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| 1 | Enhancement and selective production of avermectin B by recombinants of Streptomyces avermitilis via intraspecific protoplast fusion显示文摘Among eight components of avermectin, B1 fractions have the most effective antiparasitic activities and the lowest level of toxic side-effects and are used widely in veterinary and agricultural fields. In-traspecific protoplast fusion between two strains of Streptomyces avermitilis, one an avermectin high producer (strain 76-05) and the other a genetically engineered strain containing the mutations aveDˉ and olmAˉ (strain 73-12) was performed for enhancement and selective production of avermectin B in the absence of oligomycin. Two recombinant strains (F23 and F29) were isolated and characterized with regards to the parental merits. F23 and F29 produced only the four avermectin B components with high yield and produced no oligomycin. The avermectin production of F23 and F29 was about 84.20% and 103.45% of the parental strain 76-05, respectively, and increased about 2.66-fold and 3.50-fold, re-spectively, compared to that of parental strain 73-12. F23 and F29 were genetically stable prototrophic recombinants and F29 was quite tolerant of fermentation conditions compared to avermectin high producer parental strain 76-05. The ability to produce avermectin B with high yield without the produc-tion of other avermectin components and oligomycin will make F23 and F29 useful strains for aver-mectin production. Strain F29's tolerance of fermentation conditions will also make it suitable for in-dustrial applications. | CHEN Zhi WEN Jia SONG Yuant WEN Ying LI JiLun | 2007 | Chinese Science Bulletin2007，52，5： | 10 |
| 2 | NPY Genes Play an Essential Role in Root Gravitropic Responses in Arabidopsis显示文摘植物能察觉到他们保证根在土壤和那被抛锚的生长射击的严肃和东方的方向变得向上。Gravitropism 用 Arabidopsis 遗传,而是准确机制广泛地被学习了因为 gravitropism 充分没被理解。这里,我们证明五 NPY 基因在 Arabidopsis 根 gravitropism 起一个关键作用。NPY 基因以前与 AGC kinases PID, PID2, WAG1,和 WAG2 在一条基因小径作为调停植物生长素的 organogenesis 的管理者被识别。我们证明所有五 NPY 基因高度在主要的根尖端被表示。单个 npy 异种不显示明显的 gravitropism 缺点,而是五倍的异种显示出的 npy1 npy2 npy3 npy4 npy5 戏剧的 gravitropic 显型。所有 npy 的系统的分析双、三倍、四倍的联合证明五 NPY 基因都贡献 gravitropism。我们的工作显示 gravitropism,向光性,和 organogenesis 使用至少一自动增益控制 kinase,一 NPH3/NPY 基因,和一 ARF 在被要求的类似的机制。 | Yuanting Li Xinhua Dai Youfa Cheng Yunde Zhao | 2011 | Molecular Plant2011，4，1： | 7 |
| 3 | Multi-functional polyethersulfone nanofibrous membranes with ultra-high adsorption capacity and ultra-fast removal rates for dyes and bacteria显示文摘The adsorption technology has been widely applied in water remediation for contamination removal of dyes and bacteria,by virtue of the advantages of adsorption technology including high efficiency,energy conservation and ease of operation.Simultaneous removal of dyes and bacteria has been realized by some reported materials,but to achieve satisfactory adsorption amounts and rates remain an unmet goal for decades.Herein,a poly(methacrylatoethyl trimethyl ammonium chloride-co-methyl methacrylate)copolymer was synthesized,and then blended with polyethersulfone for the fabrication of nanofibrous membranes via electrospinning for the use of fast and massive removal of dyes and bacteria.Owing to the introduction of abundant quaternary ammonium groups,the maximum adsorption amount for methyl orange was up to 909.8 mg g^(-1).In addition,the modified nanofibrous membranes showed good recyclability,broad applications in severe environments,selective adsorption ability,and excellent dynamic removal performance.Especially,thanks to the abundant functional groups,the membranes showed fast adsorption ability for bacteria through electrostatic interaction.It should be noted that the clearance ratio for Staphylococcus aureus or Escherichia coli by 6 min of static adsorption could reach 93%or 90%for each.Additionally,dynamic removal ratio via filtration with the nanofibrous membranes could reach 99.7%for Staphylococcus aureus or 98.7%for Escherichia coli in 90 s.Therefore,the proposed approach towards the quaternary ammonium modified polyethersulfone nanofibrous membranes creates a new route for ultra-high adsorption capacity and ultra-fast removal rates for dyes and bacteria in water remediation. | Jianxu Bao Hang Li Yuanting Xu Shengqiu Chen Zhoujun Wang Chunji Jiang Huilin Li Zhiwei Wei Shudong Sun Weifeng Zhao Changsheng Zhao | 2021 | Journal of Materials Science & Technology2021，，19： | 4 |
| 4 | Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity显示文摘K-ras is a member of ras gene family which is involved in cell survival,proliferation and differentiation.When a mutation occurs in ras gene,the activation of Ras proteins may be prolonged to induce oncogenesis.However,the relationship between K-ras mutation and clinical outcomes in pancreatic cancer patients treated with chemotherapy agents is still under debate.In this study,we constructed five pAcGFP1-C3 plasmids for different types of K-ras gene(WT,G12V,G12R,G12D,and G13D)and stably transfected human pancreatic cancer Bxpc-3 cells with these genes.The wild type and mutant clones showed a comparable growth and expression of K-Ras-GFP fusion protein.The expression of some K-ras mutations resulted in a reduced sensitivity to gefitinib,5-FU,docetaxel and gemcitabine,while showed no effects on erlotinib or cisplatin.Moreover,compared with the wild type clone,K-Ras downstream signals(phospho-Akt and/or phospho-Erk)were increased in K-ras mutant clones.Interestingly,different types of K-ras mutation had non-identical K-Ras downstream signal activities and drug responses.Our results are the first to reveal the relationship between different K-ras mutation and drug sensitivities of these anti-cancer drugs in pancreatic cancer cells in vitro. | SHAO TengFei ZHENG YuanTing ZHAO Bei LI Tao CHENG KeGuang CAI WeiMin | 2014 | Science China(Life Sciences)2014，57，10： | 2 |
| 5 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 6 | Transient receptor potential vanilloid I activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel α subunit-mediated sodium reabsorption显示文摘 | Li Li Wang FeiiWei Xing Liang Yi Cui Yuanting Gao Feng Zhong Jian Pu Yunfei Zhao Yu Yan Zhencheng Arendshorst William J Nilius Bemd Chen Jing'Liu Daoyan Zhu Zhiming | 2014 | Hypertension2014，642，： | 1 |
| 7 | Extraction, prelim- inary structural characterization, and antioxidant activities of polysaccharides from Salvia miltiorrhiza Bunge显示文摘 | Wu Wenlin Zhu Yuanting Zhang Li | 2012 | Carbohy- drate Polymers2012，87，2： | 1 |
| 8 | 显示文摘 | Song Wei Li Dawei Li Yuanting | 2011 | Biosens Bioelec- tron2011，26，7： | 1 |
| 9 | Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag-gra- phene sensor based on eleetrophoretic preconcentration and surface-enhanced raman spectroscopy显示文摘 | LI Yuanting QU Lulu LI Dawei | 2013 | Biosensors and Bioelectron- ics2013，43，15： | 1 |
| 10 | Soft,stretchable,wireless intelligent three-lead electrocardiograph monitors with feedback functions for warning of potential heart attack显示文摘Cardiovascular diseases(CVDs)are fatal chronic diseases,where electrocardiography(ECG)monitoring could be a prominent solution for early diagnosis.In spite of available commercialized,multilead ECG devices,bulky formats,discontinuous monitoring,and no safety alarm system significantly limit their practical applications.Herein,we present a soft,and stretchable,three-lead ECG device allowing continuous monitoring and wireless transmission of ECG signals.A newly developed organohydrogel patch with a strong adhesive ability(~9.9 kPa)and higher conductivity(~6.5 kΩ)is applied for high-quality ECG signals collection.With a long operation duration(6.5 h)and wireless transmission distance(20.9 m),it could fulfill most of the daily applications.Machine learning algorithms and the graphical user interface are used for real-time ECG monitoring and cardiac abnormalities diagnosis.The vibratory flexible actuator,which is triggered by cardiac abnormalities that need immediate medical treatment,is also integrated as a warning system for the user.As a newly reported stretchable multi-lead ECG device for long-term ECG signal monitoring,there is a high potential for improving users'life quality with the high-risk population of CVDs. | Chunki Yiu Yiming Liu Chao Zhang Jingkun Zhou Huiling Jia Tsz H.Wong Xingcan Huang Jian Li Kuanming Yao Ming K.Yau Ling Zhao Hu Li Binbin Zhang Wooyoung Park Yuanting Zhang Zuankai Wang Xinge Yu | 2022 | SmartMat2022，3，4： | 1 |
| 11 | Face-centered cubic structured RuCu hollow urchin-like nanospheres enable remarkable hydrogen evolution catalysis显示文摘Ruthenium(Ru)is one of the most promising metals for its versatility in driving a wide range of catalytic reactions.However,owing to the intrinsic preference of hexagonal close-packed(hcp)phase for bulk Ru,currently,it is still challenging to construct Ru-based nanomaterials with face-centered-cubic(fcc)phase for optimizing their performance towards potential applications.Herein,we report a facile wet-chemical method to directly create unconventional fcc-structured Ru-copper hollow urchin-like nanospheres(fcc-RuCu HUNSs)as a class of efficient pH-universal hydrogen evolution reaction(HER)electrocatalyst.Interestingly,this synthetic strategy can be expanded to prepare other fcc-Ru-based alloy nanomaterials.Significantly,the novel fcc-RuCu HUNSs exhibit superior HER performance with the overpotential of only 25,34,40,and 26 m V to reach the current density of 10 mA cm^(-2)in 0.5 M H_(2)SO_(4),0.05 M H_(2)SO_(4),0.1 M KOH,and 1 M KOH,respectively,much lower than those of hcpRuCu HUNSs and commercial Pt/C.Density functional theory(DFT)calculations further indicate that their excellent pH-universal HER performance results from the optimized adsorption free energy of H and work functions.Our work highlights the importance of phase control to design high-efficiency nanocatalysts for relevant catalytic reactions in energy conversion. | Juntao Zhang Jiabo Le Yuanting Dong Lingzheng Bu Ying Zhang Jun Cheng Leigang Li Xiaoqing Huang | 2022 | Science China Chemistry2022，65，1： | 1 |
| 12 | Extraction,preliminary structural characterization, and antioxidant activities of polysaccharides from Salvia miltiorrhiza Bunge 显示文摘 | WU Wenlin ZHU Yuanting ZHANG Li | 2012 | Carbohydrate Polymers2012，87，： | 1 |
| 13 | “1+1>2”:Highly efficient removal of organic pollutants by composite nanofibrous membrane based on the synergistic effect of adsorption and photocatalysis显示文摘Adsorption and photocatalysis are regarded as two desirable technologies for wastewater remediation,but are still unsatisfactory in removal effect,eco-friendly regeneration and facile reusability.In this study,we developed a composite nanofibrous membrane material with excellent removal performance for organic pollutants based on synergistic adsorption and photocatalysis.A novel boron-doped,nitrogen-deficient graphitic carbon nitride(B-C3N4)photocatalyst as well as an amphiphilic copolymer of methyl methacrylate and acrylic acid(p(MMA-AA))were synthesized respectively,and then used to modify polyethersulfone for the fabrication of composite nanofibrous membrane with improved hydrophilicity,negativelycharge property and enhanced visible light response simultaneously.Subsequently,the synergistic effect of adsorption and photocatalytic degradation for organic pollutants were identified especially and resulted in an excellent removal efficiency even superior to the combination of adsorption and photocatalytic degradation,which could be called a“1+1>2”effect.In addition,the regeneration and reusability,the purification ability for multicomponent wastewater,and the photocatalytic mechanism,were investigated and discussed systematically.In this work,we not only prepared the nanofibrous membrane with synergistic effect of adsorption and photocatalysis,but also provided a versatile approach to design dualfunctional support material to ensure the practical applications of powdery photocatalyst in wastewater treatment. | Yuanting Xu Wanting Lin Dandan Yuan Shifan Chen Fang Li Yanping Long Chao He Weifeng Zhao Changsheng Zhao | 2022 | Journal of Materials Science & Technology2022，，29： | 1 |
| 14 | Extraction, preliminary structural characterization, and antioxidant activities of polysaccharides from Salvia miltiorrhiza Bunge显示文摘 | Wenlin Wu Yuanting Zhu Li Zhang Ruiwu Yang Yonghong Zhou | 2011 | Carbohydrate Polymers2011，，2： | 1 |
| 15 | Feasibility study of a novel crosslinking reagent (alginate dialdehyde ) for biological tissue fixation显示文摘 | XU Yuanting Li Li Yu Xixun | 2012 | Carbohydrate Polymers2012，87，2： | 1 |
| 16 | Interfacial engineering of 3D hollow CoSe_(2)@ultrathin MoSe_(2)core@shell heterostructure for efficient pH-universal hydrogen evolution reaction显示文摘Rational design and construction of low-cost and highly efficient electrocatalysts for hydrogen evolution reaction(HER)is meaningful but challenging.Herein,a robust three dimensional(3D)hollow CoSe_(2)@ultrathin MoSe_(2)core@shell heterostructure(CoSe_(2)@MoSe_(2))is proposed as an efficient HER electrocatalyst through interfacial engineering.Benefitting from the abundant heterogeneous interfaces on CoSe_(2)@MoSe_(2),the exposed edge active sites are maximized and the charge transfer at the hetero-interfaces is accelerated,thus facilitating the HER kinetics.It exhibits remarkable performance in pH-universal conditions.Notably,it only needs an overpotential(η10)of 108 mV to reach a current density of 10 mA·cm^(-2)in 1.0 M KOH,outperforming most of the reported transition metal selenides electrocatalysts.Density functional theory(DFT)calculations unveil that the heterointerfaces synergistically optimize the Gibbs free energies of H2O and H^(*)during alkaline HER,accelerating the reaction kinetics.The present work may provide new construction guidance for rational design of high-efficient electrocatalysts. | Lili Zhang Yuanting Lei Danni Zhou Chengli Xiong Zhuoli Jiang Xinyuan Li Huishan Shang Yafei Zhao Wenxing Chen Bing Zhang | 2022 | Nano Research2022，15，4： | 1 |
| 17 | Preparing amphiphilic acidic zeolite via chemically coating alkylamine显示文摘Amphiphilic ODA/HY and ODA/ Hβ zeolites have been prepared via chemically coating octadecylamine (ODA) with alcohol as solvent. IR and titrimetric results indicate that ODA molecules are chemisorbed on the acidic sites in zeolite, showing the higher thermostability and alcohol-resistance. These am- phiphilic zeolites contain both the hydrophobic and hydrophilic groups, orient at the liquid-liquid phase-boundary in both cyclohexane/water and water/carbon tetrachloride systems, and exhibit the potential to be used in the phase-boundary catalysis and adsorption. No by-products with strong acid- ity are formed in this approach, therefore, it can be used to prepare amphiphilic acidic zeolites with low Si/Al ratio. | SUN RuiQin CHUN Yuant MA BingLi LI Ping DONG JiaLu XU QinHua | 2007 | Chinese Science Bulletin2007，52，17： | 1 |
| 18 | Hierarchically aligned porous scaffold by ice-segregation-induced self-assembly and thermally triggered electrostatic self-assembly of oppositely charged thermosensitive microgels显示文摘 | Yao Xiang Yao Hongwei Li Yuanting | 2009 | Journal of Materials Chemistry2009，19，36： | 1 |
| 19 | Clinical features and outcome of 15 patients with recurrent endometrial cancer or atypical endometrial hyperplasia received primary fertility-sparing therapy followed by hysterectomy显示文摘Objective To investigate the clinical features and outcome of recurrent endometrial cancer(EC)or atypical endometrial hyperplasia(AEH)patients who underwent hysterectomy after fertility-sparing therapy.Methods Clinical data was retrospectively collected for 15 recurrent endometrial cancer or atypical endometrial hyperplasia patients who underwent hysterectomy in six hospitals from 2003 to 2019.According to the indicators of hysterectomy,patients were divided into four groups:7 patients who underwent direct hyesterectomy after the first relapse,4 due to re-treatment failure,1 after full term live birth,and 3 because of multiple recurrence.Clinical coexisting conditions,regimen and outcome of fertility-sparing therapy,pre-and post-operative pathological results,and prognosis were analyzed.Results(1)Fertility-spraring treatment was given to a total of 15 eligible patients,including 6 with EC and 9 with AEH.Median time interval from remission to recurrence was 12 months(range 3–92).Oral progestin-based medicine was the main fertility-sparing therapy in both primary treatment and re-treatment after recurrence.Six(6/8)patients received progestin combined with gonadotrophin releasing hormone agonist or metformin in three re-treatment groups.(2)Nine patients underwent hysterectomy and 6 staging surgery.Three patients had pathological upgrade after surgery.Five(5/10)EC patients had superficial myometrial invasion in postoperative pathology.All patients showed no evidence of disease in the median follow-up of 17 months(range 3–118).(3)Among seven patients who failed to re-treatment and had multiple recurrence,six were overweight/obesity and six had insulin resistance.Two of these patients had synchronous ovarian cancer in the postoperative pathology.Conclusion For the patients with recurrent EC or AEH after primary fertility-sparing therapy,overweight/obesity and insulin resistance might be the risk factors for re-treatment failure.Hysterectomy is recommended when patients had re-treatment failure or multiple recurrence;and generally the prognosis is favorable. | Yuanting Li Yiqin Wang Yijiao He Rong Zhou Huiru Tang Lijiang Xu Mian He Weili Li Chunlin Chen Weifeng Zhang Jianliu Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，1： | 0 |
| 20 | Oxalic Acid Promoted Hydrolysis of Sodium Borohydride for Transition Metal Free Hydrogen Generation显示文摘We reported an inexpensive and high-efficiency hydrogen generation method from NaBH4 hydrolysis promoted by oxalic acid.NaBH4 and H2C2O4 were premixed and hydrogen generation was initiated by adding water into the solid mixture.H2C2O4 was selected as the acid promotor due to its solid state and low mass per proton.The effect of reactant ratio on the hydrogen yield and hydrogen storage density was investigated.With optimized reactant ratio,high gravimetric hydrogen storage up to 4.4wt%based on all the reactants can be achieved with excellent hydrogen generation kinetics. | PENG Yuanting ZENG Hui SHI Yu XU Jinrong 谢镭 陈均 ZHENG Jie LI Xingguo | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，6： | 0 |
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