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| 1 | METTL3-mediated N^6-methyladenosine mRNA modification enhances long-term memory consolidation显示文摘 | Zeyu Zhang Meng Wang Dongfang Xie Zenghui Huang Lisha Zhang Ying Yang Dongxue Ma Wenguang Li Qi Zhou Yun-Gui Yang Xiu-Jie Wang | 2018 | Cell Research2018，28，11： | 29 |
| 2 | An economic and low-carbon day-ahead Pareto-optimal scheduling for wind farm integrated power systems with demand response显示文摘Demand response(DR)and wind power are beneficial to low-carbon electricity to deal with energy and environmental problems.However,the uncertain wind power generation(WG)which has anti-peaking characteristic would be hard to exert its ability in carbon reduction.This paper introduces DR into traditional unit commitment(UC)strategy and proposes a multi-objective day-ahead optimal scheduling model for wind farm integrated power systems,since incentive-based DR can accommodate excess wind power and can be used as a source of system spinning reserve to alleviate generation side reserve pressure during both peak and valley load periods.Firstly,net load curve is obtained by forecasting load and wind power output.Then,considering the behavior of DR,a day-ahead optimal dispatching scheme is proposed with objectives of minimum generating cost and carbon emission.Non-dominated sorting genetic algorithm-II(NSGA-II)and satisfaction-maximizing method are adopted to solve the multi-objective model with Pareto fronts and eclectic decision obtained.Finally,a case study is carried out to demonstrate that the approach can achieve economic and environmental aims and DR can help to accommodate the wind power. | Rui MA Kai LI Xuan LI Zeyu QIN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 20 |
| 3 | Involvement of carbon monoxide produced by heme oxygenase in ABA-induced stomatal closure in Vicia faba and its proposed signal transduction pathway显示文摘Carbon monoxide (CO) has recently proven to be an important bioactive or signaling molecule in mammalian cells. Its effects are mainly mediated by nitric oxide (NO) and cyclic GMP (cGMP). In Vicia faba leaves, CO production and heme oxygenase (HO) activity, an important CO synthetic enzyme, are first reported to increase in response to ABA treatment, which could result in stomatal closure. Inter- estingly, ABA-induced stomatal closure in V. faba guard cells is partially blocked when the synthetic CO inhibitor ZnPP, or the CO/NO scavenger Hb is added. Furthermore, we show that, exogenously applied CO donor, hematin, and CO aqueous solution not only result in the enhancement of CO release, but also time-dependently induce stomatal closure, and the latter is mimicked by the application of an NO donor SNP. The above-mentioned stomatal closure effects are differentially reversed by the addition of tungstate, a potent inhibitor of NO synthetic enzyme nitrate reductase (NR), the specific NO scavenger cPTIO, ZnPP, or Hb. During treatment for 4 h, SNP, 0.01% CO aqueous solution or hematin significantly triggers NO synthesis, whereas cPTIO, or tungstate approximately fully inhibits NO fluorescence. Ad- ditionally, application of the GC inhibitor ODQ blocks CO-induced stomatal closure. This inhibition could be reversed when 8-Br-cGMP is added. Thus, the above results suggest that CO produced by HO is involved in ABA-induced stomatal closure, and NO and cGMP may function as downstream interme- diates in the CO signaling responsible for stomatal closure. | CAO ZeYu HUANG BenKai WANG QingYa XUAN Wei LING TengFang ZHANG Bo CHEN Xi NIE Li SHEN WenBiaot | 2007 | Chinese Science Bulletin2007，52，17： | 16 |
| 4 | Chinese Marine Economy Development: Dynamic Evolution and Spatial Difference显示文摘This study focuses on China's coastal area and its marine economic development. Applying the information diffusion method, the study establishes a kernel density function and its decomposition using a marine economic per capita as the index of the model to depict the dynamic evolution law and the internal influential factors of the Chinese marine economy during 1996–2013. The relative development rate was introduced to analyze the spatial differences in the marine economy's development. In this way, space and time dimensions fully characterized the evolution of the Chinese marine economy. Additionally, the influence of growth and inequality in the process of its development can be analyzed. The study shows that the Chinese marine economy as a whole has been growing, and regional marine economic development is relatively coordinated. In addition, the marine economy began to develop even more rapidly after 2004. There are three factors affecting the dynamic evolution of China's marine economy: first, the most influential mean effect, followed by, second, the variance effect, and third, the least influential residual effect. The biggest influence on the dynamic evolution of the marine economy is the improvement of the development level of the marine economy in the coastal area. Meanwhile, due to the existence of inequality, provinces at higher development levels are more dispersed. Furthermore, the existence of the residual effect weakens the influence of the mean effect, and the influence on the dynamic evolution of the marine economy continuously increases. In the analysis of the influencing factors of the evolution and spatial difference of marine economic development, the level of opening to the outside world, the level of investment in fixed assets and the industrial structure have a positive role in promoting economic development. However, capital investment in scientific human research has a negative correlation with economic development, and does not pass the significant test. The difference in regional development levels and development speed is also very apparent; namely, the provinces with higher development levels generally displayed faster development speeds while those with lower development levels showed slower development speeds across the four periods analyzed. | SUN Caizhi LI Xin ZOU Wei WANG Song WANG Zeyu | 2018 | Chinese Geographical Science2018，28，1： | 8 |
| 5 | Strongly Coupled 2D Transition Metal Chalcogenide-MXene-Carbonaceous Nanoribbon Heterostructures with Ultrafast Ion Transport for Boosting Sodium/Potassium Ions Storage显示文摘Combining with the advantages of two-dimensional(2D)nanomaterials,MXenes have shown great potential in next generation rechargeable batteries.Similar with other 2D materials,MXenes generally suffer severe self-agglomeration,low capacity,and unsatisfied durability,particularly for larger sodium/potassium ions,compromising their practical values.In this work,a novel ternary heterostructure self-assembled from transition metal selenides(MSe,M=Cu,Ni,and Co),MXene nanosheets and N-rich carbonaceous nanoribbons(CNRibs)with ultrafast ion transport properties is designed for sluggish sodium-ion(SIB)and potassium-ion(PIB)batteries.Benefiting from the diverse chemical characteristics,the positively charged MSe anchored onto the electronegative hydroxy(-OH)functionalized MXene surfaces through electrostatic adsorption,while the fungal-derived CNRibs bonded with the other side of MXene through amino bridging and hydrogen bonds.This unique MXene-based heterostructure prevents the restacking of 2D materials,increases the intrinsic conductivity,and most importantly,provides ultrafast interfacial ion transport pathways and extra surficial and interfacial storage sites,and thus,boosts the high-rate storage performances in SIB and PIB applications.Both the quantitatively kinetic analysis and the density functional theory(DFT)calculations revealed that the interfacial ion transport is several orders higher than that of the pristine MXenes,which delivered much enhanced Na+(536.3 mAh g^(−1)@0.1 A g^(−1))and K^(+)(305.6 mAh g^(−1)@1.0 A g^(−1))storage capabilities and excel-lent long-term cycling stability.Therefore,this work provides new insights into 2D materials engineering and low-cost,but kinetically sluggish post-Li batteries. | Junming Cao Junzhi Li Dongdong Li Zeyu Yuan Yuming Zhang Valerii Shulga Ziqi Sun Wei Han | 2021 | Nano-Micro Letters2021，13，7： | 5 |
| 6 | A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy显示文摘The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes.However,there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation.Here,we report a subnanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tunable catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural transformation.The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO;and electron-rich state of CeO;-x,and active oxygen vacancies generation via the hot-electron injection.Interestingly,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 m W cm;)-activated photocatalytic therapy of tumors.Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems. | Xi Hu Nan Wang Xia Guo Zeyu Liang Heng Sun Hongwei Liao Fan Xia Yunan Guan Jiyoung Lee Daishun Ling Fangyuan Li | 2022 | Nano-Micro Letters2022，14，6： | 4 |
| 7 | Oxygen vacancy-engineered BaTiO_(3)nanoparticles for synergistic cancer photothermal,photodynamic,and catalytic therapy显示文摘With the rapid development of photo-responsive nanomaterials,photo-triggered therapeutic strategies such as photothermal therapy(PTT)and photodynamic therapy(PDT)have been new alternatives to current cancer therapeutic methods.Herein,we have fabricated oxygen vacancy-engineered BaTiO_(3)(BTO-Ov)nanoparticles(NPs)for near-infrared(NIR)light-triggered PTT,PDT,and catalytic therapy cooperatively for significantly improving cancer therapy.Compared to pristine BaTiO_(3)nanoparticles,BTO-Ov has stronger NIR light absorption and narrower band gap structure,which results in superior photothermal conversion and superoxide radical generation capabilities through PTT and PDT.Meanwhile,due to the existence of Ti^(3+),BTO-Ov also exhibits peroxidase(POD)-like activity to produce hydroxyl radical under tumor environment,which can be further improved under 808 nm light irradiation.Both in vitro and in vivo results demonstrate that such a multifunctional therapeutic nanoplatform can achieve a high therapeutic efficacy triggered by a single NIR light irradiation.The defect engineering strategy can be used as a general approach to fabricate multifunctional cancer therapeutic nanoplatform. | Yiming Ding Zhuo Wang Zeyu Zhang Yunchao Zhao Shangyu Yang Yalong Zhang Shuncheng Yao Shaobo Wang Tian Huang Yang Zhang Linlin Li | 2022 | Nano Research2022，15，8： | 3 |
| 8 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 9 | Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures显示文摘Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters. | Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 10 | The rice Raf-like MAPKKK OsILA1 confers broad-spectrum resistance to bacterial blight by suppressing the OsMAPKK4-OsMAPK6 cascade显示文摘Mitogen-activated protein kinase kinase kinase(MAPKKK)are the first components of MAPK cascades,which play pivotal roles in signaling during plant development and physiological processes.The genome of rice encodes 75 MAPKKKs,of which 43 are Raf-like MAPKKKs.The functions and action modes of most of the Raf-like MAPKKKs,whether they function as bona fide MAPKKKs and which are their downstream MAPKKs,are largely unknown.Here,we identified the osmapkkk43 mutant,which conferred broad-spectrum resistance to Xanthomonas oryzae pv.oryzae(Xoo),the destructive bacterial pathogen of rice.Oryza sativa(Os)MAPKKK43 encoding a Raf-like MAPKKK was previously known as Increased Leaf Angle 1(OsILA1).Genetic analysis indicated that OsILA1 functioned as a negative regulator and acted upstream of the OsMAPKK4-OsMAPK6 cascade in rice-Xoo interactions.Unlike classical MAPKKKs,OsILA1 mainly phosphorylated the threonine 34 site at the N-terminal domain of OsMAPKK4,which possibly influenced the stability of OsMAPKK4.The N-terminal domain of OsILA1 is required for its homodimer formation and its full phosphorylation capacity.Taken together,our findings reveal that OsILA1 acts as a negative regulator of the OsMAPKK4-OsMAPK6 cascade and is involved in rice-Xoo interactions. | Jie Chen Lihan Wang Zeyu Yang Hongbo Liu Chuanliang Chu Zhenzhen Zhang Qinglu Zhang Xianghua Li Jinghua Xiao Shiping Wang Meng Yuan | 2021 | Journal of Integrative Plant Biology2021，63，10： | 3 |
| 11 | Terahertz synthetic aperture in-line holography with intensity correction and sparsity autofocusing reconstruction显示文摘We demonstrate high-resolution and high-quality terahertz(THz)in-line digital holography based on the synthetic aperture method.The setup is built on a self-developed THz quantum cascade laser,and a lateral resolution better than 70μm(~λ)is achieved at 4.3 THz.To correct intensity differences between sub-holograms before aperture stitching,a practical algorithm with global optimization is proposed.To address the twin-image problem for in-line holography,a sparsity-based phase retrieval algorithm is applied to perform the high-quality reconstruction.Furthermore,a new autofocusing criterion termed'reconstruction objective function'is introduced to obtain the best in-focus reconstruction distance,so the autofocusing procedure and the reconstruction are unified within the same framework.Both simulation and experiment prove its accuracy and robustness.Note that all the methods proposed here can be applied to other wavebands as well.We demonstrate the success of this THz synthetic aperture in-line holography on biological and semiconductor samples,showing its potential applications in bioimaging and materials analysis. | ZEYU LI RUIJIAO ZOU WEIPENG KONG XUEMIN WANG QINGHUA DENG QIANG YAN YU QIN WEIDONG WU XUN ZHOU | 2019 | Photonics Research2019，7，12： | 3 |
| 12 | Large piezoelectric response in a family of metal-free perovskite ferroelectric compounds from first-principles calculations显示文摘Metal-free organic perovskite ferroelectric materials have been shown recently to have a number of attractive properties,including high spontaneous polarization and piezoelectric coefficients.In particular,slow evaporation of solutions containing organic amines,inorganic ammoniums,and dilute hydrohalogen acid has been shown to produce several attractive materials in the MDABCO-NH_(4)-I_(3) family(MDABCO is N-methyl-N’-diazabicyclo[2,2,2]octonium).In the present work,we study by first-principles calculations the origin of polarizaiton,electronic density of state,piezoelectric response,and elastic properties of MDABCO-NH_(4)-X_(3)(X=Cl,Br,I).We find that the dipole moments of the MDABCO and NH_(4) groups are negligible,and the large spontaneous polarization of MDABCONH_(4)-I_(3) mainly results from MDABCO and NH_(4) being off-center relative to I ions.Although the piezoelectric response of organic materials is usually very weak,we observe large piezoelectric strain components,d_(x4) and d_(x5);the calculated d_(x5) is 119 pC/N for MDABCO-NH_(4)-Cl_(3),248 pC/N for MDABCO-NH_(4)-Br_(3) and 178 pC/N for MDABCO-NH_(4)-I_(3).The large value of dx5 is found to be closely related with the large value of elastic compliance tensor,s44.These results show that MDABCO-NH_(4)-X_(3) metal-free organic perovskites have large piezoelectric response with soft elastic properties. | Hui Wang Huihui Liu Zeyu Zhang Zihan Liu Zhenlong Lv Tongwei Li Weiwei Ju Haisheng Li Xiaowu Cai Han Han | 2019 | npj Computational Materials2019，，1： | 3 |
| 13 | Effects of a check dam system on the runoff generation and concentration processes of a catchment on the Loess Plateau显示文摘As an important soil and water conservation engineering measure,more than 100,000 check dams are constructed across the Loess Plateau;these dams play a vital role in reducing floods and sediment in the region.However,the effects of check dams on hydrologic process are still unclear,particularly when they are deployed as a system for watershed soil and water management.This study examined the watershed hydrologic process modulated by the check dam system in a typical Loess Plateau catchment.By simulating scenarios with various numbers of check dams using a distributed physically-based hydro-logical model,the effects of the number of check dams on runoff generation and concentration were analyzed for the study catchment.The results showed that the presence of check dams reduced the peak discharge and the flood volume and extended the flood duration;the reduction effect on peak discharge was most significant among the three factors.The system of check dams substantially decreased the runoff coefficient,and the runoff coefficient reduction rate was greater for rainstorms with shorter return periods than for rainstorms with longer return periods.The check dams increased the capacity of the catchment regulating and storing floods and extended the average runoff concentration time in the catchment that flattened the instantaneous unit hydrograph.This study reveals the influencing mech-anism of check dam system on the watershed hydrological process under heavy rainstorm conditions and provides a theoretical basis for evaluating the effects of numerous check dams on regional hydrology and water resources on the Loess Plateau. | Shuilong Yuan Zhanbin Li Li Chen Peng Li Zeyu Zhang Junzheng Zhang Anna Wang kunxia Yu | 2022 | International Soil and Water Conservation Research2022，10，1： | 3 |
| 14 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 15 | NON-EQUILIBRIUM STATIONARY STATE IN CHEMICAL REACTION OF SiO_2/Fe AT INTERFACE OF SLAG/METAL AND ITS STABILITY DURING ARC WELDING显示文摘For characteristics of open and far from thermodynamic equilibrium in welding chemical reaction, a new kind of quantitative method, which is used to analyze direction and extent for chemi- cal reaction of SiO_2/Fe during quasi-steady state period, is introduced with the concept of non-equilibrium stationary state. The main idea is based on thermodynamic driving forces, which result in non-zero thermodynamic fluxes and lead to chemical reaction far away from thermodynamic equilibrium. There exists certain dynamic equilibrium relationship between rates of diffusion fluxes in liquid phase of reactants or products and the rate equation of chemical reaction when welding is in quasi-steady state. As result of this, a group of non-linear equations containing concentrations of all substances at interface of slag/liquid-metal may be established. Moreover the stability of this non-equilibrium stationary state is discussed using dissipative structure theory and it is concluded theoretically that this non-equilibrium stationary state for welding chemical reaction is of stability. | LI Xiaoquan DU Zeyu YANG Xuguang | 2007 | Chinese Journal of Mechanical Engineering2007，20，1： | 2 |
| 16 | A field-effect approach to directly profiling the localized states in monolayer MoS2显示文摘A fundamental understanding of the charge transport mechanism in two-dimensional semiconductors(e.g., MoS2) is crucial for fully exploring their potential in electronic and optoelectronic devices. By using monolayer graphene as the barrier-free contact to MoS2, we show that the field-modulated conductivity can be used to probe the electronic structure of the localized states. A series of regularly distributed plateaus were observed in the gate-dependent transfer curves. Calculations based on the variable-range hopping theory indicate that such plateaus can be attributed to the discrete localized states near mobility edge. This method provides an effective approach to directly profiling the localized states in conduction channel with an ultrahigh resolution up to 1 meV. | Hao Wu Yuan Liu Zeyu Deng Hung-Chieh Cheng Dehui Li Jian Guo Qiyuan He Sen Yang Mengning Ding Yun-Chiao Huang Chen Wang Yu Huang Xiangfeng Duan | 2019 | Science Bulletin2019，64，15： | 2 |
| 17 | Investigation of Droplet Evaporation on Copper Substrate with Different Roughness显示文摘In the present study,we investigated the evaporation process and deposition pattern of saline droplet on a copper substrate with different roughness under 40℃ambient temperature.These four substrates are classified as smooth surface and rough surface based on their droplet contact angles.It has been found in this study that the evaporation pattern of droplets has a strong relationship to substrate roughness.The thickness boundary of the evaporation pattern on a smooth surface is larger than that on a rough surface and the particles are closer to boundary and the tendency is more obvious on a smooth surface.The below factors contribute to the result.On the smooth surface,the contact angle of droplet increases as the roughness decreases.On the rough surface,the contact angle increases as the roughness increases.With contact angle decreasing,the evaporation rate at the boundary increases leading to the particles at the boundary more easily sedimentate.Moreover,the capillary flow is hindered by increasing the substrate roughness,while the Marangoni flow remains constant,resulting in more particles remain in the center of the droplet on the rough surface.To sum up,the coffee-ring formation is suppressed by increasing the substrate roughness on a copper substrate under 40℃temperature. | Xin Wang Zeyu Liu Li Wang Yuying Yan | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 18 | Genes in the serotonin pathway are associated with bipolar affective disorder in a Han Chinese population显示文摘Serotonin plays an important role in mood regulation, but the involvement of serotonin pathway genes in the development of bipolar I disorder (BP-I), a mood disorder, is not clear. We selected 21 singlenucleotide polymorphisms (SNPs) within the HTR2A gene, 8 within the SLC6A4 gene and 23 within the TPH2 gene for genotyping using the GoldenGate genotyping assay. A total of 375 patients with BP-I and 475 normal controls were recruited. Two out of 21 SNPs (rs1475196 and rs9567747) in the HTR2A gene and 1/23 SNPs (rs17110566) in the TPH2 gene were significantly associated with BP-I, both genotype-wise and allele-wise. Furthermore, a specific haplotype in the HTR2A gene showed a significant association with BP-I. Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. | Bo Xiang Zhenxing Yang Yin Lin Lijie Guan Xuan Li Wei Deng Zeyu Jiang Guohui Lao Qiang Wang Xiaoyu Hao Xiang Liu Yingcheng Wang Liansheng Zhao Xiaohong Ma Tao Li Liping Cao Xun Hu | 2014 | Neuroscience Bulletin2014，30，1： | 2 |
| 19 | Performance analysis of solar absorption-subcooled compression hybrid refrigeration system in subtropical city显示文摘Solar absorption-subcooled compression hybrid refrigeration system is a new type of efficient and economical solar refrigeration device which always meets the demand of cooling load with the change of solar irradiance.The perfonnance of the hybrid system is higher due to the improvement of evaporator temperature of absorption subsystem.But simultaneously,the variation of working process as well as performance is complicated since the absorption and compression subsystems are coupled strongly.Based on the measured meteorological data of Guangzhou,a subtropical city in south China,a corresponding parametric model has been developed for the hybrid refrigeration system,and a program written by Fortran has been used to analyze the performance of the hybrid system under different external conditions.As the condensation temperature ranges from 38°C to 50°C,the working time fraction of the absorption subsystem increases from 75%to 85%.Besides,the energy saving fraction also increases from 5.31%to 6.02%.The average COP of the absorption subsystem is improved from 0.366 to 0.407.However,when the temperature of the absorption increases from 36°C to 48°C,the average COP of hybrid system decreases from 2.703 to 2.312.Moreover,the working time fraction of the absorption subsystem decreases from 80%to 71.7%.The energy saving fraction falls from 5.67%to 5.08%.In addition,when the evaporate temperature increases from 4°C to 14°C,the average COP of the absorption subsystem decreases from 0.384 to 0.365.The work of the compressor decreases from 48.2 kW to 32.8 kW and the corresponding average COP of the absorption subsystem is improved from 2.591 to 3.082. | Xiangyang YE Liming LIU Zeyu LI | 2019 | Frontiers in Energy2019，13，1： | 2 |
| 20 | Analysis on internal mechanism of zedoary turmeric in treatment of liver cancer based on pharmacodynamic substances and pharmacodynamic groups显示文摘Zedoary tumeric(Curcumae Rhizoma,Ezhu in Chinese)has a long history of application and has great potential in the treatment of liver cancer.The antiliver cancer effect of zedoary tumeric depends on the combined action of multiple pharmacodynamic substances.In order to clarify the specific mechanism of zedoary tumeric against liver cancer,this paper first analyzes the mechanism of its single pharmacodynamic substance against liver cancer,and then verifies the joint anti liver cancer mechanism of its“pharmacodynamic group”.By searching the research on the antihepatoma effect of active components of zedoary tumeric in recent years,we found that pharmacodynamic substances,including curcumol,zedoarondiol,curcumenol,curzerenone,curdione,curcumin,germacrone,β-elemene,can act on multi-target and multi-channel to play an antihepatoma role.For example,curcumin can regulate miR,GLO1,CD133,VEGF,YAP,LIN28B,GPR81,HCAR-1,P53 and PI3K/Akt/mTOR,HSP70/TLR4 and NF-κB.Wnt/TGF/EMT,Nrf2/Keap1,JAK/STAT and other pathways play an antihepatoma role.Network pharmacological analysis showed that the core targets of the“pharmacodynamic group”for anti-life cancer are AKT1,EGFR,MAPK8,etc,and the core pathways are neuroactive live receiver interaction,nitrogen metabolism,HIF-1 signaling pathway,etc.At the same time,by comparing and analyzing the relationship between the specific mechanisms of pharmacodynamic substance and“pharmacodynamic group”,it is found that they have great reference significance in target,pathway,biological function,determination of core pharmacodynamic components,formation of core target protein interaction,in-depth research of single pharmacodynamic substance,increasing curative effect and so on.By analyzing the internal mechanism of zedoary tumeric pharmacodynamic substance and“pharmacodynamic group”in the treatment of liver cancer,this paper intends to provide some ideas and references for the deeper pharmacological research of zedoary tumeric and the relationship between pharmacodynamic substance and“pharmacodynamic group”. | Zeyu Li Erwei Hao Rui Cao Si Lin Linghui Zou Tianyan Huang Zhengcai Du Xiaotao Hou Jiagang Deng | 2022 | Chinese Herbal Medicines2022，14，4： | 2 |
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