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    题名 作者 年代 出处 被引量
1Apoptosis and its relationship with cell proliferation,p53,Waf1p21,bcl-2 and c-mycin esophageal carcinogenesis studied with a high-risk population in northern China显示文摘Apoptosisanditsrelationshipwithcelproliferation,p53,Waf1p21,bcl2andcmycinesophagealcarcinogenesisstudiedwithahighriskpopul...WANG LiDong1, ZHOU Qi1, WEI JunPing1, YANG WanCai1, ZHAO Xin1, WANG LiXia1, ZOU Jian Xiang1, GAO ShanShan1, LI YongXin1 and YANG C.S.2Keywords esophageal neoplasms apoptosis precancerous lesions Waf1 p21 gene p53 1998World Journal of Gastroenterology1998,4,4:295
2PREVALENCE AND RISK FACTORS OF PERIPHERAL ARTERIAL DISEASE IN DIABETIC PATIENTS OVER 50 YEARS OLD IN CHINA显示文摘Objective To investigate the prevalence of peripheral arterial disease (PAD) in China type 2 diabetic patients and to demonstrate the relationships between putative risk factors and PAD. Methods In total 1 397 type 2 diabetic patients aged 50 years and older were enrolled and determined ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) in 15 Class III Grade A hospitals in 7 major cities of China. Results Mean patient age was 63.7±8.2 years and mean duration of diabetes mellitus was 9.39±7.4 years. Two hundreds and seventy-two (19.47%) patients were diagnosed as PAD by ABI <0.9, 122 (18.37%) in male and 150 (20.46%) in female. PAD patients had a significantly longer duration of diabetes mellitus, higher hemoglobin Alc, and a significantly lower mean body mass index than non-PAD ones. Aging, smoking, and systolic blood pressure were found to be positively related with the prevalence of PAD. In terms of lipid profiles, no variable was found to relate with PAD. Notably, baPWV showed as the same significant guiding index for PAD, almost matched with ABI. Conclusions PAD is a common complication in China type 2 diabetic patients. Therefore, PAD screening and treatment should be emphasized for diabetic patients with high risk factors.Heng Guan Yong-jun Li Zhang-rong XU Guang-wei Li Xiao-hui Guo Zhi-min Liu Da-jin Zou Hui-li Xing Wei Liu Zheng-yan Sheng Hao-ming Tian Da-long Zhu De-min YU Wei-te Zhuang Lu-lu Chen Jian-ping Weng 2007Chinese Medical Sciences Journal2007,22,2:41
3Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model显示文摘Yiwu Yan Zhen Zou Yang Sun Xiao Li Kai-Feng Xu Yuquan Wei Ningyi Jin Chengyu Jiang 2013Cell Research2013,23,2:36
4SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality.Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li 2019Horticulture Research2019,6,1:39
5Water resource utilization efficiency and spatial spillover effects in China显示文摘基于水脚印和灰色的省的面板数据浇脚印,并且在数据包封分析的帮助下当模特儿就而言并且没有考虑不受欢迎的产量,这份报纸从 1997 ~ 2011 在中国估计水资源利用效率。空间 weighting 矩阵基于经济空间的距离功能被建立讨论水资源利用效率的空间自相关。在绝对集中模型的帮助下,这份报纸断定那在那里存在在水资源利用效率的集中。在考虑并且没有考虑不受欢迎的产量的条件下面,完成集中的一半的程度分别地花大约 52.6 和 5.6 年。由空间 Durbin econometric 模型的平均数,这份报纸在中国学习省的水资源利用效率的空间溢出效果。结果如下。1 ) 与考虑并且没有考虑不受欢迎的产量,在在中国的省的水资源效率有重要空间关联。2 ) 在二个盒子下面,空间 autoregressive 系数() 分别地是 0.278 和 0.507,在 1% 意义水平。在那里存在省的水资源利用效率的空间溢出效果。3 ) 与考虑不受欢迎的产量,教育资金的这些因素,交通基础结构,和工业、农业的水消费比例有积极影响。外国直接投资的这些因素,工业增值水消费每 1 万,元,人均的水消费,和全部的降水有否定影响。4 ) 没有考虑不受欢迎的产量, GDP 的因素在水资源利用效率上每劳动者有更大的积极重要影响。然而,在 1 万元和交通基础结构的工业增值水消费的事实没有重要影响。5 ) 不管水资源利用效率的不受欢迎的输出,对在中国的现在的真实的水资源利用的评价将被弄歪,政策制定的愿望被误导。就环境因素而言的水效率措施(例如灰色的水脚印) 是更合理的。SUN Caizhi ZHAO Liangshi ZOU Wei ZHENG Defeng 2014Journal of Geographical Sciences2014,24,5:29
6A Greedy Algorithm for Task Offloading in Mobile Edge Computing System显示文摘Mobile edge computing(MEC) is a novel technique that can reduce mobiles' computational burden by tasks offloading, which emerges as a promising paradigm to provide computing capabilities in close proximity to mobile users. In this paper, we will study the scenario where multiple mobiles upload tasks to a MEC server in a sing cell, and allocating the limited server resources and wireless channels between mobiles becomes a challenge. We formulate the optimization problem for the energy saved on mobiles with the tasks being dividable, and utilize a greedy choice to solve the problem. A Select Maximum Saved Energy First(SMSEF) algorithm is proposed to realize the solving process. We examined the saved energy at different number of nodes and channels, and the results show that the proposed scheme can effectively help mobiles to save energy in the MEC system.Feng Wei Sixuan Chen Weixia Zou 2018China Communications2018,15,11:28
7Influence of Tempering Process on Mechanical Properties of 00Cr13Ni4Mo Supermartensitic Stainless Steel显示文摘To investigate the influence of tempering process on microstructural evolutions and mechanical properties of 00Cr13Ni4Mo supermartensitic stainless steel(SMSS),specimens were tempered in the temperature range of 520-720 ℃ for 3 h followed by air cooling and an optimized tempering temperature was chosen to prolong holding time from 3 to 12 h.After heat treatments,microstructure examination was conducted by scanning electron microscope,X-ray diffraction examinations,hardness measurements and tensile tests.The results revealed that the superior mechanical properties were achieved by quenching at 1040 ℃ for 1 h+water cooling and tempering at 600 ℃ for 3 h+air cooling.Increasing isothermal tempering time could improve the toughness notably.It was believed that the property was correlated with the microstructure of tempered lath martensite and retained austenite.More retained austenite content is beneficial to the higher toughness of the SMSS.ZOU De-ning HAN Ying ZHANG Wei FANG Xu-dong 2010Journal of Iron and Steel Research(International)2010,17,8:26
8Analyses of the NAC Transcription Factor Gene Family in Gossypium raimondii Ulbr.:Chromosomal Location,Structure,Phylogeny,and Expression Patterns显示文摘NAC 域蛋白质是知道在各种各样的植物起多样的作用的植物特定的抄写因素发展进程。在现在的学习,我们在 Gossypium raimondii Ulbr 执行了 NAC 基因家庭的第一全面研究,合并种系发生,介绍的 chromosomal 地点,基因结构,保存主题,和表示分析。我们识别了种系发生地被聚类进 18 个不同亚科的 145 NAC 抄写因素(NAC-TF ) 基因。这些, 127 NAC-TF 基因越过 13 个染色体被散布,(55%) 80 优先地被保留位于两个的副本复制了区域,六位于 triplicated chromosomal 区域。NAC-TF 基因的多数出现了时间 -- ,空间 -- ,并且织物特定的表示模式基于 transcriptomic 和 qRT-PCR 分析。然而,几副本基因的表示模式部分是冗余的,建议在他们的进化期间的 sub-functionalization 的出现。基于他们的 genomic 组织,我们结束了复制在 G 显著地贡献了到 NAC-TF 基因家庭的扩大的那 genomic。raimondii。他们的表示侧面的全面分析能在 G 在 NAC 基因家庭的成员之中提供新奇卓见进功能的分叉。raimondii。Haihong Shang Wei Li Changsong Zou Youlu Yuan 2013Journal of Integrative Plant Biology2013,55,7:25
9Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase显示文摘Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,2007.It is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration history.The primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the moon.To achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work well.This paper introduces the status of payloads in the first phase and preliminary scientific results.OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN Huixian ZOU Yongliao LIU Jianzhong LIU Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei 2008空间科学学报2008,28,5:24
10Acupuncture promotes functional recovery after cerebral hemorrhage by upregulating neurotrophic factor expression显示文摘Acupuncture is widely used in the treatment of cerebral hemorrhage,and it improves outcomes in experimental animal models and patients.However,the mechanisms underlying the effectiveness of acupuncture treatment for cerebral hemorrhage are still unclear.In this study,a model of intracerebral hemorrhage was produced by injecting 50μL autologous blood into the caudate nucleus in Wistar rats.Acupuncture at Baihui(DU20)and Qubin(GB7)acupoints was performed at a depth of 1.0 inch,12 hours after blood injection,once every 24 hours.The needle was rotated at 200 r/min for 5 minutes,For each 30-minute session,needling at 200 r/min was performed for three sessions,each lasting 5 minutes.For the positive control group,at 6 hours,and 1,2,3 and 7 days after induction of hemorrhage,the rats were intraperitoneally injected with 1 mL aniracetam(0.75 mg/mL),three times a day.The Bederson behavioral test was used to assess palsy in the contralateral limbs.Western blot assay was used to examine the expression levels of Nestin and basic fibroblast growth factor in the basal ganglia.Immunohistochemistry was performed to count the number of Nestin-and glial cell line-derived neurotrophic factor-positive cells in the basal ganglia.Acupuncture effectively reduced hemorrhage and brain edema,elevated the expression levels of Nestin and basic fibroblast growth factor in the basal ganglia,and increased the number of Nestin-and glial cell line-derived neurotrophic factor-positive cells in the basal ganglia.Together,these findings suggest that acupuncture promotes functional recovery after cerebral hemorrhage by increasing the expression of neurotrophic factors.The study was approved by the Committee for Experimental Animals of Heilongjiang Medical Laboratory Animal Center(approval No.2017061001)on June 10,2017.Dan Li Qiu-Xin Chen Wei Zou Xiao-Wei Sun Xue-Ping Yu Xiao-Hong Dai Wei Teng 2020Neural Regeneration Research2020,15,8:24
11Field released transgenic papaya effect on soil microbial communities and enzyme activities显示文摘Soil properties, microbial communities and enzyme activities were stud ied in soil amended with replicase (RP)-transgenic or non-transgenic papaya unde r field conditions. Compared with non-transgenic papaya, significant differences (P<0.05) were observed in total nitrogen in soils grown with transgenic papaya. There were also significant differences (P<0.05) in the total number of colony forming units (CFUs) of bacteria, actinomycetes and fungi between soils amended with RP-transgenic plants and non-transgenic plants. Compared with non-transgen ic papaya, the total CFUs of bacteria, actinomycetes and fungi in soil with tran sgenic papaya increased by 0.43—1.1, 0.21—0.80 and 0.46—0.73 times respective ly. Significantly higher (P<0.05) CFUs of bacteria, actinomycetes and fungi res istant to kanamycin (Km) were obtained in soils with RP-transgenic papaya than t hose with non-transgenic papaya in all concentrations of Km. Higher resistance q uotients for Kmr (kanamycin resistant) bacteria, actinomycetes and fungi were fo und in soil planted with RP-transgenic papaya, and the resistance quotients for Kmr bacteria, actinomycetes and fungi in soils with transgenic papaya increased 1.6—4.46, 0.63—2.5 and 0.75—2.30 times. RP-transgenic papaya and non-transg enic papaya produced significantly different enzyme activities in arylsulfatase (5.4—5.9x), polyphenol oxidase (0.7—1.4x), invertase (0.5—0.79x), cellulase ( 0.23—0.35x) and phosphodiesterase (0.16—0.2x). The former three soil enzymes appeared to be more sensitive to the transgenic papaya than the others, and cou ld be useful parameters in assessing the effects of transgenic papaya. Transgen ic papaya could alter soil chemical properties, enzyme activities and microbial communities.WEI Xiang-dong ZOU Hui-ling CHU Lee-min LIAO Bin YE Chang-min LAN Chong-yu 2006Journal of Environmental Sciences2006,18,4:22
12IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang 2012Cell Research2012,22,3:22
13Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage显示文摘Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the effect of acupuncture in a rat model of cerebral hemorrhage. We examined four groups: in the control group, rats received no treatment. In the model group, cerebral hemorrhage models were established by infusing non-heparinized blood into the brain. In the acupuncture group, modeled rats had Baihui(DU20) and Qubin(GB7) acupoints treated once a day for 30 minutes. In the DAPT group, modeled rats had 0.15 μg/m L DAPT solution(10 m L) infused into the brain. Immunohistochemistry and western blot results showed that acupuncture effectively inhibits Notch1 and Hes1 protein expression in rat basal ganglia. These inhibitory effects were identical to DAPT, a Notch signaling pathway inhibitor. Our results suggest that acupuncture has a neuroprotective effect on cerebral hemorrhage by inhibiting Notch-Hes signaling pathway transduction in rat basal ganglia after cerebral hemorrhage.Wei Zou Qiu-xin Chen Xiao-wei Sun Qing-bin Chi Hong-yu Kuang Xue-ping Yu Xiao-hong Dai 2015Neural Regeneration Research2015,10,3:23
14A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang 2017Cell Research2017,27,11:22
15Presepsin as a novel sepsis biomarker显示文摘BACKGROUND: In 2004, a new biomarker sCD14-subtypes(presepsin) was found and its value was shown in the diagnosis and evaluation of sepsis. This article is a brief overview of the new biomarker.DATA SOURCES: A literature search using multiple databases was performed for articles, especially meta-analyses, systematic reviews, and randomized controlled trials.RESULTS: Compared with other markers, presepsin seems to have a better sensitivity and specificity in the diagnosis of sepsis. Presepsin as a biom1 arker is not only suitable for the early diagnosis of sepsis, but also for the assessment of its severity and prognosis.CONCLUSIONS: Presepsin has a higher sensitivity and specificity in the diagnosis of sepsis as a new biomarker, and is a predictor for the prognosis of sepsis. More importantly, preseptin seems to play a crucial role as a supplemental method in the early diagnosis of sepsis. Since there is no multicenter study on the relationship between presepsin and sepsis, further studies on the clinical values of presepsin are needed.Qi Zou Wei Wen Xin-chao Zhang 2014World Journal of Emergency Medicine2014,5,1:23
16Hydrogen sulfide inhibits homocysteine-induced endoplasmic reticulum stress and neuronal apoptosis in rat hippocampus via upregulation of the BDNF-TrkB pathway显示文摘Hai-jun WEI Jin-hua XU Man-hong LI Ji-ping TANG Wei ZOU Ping ZHANG Li WANG Chun-yan WANG Xiao-qing TANG 2014Acta Pharmacologica Sinica2014,35,6:21
17Effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease development显示文摘AIM To study the effects of different diets on intestinal microbiota and nonalcoholic fatty liver disease(NAFLD) development at the same caloric intake.METHODS Thirty male Sprague-Dawley rats were randomized into five groups(six rats each). The control diet(CON) group and free high-fat diet(FFAT) group were allowed ad libitum access to a normal chow diet and a highfat diet, respectively. The restrictive high-fat diet(RFAT) group, restrictive high-sugar diet(RSUG) group, and high-protein diet(PRO) group were fed a highfat diet, a high-sugar diet, and a high-protein diet, respectively, in an isocaloric way. All rats were killed at 12 wk. Body weight, visceral fat index(visceral fat/body weight), liver index(liver/body weight), insulin resistance, portal lipopolysaccharide(LPS), serum alanine aminotransferase(ALT), serum aspartate aminotransferase(AST), and liver triglycerides were measured. The intestinal microbiota in the different groups of rats was sequenced using high-throughput sequencing technology.RESULTS The FFAT group had higher body weight, visceral fat index, liver index, peripheral insulin resistance, portal LPS, serum ALT, serum AST, and liver triglycerides compared with all other groups(P < 0.05). Taking the same calories, the RFAT and RSUG groups demonstrated increased body weight, visceral fat index, peripheral insulin resistance and liver triglycerides compared with the PRO group(P < 0.05). The RFAT group also showed increased portal LPS compared with the PRO group(P < 0.05). Unweighted Uni Frac principal coordinates analysis of the sequencing data revealed that the intestinal microbiota structures of the CON, FFAT, RSUG and PRO groups were roughly separated away from each other. Taxon-based analysis showed that, compared with the CON group, the FFAT group had an increased abundance of Firmicutes, Roseburia and Oscillospira bacteria, a higher ratio of Firmicutes to Bacteroidetes, and a decreased abundance of Bacteroidetes, Bacteroides and Parabacteroides bacteria(P < 0.05). The RFAT group showed an increased abundance of Firmicutes and decreased abundance of Parabacteroides bacteria(P < 0.05). The RSUG group showed an increased abundance of Bacteroidetes and Sutterella bacteria, higher ratio of Bacteroidetes to Firmicutes, and a decreased abundance of Firmicutes(P < 0.05). The PRO group showed an increased abundance of Bacteroidetes, Prevotella, Oscillospira and Sutterella bacteria, and a decreased abundance of Firmicutes(P < 0.05). Compared with the FFAT group, the RFAT group had an increased abundance of Bacteroidetes, higher ratio of Bacteroidetes to Firmicutes, and decreased abundance of Firmicutes and Oscillospira bacteria(P < 0.05).CONCLUSION Compared with the high-protein diet, the NAFLDinducing effects of high-fat and high-sugar diets are independent from calories, and may be associated with changed intestinal microbiota.Jian-Ping Liu Wen-Li Zou Shui-Jiao Chen Hong-Yun Wei Ya-Ni Yin Yi-You Zou Fang-Gen Lu 2016World Journal of Gastroenterology2016,22,32:21
18Human adipose-derived mesenchymal stem cells: a better cell source for nervous system regeneration显示文摘Han Chao Zhang Liang Song Lin Liu Yang Zou Wei Piao Hua Liu Jing 2014Chinese Medical Journal2014,,2:20
19Research Progress in Occupational Health Risk Assessment Methods in China显示文摘Traditional occupational disease control and prevention has remained prevalent in China over recent decades.There are appropriately 30,000 new case reports of occupational diseases annually.Although China has already established a series of occupational disease prevention programs,occupational health risk assessment(OHRA)strategies continue to be a limitation.OHRA is a tool for controlling the healthZHOU Li Fang TIAN Fang ZOU Hua YUAN Wei Ming HAO Mo ZHANG Mei Bian 2017Biomedical and Environmental Sciences2017,30,8:20
20From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed.Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou 2016Matter and Radiation at Extremes2016,1,1:19
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