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| 1 | Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks(Poephagus grunniens) with haemorrhagic diarrhoea显示文摘Objective:To evaluate the antimicrobial efficacy of berberine,a plant alkaloid.Methods:Five multi-drug resistant(MDR) STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the study.Antibacterial activity of berberine was evaluated by broth dilution and disc diffusion methods.The binding kinetics of berberine to DNA and protein was also enumerated.Results:For both categories of enterovirulent Escherichia coli(E.roli) isolates, berberine displayed the antibaclerial effect in a dose dependent manner.The MIC50 of berberine chloride for STEC/EPEC isolates varied from 2.07μM to 3.6μM with a mean of(2.95±0.33)μM where as for ETEC strains it varied from 1.75 to 1.96μM with a mean of(1.87±0.03)μM. Berberine bind more tightly with double helix DNA with Bmax and Kd of(24.68±2.62) and(357.8±57.8),respectively.Berberine reacted with protein in comparatively loose manner with Bmax and Kd of(18.9±3.83) and <286.2±113.6),respectively.Conclusions:The results indicate clearly that berberine may serve as a good antibacterial against multi drug resistant E.coli. | Samiran Bandyopadhyay Pabitra H Patra Achintya Mahanti Dipak K Mondal Premanshu Dandapat Subhasis Bandyopadhyay Indranil Samanta Chandan Lodh Asit K Bera Debasish Bhattacharyya Mihir Sarkar Kishore K Baruah | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 11 |
| 2 | Isolation and identification of antibacterial components in seed extracts of Argemone mexicana L.(Papaveraceae)显示文摘Objective:The column chromatographic fractions of chloroform(CH1,CH2,CH3) seed extracts of Argemone mexicana(A.mexicana) were screened for antibacterial activity and phytochemical analysis.Methods:CH3 fraction was isolated and identified by column chromatography,thin layer chromatography,spectral data analysis and phytochemical screening were used for analysis. Results:CH3 fraction was significantly active at 4 to 64 mg/mL against Staphylococcus aureus, Escherichia coli,Klebsiella pneumoniae and Pseudomonas aeruginosa with minimum inhibitory concentration of 1.5625 to 3.125 mg/mL.The active fraction(CH3) revealed presence of alkaloid with retention factor value of 0.44.The active antibacterial agent in the most potent fraction (CH3) was isolated and identified as N-demethyloxysanguinarine by thin layer chromatography (TLC) and phytochemical screening.The CH1 and CH2 fractions did not show inhibitory activity. Conclusions:The results support the ethnomedicinal use of seeds of A.mexicana for treatment of bacterial diseases. | Indranil Bhattacharjee Soroj Kumar Chatterjee Goutam Chandra | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 7 |
| 3 | Isolation and identification of bioactive antibacterial components in leaf extracts of Vangueria spinosa(Rubiaceae)显示文摘Objective:The column chromatographic fraction of ethyl acetate(EA1,EA2,EA3,EA4 and EA5) leaf extracts of Vangueria spinosa(V.spinosa) were screened for antibacterial activity and phytochemical analysis.Methods:EA3 fraction was isolated and identified by column chromatography,thin layer chromatography,spectral data analysis and phytochemical screening were used for analysis.Results:EA3 fraction was significantly active at 4 to 64 mg/L against Staphylococcus aureus,Escherichia coli,Klebsiella pneumoniae and Pseudomonas aeruginosa with minimum inhibitory concentration of 1.5625 to 3.1250 mg/mL.The active fraction(EA3) revealed the presence of flavonoid with retention factor value(R_f) of 0.39.The active antibacterial agent in the most potent fraction(EA3) was isolated and identified as flavonoid(-)-epicatechin-3-O-β-glucopyranoside by thin layer chromatography(TLC) and phytochemical screening.EA1 and EA2 show inhibitory activity at 4 to 64 mg/L against Staphylococcus aureus only where as fraction EA4 and EA5 do not shows any inhibitory activity within that range of concentration against any bacteria.Conclusions:The results support the ethnomedicinal use of leaf of V.spinosa for the treatment of bacterial diseases. | Soroj Kumar Chatterjee Indranil Bhattacharjee Goutam Chandra | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，1： | 5 |
| 4 | Gene expression profile of esophageal cancer in North East India by cDNA microarray analysis显示文摘AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. METHODS: Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics). RESULTS: Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P ≤ 0.05 and ≥ 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (MAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity) were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity) were most significantly downregulated. CONCLUSION: Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent. | Indranil Chattopadhyay Sujala Kapur Joydeep Purkayastha Rupkumar Phukan Amal Kataki Jagadish Mahanta Sunita Saxena | 2007 | World Journal of Gastroenterology2007，13，9： | 3 |
| 5 | In vivo printing of growth factor-eluting adhesive scaffolds improves wound healing显示文摘Acute and chronic wounds affect millions of people around the world,imposing a growing financial burden on patients and hospitals.Despite the application of current wound management strategies,the physiological healing process is disrupted in many cases,resulting in impaired wound healing.Therefore,more efficient and easy-to-use treatment modalities are needed.In this study,we demonstrate the benefit of in vivo printed,growth factor-eluting adhesive scaffolds for the treatment of full-thickness wounds in a porcine model.A custom-made handheld printer is implemented to finely print gelatin-methacryloyl(GelMA)hydrogel containing vascular endothelial growth factor(VEGF)into the wounds.In vitro and in vivo results show that the in situ GelMA crosslinking induces a strong scaffold adhesion and enables printing on curved surfaces of wet tissues,without the need for any sutures.The scaffold is further shown to offer a sustained release of VEGF,enhancing the migration of endothelial cells in vitro.Histological analyses demonstrate that the administration of the VEGF-eluting GelMA scaffolds that remain adherent to the wound bed significantly improves the quality of healing in porcine wounds.The introduced in vivo printing strategy for wound healing applications is translational and convenient to use in any place,such as an operating room,and does not require expensive bioprinters or imaging modalities. | Kristo Nuutila Mohamadmahdi Samandari Yori Endo Yuteng Zhang Jacob Quint Tannin ASchmidt b Ali Tamayol Indranil Sinha | 2022 | Bioactive Materials2022，7，2： | 3 |
| 6 | Concurrent dengue and malaria in an area in Kolkata显示文摘Objective:To establish the nature and extent of dual dengue and malaria infections in an endemic area through a longitudinal study.Methods:A prospective study was conducted from August 2005 to December 2010 to document the nature and extent of concurrent dengue and malaria infections in an area in central Kolkata,endemic both for dengue and malaria.Results: Of 2 971 suspected cases of dengue fever,in 605(20.36%) persons dengue infection was detected, of whom 46(7.60%,46/605) patients(40 and 6 suffered from secondary and primary dengue fever respectively) were simultaneously suffering from malaria(28 and 18 were infected with Plasmodium vivax(P.vivax) and Plasmodium falciparum(P.falciparum) respectively,such dual infections of dengue and malaria were detected in all the years of the study period,except 2007,indicating intense transmission of both dengue and malaria in the study area,and the phenomenon was not an isolated one,the rate of concomitant infections ranged from 25%in 2009 to 4.9%in 2005.Out of total population surveyed,1.54%(46/2 971) had concurrent dengue and malaria infection.Conclusions:These findings added a new dimension in diagnosis,treatment, epidemiology and control of dengue and malaria.The possible risk of concurrent dengue and malaria infectioas should always be kept in mind in endemic areas for early diagnosis employing modern technology and prompt and effective treatment to avoid serious complications. | Amiya Kumar Hati Indranil Bhattacharjee Hiranmoy Mukherjee Bhaswati Bandyopadhayay Deban Bandyopadhyay Rajyasree De Goutam Chandra | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 7 | All-epiphyseal versus trans-epiphyseal screw fixation for tillaux fractures:Does it matter?显示文摘BACKGROUND Tillaux fractures occur primarily in adolescents due to the pattern of physeal closure and are classified as Salter-Harris type III physeal fractures.Operative management with screw fixation is recommended for more than 2 mm of displacement or more than 1 mm of translation.However,the efficacy and complications of trans-physeal vs all-physeal screw fixation have not been investigated extensively.AIM To compare the clinical and functional outcomes of trans-physeal(oblique)and all-epiphyseal(parallel)screw fixation in management of Tillaux fractures among pediatric patients.METHODS This was an ethics board approved retrospective review of pediatric patients who presented to our tertiary children’s care facility with Tillaux fractures.We included patients who had surgical fixation of a Tillaux fracture over a 10 year period.Data analysis included demographics,mode of injury,management protocols,and functional outcomes.The patients were divided into group 1(oblique fixation)and group 2(parallel fixation).Baseline patient characteristics and functional outcomes were compared between groups.Statistical tests to evaluate differences included Fisher’s Exact or Chi-squared and independent samples t or Mann Whitney tests for categorical and continuous variables,respectively.RESULTS A total of 42 patients(28 females and 14 males)were included.There were no significant differences in body mass index,sex,age,or time to surgery between the groups[IK2].Sports injuries accounted for 61.9%of the cases,particularly non-contact(57.1%)and skating(28.6%)injuries.Computed Tomography(CT)scan was ordered for 28 patients(66.7%),leading to diagnosis confirmation in 17 patients and change in management plan in 11 patients.[GRC3]Groups 1 and 2 consisted of 17 and 25 patients,respectively.For mid to long-term functional outcomes,there were 14 and 10 patients in groups 1 and 2,respectively.Statistical analysis revealed no significant differences in the functional outcomes,pain scores,or satisfaction between groups.No infections,non-unions,physeal arrest,or post-operative ankle deformities were reported.Two(4.8%)patients had difficulty returning to sports post-surgery due to pain.One was a dancer,and the other patient had pain while running,which led to hardware removal.Both patients had parallel fixation.Hardware removal for groups 1 and 2 were 4(23.5%)and 5(20.0%)patients,respectively.The reasons for removal was pain in 2 patients,and parental preference in the remaining.CONCLUSION This is the largest reported series of pediatric patients with Tillaux fractures comparing functional outcomes of different methods of screw fixation orientation to the physis,which showed no difference regarding functional outcomes. | Brett Heldt Isaiah Roepe Raymond Guo Elsayed Attia Ifeoma Inneh Vinitha Shenava Indranil Kushare | 2022 | World Journal of Orthopedics2022，13，2： | 2 |
| 8 | Posterior ankle impingement–an underdiagnosed cause of ankle pain in pediatric patients显示文摘BACKGROUND Posterior ankle impingement syndrome(PAIS)is a cause of ankle pain due to pinching of bony or soft tissue structures in the hindfoot.The diagnosis is primarily made based on detailed history and accurate clinical examination.The delay in its diagnosis has not yet been described in the pediatric and adolescent population.AIM To identify and characterize misdiagnosed cases of PAIS in pediatric and adolescent patients.METHODS This descriptive prospective study at a tertiary children’s hospital included patients≤18 years who underwent posterior ankle arthroscopy after presenting with chronic posterior ankle pain after being diagnosed with PAIS.Collected data included:Demographics,prior diagnoses and treatments,providers seen,time to diagnosis from presentation,and prior imaging obtained.Visual Analogue Scale(VAS)for pain and American Orthopedic Foot Ankle Society(AOFAS)ankle-hindfoot scores were noted at initial presentation and follow-up.RESULTS 35 patients(46 ankles)with average age of 13 years had an average 19 mo(range 0-60 mo)delay in diagnosis from initial presentation.25(71%)patients had previously seen multiple medical providers and were given multiple other diagnoses.All 46(100%)ankles had tenderness to palpation over the posterior ankle joint.Radiographs were reported normal in 31/42(72%)exams.In 32 ankles who underwent MRI,the most common findings included os trigonum(47%)/Stieda process(47%).Conservative treatment had already been attempted in all patients.Ankle impingement pathology was confirmed during arthroscopy in 46(100%)ankles.At an average follow-up of 13.1 mo,there was an improvement of VAS(pre-op 7.0 to post-op 1.2)and AOFAS scores(pre-op 65.1 to post-op 94).CONCLUSION This is the first study which shows that PAIS is a clinically misdiagnosed cause of posterior ankle pain in pediatric and adolescent population;an increased awareness about this diagnosis is needed amongst providers treating young patients. | Indranil Kushare Kristen Kastan Sachin Allahabadi | 2019 | World Journal of Orthopedics2019，10，10： | 2 |
| 9 | AVMON: Optimal and scalable discovery of consistent availability monitoring overlays for distributed systems 显示文摘 | Ramses M Indranil G | 2009 | IEEE Trans on Parallel and Distributed Systems2009，20，4： | 1 |
| 10 | Vortex-induced vibration of circular cylinders II: New model显示文摘 | Indranil Goswami Scanlan R H Jones N P | 1993 | Journal of Engineering Mechanics1993，119，11： | 1 |
| 11 | Molecular and structural composition of phospholipid membranes in livers of marine and freshwater fish in relation to temperature显示文摘 | Indranil Dey Csaba Buda Tarja Wiik | 1993 | Biochemistry1993，90，： | 1 |
| 12 | Covalent Linkage of the Type-2 and Type-3 Structural Mimics to Model the Active Site Structure of Multicopper Oxidases:Synthesis and Magneto-Structural Properties of Two Angular Trinuclear Copper(II) Complexes显示文摘 | Arindam M Indranil R Sunil G M | 2003 | Inorg Chem2003，42，： | 1 |
| 13 | An Audio Watermarking Scheme Using Singular Value Decomposition and Dither- modulation Quantization显示文摘 | Vivekananda B K Indranil S Abhijit D | 2010 | Multimedia Tools and Applications2010，52，23： | 1 |
| 14 | Geochemistry of some banded iron-formations of the Archean supracrustals, Jharkhand-Orissa region, India显示文摘 | H. N. Bhattacharya Indranil Chakraborty Kaushik K. Ghosh | 2007 | Journal of Earth System Science2007，，3： | 1 |
| 15 | Supply Chain Management for Effective People Management: Issues and Challenges显示文摘 | Indranil M | 2012 | Journal of Operations Management2012，11，4： | 1 |
| 16 | Understanding the Impact of Collaboration Software on Product Design and Development显示文摘 | Rajiv D. Banker Indranil Bardhan Ozer Asdemir | 2006 | Information Systems Research2006，，4： | 1 |
| 17 | Rhabdomyosarcoma of nose, nasopharynx and paranasal sinuses 显示文摘 | Mondal PK Indranil Pal Saibal M | 2009 | Indian J Otolaryngol Head Neck Surg2009，6，4： | 1 |
| 18 | Manipu- lation in digital word of mouth: A reality check for book reviews显示文摘 | Nan Hu Indranil Bose Yunjun Gao Ling Liu | 2011 | Decision Support Systems2011，50，3： | 1 |
| 19 | Auctions with shill bidding显示文摘 | Indranil Chakraborty Georgia Kosmopoulou | 2004 | Economic Theory2004，，2： | 1 |
| 20 | The structure of a polysaccharide from Fraction-Ⅱ of an edible mushroom, Pleurotus florida显示文摘 | Dilip Rout Soumitra Mondal Indranil Chakraborty | 2006 | Carbohydrate Research2006，341，： | 1 |
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