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| 1 | Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin显示文摘The aim of this study was to develop a formulation to improve the oral absorption of baicalin(BA)by combining a phospholipid complex(PC)and self-emulsifying microemulsion drug delivery system(SMEDDS),termed BA–PC–SMEDDS.BA–PC was prepared by a solvent evaporation method and evaluated by complexation percentage(CP).The physicochemical properties of BA–PC were determined.The synergistic effect of PC and SMEDDS on permeation of BA was studied in vitro with Caco-2 cells and in situ with a single pass intestinal perfusion model.The improved bioavailability of BA in BA–PC–SMEDDS was confirmed in an in vivo rat model.The CP of BA–PC reached 100%when the molar ratio of drug to phospholipid(PP)was Z1:1.The solubility of BA–PC increased in both water and octanol,and the log P o/w of BA–PC was increased significantly.BA–PC–SMEDDS could be dispersed more evenly in water,compared to BA and BA–PC.Both the Caco-2 cell uptake and single-pass intestinal perfusion models illustrated that transport of BA in BA–PC was lower than that of free BA,while improved significantly in BA–PC–SMEDDS.The relative bioavailability of BA–PC(1:2)–SMEDDS was 220.37%.The combination system of PC and SMEDDS had a synergistic effect on improving the oral absorption of BA. | Huiyi Wu Xiaoying Long Fei Yuan Li Chen Sujing Pan Yunjun Liu Yoshiko Stowell Xiaoling Li | 2014 | Acta Pharmaceutica Sinica B2014，4，3： | 14 |
| 2 | QTG-Seq Accelerates QTL Fine Mapping through QTL Partitioning and Whole-Genome Sequencing of Bulked Segregant Samples显示文摘Deciphering the genetic mechanisms underlying agronomic traits is of great importance for crop improvement. Most of these traits are controlled by multiple quantitative trait loci (QTLs), and identifying the underlying genes by conventional QTL fine-mapping is time-consuming and labor-intensive. Here, we devised a new method, named quantitative trait gene sequencing (QTG-seq), to accelerate QTL fine-mapping. QTGseq combines QTL partitioning to convert a quantitative trait into a near-qualitative trait, sequencing of bulked segregant pools from a large segregating population, and the use of a robust new algorithm for identifying candidate genes. Using QTG-seq, we fine-mapped a plant-height QTL in maize (Zea mays L.), qPH7, to a 300-kb genomic interval and verified that a gene encoding an NF-YC transcription factor was the functional gene. Functional analysis suggested that qPH7-encoding protein might influence plant height by interacting with a CO-like protein and an AP2 domain-containing protein. Selection footprint ana卜 ysis indicated that qPH7 was subject to strong selection during maize improvement. In summary, QTG-seq provides an efficient method for QTL fine-mapping in the era of “big data'. | Hongwei Zhang Xi Wang Qingchun Pan Pei Li Yunjun Liu Xiaoduo Lu Wanshun Zhong Minqi Li Linqian Han Juan Li Pingxi Wang Dongdong Li Yan Liu Qing Li Fang Yang Yuan-Ming Zhang Guoying Wang Lin Li | 2019 | Molecular Plant2019，12，3： | 13 |
| 3 | The U6 Biogenesis-Like I Plays an Important Role in Maize Kernel and Seedling Development by Affecting the 3' End Processing of U6 snRNA显示文摘 | Jiankun Li Junjie Fu Yan Chen Kaijian Fan Cheng He Zhiqiang Zhang Li Li Yunjun Liu Jun Zheng Dongtao Ren Guoying Wang | 2017 | Molecular Plant2017，10，3： | 5 |
| 4 | Maize MS2 encodes an ATP-binding cassette transporter that is essential for anther development显示文摘The anther cuticle and pollen exine play a critical role in male gametophyte development. The sporopollenin precursors and cuticular lipid monomers are transported to the surface of the microspores and the epidermis by lipid transport proteins(LTPs) and ATP-binding cassette G(ABCG) transporters for the formation of the pollen wall and anther cuticle, respectively. However, the function of ABCG transporters in maize anther development is unclear. Here, we cloned the MS2 gene from the maize male sterile2 mutant using map-based cloning and determined that it encodes an ABCG transporter. MS2 protein was experimentally confirmed to be located on the cell membrane. The quantitative real-time PCR(qRT-PCR)results showed that MS2 was ubiquitously expressed in all vegetative and reproductive tissues, whereas a high transcriptional level of MS2 was observed in anthers, especially at the young microspore stage. Gas chromatography-mass spectrometry(GC–MS) analysis showed decreased accumulation of cutin and wax components in ms2 anthers, indicating that MS2 plays a role in the transport of lipid molecules to anther cuticle and pollen exine. To our knowledge, MS2 is the first reported ABCG transporter gene that participates in anther development in maize. | Qilong Xu Li Yang Dan Kang Zhenjing Ren Yunjun Liu | 2021 | The Crop Journal2021，9，6： | 4 |
| 5 | Numerical studies of reverse flows controlled by undulating leading edge显示文摘The improved delayed detached-eddy simulation(IDDES) method is used to simulate the reverse flows past an NACA0012 airfoil at medium(10°) and large(30°) angles of attack. The numerical results of the baseline configuration are compared with the available measurements. The effects of the undulating leading edge with four different amplitudes are compared and analyzed at angle of attack of 10°. Based on these analyses, the amplitude of A/C=0.04 yields the best performance. Compared with the uncontrolled case, the performances of the undulating leading edge are greatly improved with reducing of the aerodynamic fluctuations. Furthermore, the mechanisms of performance are explored by comparing the local flow structures near the undulations. | Biao Wang Jian Liu QiBing Li YunJun Yang ZhiXiang Xiao | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，7： | 2 |
| 6 | Land use and land cover classification using Chinese GF-2 multispectral data in a region of the North China Plain显示文摘The newly launched GF-2 satellite is now the most advanced civil satellite in China to collect high spatial resolution remote sensing data.This study investigated the capability and strategy of GF?2 multispectral data for land use and land cover (LULC) classification in a region of the North China Plain.The pixel-based and object-based classifications using maximum likelihood (MLC) and support vector machine (SVM) classifiers were evaluated to determine the classification strategy that was suitable for GF?2 multispectral data.The validation results indicated that GF-2 multispectral data achieved satisfactory LULC classification performance,and object-based classification using the SVM classifier achieved the best classification accuracy with an overall classification accuracy of 94.33% and kappa coefficient of 0.911.Therefore,considering the LULC classification performance and data characteristics,GF-2 satellite data could serve as a valuable and reliable high-resolution data source for land surface monitoring.Future works should focus on improving LULC classification accuracy by exploring more classification features and exploring the potential applications of GF-2 data in related applications. | Kun JIA Jingcan LIU Yixuan TU Qiangzi LI Zhiwei SUN Xiangqin WEI Yunjun YAO Xiaotong ZHANG | 2019 | Frontiers of Earth Science2019，13，2： | 2 |
| 7 | Manipu- lation in digital word of mouth: A reality check for book reviews显示文摘 | Nan Hu Indranil Bose Yunjun Gao Ling Liu | 2011 | Decision Support Systems2011，50，3： | 1 |
| 8 | Frost formation on a super-hydrophobic surface under natural convection conditions 显示文摘 | Liu Zhongliang Gou Yunjun Wang Jieteng | 2008 | International Journal of Heat Mass Transfer2008，51，25： | 1 |
| 9 | Experimental study on the absorption behaviors of gas phase bivalent mercury in Ca-based wet flue gas desulfurization slurry system显示文摘 | Yunjun Wang Yue Liu Zhongbiao Wu Jiansong Mo Bin Cheng | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 10 | Biodiesel synthesis combining pre-esterification with alkali catalyzed process from rapeseed oil deodorizer distillate显示文摘 | Liu Yun Wang Ling Yan Yunjun | 2009 | Fuel Processing Technology2009，90，78： | 1 |
| 11 | Isolation and analysis of water stress induced genes in maize seedlings by subtraetive PCR and cDNA macroarry显示文摘 | Zheng Jun Zhao Junfeng Tao Yazhong Wang Jianhua Liu Yunjun Fu Junjie Jin Ying Gao Peng Zhang Jinpeng Bai Yunfeng Wang Guoying | 2004 | Plant Molecular Biology2004，55，： | 1 |
| 12 | Incomplete data management: a survey显示文摘 | Xiaoye MIAO Yunjun GAO Su GUO Wanqi LIU | 2018 | Frontiers of Computer Science2018，12，1： | 1 |
| 13 | Frost formation a super-hydrophobic surface under natural convection conditions显示文摘 | Liu Zhongliang Gou Yunjun WangJ ieteng et at | 2008 | IntJ Heat Mass Tran2008，37，7： | 1 |
| 14 | Overexpression of a novel crylle gene confers resistance to CrylAc-resistant cotton bollworm in transgenic lines of maize显示文摘 | Zhang Yuwen Liu Yunjun Ren Yuan | 2013 | Plant Cell Tissue and Organ Culture2013，115，： | 1 |
| 15 | Manipulation in digital word-of-mouth: A reality check for book reviews显示文摘 | Nan Hu Indranil Bose Yunjun Gao Ling Liu | 2010 | Decision Support Systems2010，，3： | 1 |
| 16 | Isolation and analysis of water stress induced genes in maize seedlings by subtractive PCR and cDNA macroarray显示文摘 | Jun Zheng Jinfeng Zhao Yazhong Tao Jianhua Wang Yunjun Liu Junjie Fu Ying Jin Peng Gao Jinpeng Zhang Yunfeng Bai Guoying Wang | 2004 | Plant Molecular Biology2004，，6： | 1 |
| 17 | MODIS -driven estimation of terrestrial latent heat flux in China based on a modified Priestley–Taylor algorithm显示文摘 | Yunjun Yao Shunlin Liang Jie Cheng Shaomin Liu Joshua B. Fisher Xudong Zhang Kun Jia Xiang Zhao Qiming Qin Bin Zhao Shijie Han Guangsheng Zhou Guoyi Zhou Yuelin Li Shaohua Zhao | 2012 | Agricultural and Forest Meteorology2012，，： | 1 |
| 18 | Frost formation on a super-hydrophobic surface under natural convection conditions显示文摘 | Zhongliang Liu Yunjun Gou Jieteng Wang Shuiyuan Cheng | 2008 | International Journal of Heat and Mass Transfer2008，，25： | 1 |
| 19 | Direct-Writing Large-Area Cross-Aligned Ag Nanowires Network:Toward High-Performance Transparent Quantum Dot Light-Emitting Diodes显示文摘Flexible transparent electrodes(FTEs)made of silver nanowires(AgNWs)have been widely used in wearable and foldable electronics devices.For obtaining FTEs with both high transparency and low resistance,the AgNWs network should be highly cross-aligned with a low density.Various solution processes have been developed,but most suffer from poor control of the distribution of the AgNWs. | Lili Meng Min Zhang Huanhuan Deng Bojie Xu Hongqin Wang Yunjun Wang Lei Jiang Huan Liu | 2021 | CCS Chemistry2021，3，8： | 1 |
| 20 | Frost formation on a super-hydrophobic surface under natural convection conditions 显示文摘 | Liu Zhongliang Gou Yunjun Wang Jieteng | 2008 | International Joumal of Heat and Mass Transfer2008，51，2526： | 1 |
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