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| 1 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 2 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 3 | Review on grid-forming converter control methods in high-proportion renewable energy power systems显示文摘Grid-forming(GFM)converters can provide inertia support for power grids through control technology,stabilize voltage and frequency,and improve system stability,unlike traditional grid-following(GFL)converters.Therefore,in future“double high”power systems,research on the control technology of GFM converters will become an urgent demand.In this paper,we first introduce the basic principle of GFM control and then present five currently used control strategies for GFM converters:droop control,power synchronization control(PSC),virtual synchronous machine control(VSM),direct power control(DPC),and virtual oscillator control(VOC).These five strategies can independently establish voltage phasors to provide inertia to the system.Among these,droop control is the most widely used strategy.PSC and VSM are strategies that simulate the mechanical characteristics of synchronous generators;thus,they are more accurate than droop control.DPC regulates the active power and reactive power directly,with no inner current controller,and VOC is a novel method under study using an oscillator circuit to realize synchronization.Finally,we highlight key technologies and research directions to be addressed in the future. | Yuting Teng Wei Deng Wei Pei Yifeng Li Li Ding Hua Ye | 2022 | Global Energy Interconnection2022，5，3： | 3 |
| 4 | Chromosomal-level genome of macadamia(Macadamia integrifolia)显示文摘Macadamia from the family Proteaceae is a plant native to Australia and has long been favoured by people for its crispy and high nutritional and medicinal value.Here,the genome of GUIRE 1(GR1),a highly heterozygous superior cultivar of macadamia nut,was sequenced and assembled using nanopore sequencing,and a 807-Mb genome(contig N50,1.9 Mb;scaffold N50,54.70 Mb)and 14 chromosomes were obtained.A total of 453 Mb(about 55.95%)repetitive sequences and 37,657 protein-coding genes were obtained by gene annotation and homologous protein comparison.Proteaceae diverged from Nelumbonaceae nearly 115.37 million years ago and from Rubiaceae about 140 million years ago.A genome-wide duplication(WGD)event occurred in macadamia 41 million years ago based on the WGD analysis.The functional enrichment analysis of M.integrifolia-specific gene families revealed their roles in signal transduction,protein phosphorylation,protein binding,and defense response.Here,a highly heterozygous genome of M.integrifolia was unlocked to provide a database for breeding and molecular mechanism research. | Chengcai Xia Sirong Jiang Qiujin Tan Wenquan Wang Long Zhao Chenji Zhang Yuting Bao Qi Liu Jianjia Xiao Ke Deng Miaohua He Pengliang An Wenlin Wang Meiling Zou Zhiqiang Xia | 2022 | Tropical Plants2022，1，1： | 3 |
| 5 | A dual-luciferase reporter system for characterization of small RNA target genes in both mammalian and insect cells显示文摘MicroRNAs(miRNAs)are regulatory RNA molecules that bind to target messenger RNAs(mRNAs)and affect the stability or translational efficiency of the bound mRNAs.Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells.These reporter systems,however,are not sensitive enough to verify miRNA-target gene relationships in insect cell lines because the promoters of the target luciferase(usually Renilla)used in these reporter systems are too weak to drive sufficient expression of the target luciferase in insect cells.In this study,we replaced the SV40 promoter in the psiCHECK-2 reporter vector,which is widely used with mammalian cell lines,with the HSV-TK or AC5.1 promoter to yield two new dual-luciferase reporter vectors,designated psiCHECK-2-TK and psiCHECK-2-AC5.1,respectively.Only psiCHECK-2 and psiCHECK-2-AC5.1 had suitable target(7?enz7/a)/reference(firefly)luciferase activity ratios in mammalian(HeLa and HEK293)and insect(Sf9,S2,Helicoverpa zea fat body and ovary)cell lines,while psiCHECK-2-TK had suitable Renilla/firefly luciferase activity ratios regardless of the cell line.Moreover,psiCHECK-2-TK successfully detected the interaction between Helicoverpa armigera miRNA9a and its target,the 3'-untranslated region of heat shock protein 90,in both mammalian and H.zea cell lines,but psiCHECK-2 failed to do so in IT.zea cell lines.Furthermore,psiCHECK-2-TK with the target sequence,HzMasc(H.zea Masculinizer),accurately differentiated between H.zea cell lines with or without the negative regulation factor(miRNA or piRNA)of HzMasc.These data demonstrate that psiCHECK-2-TK can be used to functionally characterize small RNA target genes in both mammalian and insect cells. | Zhongyuan Deng Yuting Zhang Leyao Li Xingcheng Xie Jinyong Huang Min Zhang Xinzhi Ni Xianchun Li | 2022 | Insect Science2022，29，3： | 2 |
| 6 | Coastal Gravity Anomalies from Retracked Geosat/GM Altimetry: Improvement, Limitation and the Role of Airborne Gravity Data显示文摘 | Cheinway Hwang Jinyun Guo Xiaoli Deng Hsin-Ying Hsu Yuting Liu | 2006 | Journal of Geodesy2006，，4： | 1 |
| 7 | Parallel design of convolutional neural networks for remote sensing images object recognition based on data-driven array processor显示文摘Object recognition in very high-resolution remote sensing images is a basic problem in the field of aerial and satellite image analysis.With the development of sensor technology and aerospace remote sensing technology,the quality and quantity of remote sensing images are improved.Traditional recognition methods have a certain limitation in describing higher-level features,but object recognition method based on convolutional neural network(CNN)can not only deal with large scale images,but also train features automatically with high efficiency.It is mainly used on object recognition for remote sensing images.In this paper,an AlexNet CNN model is trained using 2100 remote sensing images,and correction rate can reach 97.6%after 2000 iterations.Then based on trained model,a parallel design of CNN for remote sensing images object recognition based on data-driven array processor(DDAP)is proposed.The consuming cycles are counted.Simultaneously,the proposed architecture is realized on Xilinx V6 development board,and synthesized based on SMIC 130 nm complementary metal oxid semiconductor(CMOS)technology.The experimental results show that the proposed architecture has a certain degree of parallelism to achieve the purpose of accelerating calculations. | Shan Rui Jiang Lin Deng Junyong Cui Pengfei Zhang Yuting Wu Haoyue Xie Xiaoyan | 2020 | The Journal of China Universities of Posts and Telecommunications2020，27，6： | 1 |
| 8 | Coastal Gravity Anomalies from Retracked Geosat/GM Altimetry: Improvement, Limitation and the Role of Airborne Gravity Data显示文摘 | Cheinway Hwang Jinyun Guo Xiaoli Deng Hsin-Ying Hsu Yuting Liu | 2006 | Journal of Geodesy2006，，4： | 1 |
| 9 | Unveiling E2F4,TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis显示文摘Senescence,a stable state of growth arrest,affects many physiological and pathophysiological processes,especially aging.Previous work has indicated that transcription factors(TFs)play a role in regulating senescence.However,a systematic study of regulatory TFs during replicative senescence(RS)using multiomics analysis is still lacking.Here,we generated timeresolved RNA-seq,reduced representation bisulfite sequencing(RRBS)and ATAC-seq datasets during RS of mouse skin fibroblasts,which demonstrated that an enhanced inflammatory response and reduced proliferative capacity were the main characteristics of RS in both the transcriptome and epigenome.Through integrative analysis and genetic manipulations,we found that transcription factors E2F4,TEAD1 and AP-1 are key regulators of RS.Overexpression of E2f4 improved cellular proliferative capacity,attenuated SA-β-Gal activity and changed RS-associated differentially methylated sites(DMSs).Moreover,knockdown of Tead1 attenuated SA-β-Gal activity and partially altered the RS-associated transcriptome.In addition,knockdown of Atf3,one member of AP-1 superfamily TFs,reduced Cdkn2a(p16)expression in pre-senescent fibroblasts.Taken together,the results of this study identified transcription factors regulating the senescence program through multi-omics analysis,providing potential therapeutic targets for anti-aging. | Yuting Wang Liping Liu Yifan Song Xiaojie Yu Hongkui Deng | 2022 | Protein & Cell2022，13，10： | 1 |
| 10 | Coastal Gravity Anomalies from Retracked Geosat/GM Altimetry: Improvement, Limitation and the Role of Airborne Gravity Data显示文摘 | Cheinway Hwang Jinyun Guo Xiaoli Deng Hsin-Ying Hsu Yuting Liu | 2006 | Journal of Geodesy2006，，4： | 1 |
| 11 | Coastal Gravity Anomalies from Retracked Geosat/GM Altimetry: Improvement, Limitation and the Role of Airborne Gravity Data显示文摘 | Cheinway Hwang Jinyun Guo Xiaoli Deng Hsin-Ying Hsu Yuting Liu | 2006 | Journal of Geodesy2006，，4： | 1 |
| 12 | Fast-chargingand dendrite-free lithiummetal anodeeenabledby partial lithiation ofgraphene aerogel显示文摘The development of deeply cyclable lithium metal batteries with fast-charging capability offers a promising solution to relieve the“range anxiety”in driving electric vehicles.Conventional lithium metal anodes suffered from low operating current densities and shallow charge/discharge depths,owing to the intrinsic dendrite growth governed by Sand’s law.Herein,we come up with a novel design of heavy-duty lithium metal anode fabricated by partially infusing the three-dimensional(3D)porous graphene aerogel with molten Li.Both electroanalytical measurements and simulations show that the unique electrode architecture brings notable advantages in mediating smooth Li plating/stripping,including reduced local current density,inhibited dendrite growth,buffered volume fluctuation,as well as more efficient Li utilization.Consequently,a remarkable cycling performance in symmetric cells for over 400 cycles(800 h)with an ultrahigh cycling capacity of 15 mAh·cm^(−2) at 15 mA·cm^(−2) is achieved,which,to our best knowledge,has been never seen in literature.LiFePO4 full cells demonstrate a superb rate capability up to 10 C and a prolonged cycling of 1,600 cycles at 2 C with the per-cycle capacity decay of only 0.023%.This study paves the way for the ultimate deployment of lithium metal batteries in real-world applications that require fast charging and deep cycling. | Yong Ma Yuting Gu Ying He Le Wei Yuebin Lian Weiyi Pan Xinjian Li Yanhui Su Yang Peng Zhao Deng Zhongfan Liu | 2022 | Nano Research2022，15，11： | 1 |
| 13 | Inductive and synergistic interactions between plant allelochemical flavone and Bt toxin Cry1 Ac in Helicoverpa armigera显示文摘Genetically engineered crops simultaneously produce defensive allelochemi-cals and Bacillus thuringiensis(Bt)toxin proteins to kill some of the world's most devastating insect pests.How the two types of toxins,when ingested sequentially or simultaneously,interact at both lethal and sublethal doses in these pests remains underexplored.Here,we examined the toxicological interactions between the Bt toxin Cry 1 Ac and the flavonoid allelochemical flavone in Helicoverpa armigera.Simultaneous exposure of H.armigera neonates to lethal doses(LC25)of Cry 1 Ac and flavone caused a mortality significantly higher than that of either toxin alone and their expected additive mortality.Preexposure for 24 h to a sublethal dose(LC10)of Cry 1 Ac followed by 6-d simultaneous exposure to the same dose of Cry 1 Ac plus a lethal dose(1.6 mg/g diets,LC50)of flavone resulted in a mortality significantly higher than that of the LC50 dose of flavone alone and the expected additive mortality of the LC50 dose of flavone plus the LC10 dose of Cry 1 Ac.One-day preexposure to the sublethal dose(LC10)of flavone followed by 6-d simultaneous exposure to the LC50 dose(6 ng/cm2)of Cry 1 Ac plus the LC25 dose of flavone yielded a mortality significantly higher than that of the LC50 dose of Cry 1 Ac but similar to the expected additive mortality of the LC50 dose of Cry 1 Ac plus the LC50 dose of flavone.The results suggest that Cry 1 Ac induces and synergizes the toxicity of flavone against H.armigera larvae. | Shan Wang Min Zhang Jinyong Huang Leyao Li Kaiyuan Huang Yuting Zhang Yalu Li Zhongyuan Deng Xinzhi Ni Xianchun Li | 2021 | Insect Science2021，28，6： | 1 |
| 14 | Deployment Strategy for Multiple Controllers Based on the Aviation On-Board Software-Defined Data Link Network显示文摘In light of the escalating demand and intricacy of services in contemporary terrestrial,maritime,and aerial combat operations,there is a compelling need for enhanced service quality and efficiency in airborne cluster communication networks.Software-Defined Networking(SDN)proffers a viable solution for the multifaceted task of cooperative communication transmission and management across different operational domains within complex combat contexts,due to its intrinsic ability to flexibly allocate and centrally administer network resources.This study pivots around the optimization of SDN controller deployment within airborne data link clusters.A collaborative multi-controller architecture predicated on airborne data link clusters is thus proposed.Within this architectural framework,the controller deployment issue is reframed as a two-fold problem:subdomain partition-ing and central interaction node selection.We advocate a subdomain segmentation approach grounded in node value ranking(NDVR)and a central interaction node selection methodology predicated on an enhanced Artificial Fish Swarm Algorithm(AFSA).The advanced NDVR-AFSA(Node value ranking-Improved artificial fish swarm algorithm)algorithm makes use of a chaos algorithm for population initialization,boosting population diversity and circumventing premature algorithm convergence.By the integration of adaptive strategies and incorporation of the genetic algorithm’s crossover and mutation operations,the algorithm’s search range adaptability is enhanced,thereby increasing the possibility of obtaining globally optimal solutions,while concurrently augmenting cluster reliability.The simulation results verify the advantages of the NDVR-IAFSA algorithm,achieve a better load balancing effect,improve the reliability of aviation data link cluster,and significantly reduce the average propagation delay and disconnection rate,respectively,by 12.8%and 11.7%.This shows that the optimization scheme has important significance in practical application,and can meet the high requirements of modern sea,land,and air operations to aviation airborne communication networks. | Yuting Zhu Yanfang Fu Yang Ce Pan Deng Jianpeng Zhu Huankun Su | 2023 | Computers, Materials & Continua2023，77，12： | 0 |
| 15 | Tailoring morphology symmetry of bismuth vanadate photocatalysts for efficient charge separation显示文摘Although spatial charge separation between different facets of semiconductor crystals has been recognized as a general strategy in photocatalysis, the vital role of crystal morphology symmetry in charge separation properties still remains elusive. Herein,taking monoclinic bismuth vanadate(BiVO_(4)) as a platform, we found distinct charge separation difference via rationally tailoring the morphology symmetry from octahedral to truncated octahedral crystals. For octahedral BiVO_(4), photogenerated electrons and holes can be separated between edges and quasi-equivalent facets. However, as for truncated octahedral crystals,photogenerated electrons tend to transfer to {010} facets while photogenerated holes prefer to accumulate on {120} facets, thus realizing the spatial separation of photogenerated charge between different facets. Morphology tailoring of BiVO_(4) crystals leads to a significantly improved photogenerated charge separation efficiency and photocatalytic water oxidation activity. The built-in electric field for driving the separation of photogenerated electrons and holes is considered to be modulated by tuning the morphology symmetry of BiVO_(4) crystals. This work discloses the significant roles of morphology symmetry in photogenerated charge separation and facilitates the rational design of artificial photocatalysts. | Yuting Deng Hongpeng Zhou Chenwei Ni Fengke Sun Wenchao Jiang Ruotian Chen Wenming Tian Can Li Rengui Li | 2023 | Science China Chemistry2023，66，12： | 0 |
| 16 | ICAM-1 depletion in the center of immunological synapses is important for calcium releasing in T-cells显示文摘T-cell activation requires the formation of the immunological sy napse(IS)bet ween a T-cll and anantigen-presenting cell(AP C)to control the development of the adaptive immune response.How-ever,calcium release,an initial signal of T-cell activation,has been found to occur before IS for-mation.The mechanism for triggering the calcium signaling and relationship bet ween calciumrelease and IS format ion remains unclear.Herein,using live-cell imaging,we found that int ercellularadhesion molecule 1(ICAM-1),an essential mdlecule for IS formation,accumulated and then wasdepleted at the center of the synapse before complete IS formation.During the proces of ICAM1depletion,calcium was released.if ICAM-1 failed to be depleted from the center of the synapse,thesustained calcium signaling could not be induced.Moreover,depletion of ICAM-1 in ISs preferen-tially ccurred with the contact of antigen-specific T-cels and dendritic clls(DCs).Blocking thebinding ofICA M-1 and lymphocy te finction-associated antigen 1(LFA-1),ICAM-1 failed to depleteat the center of the synapse,and calcium release in T-clls decreased.In studying the mechanism ofhow the depletion ofiCA M1 could influence calcium release in T-clls,we found that the movementof ICAM-1 was associat ed with the localization of LFA-1 in the IS,which afected the localization ofcalcium microdomains,ORAIl and mitochondria in IS.Therefore,the depletion of ICAM-1 in the center of the synapse is an important factor for an initial sust ained calcium release in T-cells. | Yuanzhen Suo Wei Lin Yuting Deng Zhichao Fan Lizeng Qin Guosheng Jiang Yiwei Chu Xunbin Wei | 2018 | Journal of Innovative Optical Health Sciences2018，，2： | 0 |
| 17 | Nanostructures and catalytic atoms engineering of tellurium-based materials and their roles in electrochemical energy conversion显示文摘With the dramatic developments of renewable and environmental-friendly electrochemical energy conversion systems,there is an urgent need to fabricate durable and efficient electrocatalysts to address the limitation of high overpotentials exceeding thermodynamic requirements to facilitate practical applications.Recently,tellurium-based nanomaterials(Te NMs)with unique chemical,electronic,and topological properties,including Te-derived nanostructures and transition metal tellurides(TMTs),have emerged as one of the most promising electrocatalytic materials.In the absence of comprehensive and guiding reviews,this review comprehensively summarizes the main advances in designing emerging Te NMs for electrocatalysis.First,the engineering strategies and principles of Te NMs to enhance their electrocatalytic activity and stability from the nanostructures to the catalytic atoms are discussed in detail,especially on the chemical/physical/multiplex templating strategies,heteroatom doping,vacancy/defect engineering,phase engineering,and the corresponding mechanisms and structure-performance correlations.Then,typical applications of Te NMs in electrocatalysis are also discussed in detail.Finally,the existing key issues and main challenges of Te NMs for electrocatalysis are highlighted,and the development trend of Te NMs as electrocatalysts is expounded.This review provides new concepts to guide future directions for developing Te NMs-based electrocatalysts,thereby promoting their future wide applications in electrochemical energy systems. | Tiantian Li Yuting Deng Xiao Rong Chao He Mi Zhou Yuanjiao Tang Hongju Zhou Chong Cheng Changsheng Zhao | 2023 | SmartMat2023，4，1： | 0 |
| 18 | A transposon-introduced G-quadruplex motif is selectively retained and constrained to downregulate CYP321A1显示文摘Insects utilize xenobiotic compounds to up-and downregulate cytochrome P450 monooxygenases(P450s)involved in detoxification of toxic xenobiotics including phytochemicals and pesticides.G-quadruplexes(G4)-forming DNA motifs are enriched in the promoter regions of transcription factors and function as cis-acting elements to regulate these genes.Whether and how P450s gain and keep G4 DNA motifs to regulate their expression still remain unexplored.Here,we show that CYP321A1,a xenobiotic-metabolizing P450 from Helicoverpa zea,a polyphagous insect of economic importance,has acquired and preserved a G4 DNA motif by selectively retaining a transposon known as HzIS1-3 that carries this G4 DNA motif in its promoter region.The HzIS1-3 G4 DNA motif acts as a silencer to suppress the constitutive and induced expression of CYP321A1 by plant allelochemicals flavone and xanthotoxin through folding into an intramolecular parallel or hybrid-1 conformation in the absence or presence of K^(+).The G4 ligand N-methylmesoporphyrin IX(NMM)strengthens the silencing effect of HzIS1-3 G4 DNA motif by switching its structure from hybrid-1 to hybrid-2.The enrichment of transposons in P450s and other environment-adaptation genes implies that selective retention of G4 DNA motif-carrying transposons may be the main evolutionary route for these genes to obtain G4 DNA motifs. | Zhongyuan Deng Yuting Zhang Chao Gao Wei Shen Shan Wang Xinzhi Ni Sisi Liu Xianchun Li | 2022 | Insect Science2022，29，6： | 0 |
| 19 | Overexpressed PKM2 promotes macrophage phagocytosis and atherosclerosis显示文摘Background:The expression of pyruvate kinase muscle 2(PKM2)is augmented in macrophages of patients with atherosclerotic coronary artery disease.The role of PKM2 in atherosclerosis is to be determined.Methods:Global and myeloid cell-specific PKM2 knock-in mice with ApoE^(-/-)background(ApoE^(-/-),PKM2^(KI/KI)and Lyz2-cre,ApoE^(-/-),and PKM2^(flox/flox))were produced to evaluate the clinical significance of PKM2 in atherosclerosis development.Wild-type and PKM2 knock-in macrophages were isolated to assess the function of PKM2 in macrophage phagocytosis.Atherosclerotic mice were treated with PKM2 inhibitor shikonin(SKN)to evaluate the therapeutic potential of PKM2 suppression in atherosclerosis.Results:Oxidized low-density lipoprotein(oxLDL)upregulated PKM2 in macrophages.PKM2 in return promoted the uptake of oxLDL by macrophages.Overexpressed PKM2 accelerated atherosclerosis in mice.SKN blocked the progress of mouse atherosclerosis.Conclusions:PKM2 accelerates macrophage phagocytosis and atherosclerosis.Targeting PKM2 is a potential therapy for atherosclerosis. | Xiaochen Gai Fangming Liu Yuting Wu Baohui Zhang Bufu Tang Kezhuo Shang Lianmei Wang Haihong Zhang Yixin Chen Shuhui Yang Weiwei Deng Peng Li Jing Wang Hongbing Zhang | 2023 | Animal Models and Experimental Medicine2023，6，2： | 0 |
| 20 | Research progress of severe acute respiratory syndrome coronavirus 2 on aerosol collection and detection显示文摘The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in late 2019 has negatively affected people's lives and productivity.Because the mode of transmission of SARS-CoV-2 is of great concern,this review discusses the sources of virus aerosols and possible transmission routes.First,we discuss virus aerosol collection methods,including natural sedimentation,solid impact,liquid impact,centrifugal,cyclone and electrostatic adsorption methods.Then,we review common virus aerosol detection methods,including virus culture,metabolic detection,nucleic acid-based detection and immunology-based detection methods.Finally,possible solutions for the detection of SARS-CoV-2 aerosols are introduced.Point-of-care testing has long been a focus of attention.In the near future,the development of an instrument that integrates sampling and output results will enable the real-time,automatic monitoring of patients. | Xinyu Zhang Yuting Chen Yueying Pan Xinye Ma Gui Hu Song Li Yan Deng Zhu Chen Hui Chen Yanqi Wu Zhihong Jiang Zhiyang Li | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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