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| 1 | Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis显示文摘Low dose antibiotics have been used as growth promoters in livestock and fish. The use of antibiotics has been associated with reduced pathogen infections in livestock. In contrast, antibiotic growth promoter has been suspected of leading to disease outbreaks in aquaculture. However, this phenomenon is circumstantial and has not been confirmed in experimental conditions. In this study,we showed that antibiotic olaquindox increased the susceptibility of zebrafish to A. hydrophila infection. Olaquindox led to profound alterations in the intestinal microbiota of zebrafish, with a drastic bloom of Enterobacter and diminishing of Cetobacterium. Moreover, the innate immune responses of zebrafish were compromised by olaquindox(P<0.05). Transfer of microbiota to GF zebrafish indicated that while the immuo-suppression effect of olaquindox is a combined effect mediated by both OLA-altered micro biota and direct action of the antibiotic(P<0.05), the increased pathogen susceptibility was driven by the OLA-altered microbiota and was not dependent on direct antibiotic effect. Taken together, these data indicate that low level of OLA induced gut microbiota dysbiosis in zebrafish, which led to increased pathogen susceptibility. | suxu he quanmin wang shuning li chao ran xiaoze guo zhen zhang zhigang zhou | 2017 | Science China(Life Sciences)2017，60，11： | 10 |
| 2 | SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis显示文摘译解位于下面的机制种回答到不能生活的应力为改进植物压力抵抗是关键的。大部分在 transcriptional 水平响应盐应力对基因表示的规定被知道;然而,很少在 posttranscriptional 水平对这个过程被知道。最近,我们证明那个翻斗车是与钟基因 pre-mRNAs 交往并且为调整他们拼接的选择和 mRNA 成熟是必要的 spliceosome 的一个部件。在这研究,我们发现 skip-1 植物对盐和渗透的压力过分敏感,并且那个翻斗车为拼接的选择和几咸忍耐的基因的 mRNA 成熟被要求,包括 NHX1, CBL1, P5CS1, RCI2A,和 PAT10。染色体宽的分析表明那个翻斗车调停在咸压力的条件下面许多基因拼接的选择,和在 skip-1 的其他的拼接事件的那个大多数包含 intron 保留和罐头 generatea 在抄录 mRNA 的早熟的结束 codon。翻斗车也控制由 modulating 的其他的拼接 5 和 3 的识别或劈开拼接在咸压力的条件下面的施主和领受人地点。因此,这研究探讨的基本问题拼接的 mRNA 在植物的机械在 posttranscriptional 水平贡献咸压力的回答,并且提供在其他的拼接和盐忍耐之间的一个连接。 | Jinlin Feng dingjing Li Zhaoxu Gao Yaru Lu Junya Yu Qian Zheng Shuning Yan Wenjiao Zhang Hang He Ligeng Ma Zhengge Zhu | 2015 | Molecular Plant2015，8，7： | 10 |
| 3 | A model for parameter estimation of multistage centrifugal compressor and compressor performance analysis using genetic algorithm显示文摘A model for performance prediction of multistage centrifugal compressor is proposed.The model allows the users to predict the compressor performance,e.g.pressure ratio,efficiency and losses using the compressor geometric information and speed by a stage stacking calculation based on the characteristics of each stage.To develop the compressor elemental stage characteristics,the compressor losses,such as incidence losses and friction losses,are mathematically modeled.For a composite systems,for instance a gas turbine power plant,the performance of the multistage centrifugal compressor can be evaluated.Since some important parameters of the compressor model,e.g.,the slip factor,shock loss coefficient and reference diameter D1,are hard to be determined by empirical laws,a genetic algorithm(GA) is used to solve the parameter estimation problem of the proposed model,and in turn the compressor performance analysis and parameters study are performed.The surge line for the multistage centrifugal compressor can also be determined from the simulation results.Furthermore,the model presented here provides a valuable tool for evaluating the multistage centrifugal compressor performance as a function of various operation parameters. | CHU Fei WANG FuLi WANG XiaoGang ZHANG ShuNing | 2012 | Science China(Technological Sciences)2012，55，11： | 8 |
| 4 | An Adaptive Weighted Differential Game Guidance Law显示文摘For intercepting modern high maneuverable targets, a novel adaptive weighted differential game guidance law based on the game theory of mixed strategy is proposed, combining two guidance laws which are derived from the perfect and imperfect information pattern, respectively. The weights vary according to the estimated error of the target's acceleration, the guidance law is generated by directly using the estimation of target's acceleration when the estimated error is small, and a differential game guidance law with adaptive penalty coefficient is implemented when the estimated error is large. The adaptive penalty coefficients are not constants and they can be adjusted with current target maneuverability. The superior homing performance of the new guidance law is verified by computer simulations. | ZHANG Ping FANG Yangwang ZHANG Fengming XIAO Bingsong HU Shiguo ZONG Shuning | 2012 | Chinese Journal of Aeronautics2012，25，5： | 5 |
| 5 | Review of lithium-ion battery state of charge estimation显示文摘The technology deployed for lithium-ion battery state of charge(SOC)estimation is an important part of the design of electric vehicle battery management systems.Accurate SOC estimation can forestall excessive charging and discharging of lithium-ion batteries,thereby improving discharge efficiency and extending cycle life.In this study,the key lithium-ion battery SOC estimation technologies are summarized.First,the research status of lithium-ion battery modeling is introduced.Second,the main technologies and difficulties in model parameter identification for lithium-ion batteries are discussed.Third,the development status and advantages and disadvantages of SOC estimation methods are summarized.Finally,the current research problems and prospects for development trends are summarized. | Ning Li Yu Zhang Fuxing He Longhui Zhu Xiaoping Zhang Yong Ma Shuning Wang | 2021 | Global Energy Interconnection2021，4，6： | 5 |
| 6 | Glycerolipid Profiling of Yellow Sarson Seeds Using Ultra High Performance Liquid Chromatography Coupled to Triple Time-of-Flight Mass Spectrometry显示文摘Yellow sarson(Brassica rapa ssp. trillocularis) is an important rapeseed-mustard species of Brassica rapa due to its high seed oil content. Glycerolipids and fatty acid composition affect seed germination and determine the quality of seed oil. To date, no information is available on the composition of individual glycerolipids in this species. Therefore, in this study the glycerolipid profiling of yellow sarson seeds was performed using ultra high performance liquid chromatography coupled to triple time-of-flight mass spectrometry(UPLC-Triple-TOF-MS).A fast and efficient chromatographic separation of glycerolipids was accomplished based on an UPLCTMBEH C8 column within 22 min.In ESI positive ion mode, TOF-MS scan-information dependent acquisition-product ion scan was carried out to acquire both high resolution MS and MS/MS information from one injection. According to MS/MS spectra, predominant fragmentation patterns of glycerolipids were elucidated in detail. Based on retention time, accurate mass, isotopic distribution, and fragmentation patterns, the composition of 144 glycerolipids and fatty acids were finally identified in yellow sarson seeds, including 77 triacylglycerols, 32 diacylglycerols, 18sulfoquinovosyl-diacylglycerols, 5 monogalactosyl-diaclyglycerols, and 12 digalactosyl-diacylglycerols. Of them, the most abundant glycerolipids in yellow sarson seeds were triacylglycerols, the major storage form of seed oil in plants. In addition, diacylglycerols were found as a minor component of glycerolipids. The lowest amounts of glycerolipids detected in seeds were glycosyl-acylglycerols. The results revealed the composition and relative content of glycerolipids in yellow sarson seeds, which will provide a more comprehensive assessment of the quality of seed oil and also help to select functional cultivars with higher beneficial glycerolipids. This profiling method has the advantages of high throughput, high sensitivity and good accuracy, which will provide a reliable analysis platform for glycerolipids metabolism in plants. | ZHENG Shuning ZHANG Yanguo LIU Guangyang LV Jun LIU Zhongxiao XU Xiaomin LI Lingyun XU Donghui | 2017 | Horticultural Plant Journal2017，3，4： | 2 |
| 7 | Effects of Statin Therapy on Inflammatory Markers in Chronic Heart Failure: A Meta-analysis of Randomized Controlled Trials显示文摘 | Lei Zhang Shuning Zhang Hong Jiang Aijun Sun Yunkai Wang Yunzeng Zou Junbo Ge Haozhu Chen | 2010 | Archives of Medical Research2010，，6： | 1 |
| 8 | Global optimization of separable objective functions on convex polyhedra via piecewise-linear approximation 显示文摘 | ZHANG Hao WANG Shuning | 2006 | Journal of Computational and Applied Mathematics2006，197，1： | 1 |
| 9 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 10 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 11 | Real-time product quality control for batch processes based on stacked least-squares support vector regres- sion models显示文摘 | Zhang Shuning Wang Full He Dakuo Jia Runda | 2012 | Computers & Chemical Engineering2012，36，： | 1 |
| 12 | FOXP3 inhibits NF-κB activity and hence COX2 expression in gastric cancer cells显示文摘 | Qiang Hao Cun Zhang Yuan Gao Shuning Wang Jialin Li Meng Li Xiaochang Xue Weina Li Wei Zhang Yingqi Zhang | 2014 | Cellular Signalling2014，，3： | 1 |
| 13 | Online quality prediction for cobalt oxalate synthesis process using least squares support vector regression approach with dual updating 显示文摘 | ZHANG Shuning WANG Fuli HE Dakuo | 2013 | Control Engineering Practice2013，21，10： | 1 |
| 14 | Real-time product quality control for batch processes based on stacked least-squares support vector regression models显示文摘 | Shuning Zhang Fuli Wang Dakuo He Runda Jia | 2011 | Computers and Chemical Engineering2011，，： | 1 |
| 15 | Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis显示文摘DearEditor,Indole-3-carboxaldehyde(ICA)is a gut microbe-derived tryptophan metabolite.Here,we explored the role of ICA in atherosclerosis.Plasma tryptophan metabolites were measured in healthy individuals and patients with atherosclerosis(Supplementary Table S1).The latter group showed disturbed tryptophan metabolism,while no difference was observed in tryptophan levels between the two groups(Fig.1a).ICA concentration is lower in the patients group(Fig.1b),consistent with previous clinical studies.1 The concentration of other metabolites of kynurenine or serotonin pathway showed no variations between the control and the patients(Supplementary Fig.1a). | Yijing Lu Wenlong Yang Zhiyong Qi Rifeng Gao Jing Tong Tingwen Gao Yin Zhang Aijun Sun Shuning Zhang Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 16 | Enhancing single-molecule conductance of platinum (Ⅱ) complexes through synergistic aromaticity-assisted structural asymmetry显示文摘Seeking the strategies of designing highly conductive molecular structures is one of the core researches in molecular electronics.As asymmetric structure has manifested feasible properties in comprehensive fields, we introduce the structures of asymmetric platinum(Ⅱ) complexes into the charge transport study at single-molecule scale for the first time. The single-molecule conductance measurement results reveal that, in platinum(Ⅱ)-aryloligoynyl structures, the conductance of asymmetrically coordinated complexes is obviously higher than that of the symmetric isomers with the same molecular length, while the conductance is almost identical in symmetric and asymmetric platinum(Ⅱ)-oligoynyl complexes. Theoretical study uncovers that, upon connecting to the oligoynyl structure, the aromatic group effectively extends the π-system of the whole conductive backbone and gathers the HOMO population mainly on the longer oligoynyl ligand, which reduces the energy barrier in electron transport and enhances the conductance through HOMO energy lifting. This result provides feasible strategy for achieving high conductive molecular devices. | Ping Duan Junyang Liu Jin-Yun Wang Kai Qu Shuning Cai Fei Wang Lichuan Chen Xiaoyan Huang Ruihao Li Jia Shi Qian-Chong Zhang Wenjing Hong Zhong-Ning Chen | 2020 | Science China Chemistry2020，63，4： | 0 |
| 17 | Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors显示文摘Cell metabolism plays vital roles in organismal development,but it has been much less studied than transcriptional and epigenetic control of developmental programs.The difficulty might be largely attributed to the lack of in situ metabolite assays.Genetically encoded fluorescent sensors are powerful tools for noninvasive metabolic monitoring in living cells and in vivo by highly spatiotemporal visualization.Among all living organisms,the NAD(H)and NADP(H)pools are essential for maintaining redox homeostasis and for modulating cellular metabolism.Here,we introduce NAD(H)and NADP(H)biosensors,present example assays in developing organisms,and describe promising prospects for how sensors contribute to developmental biology research. | Ting Li Yejun Zou Shuning Liu Yi Yang Zhuo Zhang Yuzheng Zhao | 2022 | Cell Regeneration2022，11，1： | 0 |
| 18 | Highly selective and efficient photocatalytic NO removal:Charge carrier kinetics and interface molecular process显示文摘The widespread nitrogen oxides(NOx,mainly in NO)in the atmosphere have threatened human health and ecological environment.The dilute NO(ppb)is difficult to efficiently remove via the traditional process due to its characteristics of low concentration,wide range,large total amount,etc.Photocatalysis can utilize solar energy to purify NO pollutants under mild conditions,but its application is limited due to the low selectivity of nitrate and poor activity of NO removal.The underlying reason is that the interface mechanism of NO oxidation is not clearly understood,which leads to the inability to accurately regulate the NO oxidation process.Herein,the recent advances in the photocatalytic oxidation of NO are summarized.Firstly,the common strategies to effectively regulate carrier dynamics such as morphology control,facet engineering,defect engineering,plasma coupling,heterojunction and single-atom catalysts are discussed.Secondly,the progress of enhancing the adsorption and activation of reactants such as NO and O_(2) during NO oxidation is described in detail,and the corresponding NO oxidation mechanisms are enumerated.Finally,the challenges and prospects of photocatalytic NO oxidation are presented in term of nanotechnology for air pollution control.This review can shed light on the interface mechanism of NO oxidation and provide illuminating information on designing novel catalysts for efficient NOx control. | Huan Shang Hongbao Jia Pengpeng Li Hao Li Wenbin Zhang Shuangjun Li Qing Wang Shuning Xiao Ding Wang Guisheng Li Dieqing Zhang | 2024 | Nano Research2024，17，3： | 0 |
| 19 | Evolution of chemistry and selection technology for DNA-encoded library显示文摘DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical world.In analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical phenotypes.Importantly,DNA-compatible synthesis is the key to expanding the DEL chemical space.Besides,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection strategies.In this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL. | Peixiang Ma Shuning Zhang Qianping Huang Yuang Gu Zhi Zhou Wei Hou Wei Yi Hongtao Xu | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 20 | Dual-excitation decoding multiparameter-based ratiometric luminescence thermometry:a new strategy toward reliable and accurate thermal sensing显示文摘Luminescence thermometry can perform noninvasive thermal sensing with high spatial resolution and fast response,emerging as an exciting field of research due to its promising applications in biomedicine.Nevertheless,because of the interaction between light and complex tissues,the reliability and the accuracy of this technique suffer serious interference,which significantly restricts its practical utilization.Here,a strategy to implement effective luminescence nanothermometry is preliminarily proposed by employing the different thermal responses between Yb^(3+)→Nd^(3+)and Nd^(3+)→Yb^(3+)energy transfer processes.Different from the traditional ratiometric sensing method,where two luminescence intensities are used as the thermal response parameters,we use two intensity ratios between Yb^(3+)and Nd^(3+)near-IR emissions that are obtained under dual excitation as the detecting and reference signals to perform temperature measurement.This multiparameter-based,self-reference thermometry technique,as we define it,exhibits excellent immunity to the influences arising from the fluctuation and loss of pumping sources as well as the luminescence attenuation in media.High thermal sensitivity(~2.2%K^(-1))and good resolution(~0.35°C)are successfully achieved here,accompanied by a measurement error of~1.1°C in a biological environment test,while large errors are observed based on the traditional ratiometric approach(~8.9°C,~23.2°C).We believe the viewpoint in this work could boost luminescence thermometry and provide an ingenious route toward high-performance thermal sensing for biological systems. | WEI XU SHUNING ZONG FENGKAI SHANG LONGJIANG ZHENG ZHIGUO ZHANG | 2022 | Photonics Research2022，10，11： | 0 |
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