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| 1 | Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes显示文摘在从经由单性生殖和男性单性生殖的老鼠的胚胎的干细胞(haESCs ) 启用了在修改基因的动物的哺乳动物的房间和代的基因屏蔽的 haploid 的推导的最近的成功。然而, haESCs 是否能从首领被导出,仍然保持未知。这里,我们从 Macaca fascicularis 猴子的单性生殖的胚囊报导 haESCs 的推导。这些房间,作为 PG-haESCs 称为,是 pluripotent 并且能在 vitro 或在 vivo 区分到三胚胎的细菌层的房间。有趣地,一根猴子 PG-haESC 线(MPH1 ) 的 haploidy 与另一个(MPH2 ) 的相比是更稳定的,作为没有排序的激活荧光的房间(FACS ) ,由 haploid 房间的存在出现超过 140 天 haploid 房间的丰富。重要地,转基因的猴子 PG-haESC 线能被 lentivirus- 和 piggyBac 产生调停 transposon 的基因转移。而且,基因屏蔽在猴子 PG-haESCs 是可行的。我们的结果证明 PG-haESCs 能从猴子被产生,提供为在首领的基因分析的一个理想的工具。 | Hui Yang Zhen Liu Yu Ma Cuiqing Zhong Qi Yin Chikai Zhou Linyu Shi Yijun Cai Hanzhi Zhao Hui Wang Fan Tang Yan Wang Chenchen Zhang Xin-yuan Liu Dongmei Lai Ying Jin Qiang Sun Jinsong Li | 2013 | Cell Research2013，23，10： | 22 |
| 2 | Runxl protects against the pathological progression of osteoarthritis显示文摘Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runxl in joint diseases is not well known.In the current study,we aimed to explore the role of Runxl in osteoarthritis induced by anterior cruciate ligament transaction(ACLT)surgery.We showed that chondrocyte-specific Runxl knockout(Runx1f/fCol2a1-Cre)aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis.Moreover,we observed thinning and ossification of the growth plate,a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis.We overexpressed Runxl by adeno-associated virus(AAV)in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis.ChIP-seq analysis identified new targets that interacted with Runxl in cartilage pathology,and we confirmed the direct interactions of these factors with Runxl by ChIP-qPCR.This study helps us to understand the function of Runxl in osteoarthritis and provides new clues for targeted osteoarthritis therapy. | Chenchen Zhou Yujia Cui Yueyi Yang Daimo Guo Demao Zhang Yi Fan Xiaobing Li Jing Zou Jing Xie | 2021 | Bone Research2021，9，4： | 4 |
| 3 | Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair显示文摘Maxillofacial bone defects are commonly seen in clinical practice.A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone regeneration.The fibroblast growth factor(FGF)signalling pathway is critical for the development of maxillofacial bone.Klotho,a type I transmembrane protein,is an important components of FGF receptor complexes.Recent studies have reported the presence of Klotho expression in bone.However,the role of Klotho in cranioskeletal development and repair remains unknown.Here,we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological conditions.Klotho-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in vivo.Under conditions of inflammation and trauma-induced bone loss,we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl expression.More importantly,we show for the first time that Klotho is present in human alveolar bone,with a distinct expression pattern under both normal and pathological conditions.In summary,our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and repair.Klotho-mediated signaling is an important component of alveolar bone remodeling and regeneration.It may also be a target for future therapeutics. | Yi Fan Chen Cui Clifford JRosen Tadatoshi Sato Ruoshi Xu Peiran Li Xi Wei Ruiye Bi Quan Yuan Chenchen Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 3 |
| 4 | Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures显示文摘Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters. | Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 5 | Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes. | Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie | 2021 | Cancer Biology & Medicine2021，18，1： | 2 |
| 6 | 2-kW-level superfluorescent fiber source with flexible wavelength and linewidth tunable characteristics显示文摘The superfluorescent fiber source(SFS)with tunable optical spectrum has shown great application potential in the sensing,imaging,and spectral combination.Here,we demonstrate for the first time a 2-kW-level wavelength and linewidth tunable SFS.Based on a flexible filtered SFS seed and three stages of fiber amplifiers,the output power can be scaled from the milliwatt level to about 2 kW,with a wavelength tuning range of 1068–1092 nm and a linewidth tuning range of 2.5–9.7 nm.Moreover,a numerical simulation is conducted based on the generalized nonlinear Schr?dinger equation,and the results reveal that the wavelength tuning range is limited by the decrease of seed power and the growth of amplified spontaneous emission,whereas the linewidth tuning range is determined by the gain competition and nonlinear Kerr effects.The developed wavelength and linewidth tunable SFS may be applied to scientific research and industrial processing. | Jun Ye Chenchen Fan Jiangming Xu Hu Xiao Jinyong Leng Pu Zhou | 2021 | High Power Laser Science and Engineering2021，9，4： | 1 |
| 7 | Prognosis of gestational choriocarcinoma diagnosed incidentally during laparoscopy for a presumed cornual pregnancy:a report of five cases显示文摘The clinical presentations of gestational choriocarcinoma vary markedly, and a misdiagnosis could be made in atypical patients if simply relying on clinical features. Laparoscopic resection of uterine mass lesion is rarely used in gestational choriocarcinoma diagnosis because of the fear of heavy blood loss and distant metastasis. Five patients who were preoperatively diagnosed as having cornual pregnancy underwent laparoscopic resection of mass lesion and then proved to have gestational choriocarcinoma based on pathological examinations. Chemotherapy was started within two days after surgery, and the rate of complete remission was 100%. The mean follow-up time was 29.8±19.1 months, and no patient showed signs of relapse. Laparoscopic resection of uterine mass followed by timely postoperative chemotherapy may be an effective and safe way to obtain pathologic results in patients with suspected gestational choriocarcinoma. | Shiping Liu Chenchen Fan Fengzhi Feng Yang Xiang Xirun Wan Tong Ren | 2017 | Cancer Biology & Medicine2017，14，2： | 1 |
| 8 | Verification of Bacteroidales 16S rRNA markers as a complementary tool for detecting swine fecal pollution in the Yangtze Delta显示文摘To correctly assess and properly manage the public health risks associated with exposure to contaminated water,it is necessary to identify the source of fecal pollution in a watershed.In this study,we evaluated the efficacy of our two previously developed real time-quantitative PCR(qPCR)assays for the detection of swine-associated Bacteroidales genetic markers(gene 1-38,gene 3-53)in the Yangtze Delta watershed of southeastern China.The results indicated that the gene 1-38 and 3-53 markers exhibited high accuracy(92.5%,91.7%conditional probability,respectively)in detecting Bacteroidales spp.in water samples.According to binary logistic regression(BLR),these two swine-associated markers were well correlated(P<0.05)with fecal indicators(Escherichia coli and Enterococci spp.)and zoonotic pathogens(E.coli O157:H7,Salmonella spp.and Campylobacter spp.)in water samples.In contrast,concentrations of conventional fecal indicator bacteria(FIB)were not correlated with zoonotic pathogens,suggesting that they are noneffective at detecting fecal pollution events.Collectively,the results obtained in this study demonstrated that a swinetargeted qPCR assay based on two Bacteroidales genes markers(gene 1-38,gene 3-53)could be a useful tool in determining the swine-associated impacts of fecal contamination in a watershed. | Lihua Fan Xiaofeng Zhang Ruoxue Zeng Suhua Wang Chenchen Jin Yongqiang He Jiangbing Shuai | 2020 | Journal of Environmental Sciences2020，32，4： | 1 |
| 9 | Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors显示文摘Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesis with dedicated manners.Other than BM,extramedullary hematopoiesis is discovered in various pathophysiological settings.However,whether tumors can contribute to hematopoiesis is completely unknown.Accumulating evidence shows that,in the tumor microenvironment(TME),perivascular localized cells retain progenitor cell properties and can differentiate into other cells.Here,we sought to better understand whether and how perivascular localized pericytes in tumors manipulate hematopoiesis.Methods:To test if vascular cells can differentiate into RBCs,genome-wide expression profiling was performed using mouse-derived pericytes.Genetic tracing of perivascular localized cells employing NG2-CreERT2:R26R-tdTomato mouse strain was used to validate the findings in vivo.Fluorescence-activated cell sorting(FACS),single-cell sequencing,and colony formation assays were applied for biological studies.The production of erythroid differentiationspecific cytokine,erythropoietin(EPO),in TME was checked using quantitative polymerase chain reaction(qPCR),enzyme-linked immunosorbent assay(ELISA,magnetic-activated cell sorting and immunohistochemistry.To investigate BM function in tumor erythropoiesis,BM transplantation mouse models were employed.Results:Genome-wide expression profiling showed that in response to plateletderived growth factor subunit B(PDGF-B),neural/glial antigen 2(NG2)+perivascular localized cells exhibited hematopoietic stem and progenitor-like features and underwent differentiation towards the erythroid lineage.PDGF-B simultaneously targeted cancer-associated fibroblasts to produce high levels of EPO,a crucial hormone that necessitates erythropoiesis.FACS analysis using genetic tracing of NG2+cells in tumors defined the perivascular localized cell-derived subpopulation of hematopoietic cells.Single-cell sequencing and colony formation assays validated the fact that,upon PDGF-B stimulation,NG2+cells isolated from tumors acted as erythroblast progenitor cells,which were distinctive from the canonical BM hematopoietic stem cells.Conclusions:Our data provide a new concept of hematopoiesis within tumor tissues and novel mechanistic insights into perivascular localized cell-derived erythroid cells within TME.Targeting tumor hematopoiesis is a novel therapeutic concept for treating various cancers that may have profound impacts on cancer therapy. | Kayoko Hosaka Chenchen Wang Shiyue Zhang Xue Lv Takahiro Seki Yin Zhang Xu Jing Jieyu Wu Qiqiao Du Xingkang He Yulong Fan Xuan Li Makoto Kondo Masahito Yoshihara Hong Qian Lihong Shi Ping Zhu Yuanfu Xu Yunlong Yang Tao Cheng Yihai Cao | 2023 | Cancer Communications2023，43，6： | 1 |
| 10 | Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies显示文摘The past decade has seen significant advances in our understanding of Hedgehog(HH)signaling pathway in various biological events.HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium.HH signaling pathway has important functions in embryonic development and tissue homeostasis.It plays a central role in the regulation of the proliferation and differentiation of adult stem cells.Importantly,it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence,malignant progression,poor prognosis and even increased mortality.Understanding the integrative nature of HH signaling pathway has opened up the potential for new therapeutic targets for cancer.A variety of drugs have been developed,including small molecule inhibitors,natural compounds,and long non-coding RNA(LncRNA),some of which are approved for clinical use.This review outlines recent discoveries of HH signaling in tissue homeostasis and cancer and discusses how these advances are paving the way for the development of new biologically based therapies for cancer.Furthermore,we address status quo and limitations of targeted therapies of HH signaling pathway.Insights from this review will help readers understand the function of HH signaling in homeostasis and cancer,as well as opportunities and challenges of therapeutic targets for cancer. | Junjun Jing Zhuoxuan Wu Jiahe Wang Guowen Luo Hengyi Lin Yi Fan Chenchen Zhou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 11 | Flexible triboelectric nanogenerator toward ultrahigh-frequency vibration sensing显示文摘Flexible high-frequency vibration sensors are highly desirable in various real-world applications such as structural health monitoring,environmental monitoring,and the internet of things.However,developing a facile and effective method to fabricate vibration sensors simultaneously featuring high vibration frequency response-ability and flexibility remains a grand challenge.Herein,we report a flexible ultrahigh-frequency triboelectric vibration sensor(UTVS)prepared by a layer-particle-layer structure.Owing to the flexibility of the materials(i.e.,polyethylene terephthalate membrane)and the ultrahigh-frequency vibration response-ability of internal microparticles,the flexible UTVS exhibits an enhanced working frequency range of 3–170 kHz,which is much broader than previously reported triboelectric vibration sensors.Moreover,the UTVS can work not only in a flat state but also in a bent state due to its flexibility and the unique layer-particle-layer structural design.The UTVS shows nanometer-level vibration response-ability,omnidirectional response,stability in the temperature range of 10–70°C,good frequency resolution of 0.01 kHz,and excellent performance in burst vibration detection(e.g.,pencil lead break events and impact events from falling steel balls).With a collection of compelling features,the device is successfully demonstrated in vibration monitoring of curved structures(e.g.,real-time water pipeline leak monitoring).Such a flexible ultrahigh-frequency triboelectric vibration sensor holds great potential in a wide range of practical applications,such as communication,health care,and infrastructure monitoring. | Zhiwei Lin Chenchen Sun Gaoqiang Zhang Endong Fan Zhihao Zhou Ziying Shen Jun Yang Mingyang Liu Yushu Xia Shaobo Si Jin Yang | 2022 | Nano Research2022，15，8： | 0 |
| 12 | Allyl Glycidyl Ether-modified Animal Glue Binder for Improved Water Resistance and Bonding Strength in Sand Casting显示文摘This paper aims to develop a modified animal glue sand binder for foundry casting with improved water resistance and bonding strength.An efficient method is reported by using sodium hydroxide as the catalyst to improve the operability of animal glue binder and allyl glycidyl ether as the modifier to improve the water resistance and bonding strength.Sand specimens prepared using allyl glycidyl ether-modified animal glue binder were cured by compressed air at room temperature.The proposed method saves energy and is environmentally friendly and inexpensive.Compared with unmodified animal glue binder,standard dog bone sand specimens with allyl glycidyl ether-modified animal glue binder had higher tensile strength of 2.58 MPa,flowability of 1.95 g,better water resistance(a lower decrease in tensile strength at 25°C and relative humidity of 60%),and good collapsibility.This allyl glycidyl ether-modified animal glue binder is suitable for practical application in the foundry industry. | Chenchen Fan Qian Tang | 2020 | Organic Polymer Material Research2020，2，2： | 0 |
| 13 | Eavesdropping Area for Evaluating the Security of Wireless Communications显示文摘Compared with wired communication,the wireless communication link is more vulnerable to be attacked or eavesdropped because of its broadcast nature.To prevent eavesdropping,many researches on transmission techniques or cryptographic methods are carried out.This paper proposes a new index parameter named as eavesdropping area,to evaluate the anti-eavesdropping performance of wireless system.Given the locations of legitimate transmitter and receiver,eavesdropping area index describes the total area of eavesdropping regions where messages can be wiretapped in the whole evaluating region.This paper gives detailed explanations about its concept and deduces mathematical formulas about performance curves based on region classification.Corresponding key system parameters are analyzed,including the characteristics of eavesdropping region,transmitted beam pattern,beam direction,receiver sensitivity,eavesdropping sensitivity,path loss exponent and so on.The proposed index can give an insight on the confirmation of high-risk eavesdropping region and formulating optimal transmitting scheme for the confidential communications to decrease the eavesdropping probability. | Xiaofeng Zhong Chenchen Fan Shidong Zhou | 2022 | China Communications2022，19，3： | 0 |
| 14 | Spatiotemporal cellular dynamics and molecular regulation of tooth root ontogeny显示文摘Tooth root development involves intricate spatiotemporal cellular dynamics and molecular regulation.The initiation of Hertwig’s epithelial root sheath(HERS)induces odontoblast differentiation and the subsequent radicular dentin deposition.Precisely controlled signaling pathways modulate the behaviors of HERS and the fates of dental mesenchymal stem cells(DMSCs).Disruptions in these pathways lead to defects in root development,such as shortened roots and furcation abnormalities.Advances in dental stem cells,biomaterials,and bioprinting show immense promise for bioengineered tooth root regeneration.However,replicating the developmental intricacies of odontogenesis has not been resolved in clinical treatment and remains a major challenge in this field.Ongoing research focusing on the mechanisms of root development,advanced biomaterials,and manufacturing techniques will enable next-generation biological root regeneration that restores the physiological structure and function of the tooth root.This review summarizes recent discoveries in the underlying mechanisms governing root ontogeny and discusses some recent key findings in developing of new biologically based dental therapies. | Pengcheng Rao Junjun jing Yi Fan Chenchen Zhou | 2023 | International Journal of Oral Science2023，15，4： | 0 |
| 15 | Emerging roles of exosomes in oral diseases progression显示文摘Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine. | Jiayi Wang Junjun Jing Chenchen Zhou Yi Fan | 2024 | International Journal of Oral Science2024，16，1： | 0 |
| 16 | Chemical Synthesis of diSUMO Photoaffinity Probes for the Identification of PolySUMO Chain-Specific Interacting Proteins显示文摘Small ubiquitin-like modifiers(SUMOs)are protein modifiers that can form polymeric chains.They are important signals in cellular processes,and their study and profiling require the development of molecular tools.Herein,the authors have reported an efficient chemical protein synthesis approach for the generation of dimeric SUMO-2-based photoaffinity probes through the ligation of four readily synthesizable peptides.Proteomic studies using this diSUMO-2 probe on HeLa cell nuclear lysate found it to capture a significantly different selection of proteins compared with its monoSUMO counterparts.This resulted in the identification of several previously unknown SUMO chain-specific interacting proteins such as 40S ribosomal protein S3,which showed a significantly higher affinity for polySUMO chains than monomeric SUMO.Collectively,these results emphasize the need to develop SUMO chain-based probes in other species,and to shed light on the important role of polySUMOylation in diseases. | Yu Wang Chenchen Chen Xianbin Meng Jian Fan Man Pan Jingnan Chen Haiteng Deng Jing Shi Lei Liu Yi-Ming Li | 2021 | CCS Chemistry2021，3，4： | 0 |
| 17 | S&T PARKS:THE PARTICIPATION AND FOUNDING BY CHINESE UNIVERSITIES显示文摘There are over 1,000 regular higher education institutions (HEIs) in China with a total enrollment of over two million students and nearly 400,000 full-time teachers.There are about 1,700 research units affiliated to them staffed by over 30,000 R&D personnel;and in case all university faculty engaged in both teaching and research are converted into full-time equivalent (FTE)researchers,there are about 140,000 FTE researchers in the regular HEIs in China. China’s HEIs, being cradles of her qualified professional manpower with tertiary training and one of the bases for conducting scientific and technological re- | Fan Chenchen(Information Center, State Education Commission) | 1996 | Bulletin of the Chinese Academy of Sciences1996，10，2： | 0 |
| 18 | Morphological characteristics and atomic evolution behavior of nanojoints in Ag nanowire interconnect network显示文摘Ag nanowires(AgNWs)have shown great application value in the field of flexible electronics due to their excellent optical and electrical properties,and the quality of its joints of AgNWs in the thin film network directly plays a key role in its performance.In order to further improve the joint quality of AgNWs under thermal excitation,the thermal welding process and atomic evolution behavior of AgNWs were investigated through a combination of in situ experimental and molecular dynamics simulations.The influence of processing time,temperature,and stress distribution due to spatial arrangement on nanojoints was systematically explored.What is more,the failure mechanisms and their atomic interface behavior of the nanojoints were also investigated. | Jianlei Cui Xiaoying Ren Xuesong Mei Zhengjie Fan Chenchen Huang Zhijun Wang Xiaofei Sun Wenjun Wang | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 0 |
| 19 | A highly degradable Mg-Al-Ca alloy with superior anti-tumor efficacy显示文摘Molecule hydrogen(H_(2)) has been used to suppress tumor growth. To employ the H_(2) therapy, it is necessary to use a proper agent for continuous generation of H_(2). As a biodegradable metal, magnesium(Mg) generates H_(2) in an aqueous environment, but the H_(2) release rate is still too low. Here, we design a Mg-Al-Ca(AX) alloy that degrades very rapidly due to the presence of a secondary phase Al_(2)Ca. Having a reduction potential much higher than Mg and any other Mg-based secondary phases, Al_(2)Ca accelerates the corrosion of the Mg matrix by a micro-galvanic process. Al_(2)Ca also enhances the strength and ductility of the AX alloy. AX alloy rods show better anti-tumor efficacy than pure Mg rods in vivo. Moreover, implanted AX alloy rods can be heated under an alternating magnetic field to suppress large-size tumors.This work suggests that the H_(2) therapy using highly degradable Mg alloys may provide an effective cancer treatment. | Qiwen Chen Yunhao Fan Shu Dong Ping Han Tian Xie Chenchen Wang Xiaoqin Zeng Wenjiang Ding Zhiqiang Meng Leyun Wang | 2023 | Journal of Magnesium and Alloys2023，11，11： | 0 |
| 20 | Enabling nickel ferrocyanide nanoparticles for highperformance ammonium ion storage显示文摘Prussian blue and its analogs are extensively investigated as a cathode for ammonium-ion batteries.However,they often suffer from poor electronic conductivity.Here,we report a Ni_(2)Fe(CN)_(6)/multiwalled carbon nanotube composite electrode material,which is prepared using a simple coprecipitation approach.The obtained material consists of nanoparticles with sizes 30-50 nm and the multiwalled carbon nanotube embedded in it.The existence of multiwalled carbon nanotube ensures that the Ni_(2)Fe(CN)_(6)/multiwalled carbon nanotube composite shows excellent electrochemical performance,achieving a discharge capacity of 55.1 mAh·g^(-1)at 1 C and 43.2 mAh·g^(-1)even at 15 C.An increase in the ammoniumion diffusion coefficient and ionic/electron conductivity based on kinetic investigations accounts for their high performance.Furthermore,detailed ex situ characterizations demonstrate that Ni_(2)Fe(CN)_(6)/multiwalled carbon nanotube composite offers three advantages:negligible lattice expansion during cycling,stable structure,and the reversible redox couple.Therefore,the Ni_(2)Fe(CN)_(6)/multiwalled carbon nanotube composite presents a long cycling life and high rate capacity.Finally,our study reports a desirable material for ammonium-ion batteries and provides a practical approach for improving the electrochemical performance of Prussian blue and its analogs. | Haoxiang Yu Leiyu Fan Chenchen Deng Huihui Yan Lei Yan Jie Shu Zhen-Bo Wang | 2023 | Frontiers of Chemical Science and Engineering2023，17，2： | 0 |
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