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| 1 | SCM-198 protects endometrial stromal cells from oxidative damage through Bax/Bcl-2 and ERK signaling pathways显示文摘In creasi ng amounts of evidence dem on strated that accumulative reactive oxyge n species (ROS) and apoptosis of human endometrial stromal cells (ESCs) are closely associated with endometrial dysfunction induced by oxidative stress, which plays an important role in the pathological process of multiple gyn ecological and reproduction-related diseases. SCM-198, an alkaloid active component of Leonurus japonicas Houtt, has been reported to have anti-oxidative activity. However, the specific mechanisms of SCM-198 in the prevention of endometrial damage remain unknown. In the present study, we assessed the effect of SCM-198 on hydrogen peroxide (H2O2Hnduced oxidative injury in ESCs. ESCs were pretreated with SCM-198 for 4 h and then challenged with H2O2.Morphology ch a nges, apoptosis rate, and intracellular ROS producti on were measured to assess the level of oxidative injury. Flow cytometry and western blot analysis were performed to detect the expression levels of Bax, Bcl-2, active-caspase-3, and mitogen-activated protein kinases pathways. Classic inflammation cytokines were measured by real-time polymerase chain reactions. Our results showed that SCM-198 attenuated apoptosis and ROS generation of ESCs induced by H2O2. H2O2 induced the apparent apoptotic characteristics, including fragmentation of DNA, upregulation of Bax/Bcl2, activation of caspase-3, and secretion of inflammation cytokines, which were all ameliorated by SCM-198. Furthermore, H2O2-induced apoptosis-related ERK1/2 pathway activation was restrained by SCM-198 pretreatme nt. These fin dings suggested that SCM-198 could protect ESCs from oxidative injury, mainly by inhibiting oxidative stress and reducing apoptosis. | Yunyun Li Yikong Lin Xixi Huang Chunfang Xu Xinhua Liu Li Wang Min Yu Dajin Li Yizhun Zhu Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 10 |
| 2 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 3 | Multiphysics simulation method of Lamb wavepropagation with piezoelectric transducers under load condition显示文摘Lamb Wave(LW) simulation under time-varying conditions is an effective and low cost way to study the problem of the low reliability of the structural health monitoring methods based on the LW and Piezoelectric Transducer(PT). In this paper, a multiphysics simulation method of the LW propagation with the PTs under load condition is proposed. With this method, two key mechanisms of the load influence on the LW propagation are considered and coupled with each other. The first mechanism is the acoustoelastic effect which is the main reason of the LW velocity change. The second key mechanism is the load influence on piezoelectric materials, which results in a change of the amplitude. Based on the computational platform of the COMSOL Multiphysics, a multiphysics simulation model of the LW propagation with the PTs under load condition is established. The simulation model includes two physical phenomena. The first one is called solid mechanics, which is used to simulate the acoustoelastic effect being combined with the hyperelastic material properties of the structure in which the LW propagates. The second one is called electromechanical coupling, which considers the simulation of the piezoelectric effect of the PTs for the LW excitation and sensing. To simulate the load influence on piezoelectric materials, a non-linear numerical model of the relationship between the load and the piezoelectric coefficient d31 is established based on an experiment of the load influence on the LW. The simulation results under uniaxial tensile load condition are obtained and are compared with the data obtained from the experiment. It shows that the variations of the phase velocity and amplitude of the LW obtained from the simulation model match the experimental results well. | Lei QIU Xixi YAN Xiaodong LIN Shenfang YUAN | 2019 | Chinese Journal of Aeronautics2019，32，5： | 5 |
| 4 | Energy saving and environment-friendly element-transfer reactions with industrial application potential显示文摘Herein we wish to propose the concept of'element-transfer reaction',which may afford the access to elemental compounds by transferring certain elements from easily available resources efficiently,concisely and precisely.A good element-transfer reaction with industrial application potential shall not generate waste and is performed under energy-saving and environment-friendly conditions.During the past decade,we have developed a series of methods for the synthesis of fluorine-and seleniumcontaining compounds via the fluorine-and selenium-transfer reactions,while the redox reactions we re considered to be the oxygen-and hydrogen-transfer reactions as well and were also widely studied by our group for producing the high-value-added fine chemicals.Some of these technologies have been successfully industrialized.This review summarizes our staged research results on fluorine-,oxygen-,hydrogen-and selenium-transfer reactions and makes a prospect on the developing trend in the field. | Chao Chen Yitao Cao Xixi Wu Yuanli Cai Jian Liu Lin Xu Kehong Ding Lei Yu | 2020 | Chinese Chemical Letters2020，31，5： | 4 |
| 5 | Coverage of 13-Valent Pneumococcal Conjugate Vaccine Among Children 0–15 Months of Age—9 Provinces,China,2019–2021显示文摘Summary What is already known on this topic?Limited data exist regarding the coverage of the 13-valent pneumococcal conjugate vaccine(PCV13)in China.A lack of official statistics,coupled with an insufficient body of published literature,hinders the accurate depiction of the current situation.What is added by this report?This study investigated the utilization of PCV13 and estimated its coverage in nine provinces across eastern,central,and western China between 2019 and 2021.Despite an annual increase in PCV13 usage during this period,the overall coverage remained suboptimal. | Lijun Liu Zhaonan Zhang Xixi Zhang Changsha Xu Yifan Song Li Li Jiakai Ye Zhiguo Wang Hui Liang Weiyan Zhang Ling Lin Ning Li Shujun Zhang Qianli Ma Wen Du Yongzhuo Jiao Lingsheng Cao Qi Qi Lei Cao Wenzhou Yu | 2023 | China CDC weekly2023，5，17： | 1 |
| 6 | Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution显示文摘Proper development of fetal germ cells(FGCs)is vital for the precise transmission of genetic and epigenetic information through generations.The transcriptional landscapes of human FGC development have been revealed;however,the epigenetic reprogramming process of FGCs remains elusive.Here,we profiled the genome-wide DNA methylation and chromatin accessibility of human FGCs at different phases as well as gonadal niche cells at single-cell resolution.First,we found that DNA methylation levels of FGCs changed in a temporal manner,whereas FGCs at different phases in the same embryo exhibited comparable DNA methylation levels and patterns.Second,we revealed the phase-specific chromatin accessibility signatures at the promoter regions of a large set of critical transcription factors and signaling pathway genes.We also identified potential distal regulatory elements including enhancers in FGCs.Third,compared with other hominid-specific retrotransposons,SVA_D might have a broad spectrum of binding capacity for transcription factors,including SOX15 and SOX17.Finally,using an in vitro culture system of human FGCs,we showed that the BMP signaling pathway promoted the cell proliferation of FGCs,and regulated the WNT signaling pathway by orchestrating the chromatin accessibility of its ligand genes.Our single-cell epigenomic atlas and functional assays provide valuable insights for understanding the strongly heterogeneous,unsynchronized,yet highly robust nature of human germ cell development. | Li Li Lin Li Qingqing Li Xixi Liu Xinyi Ma Jun Yong Shuai Gao Xinglong Wu Yuan Wei Xiaoye Wang Wei Wang Rong Li Jie Yan Xiaohui Zhu Lu Wen Jie Qiao Liying Yan Fuchou Tang | 2021 | Cell Research2021，31，4： | 1 |
| 7 | The practice about deep hole pre-split blasting in mining faces of low permeability extra-thick seam显示文摘 | Wang Lin Li Xixi Zhao Yuxiang | 2012 | Advanced Materials Research2012，，： | 1 |
| 8 | Experimental study on size effect of compressive strength and Deformation properties of large size fly ash concrete 显示文摘 | He xixi Lin sheyong Zheng xuecheng | 2011 | Ecological Environment and Technology of Concrete2011，477，： | 1 |
| 9 | The Bioprospecting of Microbial-Derived Antimicrobial Peptides for Sustainable Agriculture显示文摘Strategies aimed at defining,discovering,and developing alternatives to traditional antibiotics will underlie the development of sustainable agricultural systems.Among such strategies,antimicrobial peptides(AMPs)with broad-spectrum antimicrobial activity and multifaceted mechanisms of action are recognized as ideal alternatives in the post-antibiotic era.In particular,AMPs derived from microbes with active metabolisms that can adapt to a variety of extreme environments have long been sought after.Consequently,this review summarizes information on naturally occurring AMPs,including their biological activity,antimicrobial mechanisms,and the preparation of microbial-derived AMPs;it also outlines their applications and the challenges presented by their use in the agroindustry.By dissecting the research results on microbial-derived AMPs of previous generations,this study contributes valuable knowledge on the exploration and realization of the applications of AMPs in sustainable agriculture. | Shuhua Lin Xuan Chen Huimin Chen Xixi Cai Xu Chen Shaoyun Wang | 2023 | Engineering2023，，8： | 0 |
| 10 | A note on weak laws of large numbers for arrays of rowwise negatively quadrant dependent random variables显示文摘Weak laws of large numbers for arrays of rowwise negatively dependent random variables are obtained. The conditions and results of Taylor's are weaken and generalized respectively. | LIN Zhengyan and PANG Tianxiao(Department of Mathematics, Zhejiang University, Xixi campus, Hangzhou 310028, China | 2003 | Progress in Natural Science:Materials International2003，13，7： | 0 |
| 11 | Identification of an immune classifier for predicting the prognosis and therapeutic response in triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC)poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior.Methods:We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA.Utilizing weighted gene coexpression network analysis,we pinpointed 34 TNBC immune genes linked to survival.The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction.We calculated chemotherapy sensitivity scores using the“pRRophetic”package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and Exclusion algorithm.Results:In this study,34 survival-related TNBC immune gene expression profiles were identified.A least absolute shrinkage and selection operator-Cox regression model was used and 15 candidates were prioritized,with a concomitant establishment of a robust risk immune classifier.The high-risk TNBC immune groups showed increased sensitivity to therapeutic agents like RO-3306,Tamoxifen,Sunitinib,JNK Inhibitor VIII,XMD11-85h,BX-912,and Tivozanib.An analysis of the Search Tool for Interaction of Chemicals database revealed the associations between the high-risk group and signaling pathways,such as those involving Rap1,Ras,and PI3K-Akt.The low-risk group showed a higher immunotherapy response rate,as observed through the tumor immune dysfunction and exclusion analysis in the TCGA-TNBC and METABRIC-TNBC cohorts.Conclusion:This study provides insights into the immune complexities of TNBC,paving the way for novel diagnostic approaches and precision treatment methods that exploit its immunological intricacies,thus offering hope for improved management and outcomes of this challenging disease. | KUAILU LIN QIANYU GU XIXI LAI | 2023 | BIOCELL2023，47，12： | 0 |
| 12 | Preparation and Properties of Sapphire by Edge-defined Film-fed Growth(EFG) Method with Different Growth Directions显示文摘Sapphire, belonging to hexagonal crystal system, is typically anisotropic which makes it direction-sensitive. To research the effects of growth directions on properties of sapphire, c-[0001] seed(c-sapphire) and a-[11-20] seed(a-sapphire) were used to prepare sapphire by edge-defined film-fed growth(EFG) method. The samples were analyzed through lattice integrity, dislocation and corrosion performance by double-crystal XRD, OM, AFM, SEM and EDX. It was shown that the lattice integrities of two growth-direction crystals were both well due to the small FWHM values. While the average densities of dislocation in c-sapphire and a-sapphire were 9.2×103 and 3.9×103 cm-2 respectively, the energy of dislocation in c-sapphire was lower than that in a-sapphire. During Strong Phosphoric Acid(SPA) etching, the surface of c-sapphire basically kept smooth but in a-sapphire there were many point-like corrosion pits where aluminum and oxygen atoms lost by 2:1. Our work means that it will be promising for growing c-[0001] seed sapphire by EFG if aided by parameter optimization. | 徐尚君 姚正军 PEI Guangqing LUO Xixi WU Xiaofeng LIN Yuhua | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 0 |
| 13 | New perspective of skeletal stem cells显示文摘Tissue-resident stem cells are a group of stem cells distinguished by their capacity for self-renewal and multilineage differentiation capability with tissue specificity.Among these tissue-resident stem cells,skeletal stem cells(SSCs)were discovered in the growth plate region through a combination of cell surface markers and lineage tracing series.With the process of unravelling the anatomical variation of SSCs,researchers were also keen to investigate the developmental diversity outside the long bones,including in the sutures,craniofacial sites,and spinal regions.Recently,fluorescence-activated cell sorting,lineage tracing,and single-cell sequencing have been used to map lineage trajectories by studying SSCs with different spatiotemporal distributions.The SSC niche also plays a pivotal role in regulating SSC fate,such as cell-cell interactions mediated by multiple signalling pathways.This review focuses on discussing the spatial and temporal distribution of SSCs,and broadening our understanding of the diversity and plasticity of SSCs by summarizing the progress of research into SSCs in recent years. | Guixin Yuan Zan Li Xixi Lin Na Li Ren Xu | 2022 | Biomaterials Translational2022，3，4： | 0 |
| 14 | Inductive effect of hydroxyl safflower yellow-A on apoptosis in abnormal HUVEC via the mitochondrial pathway显示文摘Objective:To investigate the mechanism by which hydroxyl safflower yellow A,an active component of safflower (Carthamus tinctorius L.),promotes apoptosis in abnormal human umbilical vein endothelial cells (HUVECs).Methods:Supernatant of BGC-823 was used to stimulate HUVECs to establish a model of abnormal proliferation of HUVECs.After determining an ideal concentration of HSYA by MTT assay,apoptosis was detected with flow cytometry and TUNEL assay.Mechanism of apoptosis was assessed using quantitative real-time polymerase chain reaction,Western blot,and ELISA.Results:A range of concentrations of HSYA inhibited proliferation and promoted apoptosis of abnormal HUVECs.As the rate of apoptosis increased,mRNA expression of caspase-3 increased while expression of mutant p53 decreased.HSYA had no effect on Fas gene expression.Analogously,protein expression of Bax was increased while those of Bcl-2,Fas,and Fas-L were decreased.Conclusions:HSYA appears to induce apoptosis of HUVECs with the stimulation of the supematant of tumor cells.The mechanism of apoptosis by HSYA may involve activation of the mitochondrial apoptotic pathway and regulation of the expressions of Bcl-2,Bax,and p53. | Na Si Jingjing Wang Yingying Xu Lintao Liu Xu Wang Hongmei Sun Zong Lin Xixi Wang Li Liu Qi Zhang Qian Zhang Cuiling Feng | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，1： | 0 |
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