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| 1 | Honeysuckle-encoded atypical microRNA2911 directly Largets influenza A viruses显示文摘 | Zhen Zhou Xihan Li Jinxiong Liu Lei Dong Qun Chen Jialing Liu Huihui Kongt Qianyi Zhang Xian Qi Dongxia Hou Lin Zhang Guoquan Zhang Yuchen Liu Yujing Zhang Jing Li Jin Wang Xi Chen Hua Wang Junfeng Zhang Hualan Chen Ke Zen Chen-Yu Zhang | 2015 | Cell Research2015，25，1： | 104 |
| 2 | Engineering osteoarthritic cartilage model through differentiating senescent human mesenchymal stem cells for testing disease-modifying drugs显示文摘Significant cellular senescence has been observed in cartilage harvested from patients with osteoarthritis(OA).In this study,we aim to develop a senescence-relevant OA-like cartilage model for developing disease-modifying OA drugs(DMOADs).Spe-cifically,human bone marrow-derived mesenchymal stromal cells(MSCs)were expanded in vitro up to passage 10(P10-MSCs).Following their senescent phenotype formation,P10-MSCs were subjected to pellet culture in chondrogenic medium.Results from qRT-PCR,histology,and immunostaining indicated that cartilage generated from P10-MSCs displayed both senescent and OA-like phenotypes without using other OA-inducing agents,when compared to that from normal passage 4(P4)-MSCs.Interestingly,the same gene expression differences observed between P4-MSCs and P10-MSC-derived cartilage tissues were also observed between the preserved and damaged OA cartilage regions taken from human samples,as demonstrated by RNA sequencing data and other analysis methods.Lastly,the utility of this senescence-initiated OA-like cartilage model in drug development was assessed by testing several potential DMOADs and senolytics.The results suggest that pre-existing cellular senescence can induce the generation of OA-like changes in cartilage.The P4-and P10-MSCs derived cartilage models also represent a novel platform for predicting the efficacy and toxicity of potential DMOADs on both preserved and damaged cartilage in humans. | Ning Wang Yuchen He Silvia Liu Meagan J.Makarcyzk Guanghua Lei Alexander Chang Peter G Alexander Tingjun Hao Anne-Marie Padget Nuria de Pedro Tsapekos Menelaos Hang Lin | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 3 | Inducing Flow Velocities to Manage Fish Reproduction in Regulated Rivers显示文摘Conservation of endangered or economic fish and control of invasive fish is a great challenge of hydraulic engineering worldwide.Flow velocity has been recognized to affect the spawning of fishes delivering drifting eggs in rivers.However,solid scientific supports and associated mechanisms to establish quantitative relations between flow velocity and fish reproduction,taking into account spawning,fertilizing,hatching,as well as surviving,are lacking.In this paper,we quantified the relationship between flow velocity and reproduction of Chinese carps through both lab and field experiments.The results showed that a minimum velocity was required to trigger Hypophthalmichthys molitrix(H.molitrix)releasing eggs,and a velocity range was preferred to sustain spawning activity.However,the embryo incubation and larvae development of H.molitrix were found to be inhibited with the increase in flow velocity.Considering the requirements of spawning and hatching,as well as larvae surviving,an optimized flow velocity processes was identified for the reproduction of H.molitrix in rivers.These findings were of great significance to the adaptive operation of reservoirs to create reasonable and precise ecological flows for managing fish reproduction,as shown by the promising results in the engineering application to the Three Gorges Reservoir. | Qiuwen Chen Jianyun Zhang Yuchen Chen Kangle Mo Jun Wang Lei Tang Yuqing Lin Lei Chen Yong Gao Wei Jiang Yuxin Zhang | 2021 | Engineering2021，7，2： | 4 |
| 4 | Analog Optical Computing for Artificial Intelligence显示文摘The rapid development of artificial intelligence(AI)facilitates various applications from all areas but also poses great challenges in its hardware implementation in terms of speed and energy because of the explosive growth of data.Optical computing provides a distinctive perspective to address this bottleneck by harnessing the unique properties of photons including broad bandwidth,low latency,and high energy efficiency.In this review,we introduce the latest developments of optical computing for different AI models,including feedforward neural networks,reservoir computing,and spiking neural networks(SNNs).Recent progress in integrated photonic devices,combined with the rise of AI,provides a great opportunity for the renaissance of optical computing in practical applications.This effort requires multidisciplinary efforts from a broad community.This review provides an overview of the state-of-the-art accomplishments in recent years,discusses the availability of current technologies,and points out various remaining challenges in different aspects to push the frontier.We anticipate that the era of large-scale integrated photonics processors will soon arrive for practical AI applications in the form of hybrid optoelectronic frameworks. | Jiamin Wu Xing Lin Yuchen Guo Junwei Liu Lu Fang Shuming Jiao Qionghai Dai | 2022 | Engineering2022，8，3： | 4 |
| 5 | Field Day Revisited (H): An Interview with Declan Kilberd显示文摘 | YUCHEN LIN | 2007 | Concentric: Literary and Cultural Studies2007，33，2： | 1 |
| 6 | Sytbetic Tet- inducible artificial microRNAs targeting 13-catenin or HIF-lc inhibit malignant phenotypes of bladder cancer cells T24 and 5637显示文摘 | Zhan Yonghao Liu Yuchen Lin Junhao | 2015 | Sci Rep2015，5，16： | 1 |
| 7 | Site-specific determination of TTR-related functional peptides by using scanning tunneling microscopy显示文摘为功能的肽的设计和优化, unravelling 单个积木的结构以及整体的性质是首要的。TTR1,源于人的 transthyretin,形成纤丝的肽在象家庭淀粉的 polyneuropathy 和老年的全身的淀粉样变性病那样的疾病被含有。基于 TTR1 脚手架,功能的肽 TTR1-RGD 被设计明确地与房间交往。这里,我们过去常扫描通道显微镜学(STM ) 与反向的顺序和修改前面的顺序分析 TTR1 相关的肽的集会结构。sitespecific 分析显示出下列:我) TTR1 肽涉及汇编,将近在订的表以内盖住全部长度组织。ii ) 为 TTR1-RGD 肽集会,当 RGDS 主题采用允许它支持房间粘附的灵活符合构造时, TTR1 主题形成订的表。关键地点清楚地作为连接器残余 Gly13 被识别。iii ) 尽管有在化学的差别,他们显示类似的集合的前面、反向的肽集会表演的仔细的检查特征,说明这些肽的柔韧的性质。iv ) Glycine 连接器残余在强烈建议顺序能被增加更多的连接器残余优化的 -strands, 被包括。进这些肽的装配结构的这些积累的卓见帮助解开驾驶肽集会的机制并且在新窗户中指示 sequenceprogrammed 肽 architectures.Open | Lanlan Yu Yongfang Zheng JingXu Fuyang Qu Yuchen Lin Yimin Zou Yanlian Yang Sally L. Gras Chen Wang | 2018 | Nano Research2018，11，1： | 1 |
| 8 | A Fast and Secure Image Hiding Scheme Based on LSB Substitution显示文摘 | Chang Chin-Chen Lin Minhui Hu Yuchen | 2002 | International Journal of Pattern Recognition and Artificial Intelligence2002，16，4： | 1 |
| 9 | Pharmaceutical contamination in residential, industrial, and agricultural waste streams: risk to aqueous environments in Taiwan 显示文摘 | LIN Yuchen YU Tsunghsien LIN Chengfang | 2008 | Chemosphere2008，74，1： | 1 |
| 10 | Application of grey relational analysis to evaluating shopping mall in Taiwan显示文摘 | Tu Yuchen Lin Chintsai | 2001 | The Journal of Grey System2001，13，4： | 1 |
| 11 | Isolation, biosynthesis, and biological activity of rubromycins derived from actinomycetes显示文摘Natural occurring aromatic polyketides from actinomycetes indicate a structurally and functionally diverse fam-ily of polycyclic polyphenols.Some of them are consequently suggested as lead structures for drug development.Among them,rubromycins are derived from a single C26 polyketide chain and exhibit an unusual bisbenzannu-lated[5,6]-spiroketal system that connects a highly oxygenated naphthazarin motif to an isocoumarin unit.This type of biosynthetically elusive polycyclic polyketides has shown promising pharmacological activities,includ-ing antimicrobial,anticancer,and enzyme inhibition activity.The unique structures,intriguing biosynthesis,and marked bioactivities of rubromycins have drawn considerable attention from several chemists and biologists.This review covers the isolation,characterization,biosynthesis,and biological studies of these structurally diverse and complex rubromycins. | Ping Lin Xue Li Yuchen Xin Hongying Li Gang Li Hongxiang Lou | 2022 | Engineering Microbiology2022，2，3： | 1 |
| 12 | A novel color image hid- ing scheme using block truncation coding显示文摘 | Hu Yuchen Lin Minhui Jiang Jihan | 2006 | Fundamenta Infor- maticae2006，70，4： | 1 |
| 13 | Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function显示文摘Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment. | Zhen Xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu Siyi Xu Tianbin Chen Jing Chen Qishui Ou | 2021 | Cellular & Molecular Immunology2021，18，2： | 1 |
| 14 | Advanced glycation end products increase carbohydrate responsive element binding protein expression and promote cancer cell proliferation显示文摘 | Hanbei Chen Lifang Wu Yakui Li Jian Meng Ning Lin Dianqiang Yang Yemin Zhu Xiaoyong Li Minle Li Ye Xu Yuchen Wu Xuemei Tong Qing Su | 2014 | 2014 (1-2)2014，，1： | 1 |
| 15 | Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine显示文摘Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based on the findings that ESCs possess globular mitochondria with blurred cristae,and the facts that ESCs have higher glycolysis activity and lower mitochondrial respiration capacity than somatic cells(Kondoh et al.,2007;Folmes et al.,2011,2012;Zhang et al.,2012;Xu et al.,2013;Ito and Suda,2014;Gu et al.,2016).However,recent studies have shown that mitochondrial autophagy and mitochondrial dynamics are pivotal for ESC self-renewal and pluripotency(Todd et al.,2010;Liu et al.,2016,2020;Wang et al.,2019;Zhong et al.,2019).These studies have raised a fundamental question:what is the contribution and functional mechanism of mitochondrial respiration in pluripotency regulation? | Jiani Cao Meng Li Kun Liu Xingxing Shi Ning Sui Yuchen Yao Xiaojing Wang Shiyu Li Yuchang Tian Shaojing Tan Qian Zhao Liang Wang Xiahua Chai Lin Zhang Chong Liu Xing Li Zhijie Chang Dong Li Tongbiao Zhao | 2023 | Protein & Cell2023，14，5： | 1 |
| 16 | A new strategy for fabrication of unique heterostructured titanium laminates and visually tracking their synchronous evolution of strain partitions versus microstructure显示文摘Heterostructured(HS)material with extraordinary mechanical properties has been regarded as one of the most promising structural materials.Here,we reported a new strategy for preparing heterostructured pure titanium laminates that possess a good combination of strength and ductility by combining gradient structure(GS)and heterogeneous lamella structure(HLS).The deformation characteristic versus microstructure evolution of GS/HLS titanium laminates,namely the strain partitions between different-sized grains(480–25μm)was visualized using a scanning electron microscope(SEM)equipped with electron backscattered diffraction(EBSD)mode combined with the digital image correlation(SEM-DIC)with an ultrahigh spatial resolution for the first time.As a result,the hetero-deformation of unique GS/HLS structure by the characteristic of strain partitions could be accurately captured.While the hetero-deformation could result in the hetero-deformation induced(HDI)stress strengthening and HDI hardening,which were regarded as the key reason that the resulting GS/HLS Ti laminates showed a superior combination of strength and ductility.This could promote a more in-depth understanding of the strengtheningtoughening mechanism of heterostructured material. | Hao Ding Xiping Cui Zhiqi Wang Tao Zhao Yuchen Wang Yuanyuan Zhang Hongtao Chen Lujun Huang Lin Geng Junfeng Chen | 2022 | Journal of Materials Science & Technology2022，，12： | 1 |
| 17 | Allosteric Modulation of Human Serum Albumin Induced by Peptide Ligand显示文摘 | Jingfei Hou Jiaxi Peng Yue Yu Yuchen Lin Changliang Liu Hongyang Duan Yanlian Yang Chen Wang | 2017 | Chinese Journal of Chemistry2017，35，8： | 1 |
| 18 | Catalyst for Increasing Ethylene and Propylene Production and Its Industrial Application in a Catalytic Pyrolysis Unit显示文摘Light olefins,particularly ethylene and propylene,are the most important building blocks for the petrochemical industry,and demand for their production has been increasing.The catalytic pyrolysis process(CPP)and the corresponding catalyst,developed by SINOPEC Research Institute of Petroleum Processing Co.,Ltd.,are designed to maximize the light olefin yield from catalytic cracking of heavy feedstocks.However,owing to the continuing degradation of feedstocks,the original catalyst can no longer maintain its activity.Herein,we describe the rational design of the new catalyst,Epylene,from a new metal-modified hierarchical ZSM-5 zeolite and matrix.Epylene was tested in the CPP unit of Shaanxi Yanchang Coal Yulin Energy and Chemical Company.A test run and base run were conducted to demonstrate the better performance of Epylene compared with the original catalyst.The properties of the feedstocks and the operating conditions in both runs were similar.The light olefin yield was increased from 33.95%to 36.50%and the coke yield was only 9.58%in the test run,which was lower than that in the base run. | Sha Yuchen Wang Peng Ouyang Ying Zhu Genquan Lu Lijun Song Haitao Lin Wei Luo Yibin | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，2： | 1 |
| 19 | Field Day Revisited (I): An Interview with Seamus Deane 显示文摘 | YUCHEN LIN | 2007 | Concentric: Literary and Cultural Studies2007，33，1： | 1 |
| 20 | Understand the Particularity of Graduates and Do a Good Job in Higher Vocational Employment Service显示文摘At present,higher vocational college graduates are facing the serious situation of high competitiveness and difficult employment.How to strengthen higher vocational employment is the key issue in the development of higher vocational education.This paper discusses the particularity of higher vocational graduates and the work content of graduation counselors,so as to do a good job in higher vocational employment service. | LIN Yuchen | 2021 | Psychology Research2021，11，9： | 0 |
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