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| 1 | Prognostic implications of epidermal growth factor receptor variant Ⅲ expression and nuclear translocation in Chinese human gliomas显示文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma. | Kaiyuan Yang Xiaohui Ren Liyuan Tao Peipei Wang Haihui Jiang Li Shen Yiming Zhao Yong Cui Mingxiao Li Song Lin | 2019 | Chinese Journal of Cancer Research2019，31，1： | 8 |
| 2 | Existence of Positive Periodic Solution of Mutualism System with Several Delays显示文摘 | Xia Yonghui Lin Muren | 2008 | Chaos Solitons and Fractals2008，36，： | 1 |
| 3 | in-situ thermoreversible gelation of block and star copolymers of poly(ethylene glycol) and poly(N-Iisopropylacrylamide) of varying architectures 显示文摘 | Lin Haihui Cheng Yuling | 2001 | Macromolecules2001，34，11： | 1 |
| 4 | Nuclear PKM2 expression predicts poor prognosis in patients with esophageal squamous cell carcinoma显示文摘 | Xuelin Zhang Chengzhi He Chunya He Baofu Chen Yanxia Liu Min Kong Chunguo Wang Lizhong Lin Yan Dong Haihui Sheng | 2013 | Pathology - Research and Practice2013，，： | 1 |
| 5 | Existence of Positive Periodic Solution of Mutualism with Several Delays 显示文摘 | WU Haihui XIA Yonghui LIN Muren | 2008 | Chaos Solitons & Fractals2008，36，2： | 1 |
| 6 | Dual inhibition of glycolysis and oxidative phosphorylation by aptamer-based artificial enzyme for synergistic cancer therapy显示文摘Dual inhibition of glycolysis and oxidative phosphorylation(OXPHOS)can break the metabolic plasticity of cancer cells to inhibit most energy supply and lead to effective cancer therapy.However,the pharmacokinetic difference among drugs hinders these two inhibitions to realize a uniform temporal and spatial distribution.Herein,we report an aptamer-based artificial enzyme for simultaneous dual inhibition of glycolysis and OXPHOS,which is constructed by arginine aptamer modified carbon-dots-doped graphitic carbon nitride(AptCCN).AptCCN can circularly capture intracellular arginine attribute to the specific binding ability of arginine aptamers to arginine,and further catalyze the oxidation of enriched arginine to nitric oxide(NO)under red light irradiation.In vitro and in vivo experiments showed that arginine depletion and NO stress could inhibit glycolysis and OXPHOS,leading to energy blockage and apoptosis of cancer cells.The presented aptamer-based artificial enzyme strategy provides a new path for cell pathway regulation and synergistic cancer therapy. | Xiao Fang Meng Yuan Junduan Dai Qianying Lin Yuhong Lin Wenli Wang Yifan Jiang Haihui Wang Fang Zhao Junye Wu Shumeng Bai Chunhua Lu Huanghao Yang | 2022 | Nano Research2022，15，7： | 0 |
| 7 | Defense of COVID-19 by Human Organoids显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),has created an immense menace to public health worldwide,exerting huge effects on global economic and political conditions.Understanding the biology and pathogenesis mechanisms of this novel virus,in large parts,relies on optimal physiological models that allow replication and propagation of SARS-CoV-2.Human organoids,derived from stem cells,are three-dimen-sional cell cultures that recapitulate the cellular organization,transcriptional and epigenetic signatures of their counterpart organs.Recent studies have indicated their great values as experimental virology platforms,making human organoid an ideal tool for investigating host-pathogen interactions.Here,we summarize research developments for SARS-CoV-2 infection of various human organoids involved in multiple systems,including lung,liver,brain,intestine,kidney and blood vessel organoids.These studies help us reveal the pathogenesis mechanism of COVID-19,and facilitate the development of effec-tive vaccines and drugs as well as other therapeutic regimes. | Ting Lv Fanlu Meng Meng Yu Haihui Huang Xinhua Lin Bing Zhao | 2021 | Phenomics2021，1，3： | 0 |
| 8 | An Efficient and Privacy-Preserving Data Aggregation Scheme Supporting Arbitrary Statistical Functions in IoT显示文摘The Internet of Things(IoT)has profoundly impacted our lives and has greatly revolutionized our lifestyle.The terminal devices in an IoT data aggregation application sense real-time data for the remote cloud server to achieve intelligent decisions.However,the high frequency of collecting user data will raise people concerns about personal privacy.In recent years,many privacy-preserving data aggregation schemes have been proposed.Unfortunately,most existing schemes cannot support either arbitrary aggregation functions,or dynamic user group management,or fault tolerance.In this paper,we propose an efficient and privacy-preserving data aggregation scheme.In the scheme,we design a lightweight encryption method to protect the user privacy by using a ring topology and a random location sequence.On this basis,the proposed scheme supports not only arbitrary aggregation functions,but also flexible dynamic user management.Furthermore,the scheme achieves faulttolerant capabilities by utilizing a future data buffering mechanism.Security analysis reveals that the scheme can achieve the desired security properties,and experimental evaluation results show the scheme's efficiency in terms of computational and communication overhead. | Haihui Liu Jianwei Chen Liwei Lin Ayong Ye Chuan Huang | 2022 | China Communications2022，19，6： | 0 |
| 9 | Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation显示文摘Oxidative phosphorylation(OXPHOS)consumes oxygen to produce ATP.However,the mechanism that balances OXPHOS activity and intracellular oxygen availability remains elusive.Here,we report that mitochondrial protein lactylation is induced by intracellular hypoxia to constrain OXPHOS.We show that mitochondrial alanyl-tRNA synthetase(AARS2)is a protein lysine lactyltransferase,whose proteasomal degradation is enhanced by proline 377 hydroxylation catalyzed by the oxygen-sensing hydroxylase PHD2.Hypoxia induces AARS2 accumulation to lactylate PDHA1 lysine 336 in the pyruvate dehydrogenase complex and carnitine palmitoyltransferase 2(CPT2)lysine 457/8,inactivating both enzymes and inhibiting OXPHOS by limiting acetyl-CoA influx from pyruvate and fatty acid oxidation,respectively.PDHA1 and CPT2 lactylation can be reversed by SIRT3 to activate OXPHOS.In mouse muscle cells,lactylation is induced by lactate oxidation-induced intracellular hypoxia during exercise to constrain high-intensity endurance running exhaustion time,which can be increased or decreased by decreasing or increasing lactylation levels,respectively.Our results reveal that mitochondrial protein lactylation integrates intracellular hypoxia and lactate signals to regulate OXPHOS. | Yunzi Mao Jiaojiao Zhang Qian Zhou Xiadi He Zhifang Zheng Yun Wei Kaiqiang Zhou Yan Lin Haowen Yu Haihui Zhang Yineng Zhou Pengcheng Lin Baixing Wu Yiyuan Yuan Jianyuan Zhao Wei Xu Shimin Zhao | 2024 | Cell Research2024，34，1： | 0 |
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