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| 1 | Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis显示文摘Gouty arthritis is a very familiar inflammatory arthritis.Controlling inflammation is the key to preventing gouty arthritis.However,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side effects.Curcumin(Cur),a natural anti-inflammatory drug,has demonstrated good safety and efficacy.However,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic effect.To strengthen the effectiveness and bioavailability of Cur.Cur loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver Cur.Compared with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.Therefore,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. | Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin | 2022 | Bioactive Materials2022，7，2： | 10 |
| 2 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 3 | Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage显示文摘Bcl-2 是 anti-apoptotic oncoprotein,它的蛋白质层次相反地在许多癌症与预后被相关。然而,在前列腺癌症的前进的 Bcl-2 的角色不是清楚的。这里,我们报导 Bcl-2 从一个雄激素依赖者为 LNCaP 前列腺癌症细胞的前进被要求到一个雄激素无关的生长阶段。Bcl-2 的信使 rna 和蛋白质层次显著地在雄激素无关的前列腺癌症被增加在雄激素无关的前列腺癌症房间的 Bcl-2 的调停 cells.shRNA 的基因 silencing 导致 promotesUV 的 apoptosis 并且压制前列腺肿瘤的生长体内。在在形成的雄激素剥夺条件结果下面的 Growingandrogen 依赖的房间 ofandrogen 独立的殖民地;并且到 androgen-independentgrowth 的从雄激素依赖者的转变被 Bcl-2 对手 Bax 或 Bcl-2 shRNA 的宫外的表示堵住。因此,我们的结果证明 Bcl-2 为 androgen-independentprostate 癌症细胞的幸存是批评的不仅,但是也为前列腺癌症细胞的前进被要求从对一个雄激素无关的生长阶段 anandrogen 依赖。 | Yuting Lin Junichi Fukuchi Richard A Hiipakka John M Kokontis Jialing Xiang | 2007 | Cell Research2007，17，6： | 5 |
| 4 | Accelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies显示文摘Social hierarchies emerged during evolution,and social rank influences behavior and health of individuals.However,the evolutionary mechanisms of social hierarchy are still unknown in amniotes.Here we developed a new method and performed a genome-wide screening for identifying regions with accelerated evolution in the ancestral lineage of placental mammals,where mammalian social hierarchies might have initially evolved.Then functional analyses were conducted for the most accelerated region designated as placental-accelerated sequence 1(PAS1,P=3.15 × 10^-18).Multiple pieces of evidence show that PAS1 is an enhancer of the transcription factor gene Lhx2 involved in brain development.PAS1s isolated from various amniotes showed different c/s-regulatory activity in vitro,and affected the expression of Lhx2 differently in the nervous system of mouse embryos.PAS1 knock-out mice lack social stratification.PAS1 knock-in mouse models demonstrate that PAS1s determine the social dominance and subordinate of adult mice,and that social ranks could even be turned over by mutated PAS1.All homozygous mutant mice had normal huddled sleeping behavior,motor coordination and strength.Therefore,PAS1-Lhx2 modulates social hierarchies and is essential for establishing social stratification in amniotes,and positive Darwinian selection on PAS1 plays pivotal roles in the occurrence of mammalian social hierarchies. | Yuting Wang Guangyi Dai Zhili Gu Guopeng Liu Ke Tang Yi-Hsuan Pan Yujie Chen Xin Lin Nan Wu Haoshan Chen Su Feng Shou Qiu Hongduo Sun Qian Li Chuan Xu Yanan Mao Yong Edward Zhang Philipp Khaitovich Yan-Ling Wang Qunxiu Liu Jing-Dong Jackie Han Zhen Shao Gang Wei Chun Xu Naihe Jing Haipeng Li | 2020 | Cell Research2020，30，5： | 4 |
| 5 | Generation of purple-violet chrysanthemums via anthocyanin B-ring hydroxylation and glucosylation introduced from Osteospermum hybrid F3'5'H and Clitoria ternatea A3'5'GT显示文摘Chrysanthemums possess no metabolic pathway to synthesize delphinidin because of the lack of endogenous F3'5'H gene encoding the key enzyme in its biosynthetic pathway;therefore,there are no blue or blue-purple chrysanthemums occurring naturally.Currently,the introduction of exogenous F3'5'H into chrysanthemums is an efficient method for breeding bluish chrysanthemums.In this study,we explored the effects of the introduction of mutant CmF3'H(generated via site-directed mutagenesis,T485S,CmF3'Hm)and exogenous Osteospermum hybrid F3'5'H(OhF3'5'H)genes combined with Clitoria ternatea A3'5'GT(CtA3'5'GT)on delphinidin synthesis in chrysanthemum.Among the F3'5'H transgenic lines,those overexpressing endogenous CmF3'Hm could not generate blue flower color,although red color was changed to light pink due to CtA3'5'GT function.Meanwhile,OhF3'5'H introduction promoted the accumulation of delphinidin and its derivatives in chrysanthemum,changing the flower color from red-purple to purple-violet.These results indicate the applicability of exogenous OhF3'5'H and CtA3'5'GT transformation for promoting delphinidin synthesis during the molecular breeding of violet/blue chrysanthemums. | Xiaoying Han Yuting Luo Jiaoyang Lin Huiying Wu Hao Sun Lijie Zhou Sumei Chen Zhiyong Guan Weimin Fang Fei Zhang Fadi Chen Jiafu Jiang | 2021 | Ornamental Plant Research2021，1，1： | 3 |
| 6 | Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy显示文摘Hepatitis C virus(HCV)is a leading cause of liver disease worldwide.Although several HCV protease/polymerase inhibitors were recently approved by U.S.FDA,the combination of antivirals targeting multiple processes of HCV lifecycle would optimize anti-HCV therapy and against potential drug-resistanee.Viral entry is an essential target step for antiviral development,but FDA-approved HCV entry inhibitor remains exclusive.Here we identify serotonin 2A receptor(5-HT2aR)is a HCV entry factor amendable to therapeutic intervention by a chemical biology strategy.The silencing of 5-HT2aR and clinically available 5-HT2aR antagonist suppress cell culture-derived HCV(HCVcc)in different liver cells and primary human hepatocytes at late endocytosis process.The mechanism is related to regulate the correct plasma membrane localization of claudin 1(CLDN1).Moreover,phenoxybenzamine(PBZ),an FDAapproved 5-HT2aR antagonist,inhibits all major HCV genotypes in vitro and displays synergy in combination with clinical used anti-HCV drugs.The impact of PBZ on HCV genotype 2a is documented in immune-competent humanized transgenic mice.Our results not only expand the understanding of HCV entry,but also present a promising target for the invention of HCV entry inhibitor. | Lin Cao Jizheng Chen Yaxin Wang Yuting Yang Jie Qing Zihe Rao Xinwen Chen Zhiyong Lou | 2019 | Protein & Cell2019，10，3： | 2 |
| 7 | Thiol-functionalized polysilsesquioxane as efficient adsorbent for adsorption of Hg(II) and Mn(II) from aqueous solution显示文摘 | Yuzhong Niu Rongjun Qu Xiguang Liu Lei Mu Baihui Bu Yuting Sun Hou Chen Yangfeng Meng Lina Meng Lin Cheng | 2014 | Materials Research Bulletin2014，，： | 2 |
| 8 | The space-time references of BeiDou Navigation Satellite System显示文摘The BeiDou Navigation Satellite System (BDS) is essentially a precise time measurement and time synchronization system for a large-scale space near the Earth. General relativity is the basic theoretical framework for the information processing in the master control station of BDS. Having introduced the basic conceptions of relativistic space-time reference systems, the space-time references of BDS are analyzed and the function and acquisition method of the Earth Orientation Parameters (EOP) are briefly discussed. The basic space reference of BDS is BeiDou Coordinate System (BDCS), and the time standard is the BDS Time (BDT). BDCS and BDT are the realizations of the Geocentric Terrestrial Reference System (GTRS) and the Terrestrial Time (TT) for BDS, respectively. The station coordinates in the BDCS are consistent with those in International Terrestrial Reference Frame (ITRF)2014 at the cm-level and the difference in scale is about 1.1 × 10^(−8) . The time deviation of BDT relative to International Atomic Time (TAI) is less than 50 ns and the frequency deviation is less than 2 × 10^(−14) . The Geocentric Celestial Reference System (GCRS) and the solar Barycentric Celestial Reference System (BCRS) are also involved in the operation of BDS. The observation models for time synchronization and precise orbit determination are established within the GCRS framework. The coordinate transformation between BDCS and GCRS is consistent with the International Earth Rotation and Reference Systems Service (IERS). In the autonomous operation mode without the support of the ground master control station, Earth Orientation Parameters (EOP) is obtained by means of long-term prediction and on-board observation. The observa-tion models for the on-board astrometry should be established within the BCRS framework. | Chunhao Han Li Liu Zhiwu Cai Yuting Lin | 2021 | Satellite Navigation2021，2，1： | 2 |
| 9 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 10 | Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase a显示文摘 | Jia Sun Yuting Yang Ke Wan Ninghui Mao Tai-Yuan Yu Yi-Chien Lin Diane C DeZwaan Brian C Freeman Jing-Jer Lin Neal FLue Ming Lei | 2011 | Cell Research2011，21，2： | 1 |
| 11 | Parallel design of convolutional neural networks for remote sensing images object recognition based on data-driven array processor显示文摘Object recognition in very high-resolution remote sensing images is a basic problem in the field of aerial and satellite image analysis.With the development of sensor technology and aerospace remote sensing technology,the quality and quantity of remote sensing images are improved.Traditional recognition methods have a certain limitation in describing higher-level features,but object recognition method based on convolutional neural network(CNN)can not only deal with large scale images,but also train features automatically with high efficiency.It is mainly used on object recognition for remote sensing images.In this paper,an AlexNet CNN model is trained using 2100 remote sensing images,and correction rate can reach 97.6%after 2000 iterations.Then based on trained model,a parallel design of CNN for remote sensing images object recognition based on data-driven array processor(DDAP)is proposed.The consuming cycles are counted.Simultaneously,the proposed architecture is realized on Xilinx V6 development board,and synthesized based on SMIC 130 nm complementary metal oxid semiconductor(CMOS)technology.The experimental results show that the proposed architecture has a certain degree of parallelism to achieve the purpose of accelerating calculations. | Shan Rui Jiang Lin Deng Junyong Cui Pengfei Zhang Yuting Wu Haoyue Xie Xiaoyan | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，6： | 1 |
| 12 | Measuring thematurity of risk management in large-scale constructionprojects显示文摘 | Guangshe Jia Xiaochuan Ni Zhen Chen Baonan Hong Yuting Chen Fangjun Yang Chen Lin | 2012 | Automation in Construction2012，，： | 1 |
| 13 | Enhancement of MoTe2 near-infrared absorption with gold hollow nanorods for photodetection显示文摘Infrared(IR)light photodetection based on two dimensional(2D)materials of proper bandgap has attracted increasing attention.However,the weak IR absorption in 2D materials,due to their ultrathin attribute and indirect bandgap in multilayer structures,degrades their performance when used as IR photodetectors.In this work,we utilize the fact that few-layer MoTe2 flake has a near-IR(NIR)bandgap and demonstrate a^60-fold enhancement of NIR response by introducing a gold hollow nanorods on the surface.Such gold hollow nanorods have distinct absorption peak located also at the NIR regime,therefore induces strong resonance,benefitting NIR absorption in MoTe2,resulting in strong near-field enhancement.With the evidence from steady and transient state optical spectra,we confirm that the enhancement of NIR response originates only photon absorption,rather than electron transport at interfaces as observed in other heterostructures,therefore,precluding the requirement of high-quality interfaces for commercial applications. | Jiawen You Ye Yu Kai Cai Dongming Zhou Haiming Zhu Renyan Wang Qingfu Zhang Hongwei Liu Yuting Cai Dong Lu Jang-Kyo Kim Lin Gan Tianyou Zhai Zhengtang Luo | 2020 | Nano Research2020，13，6： | 1 |
| 14 | ASSAT:computing answer sets of a logic program by sat solved显示文摘 | Fangzhen Lin Yuting Zhao | 2004 | Artificial Intelligence2004，157，12： | 1 |
| 15 | Estimating Just-noticeable Distortion for Video显示文摘 | Jia Yuting Lin Weisi Kassim A A | | 0，，07： | 1 |
| 16 | Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus显示文摘Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021 by the Food and Drug Administration(FDA)in the US.The launch of Saphnelo marked the only new treatment approved for systemic lupus erythematosus(SLE)in more than 10 years. | Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 17 | Design and Implementation of a High-performance and Complexity- effective VLIW DSP for Multimedia Applications 显示文摘 | Lin T Chen S Kuo Yuting | 2007 | Journal of Signal Processing Systems2007，51，3： | 1 |
| 18 | ASSAT: computing answer sets of a logic program by SAT solvers 显示文摘 | Fangzhen Lin and Yuting Zhao | 2004 | Artificial Intelligence2004，157，12： | 1 |
| 19 | Shen-Qi-Wan Protects the Renal Peritubular Capillary Injury from Adenine-mediated Damage by Upregulating Aquaporin 1显示文摘Background:Shen-Qi-Wan(SQW),a commonly used prescription against chronic kidney disease(CKD)in Tradi-tional Chinese Medicine(TCM),has a nephroprotective action in adenine-induced kidney injury.However,the mechanism of SQW in renal injury remains unclear.Objective:This study was undertaken to measure the effect of SQW on peritubular capillary injury both in vivo and in vitro assays.Methods:The effect of SQW on the peritubular capillary injury was evaluated according to measuring hypothalamic-pituitary-adrenal(HPA)function,inflammatory cytokines,VEGF(vascular endothelial growth fac-tor),CD34(Cluster of differentiation 34),and AQP1(Aquaporin 1)levels in the kidney,cell migration,and lumen forming capacity.Results:SQW supplementation could ameliorate dysfunction of the HPA and renal function loss induced by adenine.SQW also significantly inhibited the inflammatory cytokines including MCP-1(monocyte chemotactic protein-1)and VCAM-1(vascular cell adhesion molecule-1)level.Alternatively,SQW administration showed an ameliorating effect from the toxicity and alleviated the injury of capillaries around renal tubules instigated by adenine through increasing AQP1 mRNA and protein level.SQW medicated the serum enhanced the migration and lumen formation ability of HMEC-1 cells,and significantly increased AQP1 protein level.Moreover,AQP1 knockdown efficiently inhibited the migration and lumen formation ability in HMEC-1 cells,and weakened the effect of SQW medicated serum.Conclusion:These results suggested that SQW attenuated peritubular capillary injury in adenine-induced CKD model rats through boosting angiogenesis in endothelial cell,and AQP1 may be a potential target of SQW for treating the renal injury. | Yuting Bao Yehui Zhang Yuanxiao Yang Xueming Chen Luning Lin Yunbo Fu Liting Ji Changyu Li | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，1： | 1 |
| 20 | A tetravalent single-chain antibody-streptaxidin fusion protein for pretargeted lymphoma therapy 显示文摘 | Jody Schultz Yukang Lin James Sanderson Yuting Zuo Diane Stone Robert Mallett Sibylle Wilbert Donald Axworthy | 2000 | Cancer Research2000，60，： | 1 |
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