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| 1 | Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRLIIpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formation显示文摘我们以前报导了那 SM934,水溶性的 artemisinin 衍生物,是在鼠科的豺狼座模型的一个可行处理。在当前的学习,我们进一步在豺狼座容易的 MRL/lpr 老鼠上调查了 SM934 的修改剂量政体的治疗学的效果并且在 B 房间回答上探索了它的效果,在全身的豺狼座 erythematosus (SLE ) 的一个中央病原的事件。当口头上地管理了时两次每日, SM934 显著地延长了 MRL/lpr 老鼠的寿命,改善 lymphadenopathy 症状并且减少浆液的层次反原子的抗体(言论集) 并且病原的 cytokines IL-6, IL-10 和 IL-21。而且, SM934 处理由增加静止 B 房间数字在 MRL/lpr 老鼠的怒气恢复了 B 房间分隔空间,维持幼芽的中心 B 房间数字,减少激活的 B 房间数字和减少的血浆房间(PC ) 数字。前 vivo, SM934 压制了触发的像使用费的受体(TLR ) B 房间的激活和增长,以及抗体分泌物。而且,现在的学习证明 SM934 由 downregulating TLR7/9 mRNA 表示, MyD88 蛋白质表示和 NF-κ 防碍 B 房间内在的小径; B phosphorylation。在人的外部血 mononuclear 房间(PBMC ) ,与在 MRL/lpr 鼠标的结果一致, SM934 禁止了联系 TLR 的 B 房间激活和 PC 区别。在结论, SM934 的两次每日的 dosing 政体由压制 B 房间激活和血浆房间形成在豺狼座容易的 MRL/lpr 老鼠上有治疗学的效果。 | Yanwei Wu Shijun He Bingxin Bai Luyao Zhang Lu Xue Zemin Lin Xiaoqian Yang Fenghua Zhu Peilan He Wei Tang Jianping Zuo | 2016 | Cellular & Molecular Immunology2016，13，3： | 31 |
| 2 | Simultaneous incorporation of PTH(1-34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration显示文摘Tissue regeneration based on the utilization of artificial soft materials is considered a promising treatment for bone-related diseases.Here,we report cranial bone regeneration promoted by hydrogels that contain parathyroid hormone(PTH)peptide PTH(1-34)and nano-hydroxyapatite(nHAP).A combination of the positively charged natural polymer chitosan(CS)and negatively charged sodium alginate led to the formation of hydrogels with porous structures,as shown by scanning electron microscopy.Rheological characterizations revealed that the mechanical properties of the hydrogels were almost maintained upon the addition of nHAP and PTH(1-34).In vitro experiments showed that the hydrogel containing nHAP and PTH(1-34)exhibited strong biocompatibility and facilitated osteogenic differentiation of rat bone marrow mesenchymal stem cells(rBMSCs)via the Notch signaling pathway,as shown by the upregulated expression of osteogenic-related proteins.We found that increasing the content of PTH(1-34)in the hydrogels resulted in enhanced osteogenic differentiation of BMSCs.Implantation of the complex hydrogel into a rat cranial defect model led to efficient bone regeneration compared to the rats treated with the hydrogel alone or with nHAP,indicating the simultaneous therapeutic effect of nHAP and PTH during the treatment process.Both the in vitro and in vivo results demonstrated that simultaneously incorporating nHAP and PTH into hydrogels shows promise for bone regeneration,suggesting a new strategy for tissue engineering and regeneration in the future. | Zhiyuan Zou Le Wang Zhifei Zhou Qing Sun Delong Liu Yan Chen Hao Hu Yu Cai Sixiong Lin Zhengran Yu Bizhi Tan Wei Guo Zemin Ling Xuenong Zou | 2021 | Bioactive Materials2021，6，6： | 7 |
| 3 | Differential expression of immune-related genes between healthy volunteers and type 2 diabetic patients with spleen-deficiency pattern显示文摘OBJECTIVE: To investigate the clinical differentiation of spleen-deficiency pattern(SDP), a group of symptoms and signs defined in terms of Traditional Chinese Medicine for its clinical practice.METHODS: Peripheral venous blood(> 3 m L) was collected from each of six type 2 diabetes mellitus(T2DM)-SDP patients and six healthy volunteers. After the isolation of peripheral white blood cells(PWBCs), total RNA was extracted, and quality control was performed on all RNA samples. Microarray experiments were conducted using the Agilent human whole genome gene chip, and genes demonstrating differential expression were screened. Bioinformatics analysis was conducted on these genes using several online databases.RESULTS: We screened a total of 175 differentially expressed genes(DEGs), of which 111(63%) were down-regulated and 64(37%) were up-regulated in T2DM-SDP patients compared with healthy controls. Among the 175 genes, 158 had biological function annotations: 46(29%) were directly related to an individual's immune regulation or response, 25(16%) were associated with substance and energy metabolism of PWBCs which could also indirectly influence immunity, and the remaining87(55%) were involved in a variety of PWBC biological processes that might eventually influence the immune function. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis revealed that the DEGs were predominantly enriched in seven immune-related pathways. Hierarchical cluster analysis identified gene expression patterns that were distinguishable between the two study groups.CONCLUSION: Our results suggest that T2DM-SDP patients experience significant hypoimmunity and/or immune dysfunctions, and possess a specific gene expression profile. These findings offer new insights into SDP and the clinical pattern differentiation of T2DM-SDP. | Chen Longhui Yang Zemin Chen Weiwen Li Ruliu Lin Chuanquan Guan Lihua Zhu Zhangzhi Chen Ruifang Li Saimei Zhao Lingbo Zeng Jinhao Wang Jianhua | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 5 |
| 4 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 5 | Ultrathin hexagonal boron nitride as a van der Waals,force initiator activated graphene for engineering efficient non-metal electrocatalysts of Li-CO_(2) battery显示文摘Reasonably regulating electronic coupling to promote charge transfer and exciton separation has been regarded a promising approach in catalysis.The material engineering of van der Waals heterojunction(vdWsH)based on two-dimensional(2D)materials would be a potential way to optimize the as-prepared extrinsic physicochemical characteristics.However,it was still an almost uncultivated land waiting for exploration in catalysis.Herein,we introduced the inert h-boron nitride(h-BN)in non-metal reduced graphene oxide(GN)catalysts and constructed BN-GN vdWsH.The theoretical calculation demonstrated that the h-BN can effectively modify the electronic properties of graphene.With the introduction of h-BN,the BN-GN vdWsH can obviously enhance the catalytic activity of Li-CO_(2) battery.The existence of BN-GN vdWsH can reduce the overpotential more than 700 mV compared with reduced graphene oxide during the CO_(2) reduction reaction(CO_(2)RR)and CO_(2) evolution reaction(CO_(2)ER),and it extended cyclic stability more than three times,which was one structure design made it work as a high efficient electrocatalyst,catalytic materials. | Zemin Sun Di Wang Liu Lin Yuhui Liu Mengwei Yuan Caiyun Nan Huifeng Li Genban Sun Xiaojing Yang | 2022 | Nano Research2022，15，2： | 3 |
| 6 | Artemisinin analogue SM934 protects against lupus-associated antiphospholipid syndrome via activation of Nrf2 and its targets显示文摘Kidney is a major target organ in both antiphospholipid syndrome(APS)and systemic lupus erythematosus(SLE).The etiology of antiphospholipid syndrome nephropathy associated lupus nephritis(APSN-LN)is intricate and remains largely unrevealed.We proposed in present work,that generation of antiphospholipid antibodies(aPLs),especially those directed towards the oxidized neoepitopes,are largely linked with the redox status along with disease progression.Moreover,we observed that compromised antioxidative capacity coincided with turbulence of inflammatory cytokine profile in the kidney of male NZW×BXSB F1 mice suffered from APSN-LN.SM934 is an artemisinin derivative that has been proved to have potent immunosuppressive properties.In current study,we elaborated the therapeutic benefits of SM934 in male NZW×BXSB F1 mice,a murine model develops syndrome resembled human APS associated with SLE,for the first time.SM934 treatment comprehensively impeded autoantibodies production,inflammatory cytokine accumulation and excessive oxidative stress in kidney.Among others,we interpreted in present work that both anti-inflammatory and antioxidative effects of SM934 is closely correlated with the enhancement of Nrf2 signaling and expression of its targets.Collectively,our finding confirmed that therapeutic strategy simultaneously exerting antioxidant and anti-inflammatory efficacy provide a novel feasible remedy for treating APSN-LN. | Zemin Lin Yuting Liu Li Chen Shiqi Cao Yueteng Huang Xiaoqian Yang Fenghua Zhu Wei Tang Shijun He Jianping Zuo | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 7 | Non-FDG PET imaging of brain tumors显示文摘Due to relatively high uptake of glucose in the brain cortex, the use of FDG PET imaging is greatly limited in brain tumor imaging, especially for low-grade gliomas and some metastatic tumours. More and more tracers with higher specificity were developed lately for brain tumor imaging. There are 3 main types of non-FDG PET tracers: amino acid tracers, choline tracers and nucleic acid tracers. These tracers are now widely applied in many aspects of brain tumor imaging. This article summarized the general use of non-FDG PET in different aspects of brain tumor imaging. | HUANG Zemin GUAN Yihui ZUO Chuantao ZHANG Zhengwei XUE Fangping LIN Xiangtong | 2007 | Nuclear Science and Techniques2007，18，3： | 1 |
| 8 | Using genetic al- gorithm-back propagation neural network prediction and fi- nite-element model simulation to optimize the process of mul- tiple-step incremental air-bending forming of sheet metal显示文摘 | FU Zemin MO Jianhua CHEN Lin | 2010 | Materials and Desin2010，31，1： | 1 |
| 9 | Using genetic algorithm-back propagation neural network prediction and finite-element model simulation to optimize the process of multiple-step incremental air-bending forming of sheet metal显示文摘 | FU Zemin MO Jianhua CHEN Lin | 2010 | Materials and Design2010，，31： | 1 |
| 10 | Synthesis and dual response of ionic nanocomposite hydrogels with ultrahigh tensibility and transparence显示文摘 | Xiaobo Hu Lijun Xiong Tao Wang Zemin Lin Xinxing Liu Zhen Tong | 2009 | Polymer2009，，8： | 1 |
| 11 | Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus显示文摘Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021 by the Food and Drug Administration(FDA)in the US.The launch of Saphnelo marked the only new treatment approved for systemic lupus erythematosus(SLE)in more than 10 years. | Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 1 |
| 12 | Enhancing Photovoltaic Performance of Asymmetric Fused-Ring Electron Acceptor by Expanding Pyrrole to Pyrrolo[3,2-b]pyrrole显示文摘We propose a strategy to improve performance of unidirectionally extended fused-ring electron acceptors by using pyrrolo[3,2-b]pyrrole to replace pyrrole ring, and design two asymmetric nonfullerene acceptors 1PIC and 2PIC. Replacing pyrrole in 1PIC with pyrrolo[3,2-b]pyrrole remarkably red-shifts absorption peak by 109 nm, elevates the HOMO and LUMO energy levels, and improves electron mobility. The photovoltaic devices based on blend of PM6 donor and 2PIC acceptor exhibit power conversion efficiency as high as 12.6%, which is much higher than that of PM6:1PIC (3.53%), due to more efficient exciton generation and dissociation, faster and more balanced carrier transport and less charge recombination. | Zemin Wang Guilong Cai Peiyao Xue Zesheng Liu Boyu Jia Nan Li Jiayu Wang Xinhui Lu Yuze Lin Guojie Wang Xiaowei Zhan | 2022 | Chinese Journal of Chemistry2022，40，24： | 1 |
| 13 | Preparation of Multistage Sheet-cluster ZnO Photoanode via a Solid State Reaction and Its Property in DSSCs显示文摘 | WEN Qiuxiang DONG Lin SUN Xiaoyong ZHUANG Jia CHEN Zemin | 2016 | Chemical Research in Chinese Universities2016，32，3： | 0 |
| 14 | Influences of AMY1 gene copy number and protein expression on salivary alpha-amylase activity before and after citric acid stimulation in splenic asthenia children显示文摘OBjECTIVE:To compare the correlations between salivary alpha-amylase(sAA) activity and amylase,alpha 1(salivary) gene(AMY1) copy number or its gene expression between splenic asthenia and healthy children,and investigate the reasons of attenuated sAA activity ratio before and after citric acid stimulation in splenic asthenia children.METHODS:Saliva samples from 20 splenic asthenia children and 29 healthy children were collected before and after citric acid stimulation.AMY1 copy number,sAA activity,and total sAA and glycosylated sAA contents were determined,and their correlations were analyzed.RESULTS:Although splenic asthenia and healthy children had no differences in AMY1 copy number,splenic asthenia children had positive correlations between AMY1 copy number and sAA activity before or after citric acid stimulation.Splenic asthenia children had a higher sAA glycosylated proportion ratio and glycosylated sAA content ratio,while their total sAA content ratio and sAA activity ratio were lower compared with healthy children.The glycosylated sAA content ratio was higher than the total sAA content ratio in both groups.Splenic asthenia and healthy children had positive correlations between total sAA or glycosylated sAA content and sAA activity.However,the role played by glycosylated sAA content in sAA activity in healthy children increased after citric acid stimulation,while it decreased in splenic asthenia children.CONCLUSION:Genetic factors like AMY1 copy number variations,and more importantly,sAA glycosylation abnormalities leading to attenuated sAA activity after citric acid stimulation,which were the main reasons of the attenuated sAA activity ratio in splenic asthenia children compared with healthy children. | Yang Zemin Lin Jing Chen Longhui Zhang Min Yang Xiaorong Chen Weiwen | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 0 |
| 15 | ECCENTRIC CIRCULAR GROOVE LAPPING TECHNIQUE FOR CERAMIC BALLS显示文摘ECCENTRICCIRCULARGROOVELAP-PINGTECHNIQUEFORCERAMICBALLSECCENTRICCIRCULARGROOVELAP-PINGTECHNIQUEFORCERAMICBALLSRenChengzu,XuYa... | Ren Chengzu,Xu Yanshan, Lin Bin, Guo Hongqi , Peng Zemin (Tianjin University) | 1996 | Chinese Journal of Mechanical Engineering1996，9，1： | 0 |
| 16 | VBR WAVELET VIDEO CODING AND ITS RATE CONTROL IN ATM NETWORKS显示文摘This paper presents a new video coding system based on wavelet transform and its rate control scheme over ATM networks. First, three dimensional wavelet transform is performed for the original image sequence, and an extension of set partitioning in hierarchical trees algorithm is employed to quantize the wavelet coefficients. Then, the output rate of the coder is controlled at group of frame scale, ensuring that it conforms to the parameters of a leaky bucket controller. Several leaky buckets with different sizes are discussed too. Simulation shows the efficiency of this codec and the effectiveness of the proposed rate control scheme. | Lin Gang Tian Tiehong Liu Zemin(P.O.Box 96, School of Telecom. Engineering, Beijing Univ. of Posts and Telecom, Beijing 100876) | 2000 | Journal of Electronics(China)2000，17，3： | 0 |
| 17 | High strength and high creep resistant ZrB2/Al nanocomposites fabricated by ultrasonic-chemical in-situ reaction显示文摘In this study, the ZrB2/Al nanocomposites were fabricated via in-situ reaction of the Al-K2ZrF6-KBF4 system, assisted with ultrasonic vibration and spiral electromagnetic stirring. Microstructure, tensile property and creep behavior of the fabricated nanocomposites were further investigated. Microstructure observation showed that the ultrasonic vibration could prevent the fast growth as well as break the clusters of in-situ synthesized nanoparticles in melt, resulted in smaller size (10-50 nm) and relatively more uniform distribution of the in-situ nanoparticles located on the boundary of and/or inside the aluminum matrix grains in the final composites. The fabricated nanocomposites exhibited an enhancement in both strength and ductility, due to the elevated work hardening ability, i.e., improved dislocation propagating ability and decreased dynamic recovery of the existing dislocations induced by the in-situ nanoparticles. Meanwhile, the nanocomposites exhibited excellent creep resistance ability, which was about 2-18 times higher than those of the corresponding aluminum matrix. The stress exponent of 5 was identified for the fabricated nanocomposites, which suggested that their creep behavior was related to dislocation climb mechanism. The enhanced creep resistance of the nanocomposites was attributed to the Orowan strengthening and grain boundary strengthening induced by the ZrB2 nanoparticles. Thus, the ultrasonicchemical in-situ reaction promises a low cost but effective way to fabricate aluminum nanocomposites with high strength and high creep resistance. | Xizhou Kai Shuoming Huang Lin Wu Ran Tao Yanjie Peng Zemin Mao Fei Chen Guirong Li Gang Chen Yutao Zhao | 2019 | Journal of Materials Science & Technology2019，35，9： | 0 |
| 18 | 3D Radio Map Reconstruction and Trajectory Optimization for Cellular-Connected UAVs显示文摘This paper introduces an innovative approach to address the trajectory optimization challenge for cellular-connected unmanned aerial vehicles(UAVs)operating in three-dimensional(3D)space.In most cases,optimizing UAV trajectories necessitates ensuring reliable network connectivity.H.owever,achieving dependable connectivity in 3D space poses a significant challenge due to terrestrial base stations primarily designed for ground users.Additionally,UAVs possess network information only for the areas they have visited,with global network information being inaccessible.To address this issue,we propose a collaborative approach in which multiple UAVs create a global model of outage probability using federated learning,enabling more precise and effective trajectory design.Building upon the constructed global information,we conduct the trajectory design.Initially,we introduce A-star(A*)algorithm for trajectory design in small-scale scenarios.Nevertheless,recognizing the limitations of A*algorithm in large-scale scenarios,we further introduce improved rapidly-exploring random trees(RRTs)algorithm for weighted path optimization.Simulation results are provided to validate the effectiveness of the proposed algorithms. | Qiuhu Gong Fahui Wu Dingcheng Yang Lin Xiao Zemin Liu | 2023 | Journal of Communications and Information Networks2023，8，4： | 0 |
| 19 | Estimation and Long-term Trend Analysis of Surface Solar Radiation in Antarctica: A Case Study of Zhongshan Station显示文摘Long-term,ground-based daily global solar radiation (DGSR) at Zhongshan Station in Antarctica can quantitatively reveal the basic characteristics of Earth’s surface radiation balance and validate satellite data for the Antarctic region.The fixed station was established in 1989,and conventional radiation observations started much later in 2008.In this study,a random forest (RF) model for estimating DGSR is developed using ground meteorological observation data,and a highprecision,long-term DGSR dataset is constructed.Then,the trend of DGSR from 1990 to 2019 at Zhongshan Station,Antarctica is analyzed.The RF model,which performs better than other models,shows a desirable performance of DGSR hindcast estimation with an R^2 of 0.984,root-mean-square error of 1.377 MJ m^(-2),and mean absolute error of 0.828 MJ m^(-2).The trend of DGSR annual anomalies increases during 1990–2004 and then begins to decrease after 2004.Note that the maximum value of annual anomalies occurs during approximately 2004/05 and is mainly related to the days with precipitation (especially those related to good weather during the polar day period) at this station.In addition to clouds and water vapor,bad weather conditions (such as snowfall,which can result in low visibility and then decreased sunshine duration and solar radiation) are the other major factors affecting solar radiation at this station.The high-precision,longterm estimated DGSR dataset enables further study and understanding of the role of Antarctica in global climate change and the interactions between snow,ice,and atmosphere. | Zhaoliang ZENG Zemin WANG Minghu DING Xiangdong ZHENG Xiaoyu SUN Wei ZHU Kongju ZHU Jiachun AN Lin ZANG Jianping GUO Baojun ZHANG | 2021 | Advances in Atmospheric Sciences2021，38，9： | 0 |
| 20 | Surrogate cytokine agonists:promising agents against COVID-19显示文摘Cytokines are small cell-signaling proteins which are critical coordinators for the immune response that takes place in infection and inflammation.A recent study published in Cell by Yen et al.1 demonstrated an innovative modular platform enabled engineering surrogate ligand for cytokine receptors therein displayed versatile functional activities.Further,the novel“cytokine med-chem”strategy they presented has been proved to be applicable to many cell surface transmembrane receptor systems,especially for the surrogate interferons(IFNs),that exhibited potent inhibition of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)with restrained proinflammatory effects.This research provided a powerful screening platform for cytokine drug discovery and particularly inspired the development of small molecule drugs for Corona virus disease-2019(COVID-19). | Zemin Lin Jianping Zuo Shijun He | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 0 |
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