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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Factors influencing clinical outcomes of acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator显示文摘 | HUANG Yin-hui ZHUO Shi-tu CHEN Ya-fang LI Ming-mei LIN You-yu YANG Mei-li CHEN Zhen-jie CAI Ruo-wei | 2013 | Chinese Medical Journal2013，，24： | 19 |
| 3 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 4 | Comparison of combined phacotrabeculectomy with trabeculectomy only in the treatment of primary angle-closure glaucoma显示文摘 | WANG Mei FANG Min BAI Yu-jing ZHANG Wei-zhong LIN Ming-kai LIU Bing-qian HAO Yuan-tao LING Yun-lan ZHUO Ye-hong GE Jian | 2012 | Chinese Medical Journal2012，，8： | 15 |
| 5 | Screening for Y chromosome microdeletions in idiopathic and nonidiopathic infertile men with varicocele and cryptorchidism显示文摘Background Cytogenetic and molecular studies of azoospermic and oligozoospermic males have suggested thepresence of azoospermia factors (AZF) in the Y chromosome.Deletion in AZF regions has been reported todisrupt spermatogenesis and cause infertility.Several candidate genes responsible for spermatogenesis have beenidentified in this region and some of them are thought to be functional in human spermatogenesis.And wereported clinical and molecular studies of Ychromosome microdeletions in Chinese.This study aimed atassessingthe frequency of microdeletions in Chinese men with idiopathic and nonidiopathic infertility problems anddicussing the clinical significance of the AZF region.Methods In this study, we screened 143 infertile men (62 with idiopathic infertilitas and 81 withnonidiopathic infertilitas), in whom karyotype, sperm count, hormonal parameters and fine needle aspirationcytology were evaluated.Genomic DNA was extracted from the peripheral leukocytes.Molecular analysis wasperformed by two multiplexpolymerase chain reactions (PCR) using a set of a sequence tagged sites (STS) from3 different regions of the Y chromosome: AZFa (sY84, sY86), AZFb (sY127, sY134), AZFc (sY254,sY255).Results Nineteen point four percent of idiopathic males (12/62, 19.4%) had microdeletions of either theAZFa, AZFb, AZFc or AZFb +c region.Significantly, a high frequency of microdeletions (9/81, 11.1%) wasfound in nonidiopathic patients with varicocele and cryptorchidism.No deletions were found in healthy fertilemen.There were no significant differences in the localization and extent of deletions between idiopathic andnonidiopathic patients.Conclusions The knowledge of the presence of these deletions in idiopathic and nonidiopathic cases isimportant to understand the prognosis, better management and counsel these patients accordingly.Furthermore,a more extended screening for Y chromosome microdeletions in idiopathic and nonidiopathic men, particularlycandidates for intracytoplasmic sperm injection, is recommended. | SONG Ning-hong WU Hong-fei ZHANG Wei ZHUO Zuo-min QIAN Li-xing HUA Li-xing GUO Lin FENG Ning-han | 2005 | Chinese Medical Journal2005，，17： | 12 |
| 6 | Current Status of Surgical Treatment of Biliary Diseases in Elderly Patients in China显示文摘 | Zong-Ming Zhang Jia-Hong Dong Fang-Cai Lin Qiu-Sheng Wang Zhi Xu Xiao-Dong He Chong Zhang Zhuo Liu Li-Min Liu Hai Deng Hong-Wei Yu Bai-Jiang Wan Ming-Wen-Zhu Hai-Yan Yang Meng-Meng Song Yue Zhao | 2018 | Chinese Medical Journal2018，，15： | 11 |
| 7 | Bedaquiline-containing regimens in patients with pulmonary multidrug-resistant tuberculosis in China:focus on the safety显示文摘Background:World Health Organization recommends countries introducing new drug and short treatment regimen for drug resistant tuberculosis(DR-TB)should develop and implement a system for active pharmacovigilance that allows for detection,reporting and management of adverse events.The aim of the study is to evaluate the frequency and severity of adverse events(AEs)of bedaquiline-containing regimen in a cohort of Chinese patients with multidrug-resistant(MDR)/extensively drug-resistant(XDR)-TB based on active drug safety monitoring(aDSM)system of New Drug Introduction and Protection Program(NDIP). | Jing-Tao Gao Juan Du Gui-Hui Wu Yi Pei Meng-Qiu Gao Leonardo Martinez Lin Fan Wei Chen Li Xie Yu Chen Hua Wang Long Jin Guo-Bao Li Pei-Lan Zong Yu Xiong Qian-Hong Wu Ming-Wu Li Xiao-Feng Yan Yan-Fang Miao Qing-Shan Cai Xin-Jie Li Da-Peng Bai Shu-Jun Geng Guo-Li Yang Pei-JunTang Yi Zeng Xiao-Hong Chen Tong-Xia Li Cui Cai Yun Zhou Ma Zhuo Jian-Yun Wang Wen-Long Guan Lin Xu Ji-Chan Shi Wei Shu Li-Li Cheng FeiTeng Yu-Jia Ning Shi-Heng Xie Yu-Xian Sun Li-Jie Zhang Yu-Hong Liu | 2021 | Infectious Diseases of Poverty2021，10，2： | 11 |
| 8 | Expression of stromal cell-derived factor-1 in diabetic retinopathy显示文摘背景 Neovascularization 能在 proliferative 糖尿病患者 retinopathy (PDR ) 引起视觉损失并且可以被许多因素影响。Stromal 导出房间的 factor-1 (SDF-1 ) 是 angiogenesis 的一个有势力激发器。学习被瞄准与糖尿病的 retinopathy.Methods 在眼睛调查有脉管的 endothelial 生长因素( VEGF )的 SDF-1 和它的关联的表示 SDF-1 和 VEGF 的层次被连接酶的 immunosorbent 试金测量在有 PDR 的 41 个病人的 41 只眼睛和 12 个病人的 12 只眼睛玻璃与自发的有斑点的洞( IMH )。玻璃的液体样品和维管组织的 preretinal 膜在 vitrectomy 被获得。SDF-1 和 VEGF 用 VEGF 的玻璃的集中是的 immunohistochemistry.Results 是局部性的在有 PDR 的眼睛显著地更高((2143.7 湯捩琠牨浯潢浥潢楬? 異浬湯牡 ? 票数瑲湥楳湯 ? 牰汥浩湩牡 ? 硥汰牯瑡潩 ? 湩 ? | CHEN Ling-yan ZHUO Ye-hong LI Yong-hao HUANG Xin-hua ZHANG Jing-lin LI Shi-yi WANG Xiang-gui Lu Lin | 2010 | Chinese Medical Journal2010，，8： | 11 |
| 9 | Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods显示文摘Two phenylethanoid glycosides, acteoside and forsythoside B, were first isolated from the traditional Chinese herb Callicarpa peii H.T. Chang. The interaction between the two phenylethanoid glycosides and bovine serum albumin (BSA) was investigated by fluorescence, UV-vis absorbance and circular dichroism (CD). The results showed that the quenching mechanism in the drug-BSA binary systems was a combination of static quenching and non-radiative energy transfer. Displacement experiments confirmed that the drug bound to the site I of BSA. UV-vis and CD measurements indicated that the binding of the drug to BSA induced conformational changes in BSA. | Ai-Zhi Wu Chao-Zhan Lin Ya-Jing Zhai Jia-Lin Zhuo Chen-Chen Zhu | 2013 | Journal of Pharmaceutical Analysis2013，3，1： | 11 |
| 10 | Caspase-dependent retinal ganglion cell apoptosis in the rat model of acute diabetes显示文摘背景神经 apoptosis 通常被相信被二条不同小径, caspase 家属和 caspase 独立的小径调停。这研究调查了涉及网膜的中心的 apoptotic 小径在老鼠在急性糖尿病装壁板圩。方法糖尿病被 streptozotocin (STZ ) 的腹注射在男 Wistar 老鼠导致。caspase-3 和导致 apoptosis 因素(AIF ) 的表示和本地化在糖尿病的老鼠的视网膜的蛋白质被西方的弄污和 immunohistochemistry 分析检验。标记的终端 transferase dUTP 刻痕结束(TUNEL ) 试金和为 caspase-3 和 AIF 特定的染色的 immunofluorescent 为网膜的中心房间的 apoptosis 被用于分析。另外, caspase-3 禁止者 DEVD-CHO intravitreally 被注射进一步决定网膜的中心房间的 apoptotic 小径在急性糖尿病被触发。二个星期在糖尿病的正式就职以后结果, caspase-3 蛋白质表示和本地化的重要增加发生在神经纤维层,中心细胞层,和视网膜的内部 plexiform 层。在糖尿病的发作以后的四个星期, caspase-3 表示的增加八个星期是深刻的糖尿病(P0.05 ) 的 postinduction。同时,没有 AIF 蛋白质表示在这研究被检测。另外, caspase-3 禁止者 DEVD-CHO 的 intravitreal 管理在 caspase-3 上由它的直接禁止的行动减少了网膜的中心房间的 apoptosis。结论 Caspase 依赖的 apoptotic 小径可以是在急性糖尿病的导致 STZ 的网膜的中心房间 apoptosis 的主要兴奋剂。 | LI Yong-hao ZHUO Ye-hong LU Lin CHEN Ling-yan HUANG Xin-hua ZHANG Jing-lin LI Shi-yi WANG Xiang-gui | 2008 | Chinese Medical Journal2008，，24： | 9 |
| 11 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 12 | Attenuated Listeria monocytogenes as a cancer vaccine vector for the delivery of CD24, a biomarker for hepatic cancer stem cells显示文摘稀释 Listeria monocytogenes (LM ) 是为癌症疫苗的交货的有希望的候选人向量。在由介绍抗原的房间的吞噬作用以后,这个细菌刺激主要 histocompatibility 建筑群(MHC ) 我和 MHC-II 小径并且导致抗原特定的 T 淋巴细胞的增长。包含复制缺乏的 LM 种类 Δ 的基因修正的新策略; dalΔ dat (Lmdd ) 被开发了表示并且藏匿人的 CD24 蛋白质。CD24 是仔细与 hepatocellular 癌(HCC ) 的 apoptosis,转移和复发被联系的肝的癌症干细胞 biomarker。在在老鼠的静脉内的管理以后, Lmdd-CD24 首先在怒气和肝被散布并且没引起严重机关损害。Lmdd-CD24 有效地增加了干扰素(IFN ) 的数字 -γ-producing CD8 + T 房间和 IFN-γ分泌物。Lmdd-CD24 也提高了 IL-4- 和 IL-10-producing T 助手 2 房间的数字。Lmdd-CD24 疫苗的功效进一步对 Hepa1-6-CD24 肿瘤被调查,它腹股沟地被接种进老鼠。Lmdd-CD24 显著地在老鼠减少了肿瘤尺寸并且增加了他们的幸存。尤其是, T 规章的房间(Treg ) 的减小数并且特定的 CD8 +T 房间活动的改进在渗入肿瘤的淋巴细胞(TIL ) 被观察。这些结果对 HCC 建议 Lmdd-CD24 疫苗的一个潜在的应用程序。 | Yu Yang Jiajie Hou Zhe Lin Han Zhuo DianyuChen Xudong Zhang Yun Chen Beicheng Sun | 2014 | Cellular & Molecular Immunology2014，11，2： | 9 |
| 13 | Large-conductance Ca^2+-activated K^+ channel involvement in suppression of cerebral ischemia/reperfusion injury after electroacupuncture at Shuigou(GV26) acupoint in rats显示文摘Excess activation and expression of large-conductance Ca^(2+)-activated K^+ channels(BKCa channels) may be an important mechanism for delayed neuronal death after cerebral ischemia/reperfusion injury. Electroacupuncture can regulate BKCa channels after cerebral ischemia/reperfusion injury, but the precise mechanism remains unclear. In this study, we established a rat model of cerebral ischemia/reperfusion injury. Model rats received electroacupuncture of 1 m A and 2 Hz at Shuigou(GV26) for 10 minutes, once every 12 hours for a total of six times in 72 hours. We found that in cerebral ischemia/reperfusion injury rats, ischemic changes in the cerebral cortex were mitigated after electroacupuncture. Moreover, BKCa channel protein and m RNA expression were reduced in the cerebral cortex and neurological function noticeably improved. These changes did not occur after electroacupuncture at a non-acupoint(5 mm lateral to the left side of Shuigou). Thus, our findings indicate that electroacupuncture at Shuigou improves neurological function in rats following cerebral ischemia/reperfusion injury, and may be associated with down-regulation of BKCa channel protein and m RNA expression. Additionally, our results suggest that the Shuigou acupoint has functional specificity. | Yong Wang Yan Shen Hai-ping Lin Zhuo Li Ying-ying Chen Shu Wang | 2016 | Neural Regeneration Research2016，11，6： | 8 |
| 14 | Effects of lipid-lowering agents on diabetic retinopathy: a Meta-analysis and systematic review显示文摘AIM: To clarify this controversy and to provide evidence for application of lipid lowering agents in treatment of diabetic retinopathy(DR).METHODS: We searched the databases of Pub Med, Embase and Cochrane Library Central Register of Controlled Trials(CENTRAL) and abstracts from main annual meetings up to January 1, 2017. Google scholar and ClinicalT rials.gov were also searched for unpublished relevant studies. We included randomized controlled trials(RCTs) that studied lipid-lowering agents in type 1 or type 2 diabetes in this Meta-analysis. The primary endpoint was the progression of DR, and the secondary endpoints included vision loss, development of diabetic macular edema(DME) and aggravation of hard exudates. The pooled odds ratios(OR)with corresponding 95% confidence intervals(95%CIs) were calculated.RESULTS: After systemic and manual literature search by two independent investigators, we included 8 RCTs from 7 published articles with 13 454 participants in this Meta-analysis. The results revealed that lipid-lowering drugs were associated with reduced risk in DR progression [OR=0.77(95%CI: 0.62, 0.96), P=0.02]. Lipid-lowering agents might have protective effect on DME compared to placebo, although the difference was not statistically significant [OR=0.60(95%CI: 0.34, 1.08), P=0.09]. However, no significant differences in the worsening of vision acuity [OR=0.96(95%CI: 0.81,1.14), P=0.64] and hard exudates [OR=0.50(95%CI:0.15, 1.74), P=0.28] were found between the lipidlowering drugs and the placebo groups.CONCLUSION: In DR patients, lipid-lowering agents show a protective effect on DR progression and might be associated with reduced risk in the development of DME. However, lipid-lowering agents have no effects on vision loss and hard exudates aggravation. Further clinical trials in larger scale are required to confirm the conclusion of this study and thus justify the use of intensive control lipids with anti-lipid agents at the early stages of DR. | Rui Shi Lei Zhao Feng Wang Fen Liu Zhuo Chen Rong Li Yang Liu Rong Lin | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 8 |
| 15 | Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital,China显示文摘Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of“Guidance for maternal and fctal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital'.This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection diagnostic criteria,inspection precautions,drug treatment options,indications and methods of termination of pregnancy,postpartum fever,breastfeeding considerations,mode of mother-to-child transmission,neonatal isolation and advice on nconatal nursing,to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. | Shao-shuai WANG Xuan ZHOU Xing-guang LIN Yan-yan LIU Jian-li WU Lali Mwamaka Shariful Xiao-lin HU Zhi-bui RONG Wei LIU Xiao-ping LUO Zhuo CHEN Wan-jiang ZENG Su-hua CHEN Ding MA Ling CHEN Ling FENG | 2020 | Current Medical Science2020，40，2： | 8 |
| 16 | Effects of dietary supplementation with essential oils and protease on growth performance,antioxidation,inflammation and intestinal function of weaned pigs显示文摘This experiment evaluated the impacts of essential oils(EO)and protease(PRO),independently or in combination,on growth performance,antioxidation,inflammation and intestinal function of weaned pigs.One hundred and sixty weaned pigs(21 d of age,BW of 6.74±0.20 kg)were randomly divided into 4 treatments with 8 replicate pens of 5 pigs per pen.Dietary treatments included the following:1)control diet(CON),2)CON with 300 mg/kg essential oils(EO),3)CON with 500 mg/kg protease(PRO),4)CON with 300 mg/kg essential oil and 500 mg/kg protease(EO + PRO).On d 8,one pig from each penwas selected for sampling.The remaining pigs were fed for an additional week and growth performance was monitored during this period.Dietary treatments had no marked effects(P>0.05)on the growth performance of pigs.However,pigs receiving EO diet had higher(P<0.05)serumglutathione peroxidase(GSH-Px)activity,and tended to decrease(P=0.063)serum concentration of tumor necrosis factor-a(TNF-a).In addition,pigs receiving EO diet had higher(P<0.05)abundances of phylum Actinobacteria,and genera Bifidobacterium,and lower(P<0.05)phylum Bacteroidetes and genera Alloprevotella in colonic digesta.Pigs receiving PRO diet decreased(P<0.05)the serum concentration of malondialdehyde(MDA)and diamine oxidase activity,increased(P<0.05)the villus height and the ratio of villus height to crypt depth in duodenum,increased sucrase activity in jejunal mucosa,and also increased the abundance of phylum Actinobacteria in colonic digesta.Furthermore,the synergistic effects of EO and PROwas observed(P<0.05)for pigs with decreasing serum TNF-a concentration and increasing serum GSH-Px activity.Collectively,the results indicated that dietary supplementation of EO and PRO had no significant effects on growth performance of weaned pigs.EO diet appeared to improve antioxidant activity and intestinal microbiota,while PRO diet improved intestinal morphology and digestive enzyme activity,and there was a synergistic effect of EO and PRO on reducing inflammatory parameters in weaned pigs. | Xie Peng Qiang Zhou Cheng Wu Jian Zhao Quan Tan Ying He Liang Hu Zhengfeng Fang Yan Lin Shengyu Xu Bin Feng Jian Li Yong Zhuo Chris Van Ginneken Xuemei Jiang De Wu Lianqiang Che | 2022 | Animal Nutrition2022，，2： | 8 |
| 17 | Construct hepatic analog by cell-matrix controlled assembly technology显示文摘A mixture of hepatic cells and chito- san/gelatin solution was deposited to construct a hepatic analog by way of layer-by-layer deposition technique using a home-made devise. The size and cell concentration of the analogs can be controlled freely. Approximately 90% of the hepatic cells re- mained viable under 0.2 Mpa extrusion pressure. Cultured in vitro 8 weeks before animal test, hepatic cells in structure maintained their phenotype and kept proliferating, and albumin and other secretion of the cells increased. Cords and hepaton-like structures were observed after culture for 20 d. These results indicate that hepatic cells could be assembled di- rectly into a 3D viable structure and expanded to form a hepatic organoid. This accomplishment is consid- ered to be an interesting means for the fabrication of liver replacements. | LIU Haixia YAN Yongnian WANG Xiaohong CHENG Jie LIN Feng XIONG Zhuo Wu Rendong | 2006 | Chinese Science Bulletin2006，51，15： | 7 |
| 18 | A Quantitative Evaluation of Shale Gas Content in Different Occurrence States of the Longmaxi Formation: A New Insight from Well JY-A in the Fuling Shale Gas Field,Sichuan Basin显示文摘Comprehensive quantitative evaluation of shale gas content and the controlling factors in different occurrence states is of great significance for accurately assessing gas-bearing capacity and providing effective well-production strategies. A total of 122 core samples from well JY-A in the Fuling shale gas field were studied to reveal the characteristics of S_1 l shale,15 of which were selected to further predict the shale gas content in different occurrence states, which are dependent on geological factors in the thermal evolution process. Geological parameters were researched by a number of laboratory programs, and the factors influential in controlling shale gas content were extracted by both PCA and GRA methods and prediction models were confirmed by the BE method using SPSS software. Results reveal that the adsorbed gas content is mainly controlled by TOC, Ro, SSA, PD and pyrite content, and the free gas content is mainly controlled by S_2, quartz content, gas saturation and formation pressure for S_1 l in well JY-A. Three methods, including the on-site gas desorption method, the empirical formula method, and the multiple regression analysis method were used in combination to evaluate the shale gas capacity of well JY-A, all of which show that the overall shale gas content of well JY-A is in the range of 2.0–5.0 m^3/t and that the free gas ratio is about 50%, lower than that of well JY-1. Cause analysis further confirms the tectonics and preservation conditions of S_1 l in the geological processes, especially the influence of eastern boundary faults on well JY-A, as the fundamental reasons for the differences in shale gas enrichment in the Jiaoshiba area. | TANG Ling SONG Yan LI Qianwen PANG Xiongqi JIANG Zhenxue LI Zhuo TANG Xianglu YU Hailong SUN Yue FAN Shichao ZHU Lin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 7 |
| 19 | STEADY-STATE AND IDLE OPTIMIZA-TION OF INTERNAL COMBUSTION ENGINE CONTROL STRATEGIES FOR HYBRID ELECTRIC VEHICLES显示文摘A novel steedy-state optimization (SSO) of internal combustion engine (ICE) strategy is proposed to maximize the efficiency of the overall powertrain for hybrid electric vehicles,in which the ICE efficiency,the effciencies of the electric motor (EM) and the energy storage device are all explicitly taken into account.In addition,a novel idle optimization of ICE strategy is implemented to obtain the optimal idle operating point of the ICE and corresponding optimal parking generation power of the EM using the view of the novel SSO of ICE strategy.Simulations results show that potential fuel economy improvement is achieved relative to the conventional one which only optimized the ICE efficiency by the novel SSO of ICE strategy,and fuel consumption per voltage increment decreases a lot during the parking charge by the novel idle optimization of ICE strategy. | WANG Feng MAO Xiaojian YANG Lin ZHUO Bin | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 6 |
| 20 | Over-expression of the AtGA2ox8 gene decreases the biomass accumulation and lignification in rapeseed (Brassica napus L.)显示文摘Gibberellin 2-oxidase (GA 2-oxidase) plays very important roles in plant growth and development. In this study, the AtGA2ox8 gene, derived from Arabidopsis (Arabidopsis thaliana), was transformed and over-expressed in rapeseed (Brassica napus L.) to assess the role of AtGA2ox8 in biomass accumulation and lignification in plants. The transgenic plants, identified by resistant selection, polymerase chain reaction (PCR) and reverse-transcription PCR (RT-PCR) analyses, and green fluorescence examination, showed growth retardation, flowering delay, and dwarf stature. The fresh weight and dry weight in transgenic lines were about 21% and 29% lower than those in wild type (WT), respectively, and the fresh to dry weight ratios were higher than that of WT. Quantitative measurements demonstrated that the lignin content in transgenic lines decreased by 10%-20%, and histochemical staining results also showed reduced lignification in transgenic lines. Quantitative real-time PCR analysis indicated that the transcript levels of lignin biosynthetic genes in transgenic lines were markedly decreased and were consistent with the reduced lignification. These results suggest that the reduced biomass accumulation and lignification in the AtGA2ox8 over-expression rapeseed might be due to altered lignin biosynthetic gene expression. | Xiao-ying ZHAO Deng-feng ZHU Bo ZHOU Wu-sheng PENG Jian-zhong LIN Xing-qun HUANG Re-qing HE Yu-hong ZHUO Dan PENG Dong-ying TANG Ming-fang LI Xuan-ming LIU | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，7： | 6 |
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