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| 1 | Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy. | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 26 |
| 2 | Visualization of CO_2 and oil immiscible and miscible flow processes in porous media using NMR micro-imaging显示文摘CO_2 flooding is considered not only one of the most effective enhanced oil recovery(EOR) methods,but also an important alternative for geological CO_2 storage.In this paper,the visualization of CO_2 flooding was studied using a 400 MHz NMR micro-imaging system.For gaseous CO_2 immiscible displacement,it was found that CO_2 channeling or fingering occurred due to the difference of fluid viscosity and density.Thus,the sweep efficiency was small and the final residual oil saturation was 53.1%.For supercritical CO_2 miscible displacement,the results showed that piston-like displacement occurred,viscous fingering and the gravity override caused by the low viscosity and density of the gas was effectively restrained,and the velocity of CO_2 front was uniform.The sweep efficiency was so high that the final residual oil saturation was 33.9%,which indicated CO_2 miscible displacement could enhance oil recovery more than CO_2 immiscible displacement.In addition,the average velocity of CO_2 front was evaluated through analyzing the oil saturation prof ile.A special core analysis method has been applied to in-situ oil saturation data to directly evaluate the local Darcy phase velocities and capillary dispersion rate. | Zhao Yuechao SongYongchen Liu Yu Jiang Lanlan Zhu Ningjun | 2011 | Petroleum Science2011，8，2： | 9 |
| 3 | A predicted NEDD8 conjugating enzyme gene identified as a Capsicum candidate Rf gene using bulk segregant RNA sequencing显示文摘Cytoplasmic male sterility(CMS)is an important tool for producing F1 hybrids,which can exhibit heterosis.The companion system,restorer-of-fertility(Rf),is poorly understood at the molecular level and would be valuable in producing restorer lines for hybrid seed production.The identity of the Rf gene in Capsicum(pepper)is currently unclear.In this study,using bulked segregant RNA sequencing(BSR-seq),a strong candidate Rf gene,Capana06g002866,which is annotated as a NEDD8 conjugating enzyme E2,was identified.Capana06g002866 has an ORF of 555 bp in length encoding 184 amino acids;it can be cloned from F1 plants from the hybridization of the CMS line 8A and restorer line R1 but is not found in CMS line 8A.With qRT-PCR validation,Capana06g002866 was found to be upregulated in restorer accessions compared to sterile accessions.The relative expression in flower buds increased with the developmental stage in F1 plants,while the expression was very low in all flower bud stages of the CMS lines.These results provide new insights into the Rf gene in pepper and will be useful for other crops utilizing the CMS system. | Bingqiang Wei Paul W.Bosland Zhenghai Zhang Yongfu Wang Gaoyuan Zhang Lanlan Wang Jihua Yu | 2020 | Horticulture Research2020，7，1： | 3 |
| 4 | Construction of trace silver modified core@shell structured Pt-Ni nanoframe@CeO2 for semihydrogenation of phenylacetylene显示文摘The Pt-Ni nanoframe catalysts have attracted great interest owing to their unique electronic structure and excellent catalytic performance. However, the stability of the tenu ous edges of nano frame-structures is dissatisfactory and their un iversal applicati ons in catalytic market beyond electrocatalytic reactions are yet to be tapped and explored. Herein, we developed a new core@ shell structured Pt-Ni nanoframe@CeO2 (Pt-Ni NF@CeO2) composite via etching the Ni from inhomogeneous Pt-Ni rhombic dodecahedra (Pt-Ni RD) by cerium(lll) acetate hydrate (Ce(OAc)3). In this path, Pt-Ni RD was used as self-sacrificial 怕mplate, while the Ce(OAc)3 serves as the provider of the Ce3* source and OH' for the formation of CeO2 shell, etchant of Pt-Ni RD, and the surface modification agent. By this way, the etching of Pt-Ni RD and the formation of the CeO2 shell are simultaneously proceeded to form the final Pt-Ni NF@CeO2 in one step. The obtained Pt-Ni NF@CeO2 exhibits strong in terfacial charge tran sfer interactio n betwee n Pt-Ni NF core and CeO2 shell eve n without reductio n treatment, leading to enhan ced catalytic activity in the hydrogenation of phenylacetylene. After introduction of trace silver, the Pt-Ni-Ag4.9 NF@CeO2 achieves remarkable catalytic performa nee for the selective con versi on of phe ny lacetyle ne to styrene: high con version (100%), styre ne selectivity (86.5%), and good stability. It reveals that enc apsulatio n n oble metal nano frames into metal oxide to form core @ shell structured hybrids will in deed enhance their stability and catalytic properties. Particularly, this work expends the application of noble metal nanoframes materials to hydrogenation reacti ons. | Yan Long Jian Li Lanlan Wu Qishun Wang Yu Liu Xiao Wang Shuyan Song Hongjie Zhang | 2019 | Nano Research2019，12，4： | 3 |
| 5 | C4 Rice-an Ideal Arena for Systems Biology Research显示文摘Engineering the C4 photosynthetic pathway into C3 crops has the potential to dramatically increase the yields of major C3 crops. The genetic control of features involved in C4 photosynthesis are still far from being understood; which partially explains why we have gained little success in C4 engineering thus far. Next generation sequencing techniques and other high throughput technologies are offering an unprecedented opportunity to elucidate the developmental and evolutionary processes of C4 photosynthesis. Two contrasting hypotheses about the evolution of C4 photosynthesis exist, i.e. the master switch hypothesis and the incremental gain hypothesis. These two hypotheses demand two different research strategies to proceed in parallel to maximize the success of C4 engineering. In either case, systems biology research will play pivotal roles in identifying key regulatory elements controlling development of C4 features, identifying essential biochemical and anatomical features required to achieve high photosynthetic efficiency, elucidating genetic mechanisms underlining C4 differentiation and ultimately identifying viable routes to engineer C4 rice. As a highly interdisciplinary project, the C4 rice project will have far-reaching impacts on both basic and applied research related to agriculture in the 21st century. | Xin-Guang Zhu Lanlan Shan Yu Wang William Paul Quick | 2010 | Journal of Integrative Plant Biology2010，52，8： | 2 |
| 6 | Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G). | Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang | 2020 | Science China(Life Sciences)2020，63，9： | 2 |
| 7 | Clay mineral assemblages at IODP Site U1340 in the Bering Sea and their paleoclimatic significance显示文摘在从在 Bering 海的 IODP 地点 1340 的沉积的克莱矿物质集合和 crystallinities 被分析以便跟踪沉积来源并且重建 Bering 海的 paleoclimatic 历史自从上新世最后 4.3 Myr。结果证明在地点 U1340 的泥土矿物质被 illite 统治,与绿土和绿泥石的中等数量,并且次要的 kaolinite。沉积来源研究建议在学习核心的泥土矿物质集合和他们的来源首先被气候条件控制。在温暖的时期期间,泥土矿物质主要从邻近的阿留申群岛之土人岛发源,并且 smectite/illite+chlorite 比率增加了。在冷时期期间,泥土矿物质首先从阿拉斯加人区域被导出,并且 smectite/illite+chlorite 比率减少了。把比率和泥土矿物质 crystallinities 基于 smectite/illite+chlorite,古气候的进化历史在 Bering 海被揭示。一般来说, Bering 海被温暖、湿的气候状况从 4.3 ~ 3.94 Myr,然后从 3.94 ~ 3.6 Myr 与提高的火山作用联系的冷、干燥的状况描绘。此后,气候逐渐地变得冷、湿,然后自从 2.74 Myr,被一个冷、干燥的条件统治,可能由北半球冻结成冰的增强导致了。从 1.95 ~ 1.07 Myr 的间隔是逐渐地变得冷、湿的气候的一个过渡时期。在中间的更新世以后转移 1.07 ~ 0.8 Myr, Bering 海主要被冷、湿的气候分别地在 0.42 妈 MIS 11, 0.33 妈 MIS 9 和 0.12 妈 MIS 5 与温暖的气候的几间隔管理。在最后 9.21 kyr 期间 Holocene, Bering 海首先被相对温暖、湿的气候的条件描绘。 | ZHANG Qiang CHEN MuHong LIU JianGuo YU ZhaoJie ZHANG LanLan XIANG Rong | 2015 | Science China Earth Sciences2015，58，5： | 2 |
| 8 | CHH methylation of genes associated with fatty acid and jasmonate biosynthesis contributes to cold tolerance in autotetraploids of Poncirus trifoliata显示文摘Polyploids have elevated stress tolerance,but the underlying mechanisms remain largely elusive.In this study,we showed that naturally occurring tetraploid plants of trifoliate orange(Poncirus trifoliata(L.) Raf.) exhibited enhanced cold tolerance relative to their diploid progenitors.Transcriptome analysis revealed that whole-genome duplication was associated with higher expression levels of a range of well-characterized cold stress-responsive genes.Global DNA methylation profiling demonstrated that the tetraploids underwent more extensive DNA demethylation in comparison with the diploids under cold stress.CHH methylation in the promoters was associated with up-regulation of related genes,whereas CG,CHG,and CHH methylation in the 3’-regions was relevant to gene down-regulation.Of note,genes involved in unsaturated fatty acids(UFAs) and jasmonate(JA)biosynthesis in the tetraploids displayed different CHH methylation in the gene flanking regions and were prominently up-regulated,consistent with greater accumulation of UFAs and JA when exposed to the cold stress.Collectively,our findings explored the difference in cold stress response between diploids and tetraploids at both transcriptional and epigenetic levels,and gained new insight into the molecular mechanisms underlying enhanced cold tolerance of the tetraploid.These results contribute to uncovering a novel regulatory role of DNA methylation in better cold tolerance of polyploids. | Yue Wang Lanlan Zuo Tonglu Wei Yu Zhang Yang Zhang Ruhong Ming Dahro Bachar Wei Xiao Khan Madiha Chuanwu Chen Qijun Fan Chunlong Li Ji-Hong Liu | 2022 | Journal of Integrative Plant Biology2022，64，12： | 2 |
| 9 | Engineering cobalt sulfide/oxide heterostructure with atomically mixed interfaces for synergistic electrocatalytic water splitting显示文摘It remains challenging to develop economical and bifunctional electrocatalysts toward oxygen/hydrogen evolution reactions(OER/HER).Herein,we construct Co_(9)S_(8) nanoflakes decorated Co_(3)O_(4) nanoarrays with enriched heterogeneous interface zones on Ni foam(Co_(9)S_(8)@CO_(3)O_(4)/NF)via a novel step-wise approach.The Co_(9)S_(8)@Co_(3)O_(4)/NF hybrid manifests excellent performance with low overpotentials of 130 mV for HER(10 mA·cm^(-2))and 331 mV for OER(100 mA·cm^(-2)),delivering a small voltage of 1.52 V for water splitting at 10 mA·cm^(-2) as well as outstanding catalytic durability,which surpasses precious metals and previously reported earth-abundant nanocatalysts.Further experimental and theoretical investigations demonstrate that the excellent performance is attributed to the followings:(i)Highly conductive Ni facilitates the efficient charge transfer;(ii)porous core-shell nanoarchitecture benefits the infiltration and transportation of gases/ions;(iii)heterogeneous interface zones synergistically lower the chemisorption energy of hydrogen/oxygen intermediates.This work will shed light on the controllable synthesis and engineering of heterostructure nanomaterials for clean energy storage and conversion technologies. | Xiaoyang Wang Yu He Xiaopeng Han Jun Zhao Lanlan Li Jinfeng Zhang Cheng Zhong Yida Deng Wenbin Hu | 2022 | Nano Research2022，15，2： | 2 |
| 10 | Experimental Study on Analgesia and Hemostasis of Paris polyphylla,Scutellaria baicalensis and Their Compatibility显示文摘[Objectives]The analgesic and hemostatic effects of Paris polyphylla,Scutellaria baicalensis,and their compatibility were studied.[Methods](i)In the experiment on the writhing of mice induced by acetic acid,60 Kunming SPF mice were randomly selected,and were randomly divided into 6 groups according to the male-to-female ratio of 1∶1,including blank control group,P.polyphylla group,S.baicalensis group,and three P.polyphylla and S.baicalensis compatibility groups(with the ratio of 1∶2,1∶1 and 1∶2).There were 10 mice in each group.In the experimental groups,the mice were given 1 g/mL Chinese medicine extract according to a dose of 20 mL/kg.In the control group,the mice were given 0.9%normal saline in equal volumes.Gavage was performed one time every 24 h and lasted for 14 d.1 h after the gavage on the 14th day,they were given 0.5%glacial acetic acid solution via intraperitoneal injection.(ii)In the hot plate experiment,60 Kunming SPF mice were selected,and the ratio of male to female,grouping,administration and gavage were the same as those of the glacial acetic acid-induced writhing experiment.Gavage was lasted for 14 d.1 h after the gavage on the 14th day,the mice were placed on a hot plate apparatus at(55±0.5)℃,and the time of licking hindfoot was measured.(iii)The hemostatic effect was explored through three experimental methods of tail hemostasis,femoral artery hemostasis and liver hemostasis.60 Kunming SPF mice were taken in each of the three experiments,and the male-female ratio and grouping were the same as above.The powder was covered on the surface of the wound sites,and the bleeding was observed.The hemostatic time was recorded,and the hemostatic time was recorded as 3 min if it exceeded 3 min.[Results](i)In the acetic acid-induced writhing experiment,compared with the blank control group,the pain of mice in the experimental groups was inhibited.Among them,P.polyphylla group,S.baicalensis group,compatibility 1∶2 group,compatibility 1∶1 group,and compatibility 2∶1 group had significant effects(P<0.05),and the inhibition rate of writhing was 20.43%,28.32%,52.30%,32.79%,and 39.02%,respectively.The analgesic effect of the compatibility 1∶2 group was the most obvious.(ii)In the hot plate experiment,compared with the blank control group,the experimental groups had analgesic effect.Among them,P.polyphylla group,S.baicalensis group,compatibility 1∶2 group,compatibility 1∶1 group,and compatibility 2∶1 group had significant effects(P<0.05),and the increase rate of pain threshold was 29.17%,47.83%,61.54%,and 50.61%,and 53.83%,respectively.The analgesic effect of the compatibility 2∶1 group was the most significant.(iii)In the hemostatic experiment,there was a significant difference in hemostatic time between the compatibility 1∶2 group and the blank control group,P.polyphylla group,and S.baicalensis group(P<0.05).The hemostatic effect of the compatibility 1∶2 group was the best.[Conclusions]P.polyphylla,S.baicalensis,and its compatibility had good analgesic and hemostatic effects,and the best compatibility ratio was 1∶2. | Shibo ZHAO Suoyi HUANG Zhenjing SI Lanlan GAN Shusheng HUANG Ye FU Jianjie LAN Xueying YU Yuekong CEN | 2020 | Medicinal Plant2020，11，2： | 2 |
| 11 | Phosphorylation of Histone H3 is Required for proper chromosome condensation and segregations显示文摘 | Yi Wei Lanlan Yu Josephine Bowen | 1999 | Cell1999，97，： | 1 |
| 12 | Genotoxic and inflammatory effects of organic extracts from traffic-related particulate matter in human lung epithelial A549 cells: The role of quinones显示文摘 | Yu Shang Lanlan Fan Jialiang Feng Senlin Lv Minghong Wu Bing Li Yuan-Sheng Zang | 2013 | Toxicology in Vitro2013，，2： | 1 |
| 13 | Simultaneous determination of chloramphenicol, florfenicol and florfenicol amine in ham sausage with a hybrid chemiluminescent immunoassay显示文摘 | Xiaoqi Tao Haiyang Jiang Xuezhi Yu Jinghui Zhu Xia Wang Zhanhui Wang Lanlan Niu Xiaoping Wu Jianzhong Shen | 2013 | Food Additives & Contaminants: Part A2013，，5： | 1 |
| 14 | An e?ective approach for the immobilization of chiral Mn(Ⅲ)salen complexes through a supported ionic liquid phase显示文摘 | Lou Lanlan Yu Kai Ding Fei | 2006 | Tetrahedron Letters2006，47，： | 1 |
| 15 | Cryoablation Combined with TACE for Treating Large Hepatocellular Carcinoma: Tumor Load and Cellular Immunity显示文摘 | Haipeng Yu Lanlan Yang Zhi Guo Wenge Xin Fang Liu Xiuying Guo Baoguo Li | 2005 | Chinese Journal of Clinical Oncology2005，2，6： | 1 |
| 16 | Variations of temperature, precipitation, and extreme events in Heilongjiang River 显示文摘 | Yu Lanlan Xia Ziqiang Cai Tao | 2012 | ProeediaEngineering2012，28，： | 1 |
| 17 | Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects显示文摘Tumor drug resistance and systemic side effects of chemotherapeutic drugs are the main reasons for the failure of cancer treatment.In recent years,it was found that some natural active ingredients can reverse MDR and regulate body immunity to enhance the efficacy and reduce toxicity of chemotherapeutic drugs.In this paper,a new nanosuspensions,HCPT and QUR hybrid nanosuspensions(HQ-NPs),was prepared by the microprecipitation-high pressure homogenization method to reverse tumor drug resistance,reduce toxicity,and increase therapeutic efficacy.The in vitro investigation results showed that HQ-NPs had a unique shape(particle size was about 216.3±5.9 nm),changed crystalline,and different dissolution rates compared with HCPT-NPs and QUR-NPs,which is attributed to the strong intermolecular forces between HCPT and QUR as indicated by the results of the molecule dock.It was verified that the HQ-NPs could double the retention of HCPT in cells and enhance the cytotoxicity to A549/PTX cells in vitro tests compared with HCPT-NPs.We also found that HQ-NPs can significantly enhance the accumulation of HCPT in tumor sites,improve the antitumor activity of HCPT,and protect the immune organs and other normal tissues(P<0.01),compared with HCPT-NPs.Therefore,hybrid nanosuspensions can offer promising potential as the drug delivery system for HCPT and QUR to increase the therapeutic efficacy and reduce the toxicity of HCPT. | Yonghui Qiao Zhihao Wei Tingting Qin Rufeng Song Zhiqiang Yu Qi Yuan Juan Du Qingbing Zeng Lanlan Zong Shaofeng Duan Xiaohui Pu | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 18 | Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy显示文摘为功能的肽的设计和优化, unravelling 单个积木的结构以及整体的性质是首要的。TTR1,源于人的 transthyretin,形成纤丝的肽在象家庭淀粉的 polyneuropathy 和老年的全身的淀粉样变性病那样的疾病被含有。基于 TTR1 脚手架,功能的肽 TTR1-RGD 被设计明确地与房间交往。这里,我们过去常扫描通道显微镜学(STM ) 与反向的顺序和修改前面的顺序分析 TTR1 相关的肽的集会结构。sitespecific 分析显示出下列:我) TTR1 肽涉及汇编,将近在订的表以内盖住全部长度组织。ii ) 为 TTR1-RGD 肽集会,当 RGDS 主题采用允许它支持房间粘附的灵活符合构造时, TTR1 主题形成订的表。关键地点清楚地作为连接器残余 Gly13 被识别。iii ) 尽管有在化学的差别,他们显示类似的集合的前面、反向的肽集会表演的仔细的检查特征,说明这些肽的柔韧的性质。iv ) Glycine 连接器残余在强烈建议顺序能被增加更多的连接器残余优化的 -strands, 被包括。进这些肽的装配结构的这些积累的卓见帮助解开驾驶肽集会的机制并且在新窗户中指示 sequenceprogrammed 肽 architectures.Open | Lanlan Yu Yongfang Zheng JingXu Fuyang Qu Yuchen Lin Yimin Zou Yanlian Yang Sally L. Gras Chen Wang | 2018 | Nano Research2018，11，1： | 1 |
| 19 | 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection显示文摘 | Wang, Song Luo, Xiaoqin Yan, Ruoxiang Wang, Quanxin Qi, Qiuyue Chi, Xiaojuan Zhang, Lanlan Yu, Ziding Cai, Binxiang Chen, Ji-Long Liu, Hongwei | 2016 | Protein & Cell2016，7，11： | 1 |
| 20 | Okra‑Like Multichannel TiO@NC Fibers Membrane with Spatial and Chemical Restriction on Shuttle‑Effect for Lithium–Sulfur Batteries显示文摘It is especially important to coordinately design the structure and composition of the host in lithium–sulfur batteries(LSBs)for improving its physicochemical adsorption and conversion of lithium polysulfide,which can alleviate the harmful shuttle effect.Herein,a self-supporting multichannel nitrogen-doped carbon fibers membrane embedded with TiO nanoparticles(TiO@NC)was constructed as the electrode for LSBs.The inner channels and the embedded TiO nanoparticles offer spatial confinement and chemical binding for polysulfides,respectively.Moreover,the TiO nanoparticles have abundant oxygen vacancies that promote the conversion of polysulfides.In addition,the nitrogen-doped carbon skeleton can not only serve as highly conductive transportation paths for electrons,but also integrate with the inner channels to sustain the morphology and bear volume expansion during cycling processes.Therefore,the fabricated self-supporting quadruple-channel TiO@NC ultrathin fibers electrode exhibits a high initial specific capacity of 1342.8 mAh g^(-1)at 0.5 C and high-rate capability of 505.8 mAh g^(-1)at 4.0 C.In addition,it maintains 696.0 mAh g^(-1)over 500 cycles with only 0.059%capacity decay per cycle at the high current density of 2.0 C.The multichannel configuration combined with TiO nanoparticles provides a synergetic design strategy for fabricating high-performance electrodes in LSBs. | Shuai Li Jingchong Liu Linlin Ma Li‑Juan Yu Lanlan Hou Dianming Li Songwei Gao Guichu Yue Zhimin Cui NüWang Xiaoxian Zhao Yong Zhao | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
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