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| 1 | Early Paleozoic granitic magmatism related to the processes from subduction to collision in South Altyn, NW China显示文摘Four episodes of granitic rocks at 517, 501–496, 462–451, and 426–385 Ma occurred in the South Altyn subduction-collision complex. The first episode of granite emplacement predates the formation of the ophiolite type mafic rock(?500 Ma), and the three subsequent episodes can be temporally correlated to high-pressure(HP) to ultrahigh-pressure(UHP) metamorphism at ca. 500 Ma, retrograde granulite-facies metamorphism at ca. 450 Ma, and amphibolite-facies metamorphism at ca. 420 Ma, respectively. A comprehensive study of these granitic rocks, along with the regional geological background, mafic-ultramafic rocks, and HP-UHP metamorphism, indicates that the four episodes of granitic magmatism are sequentially derived from the partial melting of the earlier subducted oceanic crust at 517 Ma, the thickened continental crust due to continental subduction at ca. 500 Ma, the mid-upper crust in response to slab breakoff at ca. 450 Ma, and the tectonic transition from contraction to extension at ca. 420 Ma. The formation age of 517 Ma for oceanic adakite provides a direct constraint on the time of the oceanic subduction in South Altyn. In addition, there is a ca. 10 Myr interval between the oceanic subduction to the continental deep subduction, suggesting that the Early Paleozoic tectonic evolution might have been a successive process in South Altyn. The four episodes of formation of granitic rocks, mafic-ultramafic rocks, and HP-UHP metamorphic rocks have fully recorded the tectonic evolution, beginning with the oceanic subduction, followed by continental subduction, and later exhumation during the Early Paleozoic in South Altyn. | LIU Liang KANG Lei CAO YuTing YANG WenQiang | 2015 | Science China Earth Sciences2015，58，9： | 25 |
| 2 | Geochemistry and Zircon U-Pb Dating of Changshagou Adakite from the South Altyn UHPM Terrane: Evidence of the Partial Melting of the Lower Crust显示文摘Changshagou adakite, an outcrop in the middle segment of the South Altyn Tagh ultra-high pressure metamorphism(UHPM) terrane, contains medium-K cal-alkaline and weakly peraluminous compositions(Si O2 = 66.79% to 68.65%, Al2O3 = 17.48% to 18.31%, K2 O + Na2 O = 6.32% to 6.88%, K2O/Na2 O = 0.25 to 0.33, A/CNK = 1.01 to 1.06). This outcrop is also enriched with large ion lithophile elements but with depleted high-field strength elements(HFSE) showing clearly negative Nb, Ta, and Ti anomalies. REE distribution patterns show a positive anomaly of Eu(δEu = 1.15 to 1.31) and weakly enriched with LREE compared with HREE(LREE/HREE = 1.02 to 4.20). Experimental results and several characteristics, including relatively low Nb/Ta ratios(6.03 to 8.45) and high Sr, Sr/Y,(La/Yb)N and low Y and Yb, which indicate the presence of residual garnet and the absence of plagioclase in the source region, show that adakite may form at a pressure ranging from 1.2 GPa to 1.5 GPa and at a temperature of approximately 900°C. Low Cr, Ni, and Mg# values, trace element patterns, and Si O2–Mg# and Si O2–Mg O diagrams indicate that rocks are formed by the partial melting of a thickened lower continental crust. LA-ICP-MS in situ U-Pb dating yields two group ages: 503.1 ± 1.7 Ma(core) and 453.1 ± 3.0 Ma(rim). The Th/U ratios of the core and the rim are 0.11 to 0.40 and 0.03 to 0.07, respectively. Considering the zircon CL image characteristics, Th/U ratios, and previous studies on regional UHPM rocks, adakite formed at 503.1 ± 1.7 Ma and underwent a tectothermal event as a result of the break-off of the Altyn deep subducted continental crust at 453.1 ± 3.0 Ma. | KANG Lei LIU Liang WANG Chao CAO Yuting YANG Wenqiang WANG Yawei LIAO Xiaoying | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 15 |
| 3 | 3D bioprinting: an emerging technology full of opportunities and challenges显示文摘 | Bin Zhang Yichen Luo Liang Ma Lei Gao Yuting Li Qian Xue Huayong Yang Zhanfeng Cui | 2018 | Bio-Design and Manufacturing2018，1，1： | 13 |
| 4 | Development of a soil-plant-atmosphere continuum model (HDS-SPAC) based on hybrid dual-source approach and its verification in wheat field显示文摘HDS-SPAC,a new soil-plant-atmosphere continuum(SPAC) model,is developed for simulating water and heat transfer in SPAC.The model adopts a recently proposed hybrid dual source approach for soil evaporation and plant transpiration partitioning.For the above-ground part,a layer approach is used to partition available energy and calculate aerodynamic resistances,while a patch approach is used to derive sensible heat and latent heat fluxes from the two sources(soil and vegetation).For the below-ground part,soil water and heat dynamics are described by the mixed form of Richards equation,and the soil heat conductivity equation,respectively.These two parts are coupled through ground heat flux for energy transfer,root-zone water potential-dependent stomatal resistance,and surface soil water potential-dependent evaporation for water transfer.Evaporation is calculated from the water potential gradient at soil-atmosphere interface and aerodynamic resistance,and transpiration is determined using a Jarvis-type function linking soil water availability and atmospheric conditions.Some other processes,such as canopy interception and deep percolation,are also considered in the HDS-SPAC model.The hybrid dual-source approach allows HDS-SPAC to simulate heat and water transfer in an ecosystem with a large range of vegetation cover change temporally or spatially.The model was tested with observations at a wheat field in North China Plain over a time of three months covering both wet and dry conditions.The fractional crop covers change from 30% to over 90%.The results indicated that the HDS-SPAC model can estimate actual evaporation and transpiration partitioning and soil water content and temperature over the whole range of tested vegetation coverage. | YANG YuTing SHANG SongHao GUAN Huade | 2012 | Science China(Technological Sciences)2012，55，10： | 12 |
| 5 | Discovery of coesite in eclogite from Keqike Jianggalesayi: new evidence for ultrahigh-pressure metamorphism in South Altyn Tagh, northwestern China显示文摘Coesite is a polymorph of Si O2formed at speci?c high-pressure conditions, and its presence in some crustal rocks as relicts marks the exhumation of deep subducted material to mantle depths, thus providing robust evidence for the hypothesis on ultrahigh pressur (UHP) metamorphism [1]. The discovery of coesite and other | Yongsheng Gai Liang Liu Chao Wang Wenqiang Yang Lei Kang Yuting Cao Xiaoying Liao | 2017 | Science Bulletin2017，62，15： | 8 |
| 6 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 7 | Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors显示文摘Achievement of immunocompetent and therapeutic T lymphopoiesis from pluripotent stem cells(PSCs)is a central aim in T cell regenerative medicine.To date,preferentially reconstituting T lymphopoiesis in vivo from PSCs remains a practical challenge.Here we documented that synergistic and transient expression of Runx1 and Hoxa9 restricted in the time window of endothelial-to-hematopoietic transition and hematopoietic maturation stages in a PSC differentiation scheme(iR9-PSC)in vitro induced preferential generation of engraftable hematopoietic progenitors capable of homing to thymus and developing into mature T cells in primary and secondary immunodeficient recipients.Single-cell transcriptome and functional analyses illustrated the cellular trajectory of T lineage induction from PSCs,unveiling the T-lineage specification determined at as early as hemogenic endothelial cell stage and identifying the bona fide pre-thymic progenitors.The induced T cells distributed normally in central and peripheral lymphoid organs and exhibited abundant TCRαβrepertoire.The regenerative T lymphopoiesis restored immune surveillance in immunodeficient mice.Furthermore,gene-edited iR9-PSCs produced tumor-specific T cells in vivo that effectively eradicated tumor cells.This study provides insight into universal generation of functional and therapeutic T cells from the unlimited and editable PSC source. | Rongqun Guo Fangxiao Hu Qitong Weng Cui Lv Hongling Wu Lijuan Liu Zongcheng Li Yang Zeng Zhijie Bai Mengyun Zhang Yuting Liu Xiaofei Liu Chengxiang Xia Tongjie Wang Peiqing Zhou Kaitao Wang Yong Dong Yuxuan Luo Xiangzhong Zhang Yuxian Guan Yang Geng Juan Du Yangqiu Li Yu Lan Jiekai Chen Bing Liu Jinyong Wang | 2020 | Cell Research2020，30，1： | 7 |
| 8 | Hydrological cycle and water resources in a changing world:A review显示文摘Water is the fundamental natural resource that supports life,ecosystems and human society.Thus studying the water cycle is important for sustainable development.In the context of global climate change,a better under-standing of the water cycle is needed.This study summarises current research and highlights future directions of water science from four perspectives:(i)the water cycle;(ii)hydrologic processes;(iii)coupled natural-social water systems;and(iv)integrated watershed management.Emphasis should be placed on understanding the joint impacts of climate change and human activities on hydrological processes and water resources across temporal and spatial scales.Understanding the interactions between land and atmosphere are keys to addressing this is-sue.Furthermore systematic approaches should be developed for large basin studies.Areas for focused research include:variations of cryosphere hydrological processes in upper alpine zones;and human activities on the wa-ter cycle and relevant biogeochemical processes in middle-lower reaches.Because the water cycle is naturally coupled with social characteristics across multiple scales,multi-process and multi-scale models are needed.Hy-drological studies should use this new paradigm as part of water-food-energy frontier research.This will help to promote interdisciplinary study across natural and social sciences in accordance with the United Nation’s sustainable development goals. | Dawen Yang Yuting Yang Jun Xia | 2021 | Geography and Sustainability2021，2，2： | 7 |
| 9 | Effects of Straw Incorporation Methods on Nitrous Oxide and Methane Emissions from a Wheat-Rice Rotation System显示文摘The incorporation of straw with a microbial inoculant(a mixture of bacteria and fungi, designed to accelerate straw decomposition)is being increasingly adopted within the agricultural sector in China. However, its effects on N and C trace gas emissions remain unclear.We conducted a field experiment to investigate the effects of different straw incorporation methods(with and without microbial inoculant) in the wheat season on nitrous oxide(N_2O) and methane(CH_4) emissions from a wheat-rice rotation system in China.The treatments comprised N, P, and K fertilizers only(NPK), NPK plus rice straw(NPKS), NPKS plus Ruilaite microbial inoculant(NPKSR), and NPKS plus Jinkuizi microbial inoculant(NPKSJ). Rice straw incorporation before wheat sowing significantly decreased N_2O emissions during the wheat season and stimulated N_2O and CH_4 emissions during the subsequent rice season. Compared with the NPKS treatment, the NPKSR and NPKSJ treatments decreased N_2O emissions during the wheat season, but had no effect on N_2O or CH_4 emissions during the subsequent rice season. Annually, the two treatments were comparable regarding N_2O emissions.Although the global warming potentials of the NPKSR and NPKSJ treatments were lower than that of the NPKS treatment during the wheat season, no significant differences were observed during the subsequent rice season, or over the entire rotation cycle. The annual greenhouse gas intensity was slightly lower in the NPKSR and NPKSJ treatments than in the NPKS treatment. Overall, these results suggest that the incorporation of rice straw with a microbial inoculant in the wheat season was the best strategy tested for managing straw resources within the wheat-rice rotation system. | LIU Gang MA Jing YANG Yuting YU Haiyang ZHANG Guangbin XU Hua | 2019 | Pedosphere2019，29，2： | 7 |
| 10 | Aeroelastic optimization design for wing with maneuver load uncertainties显示文摘An aeroelastic optimization design methodology for air vehicle considering the uncertainties in maneuver load conditions is presented and applied to a structural design process of low-aspect-ratio wing. An aerodynamic load correction model is developed and used to predict the critical load conditions with the perturbations of theoretical linear aerodynamic forces and experimental aerodynamic forces from wind-tunnel test, when concerning the uncertainties in use of theoretical linear and experimental aerodynamic forces. Three objective functions of critical loads are defined. The load evaluations for three wing sections are investigated in four characteristic maneuvers, and the most critical load conditions are confirmed by using the sequential quadratic programming method. On this basis, the aeroelastic optimization design employing the genetic-gradient hybrid algorithm is conducted, in which the objective is to minimize structural mass subject to the constraints of stress, deformation and flutter speed. The resulting optimal structure is heavier than the one simply based on the theoretical linear or experimental aerodynamic forces. However, it is more robust when encountering the critical load conditions in actual flight due to the consideration of uncertainties in aerodynamic forces in the early design phase, thereby, the risk of structural redesign can be reduced. | YANG Chao, XIAO ZhiPeng*, WAN ZhiQiang, YAN De & DAI YuTing School of Aeronautic Science and Engineering, Beihang University, Beijing 100191, China | 2010 | Science China(Technological Sciences)2010，53，11： | 6 |
| 11 | A comprehensive update:gastrointestinal microflora,gastric cancer and gastric premalignant condition,and intervention by traditional Chinese medicine显示文摘With the recent upsurge of studies in the field of microbiology,we have learned more about the complexity of the gastrointestinal microecosystem.More than 30 genera and 1000 species of gastrointestinal microflora have been found.The structure of the normal microflora is relatively stable,and is in an interdependent and restricted dynamic equilibrium with the body.In recent years,studies have shown that there is a potential relationship between gastrointestinal microflora imbalance and gastric cancer(GC)and precancerous lesions.So,restoring the balance of gastrointestinal microflora is of great significance.Moreover,intervention in gastric premalignant condition(GPC),also known as precancerous lesion of gastric cancer(PLGC),has been the focus of current clinical studies.The holistic view of traditional Chinese medicine(TCM)is consistent with the microecology concept,and oral TCM can play a two-way regulatory role directly with the microflora in the digestive tract,restoring the homeostasis of gastrointestinal microflora to prevent canceration.However,large gaps in knowledge remain to be addressed.This review aims to provide new ideas and a reference for clinical practice. | Yuting LU Huayi LIU Kuo YANG Yijia MAO Lingkai MENG Liu YANG Guangze OUYANG Wenjie LIU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，1： | 6 |
| 12 | Variations of Stable Carbon Isotopes of CH4 Emission from Three Typical Rice Fields in China显示文摘Little is known about the stable carbon isotopes of methane(CH4) emitted(δ^(13)CH_(4emitted)) from permanently flooded rice fields and double rice-cropping fields.The CH4 emission and corresponding δ^(13)CH_(4emitted) under various field managements(mulching,water regime,tillage,and nitrogen(N) fertilization) were simultaneously measured in three typical Chinese rice fields,a permanently flooded rice field in Ziyang City,Sichuan Province,Southwest China,a double-rice cropping field in Yingtan City,Jiangxi Province,Southeast China,and a rice-wheat rotation field in Jurong City,Jiangsu Province,East China,from 2010 to 2012.Results showed different seasonal variations of δ^(13)CH_(4emitted) among the three fields during the rice-growing season.The values of δ^(13)CH_(4emitted) were negatively correlated with corresponding CH4 emissions in seasonal variation and mean,indicating the importance of CH_4 production,oxidation,and transport associated with isotopic fractionation effects to the δ^(13)CH_(4emitted).Seasonal variations of δ^(13)CH_(4emitted) were slightly impacted by mulching cultivation,tillage,and N application,but highly controlled by drainage.Meanwhile,tillage,N application,and especially mulching cultivation had important effects on seasonal mean CH4 emissions and corresponding δ^(13)CH_(4emitted) with low emissions accompanied by high values of δ^(13)CH_(4emitted).Seasonal mean values of δ^(13)CH_(4emitted) from the three fields were similar,mostly ranging from —60‰ to — 50‰,which are well in agreement with previously published data.These demonstrated that seasonal variations of δ^(13)CH_(4emitted) mainly depended on the changes in CH4 emission from rice fields and further indicated the important effects of methanogenic pathways,CH4 oxidation,and CH4 transport associated with isotope fractionation effects influenced by field managements on δ^(13)CH_(4emitted). | ZHANG Guangbin MA Jing YANG Yuting YU Haiyang SHI Yaping XU Hua | 2017 | Pedosphere2017，27，1： | 6 |
| 13 | Genome-and transcriptome-wide association studies provide insights into the genetic basis of natural variation of seed oil content in Brassica napus显示文摘Seed oil content(SOC)is a highly important and complex trait in oil crops.Here,we decipher the genetic basis of natural variation in SOC of Brassica napus by genome-and transcriptome-wide association studies using 505 inbred lines.We mapped reliable quantitative trait loci(QTLs)that control SOC in eight environments,evaluated the effect of each QTL on SOC,and analyzed selection in QTL regions during breeding.Six-hundred and ninety-two genes and four gene modules significantly associated with SOC were identified by analyzing population transcriptomes from seeds.A gene prioritization framework,POCKET(prioritizing the candidate genes by incorporating information on knowledge-based gene sets,effects of variants,genome-wide association studies,and transcriptome-wide association studies),was implemented to determine the causal genes in the QTL regions based on multi-omic datasets.A pair of homologous genes,BnPMT6s,in two QTLs were identified and experimentally demonstrated to negatively regulate SOC.This study provides rich genetic resources for improving SOC and valuable insights toward understanding the complex machinery that directs oil accumulation in the seeds of B.napus and other oil crops. | Shan Tang Hu Zhao Shaoping Lu Liangqian Yu Guofang Zhang Yuting Zhang Qing-Yong Yang Yongming Zhou Xuemin Wang Wei Ma Weibo Xie Liang Guo | 2021 | Molecular Plant2021，14，3： | 6 |
| 14 | Methods and advances in the study of aeroelasticity with uncertainties显示文摘Uncertainties denote the operators which describe data error, numerical error and model error in the mathematical methods. The study of aeroelasticity with uncertainty embedded in the subsystems, such as the uncertainty in the modeling of structures and aerodynamics, has been a hot topic in the last decades. In this paper, advances of the analysis and design in aeroelasticity with uncertainty are summarized in detail. According to the non-probabilistic or probabilistic uncertainty, the developments of theories, methods and experiments with application to both robust and probabilistic aeroelasticity analysis are presented, respectively. In addition, the advances in aeroelastic design considering either probabilistic or non-probabilistic uncertainties are introduced along with aeroelastic analysis. This review focuses on the robust aeroelasticity study based on the structured singular value method, namely the l method. It covers the numerical calculation algorithm of the structured singular value, uncertainty model construction, robust aeroelastic stability analysis algorithms, uncertainty level verification, and robust flutter boundary prediction in the flight test, etc. The key results and conclusions are explored. Finally, several promising problems on aeroelasticity with uncertainty are proposed for future investigation. | Dai Yuting Yang Chao | 2014 | Chinese Journal of Aeronautics2014，27，3： | 5 |
| 15 | Recent Advances on MOF Derivatives for Non-Noble Metal Oxygen Electrocatalysts in Zinc-Air Batteries显示文摘Oxygen electrocatalysts are of great importance for the air electrode in zinc-air batteries(ZABs).Owing to the high specific surface area,controllable pore size and unsaturated metal active sites,metal-organic frameworks(MOFs)derivatives have been widely studied as oxygen electrocatalysts in ZABs.To date,many strategies have been developed to generate efficient oxygen electrocatalysts from MOFs for improving the performance of ZABs.In this review,the latest progress of the MOF-derived non-noble metal-oxygen electrocatalysts in ZABs is reviewed.The performance of these MOF-derived catalysts toward oxygen reduction,and oxygen evolution reactions is discussed based on the categories of metal-free carbon materials,single-atom catalysts,metal cluster/carbon composites and metal compound/carbon composites.Moreover,we provide a comprehensive overview on the design strategies of various MOF-derived non-noble metal-oxygen electrocatalysts and their structure-performance relationship.Finally,the challenges and perspectives are provided for further advancing the MOF-derived oxygen electrocatalysts in ZABs. | Yuting Zhu Kaihang Yue Chenfeng Xia Shahid Zaman Huan Yang Xianying Wang Ya Yan Bao Yu Xia | 2021 | Nano-Micro Letters2021，13，9： | 5 |
| 16 | Natural orifice transluminal endoscopic surgery in urology: The Chinese experience显示文摘Objective:To describe the Chinese experience of natural orifice transluminal endoscopic surgery(NOTES)in urology.Methods:From December 2008 to May 2017,35 animal experiments and 305 clinical surgeries of NOTES or natural orifices specimen extractions(NOSE)were performed in China.The animal experiments included five kidney biopsies,24 nephrectomies and six partial nephrectomies.The clinical surgeries included 12 transvaginal NOSE(TV-NOSE),266 hybrid transvaginal NOTES(TV-NOTES)and 27 pure TV-NOTES.The TV-NOSE procedure was performed in five transumbilical laparoendoscopic single-site(U-LESS)nephrectomies,four suprapubic-assisted laparoendoscopic single-site surgery(SA-LESS)nephroureterectomies,and three laparoscopic radical cystectomies.The hybrid TV-NOTES procedure included 210 nephrectomies,31 adrenalectomies,eight nephroureterectomies,13 partial nephrectomies,and four heminephrectomies.The pure TV-NOTES procedure included five renal cyst decortications and 22 nephrectomies.Results:A total of 29 animal experiments were successfully performed.One partial nephrectomy was converted to standard laparoscopic surgery.Two kidney biopsies and two nephrectomies were unsuccessful.A total of 297 clinical surgeries were successfully performed.Six patients who underwent hybrid TV-NOTES were converted to open surgery.Two patients who underwent pure TV-NOTES were converted to SA-LESS.There were 22 major complications,16 occurred intraoperatively and six postoperatively.The mean visual analog score(VAS)of 48 h after the operation was 2.5 points in TV-NOSE,2.3 points in hybrid TV-NOTES and 1.7 points in pure TV-NOTES.The mean follow-up of 50.6(3.0-87.0)months showed that all patients were in good condition.The umbilicus scars were nearly invisible in TV-NOSE and hybrid TV-NOTES.The vaginal incision healed well.Conclusions:TV-NOSE and TV-NOTES are feasible,safe,and effective with little injury,low pain,fast recovery,and good cosmetic outcomes in properly selected patients.They are worth consideration for urological clinical practice. | Xiaofeng Zou Guoxi Zhang Tianpeng Xie Yuanhu Yuan Rihai Xiao Gengqing Wu Xiaoning Wang Hui Xu Folin Liu Yuting Wu Yunfeng Liao Quanliang Liu Yinghao Sun Bo Yang Linhui Wang Chuanliang Xu Xiaofeng Gao | 2020 | Asian Journal of Urology2020，7，1： | 5 |
| 17 | Mitochondrial replacement in macaque monkey offspring by first polar body transfer显示文摘Dear Editor,Mitochondrial DNA(mtDNA)mutations are materally inherited to the offspring and mitochondrial replacement therapy(MRT)provides.a promising approach for preventing mtDNA-related 1,2 diseases.First polar body transfer(PB1T)has been used for mitochondrial replacement to generate mouse offspring and normal human embryos that yield embryonic stem cells.However,generation of primate offspring using PB1T has not been reported.Here,we show that PB1T-based mitochondrial replacement could generate healthy macaque monkey(Macaca fascicularis),a useful non-human primate model for evaluating methods that may improve the efficiency and safety of PB1T for MRT. | Zhanyang Wang Yuzhuo Li Xianfa Yang Yan Wang Yanhong Nie Yuting Xu Xiaotong Zhang Yong Lu Tikui Zhang Qiming Liu Naihe Jing Zhen Liu Qiang Sun | 2021 | Cell Research2021，31，2： | 4 |
| 18 | Multi-Stage Metamorphism of the UHP Pelitic Gneiss from the Southern Altyn Tagh HP/UHP Belt,Western China:Petrological and Geochronological Evidence显示文摘The kyanite-bearing garnet pelitic gneiss from the Jianggalesavi area in southern Altyn Tagh high pressure/ultra-high pressure belt was proved to have been experienced UHP metamorphism (>12 GPa) by the discovery of kyanite and spinel exsolution microstructure in quartz (precursor stishovite). In this study, three stages of retrograded metamorphism (M2-M4) after the UHP metamorphism (Ml) were identified for the UHP pelitic gneiss. The HP granulite-facies stage (M2) was characterized by the mineral assemblage of garnet+kyanite+K?feldspar+nitile+qiiartz±ilinenite, recording the P-T condition of >1.12 GPa and ?850-930℃. The granulite-facies stage (M3) was represented by the mineral assemblage of garnet rim+K-feldspar+sillimanite (SillJ+biotite (Bti)+plagioclase (Pli)+ilmenite+quartz, and confined under P-T conditions of 0.5-0.8 GPa and^770-795℃. The late cooling stage M4 was accompanied by the appearance of fine-grained Pl2, Sill2 and Bt2 in the matrix, and the P-T conditions were 0.4-0.6 GPa and <675℃. A clockvvised P-T path was obtained for the pelitic gneiss in the P-T pseudosection, which showed a deep subduction/collision processes with subsequent exhumation and cooling. Com? bined with the corresponding multistage metamorphic assemblages, the age dating results implied that the zircons from the gneiss have integrated the recording peak metamorphic (Ml,484±3 Ma) and retrograded metamorphic ages (M2 to M3, 450±2 Ma). There was about 32 Ma interval during the first exhumation from the upper mantle depth (>350 km) to the lower crust depth (-40-20 km), resulting in an average exhumation rate of 9.11-9.70 mm/yr. In the southern Altyn Tagh region, the HP and UHP rocks from different areas had identical peak metamorphic ages. Therefore, contemporary UHP and HP rocks with different metamorphic evolutions were recognized coexisting in the same orogenic belt, which can be interpreted by the model of subduction channel. The continental crustal were subducted to different depths along the direction of the subduction channels at ~500 Ma, suffered different grade metamorphism, and then returned to the surface along the subduction channel. | Yuting Cao Liang Liu Chao Wang Cong Zhang Lei Kang Wenqiang Yang Xiaohui Zhu | 2019 | Journal of Earth Science2019，30，3： | 4 |
| 19 | Reconstruction the Process of Partial Melting of the Retrograde Eclogite from the North Qaidam,Western China: Constraints from Titanite U-Pb Dating and Mineral Chemistry显示文摘Retrograde eclogite and garnet amphibolite of the Lüliangshan unit of the Shenglikou area,North Qaidam,were studied with emphasis on rutile and titanite.A special focus is on the formation of rutile and its corona of titanite(Ttn1)in retrograde eclogite and on coarse-grained titanite(Ttn2)from the garnet amphibolite.Using zirconium(Zr)-in-rutile and Zr-in-titanite thermometers,the temperatures estimated for the formation of an early generation of rutile are 823–884℃at 2.5–2.8 GPa,while 812–894℃at 1.3–1.5 GPa are derived for the formation of coronitic Ttn1 in the retrograde eclogite.Therefore,isothermal decompression must have occurred during exhumation,which also has triggered the partial melting of the retrograde eclogite.Ttn2 of the garnet amphibolite has high REE contents and high Th/U ratios,indicating that it is newly grown from a Ti,Ca,and LREE enriched anatectic melt derived from the partial melting of retrograde eclogite.LA-ICP MS U-Pb dating yields a lower intercept age of 423±4 Ma for Ttn2,which is consistent with the granulite-facies metamorphic age of the retrograde eclogite.Moreover,a temperature of 781–823℃at 1.0–1.2 GPa is obtained for Ttn2,which fits the P-T conditions of the HP granulite-facies metamorphic stage(P=1.07–1.24 GPa and T=774–814℃),and documents that the crystallization of the melt occurred at the granulite-facies stage at 423 Ma.The high amount of REE of the garnet amphibolite is a consequence of the formation of Ttn2 from the melt.The contents and ratios of Zr and Hf in rutile and Ttn2 differ from those in the garnet amphibolite,and the whole rock Zr/Hf ratios of retrograde eclogite and garnet amphibolite are both higher than the respective ratios in rutile and Ttn2,suggesting that rutile and titanite cannot be the major carriers of Zr and Hf accounting for the high whole rock Zr/Hf ratios. | Yuting Cao Liang Liu Wenqiang Yang Yuan Gao Xiaohui Zhu | 2019 | Journal of Earth Science2019，30，6： | 4 |
| 20 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
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