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| 1 | The use of phase-change cooling strategy in proton exchange membrane fuel cells:A numerical study显示文摘Thermal management is considered a critical issue in proton exchange membrane fuel cells(PEMFCs),since it not only influences the cell performance but also impacts PEMFC’s reliability and durability.With the ever-increasing power density of PEMFC,traditional cooling approaches including air cooling and water cooling become difficult to meet the demand for highpower heat dissipation.Therefore,phase-change cooling is proposed for fuel cell application in this work,and the potential advantages are discussed and demonstrated via a mathematical model incorporating phase-change heat transfer.The thermal management performance is evaluated by temperature uniformity,maximum temperature difference,and the cooling capacity to compare the difference between phase-change cooling and traditional methods,which demonstrates that phase-change cooling owns a greatly improved thermal management performance.In addition,a simple method to broaden the operating temperature of phase-change cooling based on one certain coolant is offered,which is pressurizing in the coolant channel to regulate the boiling temperature that could further improve the application feasibility of phase-change cooling strategy in fuel cells. | YAN XiaoHui PENG YiMeng SHEN YuanTing SHEN ShuiYun WEI GuangHua YIN JieWei ZHANG JunLiang | 2021 | Science China(Technological Sciences)2021，64，12： | 4 |
| 2 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 3 | A single mutation underlying phenotypic convergence for hypoxia adaptation on the Qinghai-Tibetan Plateau显示文摘Dear Editor,The Qinghai-Tibet Plateau(QTP)is the highest and largest plateau in the world;its altitude exceeds 4500 m on average,posing great physiological challenges such as severe hypoxia for endemic wild mammals on the plateau.1 To cope with such a harsh environment,the phylogenetically distant QTP endemic mammals have independently evolved similar morphological and physiological traits. | Donqming Xu Cuiping Yang Qiushuo Shen Shengkai Pan Zhen Liu Tongzuo Zhang Xin Zhou Menglong Lei Peng Chen Hui Yang Tao Zhang Yuanting Guo Xiangjiang Zhan Yongbin Chen Peng Shi | 2021 | Cell Research2021，31，9： | 1 |
| 4 | Oxalic Acid Promoted Hydrolysis of Sodium Borohydride for Transition Metal Free Hydrogen Generation显示文摘We reported an inexpensive and high-efficiency hydrogen generation method from NaBH4 hydrolysis promoted by oxalic acid.NaBH4 and H2C2O4 were premixed and hydrogen generation was initiated by adding water into the solid mixture.H2C2O4 was selected as the acid promotor due to its solid state and low mass per proton.The effect of reactant ratio on the hydrogen yield and hydrogen storage density was investigated.With optimized reactant ratio,high gravimetric hydrogen storage up to 4.4wt%based on all the reactants can be achieved with excellent hydrogen generation kinetics. | PENG Yuanting ZENG Hui SHI Yu XU Jinrong 谢镭 陈均 ZHENG Jie LI Xingguo | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，6： | 0 |
| 5 | 盐摄入通过PPARδ/脂联素介导的SGLT2通路调控糖稳态显示文摘高盐摄入是糖尿病发生高血压的主要危险因素.促进肾脏盐排泄可减少糖尿病的心血管损害,但摄盐与糖稳态的相互作用尚不清楚。 | Yu Zhao Peng Gao Fang Sun Qiang Li Jing Chen Hao Yu Li Li Xing Wei Hongbo He Zongshi Lu Xiao Wei Bin Wang Yuanting Cui Shiqiang Xiong Qianhui Shang Aimin Xu Yu Huang Daoyan Liu 祝之明 | 2017 | 科学新闻2017，19，4： | 0 |
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