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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 3 | A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs显示文摘 | Mihaela Crisan Solomon Yap Louis Casteilla Chien-Wen Chen Mirko Corselli Tea Soon Park Gabriella Andriolo Bin Sun Bo Zheng Li Zhang Cyrille Norotte Pang-Ning Teng Jeremy Traas Rebecca Schugar Bridget M. Deasy Stephen Badylak Hans-J?rg B?hring Jean-Paul Gi | 2008 | Cell Stem Cell2008，，3： | 3 |
| 4 | Environmental implications of the magnetic record in Pleistocene lacustrine sediments of the Qaidam Basin, NE Tibetan Plateau显示文摘 | Christian Herb Weilin Zhang Andreas Koutsodendris Erwin Appel Xiaomin Fang J?rg Pross | 2013 | Quaternary International2013，，： | 2 |
| 5 | Vascugraft R Polyurethanes Arterial Prosthesis as Femoro-popliteal and Femoro-peroneal Bypasses in Humans:Pathological,Structural and Chemical Analyses of Four Excised Grafts显示文摘 | Zhang Z Marois Y Guidoin RG | 1997 | Biomaterials1997，18，2： | 1 |
| 6 | Cross-reactive HIV-l-neutralizing activity of serum IgG from a rabbit immunized with gp41 fused to IgG1 Fc: possible role of the prolonged half-life of the immunogen显示文摘 | Zhang MY Wang Y Mankowski MK Ptak RG Dimitrov DS | 2009 | Vaccine2009，27，6： | 1 |
| 7 | Nitric oxide deficiency as a cause of clinical hypertension: promising new drug targets for refractory hypertension显示文摘 | Thomas GD Zhang W Victor RG | 2001 | JAMA2001，285，： | 1 |
| 8 | Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway显示文摘 | DAI XF DING J ZHANG RG | 2013 | International Journal of Radiation Biology:Covering the Physical Chemical Biological and Medical Effects of Ionizing and Non-ionizing Radiations2013，89，9： | 1 |
| 9 | Regulation of histone methylation by demethylimination and demethylation 显示文摘 | Klose RG Zhang Y | 2007 | Nat Rev Mol Cell Biol2007，8，4： | 1 |
| 10 | Propagation of a hydraulic fracture parallel to a free surface显示文摘 | Zhang X Jeffrey RG Detournay E | 2005 | International Joumal for Nu- merical and Analytical Methods in Geomechanics2005，29，13： | 1 |
| 11 | The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down regulation of Mcl-1显示文摘 | Gojo I Zhang B Fenton RG | 2002 | Clin Cancer Res2002，8，8： | 1 |
| 12 | Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA显示文摘 | Zhang RG Pappas KM Brace JL Miller PC Oulmassov T Molyneaux JM Anderson JC Bashkin JK Winans SC Joachimiak A | 2002 | Nature2002，417，6892： | 1 |
| 13 | ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection 显示文摘 | Cote R Zhang Y Hart RG | 2014 | Neurology2014，82，5： | 1 |
| 14 | Distribution of cervical intraepithelial neoplasia2,3and cancer on the uterine cervix 显示文摘 | Pretorius RG Zhang X Belinson JL | 2006 | J low Genit Tract Dis2006，10，1： | 1 |
| 15 | Optical Diode Made from a Moving Photonic Crystal 显示文摘 | Wang Da-Wei Zhou Hai-Tao Guo Miao-Jun Zhang Jun-Xiang Jo' rg Evers Zhu Shi-Yao | 2013 | Phys Rev Lett2013，110，09： | 1 |
| 16 | Cross-sectional surveys and subtype classification of human Blastocystis isolates from four epidemiological settings in China显示文摘 | Lan Hua Li Xiao Ping Zhang Shan Lv Ling Zhang Hisao Yoshikawa Zhiliang Wu Peter Steinmann Jürg Utzinger Xiao Mei Tong Shao Hong Chen Xiao Nong Zhou | 2007 | Parasitology Research2007，，1： | 1 |
| 17 | A thin-layer,liquidbased pap Test for mass Screening in an area of China With a high incidence of cervical carcinoma显示文摘 | Belinson JL Li L Pretorius RG Qiao YL Zhang WH Zhang X Wu LY Rong SD Sun TY | 2003 | A cross-sectional comparative study Autocytol2003，47，1： | 1 |
| 18 | Robust simple sequence repeat markers for spruce (Picea spp.) from expressed sequence tags显示文摘 | Dainis Rungis Yanik Bérubé Jun Zhang Steven Ralph Carol E. Ritland Brian E. Ellis Carl Douglas J?rg Bohlmann Kermit Ritland | 2004 | Theoretical and Applied Genetics2004，，6： | 1 |
| 19 | Human hepatoma cell telomerase activity inhibition and cell cycle modulation by its RNA component antisense oligodeox bonucleotides显示文摘 | ZHANG RG WANG XW YUAN JH | 2010 | Acta Pharmacol Sin2010，21，： | 1 |
| 20 | Nitric oxide deficiency as a cause of clinical hypertension:promising new drug targets for refractory hypertension显示文摘 | Thomas GD Zhang W Victor RG | 2001 | JAMA2001，285，： | 1 |
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