,a matrix is composed of the coefficients of the known channel state and whether the matrix is unitary decides the criterion.As the criterion is apparently different from the usual standard entanglement criterion (USEC),its applicability is enlarged and verified by other measuring bases.Thorough analyses have further simplified the resultant criterion,so that a much simpler criterion than the USEC is conclusively obtained.Moreover,the flexibility of operation complexity between the non-unitary measurements and the unitary reconstructions is explicitly exhibited. | ZUO XueQin 1,LIU YiMin 2,ZHANG ZiYun 1,ZHANG Wen 1 & ZHANG ZhanJun 1 1 Key Laboratory of Optoelectronic Information Acquisition & Manipulation of Ministry of Education of China,School of Physics & Material Science,Anhui University,Hefei 230039,China 2 Department of Physics,Shaoguan University,Shaoguan 512005,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，11： | 5 |
| 10 | Senegenin promotes in vitro proliferation of human neural progenitor cells显示文摘Senegenin,an effective component of Polygala tenuifolia root extract,promotes proliferation and differentiation of neural progenitor cells in the hippocampus.However,the effects of senegenin on mesencephalon-derived neural progenitor cells remain poorly understood.Cells from a ventral mesencephalon neural progenitor cell line(ReNcell VM) were utilized as models for pharmaceutical screening.The effects of various senegenin concentrations on cell proliferation were analyzed,demonstrating that high senegenin concentrations(5,10,50,and 100 μmo/L),particularly 50 μmol/L,significantly promoted proliferation of ReNcell VM cells.In the mitogen-activated protein kinase signal transduction pathway,senegenin significantly increased phosphorylation levels of extracellular signal-regulated kinases.Moreover,cell proliferation was suppressed by extracellular signal-regulated kinase inhibitors.Results suggested that senegenin contributed to in vitro proliferation of human neural progenitor cells by upregulating phosphorylation of extracellular signal-regulated kinase. | Shi, Fang Liang, Zhigang Guo, Zixuan Li, Ran Yu, Fen Zhang, Zhanjun Wang, Xuan Wang, Xiaomin | 2011 | Neural Regeneration Research2011，6，3： | 5 |
| 11 | Numerical investigation on synthetic jet flow control inside an S-inlet duct显示文摘The high degree of centerline curvature and cross-stream pressure gradient in S-inlet ducts gives rise to boundary layer separation and secondary flows,which result in poor pressure recovery and non-uniform flow in the outlet interface with the engine.The flowfield in ducts is three-dimensional due to the existence of secondary flow,so ordinary two-dimensional actuations have poor effect on reforming the flow.Synthetic jet actuations extended in different spanwise positions were employed to manipulate the flow,and compared with the two-dimensional actuation.The interaction mechanics between flow separation and secondary flow was studied at first.It was found that the secondary flow enhanced or weakened flow separation depending on the spanwise position of synthetic jet actuators.Moreover,the flow separation enhanced the secondary flow,thus causing lower pressure recovery and flow distortion in the duct outlet.The actuators located at different spanwise positions will weaken the secondary flows by improving the flow separation to get energetic and uniform main flow. | CHEN ZhanJun WANG JinJun | 2012 | Science China(Technological Sciences)2012，55，9： | 5 |
| 12 | An Improved Kalman Filter Positioning Method in NLOS Environment显示文摘In the precision positioning system, NLOS(Non Line of Sight) propagation and clock synchronization error caused by multiple base stations are the main reasons for reducing the reliability of communication and positioning accuracy. So, in the NLOS environment, it has an important role to eliminate the clock synchronization problem in the positioning system. In order to solve this problem, this paper proposes an improved Kalman filter localization method NLOS-K(Non Line of Sight-Kalman filter). First, the maximum likelihood estimation algorithm is used to iterate. Then, the Kalman filter algorithm is implemented and the Kalman gain matrix is redefined. The clock drift is compensated so that the clock between the master and slave base stations remains synchronized. The experimental results show that in the non-lineof-sight environment, compared with other algorithms, the positioning accuracy error of the improved algorithm is about 5 cm, and the accuracy compared with other algorithms is 97%. In addition, the influence of bandwidth and spectral density on the method is analyzed, and the accuracy and stability of positioning are improved as a whole. | Zhanjun Hao Beibei Li Xiaochao Dang | 2019 | China Communications2019，16，12： | 4 |
| 13 | Natural gas consumption forecasting model based on coal-to-gas project in China显示文摘Natural gas is widely used because it is environmentally friendly,particularly in reducing carbon emission and improving the Air Quality Index(AQI)around densely populated cities.China has initiated a coal-to-gas project(CGP)to improve the air quality in northern China.As a subcompany of China National Petroleum Corporation,PetroChina Natural Gas Marketing North Company has been focusing on natural gas resource allocation while considering numerous issues such as ensuring the bottom line of livelihood requirements in winter and the performance of economic indicators for an entire calendar year in the northern part of China.Therefore,the accurate prediction of natural gas consumption is important to PetroChina Natural Gas Marketing North Company.It has become a challenge to forecast natural gas consumption because the natural gas market has changed considerably because of the CGP.Natural gas consumption cannot be forecasted using conventional models.This study analyzes the characteristics of the CGP based on the data obtained from rural individual users and company users.Based on the analysis,the gas consumption in winter is predicted using two different forecasting approaches.The methods presented in this paper provide a basis for formulating effective measures for natural gas scheduling in the northern part of China. | Zhiqiang Wang Yichen Li Zhanjun Feng Kai Wen | 2019 | Global Energy Interconnection2019，2，5： | 4 |
| 14 | Multilevel Feature Moving Average Ratio Method for Fault Diagnosis of the Microgrid Inverter Switch显示文摘Multilevel feature moving average ratio method is proposed to realize an open-switch fault diagnosis for any switch of the microgrid inverter. The main steps of the proposed method include multilevel signal decomposition, coefficient reconstruction, absolute average ratio process and artificial neural network(ANN) classification. Specifically, multilevel signal decomposition is realized by using the means of multi resolution analysis to obtain the different frequency band coefficients of the three-phase current signal. The related coefficient reconstruction is executed to achieve signals decomposition in different levels. Furthermore,according to the obtained data, the absolute average ratio process is used to extract absolute moving average ratio of signal decomposition in different levels for the three-phase current.Finally, to intelligently classify the inverter switch fault and realize the adaptive ability, the ANN technology is applied.Compared to conventional fault diagnosis methods, the proposed method can accurately detect and locate the open-switch fault for any location of the microgrid inverter. Additionally, it need not set related threshold of algorithm and does not require normalization process, which is relatively easy to implement. The effectiveness of the proposed fault diagnosis method is demonstrated through detailed simulation results. | Zhanjun Huang Zhanshan Wang Huaguang Zhang | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，2： | 4 |
| 15 | The influence of different underlying surface on sand-duststorm in northern China显示文摘In thispaper,a quantitative research on the relationship between differentunderlying surface and sand-duststorm has been made by using 40 years meteorologicaldata offive differenttypes of underlying surface in northern China,which include farmland,grassland,sandland,gobiand saltcrust. These metrologicaldata comprise sand-duststorm days and strong wind days.By analyzing,we can find that there are certain correlations between the days of sand-dust storm and strong wind for differentunderlying surface,which has greatinfluence on sand-duststorm.Butthere are pronounced differences in differenttypes ofunderlying surface.The sand-duststorm days ofgrassland,gobiand saltcrust,with smallerinterannualvariation are obviously less than strong wind days.On the other hand,the sand-duststorm days offarmland and sandland increase evidently,even in many years,are much more than strong wind days.The differencesare mainly induced by the influencing mechanism of different underlying surface on sand-dust storm. Grassland, gobi and salt crust with stable underlying surface are not prone to sand-dust storm under strong wind condition. W hereas, the underlying surface offarmland and sandland isunstable,thatiseasy to induce sand-duststorm under strong wind condition. | SONG Yang QUAN Zhanjun LIU Lianyou YAN Ping CAO Tong | 2005 | Journal of Geographical Sciences2005，15，4： | 4 |
| 16 | New Activated Carbon with High Thermal Conductivity and Its Microwave Regeneration Performance显示文摘Using a walnut shellas a carbon source and ZnCl_2 as an activating agent,we resolved the temperature gradient problems of activated carbon in the microwave desorption process.An appropriate amount of silicon carbide was added to prepare the composite activated carbon with high thermalconductivity while developing VOC adsorption-microwave regeneration technology.The experimentalresults show that the coefficient of thermalconductivity of SiC-AC is three times as much as those of AC and SY-6.When microwave power was 480 W in its microwave desorption,the temperature of the bed thermaldesorption was 10 ℃ to 30 ℃ below that of normalactivated carbon prepared in our laboratory.The toluene desorption activation energy was 16.05 k J·mol^(-1),which was 15% less than the desorption activation energy of commercialactivated carbon.This study testified that the process could maintain its high adsorption and regeneration desorption performances. | 谷雪贤 SU Zhanjun 奚红霞 | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，2： | 4 |
| 17 | α-Tocopheryl succinate induces apoptosis in erbB2- expressing breast cancer cell via NF-κB pathway显示文摘 | Xiu-fang WANG Ying XIE Hong-gang WANG Yuan ZHANG Xiao-cui DUAN Zhanjun LU | 2010 | Acta Pharmacologica Sinica2010，31，12： | 4 |
| 18 | Preparation of genuine Yeo-Chua entangled state and teleportation of two-atom state via cavity QED显示文摘We first propose a scheme for preparing the genuine Yeo-Chua 4-qubit entangled state via cavity QED. Using the genuine Yeo-Chua atomic state, we further propose a cavity QED scheme for teleporting an arbitrary two-atom state. In two schemes the large-detuning is chosen and the necessary time is designed to be much shorter than Rydberg-atom’s lifespan. Both schemes share the distinct advantage that cavity decay and atom decay can be neglected. As for the interaction manipulation, our preparation scheme is more feasible than a recent similar one. Compared with the Yeo and Chua’s scheme, our teleportation scheme has significantly reduced the measuring difficulty. | ZHANG Wen 1 , LIU YiMin 2 , ZUO XueQin 1 & ZHANG ZhanJun 1* 1 School of Physics & Material Science, Anhui University, Hefei 230039, China 2 Department of Physics, Shaoguan University, Shaoguan 512005, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 3 |
| 19 | Toxicity of manufactured nanomaterials显示文摘Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanomaterial toxicity.The'nano-paradox'has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate nanomaterials.The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions.To this end,we start the present work with a brief intro-duction to nano-bio interactions at different levels.Based on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply explored.Moreover,advanced analytical methods for studying nano-bio interactions are introduced.Furthermore,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented.Finally,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials. | Yaping Liu Shuang Zhu Zhanjun Gu Chunying Chen Yuliang Zhao | 2022 | Particuology2022，20，10： | 3 |
| 20 | Near infrared light triggered nitric oxide releasing platform based on upconversion nanoparticles for synergistic therapy of cancer stem-like cells显示文摘Near infrared(NIR) light-driven nitric oxide(NO) release nano-platform based on upconversion nanoparticles(UCNPs) and light sensitive NO precursor Roussin's black salt(RBS) was fabricated to generate NO upon 808 nm irradiation. The application of 808 nm laser as the excitation source could achieve better penetration depth and avoid overheating problem. The combination of UCNPs and RBS could realize the on-demand release of NO at desired time and location by simply controlling the output of NIR laser.Cellular uptake results showed that more nanoparticles were internalized in cancer stem-like cells(CSCs)rather than non-CSCs. Therefore, a synergistic cancer therapy strategy to eradicate both CSCs and nonCSCs simultaneously was developed. Traditional chemo-drug could inhibit non-CSCs but has low killing efficiency in CSCs. However, we found that the combination of NO and chemotherapy could efficiently inhibit CSCs in bulk cells, including inhibiting mammosphere formation ability, decreasing CD44^+/CD24^- subpopulation and reducing tumorigenic ability. The mechanism studies confirmed that NO could not only induce apoptosis but also increase drug sensitivity by declining drug efflux in CSCs. This UCNPsbased platform may provide a new combinatorial strategy of NO and chemotherapy to improve cancer treatment. | Xiao Zhang Zhao Guo Jing Liu Gan Tian Kui Chen Shicang Yu Zhanjun Gu | 2017 | Science Bulletin2017，62，14： | 3 |
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