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| 1 | Elimination of senescent cells byβ-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice显示文摘Cellular senescence,a persistent state of cell cycle arrest,accumulates in aged organisms,contributes to tissue dysfunction,and drives age-related phenotypes.The clearance of senescent cells is expected to decrease chronic,low-grade inflammation and improve tissue repair capacity,thus attenuating the decline of physical function in aged organisms.However,selective and effective clearance of senescent cells of different cell types has proven challenging.Herein,we developed a prodrug strategy to design a new compound based on the increased activity of lysosomalβ-galactosidase(β-gal),a primary characteristic of senescent cells.Our prodrug SSK1 is specifically activated byβ-gal and eliminates mouse and human senescent cells independently of senescence inducers and cell types.In aged mice,our compound effectively cleared senescent cells in different tissues,decreased the senescence-and age-associated gene signatures,attenuated low-grade local and systemic inflammation,and restored physical function.Our results demonstrate that lysosomalβ-gal can be effectively leveraged to selectively eliminate senescent cells,providing a novel strategy to develop anti-aging interventions. | Yusheng Cai Huanhuan Zhou Yinhua Zhu Qi Sun Yin Ji Anqi Xue Yuting Wang Wenhan Chen Xiaojie Yu Longteng Wang Han Chen Cheng Li Tuoping Luo Hongkui Deng | 2020 | Cell Research2020，30，7： | 12 |
| 2 | Underground ground control monitoring and interpretation,and numerical modeling, and shield capacity design显示文摘Mine or longwall panel layout is a 3D structure with highly non-uniform stress distribution. Recognition of such fact will facilitate underground problem identification/investigation and solving by numerical modeling through proper model construction. Due to its versatility, numerical modeling is the most popular method for ground control design and problem solving. However numerical modeling results require highly experienced professionals to interpret its validity/applicability to actual mining operations due to complicated mining and geological conditions. Underground ground control monitoring is routinely performed to predict roof behavior such as weighting and weighting interval without matching observation of face mining condition while the mining pressures are being monitored, resulting in unrealistic interpretation of the obtained data on mining pressure. The importance of ground control pressure monitoring and simultaneous observation of mining and geological conditions is illustrated by an example of shield leg pressure monitoring and interpretation in an U.S. longwall coal mine: it was found that the roof strata act like a plate, not an individual block of the size of a shield dimension, as commonly assumed by all researchers and shield capacity is not a fixed property for a longwall panel or a mine or a coal seam. A new mechanism on the interaction between shield's hydraulic leg pressure and roof strata for shield loading is proposed. | Syd S.Peng Jingyi Cheng Feng Du Yuting Xue | 2019 | International Journal of Mining Science and Technology2019，29，1： | 7 |
| 3 | Confined van der Waals Epitaxial Growth of Two-Dimensional Large Single-Crystal In_(2)Se_(3) for Flexible Broadband Photodetectors显示文摘The controllable growth of two-dimensional(2D)semiconductors with large domain sizes and high quality is much needed in order to reduce the detrimental efect of grain boundaries on device performance but has proven to be challenging.Here,we analyze the precursor concentration on the substrate surface which signifcantly infuences nucleation density in a vapor deposition growth process and design a confned micro-reactor to grow 2D In_(2)Se_(3) with large domain sizes and high quality.Te uniqueness of this confned micro-reactor is that its size is∼102-103 times smaller than that of a conventional reactor.Such a remarkably small reactor causes a very low precursor concentration on the substrate surface,which reduces nucleation density and leads to the growth of 2D In_(2)Se_(3) grains with sizes larger than 200�m.Our experimental results show large domain sizes of the 2D In_(2)Se_(3) with high crystallinity.Te fexible broadband photodetectors based on the as-grown In_(2)Se_(3) show rise and decay times of 140 ms and 25 ms,efcient response(5.6 A/W),excellent detectivity(7×10^(10) Jones),high external quantum efciency(251%),good fexibility,and high stability.Tis study,in principle,provides an efective strategy for the controllable growth of high quality 2D materials with few grain boundaries. | Lei Tang Changjiu Teng Yuting Luo Usman Khan Haiyang Pan Zhengyang Cai Yue Zhao Bilu Liu Hui-Ming Cheng | 2019 | Research2019，，1： | 7 |
| 4 | Nitrogen and Phosphorus Dual-Doped Multilayer Graphene as Universal Anode for Full Carbon-Based Lithium and Potassium Ion Capacitors显示文摘Lithium/potassium ion capacitors(LICs/PICs) have been proposed to bridge the performance gap between high-energy batteries and high-power capacitors.However,their development is hindered by the choice,electrochemical performance,and preparation technique of the battery-type anode materials.Herein,a nitrogen and phosphorus dual-doped multilayer graphene(NPG) material is designed and synthesized through an arc discharge process,using low-cost graphite and solid nitrogen and phosphorus sources.When employed as the anode material,NPG exhibits high capacity,remarkable rate capability,and stable cycling performance in both lithium and potassium ion batteries.This excellent electrochemical performance is ascribed to the synergistic effect of nitrogen and phosphorus doping,which enhances the electrochemical conductivity,provides a higher number of ion storage sites,and leads to increased interlayer spacing.Full carbon-based NPG‖LiPF6‖active carbon(AC) LICs and NPG‖KPF6‖AC PICs are assembled and show excellent electrochemical performance,with competitive energy and power densities.This work provides a route for the large-scale production of dual-doped graphene as a universal anode material for high-performance alkali ion batteries and capacitors. | Yuting Luan Rong Hu Yongzheng Fang Kai Zhu Kui Cheng Jun Yan Ke Ye Guiling Wang Dianxue Cao | 2019 | Nano-Micro Letters2019，11，2： | 6 |
| 5 | Domain Adaptation Network Based on Autoencoder显示文摘The domain adaptation uses labeled source domain data to train a classifier to be used in the target domain with no or small amount of labeled data. Usually there exists discrepancy in terms of marginal and conditional distributions for both source and target domains,which is of critical importance to minimize the distribution discrepancy between domains. As a classical model in deep learning, the autoencoder is capable of realizing distribution matching and enhancing classification accuracy by extracting more abstract and effective features from data. A Domain adaptation network based on autoencoder(DANA) is proposed. The DANA structure consists of a couple of encoding layers: a feature extraction layer and a classification layer. For the feature extraction layer,the marginal distributions of source and target domains are matched by using the nonparametric maximum mean discrepancy measurement. For the classification layer, the softmax regression model is applied to encode the label information of source domains meanwhile to match the conditional distribution. Experimental results on ImageNet,Corel and Leaves datasets have shown the enhanced classification accuracy by our proposed algorithm compared with the classical methods. | WANG Xuesong MA Yuting CHENG Yuhu | 2018 | Chinese Journal of Electronics2018，27，6： | 3 |
| 6 | Thiol-functionalized polysilsesquioxane as efficient adsorbent for adsorption of Hg(II) and Mn(II) from aqueous solution显示文摘 | Yuzhong Niu Rongjun Qu Xiguang Liu Lei Mu Baihui Bu Yuting Sun Hou Chen Yangfeng Meng Lina Meng Lin Cheng | 2014 | Materials Research Bulletin2014，，： | 2 |
| 7 | The Scorpion Venom Peptide Smp76 Inhibits Viral Infection by Regulating Type-Ⅰ Interferon Response显示文摘Dengue virus(DENV) and Zika virus(ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery of new antiviral agents is critical.Herein, a scorpion venom peptide(Smp76) characterized from Scorpio maurus palmatus was successfully expressed and purified in Escherichia coli BL21(DE3). The recombinant Smp76(rSmp76) was found to effectively inhibit DENV and ZIKV infections in a dose-dependent manner in both cultured cell lines and primary mouse macrophages. Interestingly,rSmp76 did not inactivate the viral particles directly but suppressed the established viral infection, similar to the effect of interferon(IFN)-b. Mechanistically, rSmp76 was revealed to upregulate the expression of IFN-b by activating interferon regulatory transcription factor 3(IRF3) phosphorylation, enhancing the type-Ⅰ IFN response and inhibiting viral infection.This mechanism is significantly different from traditional virucidal antimicrobial peptides(AMPs). Overall, the scorpion venom peptide Smp76 is a potential new antiviral agent with a unique mechanism involving type-Ⅰ IFN responses,demonstrating that natural AMPs can enhance immunity by functioning as immunomodulators. | Zhenglin Ji Fangfang Li Zhiqiang Xia Xingchen Guo Minjun Gao Fang Sun Yuting Cheng Yingliang Wu Wenxin Li Syed Abid Ali Zhijian Cao | 2018 | Virologica Sinica2018，33，6： | 2 |
| 8 | Integrative Analysis of Genome,3D Genome,and Transcriptome Alterations of Clinical Lung Cancer Samples显示文摘Genomic studies of cancer cell alterations,such as mutations,copy number variations(CNVs),and translocations,greatly promote our understanding of the genesis and development of cancers.However,the 3D genome architecture of cancers remains less studied due to the complexity of cancer genomes and technical difficulties.To explore the 3D genome structure in clinical lung cancer,we performed Hi-C experiments using paired normal and tumor cells harvested from patients with lung cancer,combining with RNA sequenceing analysis.We demonstrated the feasibility of studying 3D genome of clinical lung cancer samples with a small number of cells(1×10^(4)),compared the genome architecture between clinical samples and cell lines of lung cancer,and identified conserved and changed spatial chromatin structures between normal and cancer samples.We also showed that Hi-C data can be used to infer CNVs and point mutations in cancer.By integrating those different types of cancer alterations,we showed significant associations between CNVs,3D genome,and gene expression.We propose that 3D genome mediates the effects of cancer genomic alterations on gene expression through altering regulatory chromatin structures.Our study highlights the importance of analyzing 3D genomes of clinical cancer samples in addition to cancer cell lines and provides an integrative genomic analysis pipeline for future larger-scale studies in lung cancer and other cancers. | Tingting Li Ruifeng Li Xuan Dong Lin Shi Miao Lin Ting Peng Pengze Wu Yuting Liu Xiaoting Li Xuheng He Xu Han Bin Kang Yinan Wang Zhiheng Liu Qing Chen Yue Shen Mingxiang Feng Xiangdong Wang Duojiao Wu Jian Wang Cheng Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 1 |
| 9 | Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m^(6)A methylation and increasing the stability of SREBF1 and ChREBP mRNAs显示文摘Previous studies have indicated an association of fat mass and obesity-associated(FTO)with nonalcoholic fatty liver disease(NAFLD),the most common chronic liver disease worldwide.This study aimed to decipher the complex role of FTO in hepatic lipid metabolism.We found that a decrease in N^(6)-methyladenosine(m^(6)A)RNA methylation in the liver of mice fed with a high-fat diet(HFD)was accompanied by an increase in FTO expression.Overexpression of FTO in the liver promoted triglyceride accumulation by upregulating the expression of lipogenic genes.Mechanistical studies revealed that FTO could stabilize the mRNAs of sterol regulatory element binding transcription factor 1(SREBF1)and carbohydrate responsive element binding protein(ChREBP),two master lipogenic transcription factors,by demethylating m^(6)A sites.Knockdown ofeither SREBF1 or ChREBP attenuated the lipogenic effect of FTO,suggesting that they are bona fide effectors for FTO in regulating lipogenesis.Insulin could stimulate FTO transcription through a mechanism involving the action of intranuclear insulin receptor beta,while knockdown of FTO abrogated the lipogenic effect of insulin.Inhibition ofFTo by entacapone decreased the expression of SREBF1,ChREBP,and downstream lipogenic genes,ameliorating liver steatosis in HFD-fed mice.Thus,our study established a critical role of FTO in both the insulin-regulated hepatic lipogenesis and the pathogenesis of NAFLD and provided a potential strategyfor treating NAFLD. | Zhili Tang Chao Sun Ying Yan Zhoumin Niu Yuying Li Xi Xu Jing Zhang Yuting Wu Yan Li Li Wang Cheng Hu Zhuoyang Li Jingjing Jiang Hao Ying | 2022 | Journal of Molecular Cell Biology2022，14，9： | 1 |
| 10 | Catalytic Conversion of Biomass-Derived Feedstocks Into Olefins and Aromatics With ZSM-5: the Hydrogen to Carbon Effective Ratio 显示文摘 | ZHANG Huiyan CHENG Yuting Vispute T P | 2011 | Energy Environment Science2011，4，22： | 1 |
| 11 | Development and Verification of PWR Burnup Code Based on CRAM显示文摘A burnup calculation code MCRAM based on CRAM was developed.The Cinder90burnup database was introduced to generate the burnup matrix(Fig.1).The reaction cross sections of some important actinides and fission products were modified by coupling with the MCNP program.The OECD/NEA Takahama-3 PWR | CHENG Yuting ZHOU Qi ZHU Qingfu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 12 | Control Effect of UAV Low Volume Spray Technology on Thrips and Tomato Spotted Wilt Virus in Tobacco Field显示文摘[Objectives]The paper was to explore the influence of unmanned aerial vehicle(UAV)low volume spray technology on the control effect of viruliferous thrips and tomato spotted wilt virus(TSWV)under different pesticide concentrations,and to explore the effective control nodes and methods of thrips and TSWV.[Methods]According to the occurrence characteristics of thrips and TSWV,the field control effects of 4 pesticides on thrips and TSWV were tested by UAV with the thrips number and disease index as indicators,following the principle of regional and periodic control trials.[Results]In the groups of UAV and artificial prevention and control,4 agents were used alternatively,including 1%emamectin benzoate ME,1.7%abamectin imidacloprid ME,5%emamectin benzoate WDG,and 30%pyriproxyfen dinotefuran SL.There was no significant difference in the control effect of thrips and TSWV among treatment 1(recommended dosage of UAV agent),treatment 2(reduction of recommended dosage of UAV agent by 25%)and treatment 4(recommended dosage of artificial control agent),and the control effects on thrips were more than 83.16%in the 3 treatments.The disease index of TSWV in the 3 treatments decreased from 8.64±1.37 in the blank control group to less than 3,which reached the prevention and control threshold.But treatment 3(reduction of recommended dosage of UAV agent by 50%)did not reach the prevention and control threshold.The disease index of TSWV in the blank control area increased with the increase of the number of live nymphs of thrips,and there was a significant positive correlation,with good fitness.[Conclusions]UAV has a significant impact on the control effect of thrips and TSWV under different pesticide concentrations.In the actual flight control application,it is recommended that the amount of the pesticides is about 3/4 and not less than 1/2 of that of the artificial application.The control area should be extended to 100 m of the ridge of the tobacco field,and UAV is used periodically to control thrips and TSWV for 5 times from pre-transplanting stage to pre-squaring stage of flue-cured tobacco.The control effect is significantly different from the traditional artificial application. | Zefan LIU Dean XIE Jiabao HAN Yanfen XIE Li MA Siyuan GAO Ruiqi PENG Yuting ZHAO Xiangze FU Wengang CHENG Yonghong FENG Yan ZHANG Huaping ZHANG Ying HUANG Leijie DAI Lanfeng WANG | 2023 | Plant Diseases and Pests2023，14，4： | 0 |
| 13 | Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposureinduced anxiety-like behaviors in offspring显示文摘Pyridaben(PY)is a widely used organochlorine acaricide,which can be detected in the peripheral blood of pregnant women.Available evidence suggests that PY has reproductive toxicity.However,it remains uncertain whether prenatal PY exposure impacts neurobehavioral development in offspring.Here,we administered PY to pregnant mice at a dose of 0.5 and 5 mg kg^(-1)day^(-1)via gavage and observed anxietylike behaviors in PY offspring aged five weeks.We then integrated the metabolome and transcriptome of the offspring's brain to explore the underlying mechanism.Metabolome data indicated that the vitamin B6 metabolism pathway was significantly affected,and the pyridoxal 50-phosphate(PLP)concentration and the active form of vitamin B6 was significantly reduced.Moreover,the transcriptome data showed that both PLP generation-related Pdxk and anxiety-related Gad1 were significantly down-regulated.Meanwhile,there was a decreasing trend in the concentration of GABA in the hippocampal DG region.Next,we supplemented PLP at a dose of 20 mg kg^(-1)day^(-1)to the PY offspring via intraperitoneal injection at three weeks.We found up-regulated expression of Pdxk and Gad1 and restored anxiety-like behaviors.This study suggests that prenatal exposure to PY can disrupt vitamin B6 metabolism,reduce the concentration of PLP,down-regulate the expression levels of Pdxk and Gad1,inhibit the production of GABA,and ultimately lead to anxiety-like behaviors in offspring. | Xingwang Ding Ya Wen Xuan Ma Yuepei Zhang Yuting Cheng Zhaofeng Liu Weiyue Hu Yankai Xia | 2023 | Environmental Science and Ecotechnology2023，，1： | 0 |
| 14 | Analysis of Isotopic Composition of Spent Fuel Waste Cladding Residue显示文摘In the reprocessing of the spent fuel assembly,the fuel rod is cut into small pieces and gradually dissolved in the dissolved liquid.The residual materials in the waste cladding still contain uranium and transuranic nuclides and fission products such as Pu,Cm and Am,which are highly radioactive.The radioactive level of the waste cladding must meet the standard before it can be poured into the cladding disposal container,and then placed on the grid of the storage pool.In this process,the content of radionuclides U,Pu and other key nuclide in the waste cladding residual material must be analyzed. | LYU Niu XIA Zhaodong CHENG Yuting ZHENG Jiye | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 15 | Physical Design of Key Critical Experimental Device in Post-treatment Plant显示文摘In order to study the multi-body criticality safety problem of the post-treatment plant,the existing critical safety analysis software was used to analyze the applicability of the problem,and a multi-body critical experimental device for uranyl nitrate solution(uranium solution)was designed.Aiming at suiting two different enrichment of uranium nitrate,a critical experimental device compatible with the loading of two kinds of nuclear materials was designed by rationally planning the concentration of uranium solution and the value of control rod. | CHENG Yuting XIA Zhaodong ZHU Qingfu ZHOU Qi | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 16 | Multi-View & Transfer Learning for Epilepsy Recognition Based on EEG Signals显示文摘Epilepsy is a central nervous system disorder in which brain activity becomes abnormal.Electroencephalogram(EEG)signals,as recordings of brain activity,have been widely used for epilepsy recognition.To study epilep-tic EEG signals and develop artificial intelligence(AI)-assist recognition,a multi-view transfer learning(MVTL-LSR)algorithm based on least squares regression is proposed in this study.Compared with most existing multi-view transfer learning algorithms,MVTL-LSR has two merits:(1)Since traditional transfer learning algorithms leverage knowledge from different sources,which poses a significant risk to data privacy.Therefore,we develop a knowledge transfer mechanism that can protect the security of source domain data while guaranteeing performance.(2)When utilizing multi-view data,we embed view weighting and manifold regularization into the transfer framework to measure the views’strengths and weaknesses and improve generalization ability.In the experimental studies,12 different simulated multi-view&transfer scenarios are constructed from epileptic EEG signals licensed and provided by the Uni-versity of Bonn,Germany.Extensive experimental results show that MVTL-LSR outperforms baselines.The source code will be available on http://gffzz188fe103f8f1460as0vk660c6vfwx60bb.ffgz.tsg.suse.edu.cn/didid5/MVTL-LSR. | Jiali Wang Bing Li Chengyu Qiu Xinyun Zhang Yuting Cheng Peihua Wang Ta Zhou Hong Ge Yuanpeng Zhang Jing Cai | 2023 | Computers, Materials & Continua2023，，6： | 0 |
| 17 | Strengthening synergistic effects between hard carbon and soft carbon enabled by connecting precursors at molecular level towards high-performance potassium ion batteries显示文摘Synergistic effects between hard carbons and soft carbons are proven to be helpful for improving the electrochemical performance of carbonaceous anode for potassium-ion batteries(PIBs).However,the phase separation of precursors limits the synergistic effects and improvement of electrochemical performance.Here,inspired by the esterification reaction,the precursors of two sorts of carbon are connected at the molecular level,which boosts the synergistic effects in hybrid carbon,resulting in excellent electrochemical kinetics and low charge/discharge voltage.Consequently,the hybrid carbon anode exhibited a high specific capacity of 121 mAh·g^(−1)at 3.2 A·g^(−1),a high-rate capability,and stable cycling performance.After 500 cycles at 1 A·g^(−1),the average capacity fading is only 0.078%per cycle. | Hongqiang Xu Boshi Cheng Quan Du Yuting Zhang Haojie Duan Ishioma L.Egun Bo Yin Haiyong He | 2023 | Nano Research2023，16，8： | 0 |
| 18 | Nanostructures and catalytic atoms engineering of tellurium-based materials and their roles in electrochemical energy conversion显示文摘With the dramatic developments of renewable and environmental-friendly electrochemical energy conversion systems,there is an urgent need to fabricate durable and efficient electrocatalysts to address the limitation of high overpotentials exceeding thermodynamic requirements to facilitate practical applications.Recently,tellurium-based nanomaterials(Te NMs)with unique chemical,electronic,and topological properties,including Te-derived nanostructures and transition metal tellurides(TMTs),have emerged as one of the most promising electrocatalytic materials.In the absence of comprehensive and guiding reviews,this review comprehensively summarizes the main advances in designing emerging Te NMs for electrocatalysis.First,the engineering strategies and principles of Te NMs to enhance their electrocatalytic activity and stability from the nanostructures to the catalytic atoms are discussed in detail,especially on the chemical/physical/multiplex templating strategies,heteroatom doping,vacancy/defect engineering,phase engineering,and the corresponding mechanisms and structure-performance correlations.Then,typical applications of Te NMs in electrocatalysis are also discussed in detail.Finally,the existing key issues and main challenges of Te NMs for electrocatalysis are highlighted,and the development trend of Te NMs as electrocatalysts is expounded.This review provides new concepts to guide future directions for developing Te NMs-based electrocatalysts,thereby promoting their future wide applications in electrochemical energy systems. | Tiantian Li Yuting Deng Xiao Rong Chao He Mi Zhou Yuanjiao Tang Hongju Zhou Chong Cheng Changsheng Zhao | 2023 | SmartMat2023，4，1： | 0 |
| 19 | 2018年在线离子源运行报告显示文摘HIRFL accelerator facility has been operated with two ion sources as its pre-injectors,which are LECR3 and SECRAL-II.In 2018,there were 19 kinds of ion beams delivered successfully,and the service time of the two sources are 4594.5 and 2231 h respectively,amounting to 6825.5 h in total,in which SECRAL and LECR3 provided 4 and 1 kinds of metallic ion beams respectively,and the total service time for the metallic ones is 2322 h,accounting for 34%of the total service time.Table 1 summarizes the main information about the ion beams delivered by the two ion sources. | Feng Yucheng Zhang Wenhui Ma Hongyi Fang Xing Guo Junwei Huang Wei Jia Zehua Jin Qianyu Li Jiaqing Li Jibo Li Libin Li Lixuan Lu Yuting Qian Cheng Shen Zhen Wang Guicai Wang Hui Yang Yao Zhai Yuhan Zhang Junjie Zhang Sheng Zhang Xuezhen Sun Liangting | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 20 | Study on Reducing Variance of Monte Carlo about Deep-penetration Problem Based on CADIS Method显示文摘The deep-penetration shielding problem is the problem which has a low result because of the deep shielding,the weak source or the small detector.With regard to the deep-penetration shielding problems in the Monte Carlo method,this paper takes advantage of the Consistent Adjoint Driven Importance Sampling(CADIS)method to reduce the variance of Monte Carlo code MCNP.At first,the adjoint flux is got through the multigroup/adjoint calculations.Then,the weight window parameter and the source biasing parameter are calculated by the formulas of the CADIS. | MA Xiaodi ZHOU Qi ZHU Qingfu CHENG Yuting | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
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