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| 1 | Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures显示文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures. | Yu Jin Kim Dong Hyun Sinn Geum-Youn Gwak Moon Seok Choi Kwang Cheol Koh Seung Woon Paik Byung Chul Yoo Joon Hyeok Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 16 |
| 2 | Hepatic artery pseudoaneurysm caused by acute idiopathic pancreatitis显示文摘Hepatic artery pseudoaneurysm(HAP) is a very rare disease but in cases of complication,there is a very high mortality.The most common cause of HAP is iatrogenic trauma such as liver biopsy,transhepatic biliary drainage,cholecystectomy and hepatectomy.HAP may also occur with complications such as infections or inflammation associated with septic emboli.HAP has been reported rarely in patients with acute pancreatitis.As far as we are aware,there is no report of a case caused by acute idiopathic pancreatitis,particularly.We report a case of HAP caused by acute idiopathic pancreatitis which developed in a 61-year-old woman.The woman initially presented with acute pancreatitis due to unknown cause.After conservative management,her symptoms seemed to have improved.But eight days after admission,abdominal pain abruptly became worse again.Abdominal computed tomography(CT) was rechecked and it detected a new HAP that was not seen in a previous abdominal CT.Endoscopic retrograde cholangiopancreatography(ERCP) was performed because of a suspicion of hemobilia as a cause of aggravated abdominal pain.ERCP confirmed hemobilia by observing fresh blood clots at the opening of the ampulla and several filling defects in the distal common bile duct on cholangiogram.Without any particular treatment such as embolization or surgical ligation,HAP thrombosed spontaneously.Three months after discharge,abdominal CT demonstrated that HAP in the left lateral segment had disappeared. | Yeon Hwa Yu Joo Hyun Sohn Tae Yeob Kim Jae Yoon Jeong Dong Soo Han Yong Cheol Jeon Min Young Kim | 2012 | World Journal of Gastroenterology2012，18，18： | 8 |
| 3 | One-year clinical outcomes in invasive treatment strategies for acute ST-elevation myocardial infarction complicated by cardiogenic shock in eld-erly patients显示文摘Objective To investigate the clinical outcomes of an invasive strategy for elderly (aged≥75 years) patients with acute ST-segment elevation myocardial infarction (STEMI) complicated by cardiogenic shock (CS). Methods Data on 366 of 409 elderly CS patients from a total of 6,132 acute STEMI cases enrolled in the Korea Acute Myocardial Infarction Registry between January 2008 and June 2011, were collected and analyzed. In-hospital deaths and the 1-month and 1-year survival rates free from major adverse cardiac events (MACE;defined as all cause death, myocardial infarction, and target vessel revascularization) were reported for the patients who had undergone invasive (n=310) and conservative (n=56) treatment strategies. Results The baseline clinical characteristics were not significantly different between the two groups. There were fewer in-hospital deaths in the invasive treatment strategy group (23.5%vs. 46.4%, P<0.001). In addition, the 1-year MACE-free survival rate after invasive treatment was significantly lower compared with the conservative treatment (51%vs. 66%, P=0.001). Conclusions In elderly patients with acute STEMI complicated by CS, the outcomes of invasive strategy are similar to those in younger patients at the 1-year follow-up. | Yeon Pyo Yoo Ki-Woon Kang Hyeon Soo Yoon Jin Cheol Myung Yu Jeong Choi Won Ho Kim Sang Hyun Park Kyung Tae Jung Myung Ho Jeong | 2013 | Journal of Geriatric Cardiology2013，10，3： | 7 |
| 4 | Hepatobiliary scintigraphy for detecting biliary strictures after living donor liver transplantation显示文摘AIM:To investigate the diagnostic accuracy of hepatobiliary scintigraphy(HBS) in detecting biliary strictures in living donor liver transplantation(LDLT) patients.METHODS:We retrospectively reviewed 104 adult LDLT recipients of the right hepatic lobe with duct-toduct anastomosis,who underwent HBS and cholangiography.The HBS results were categorized as normal,parenchymal dysfunction,biliary obstruction,or bile leakage without re-interpretation.The presence of biliary strictures was determined by percutaneous cholangiography or endoscopic retrograde cholangiopancreatography(ERCP).RESULTS:In 89 patients with biliary strictures,HBS showed biliary obstruction in 50 and no obstruction in 39,for a sensitivity of 56.2%.Of 15 patients with no biliary strictures,HBS showed no obstruction in 11,for a specificity of 73.3%.The positive predictive value(PPV) was 92.6%(50/54) and the negative predictive value(NPV) was 22%(11/50).We also analyzed the diagnostic accuracy of the change in bile duct size.The sensitivity,NPV,specificity,and PPV were 65.2%,27.9%,80% and 95%,respectively.CONCLUSION:The absence of biliary obstruction on HBS is not reliable.Thus,when post-LDLT biliary strictures are suspected,early ERCP may be considered. | Yu Jin Kim Kyu Taek Lee Young Cheol Jo Kwang Hyuck Lee Jong Kyun Lee Jae-Won Joh Choon Hyuck David Kwon | 2011 | World Journal of Gastroenterology2011，17，21： | 6 |
| 5 | 韩国中年男性血清25-羟维生素D水平与皋酮缺乏:一项横向研究显示文摘原先的研究证明,男性性腺机能减退与维生素D低水平有关。然而,有关韩国男性维生素D对睾酮水平影响的研究尚未见报道。本研究的目的在于探讨睾酮的水平是否与血清维生素D水平相关,以及是否存在季节性变化。本横向研究分析了652名40岁以上韩国男性的血清25.羟维生素D[25(OH)D]、总睾酮(TT)以及游离睾酮(FT)水平。这些男性都经过了全面的体检。受试者的平均年龄56.7±7.9岁,平均血清血25.羟维生素D、总睾酮以及游离睾酮水平分别为21.23±7.9ngml-1,4.70±1.6ngml-1和8.12±3.3pgml-1。在多元线性回归模型,25.羟维生素D与总睾酮水平(B=O.137,P〈O.001)以及游离睾酮水平(B=0.103,P=O.008)呈现正相关。在调整了年龄因素之后,25.羟维生素D与游离睾酮水平之间呈现相似的季节性变化或月变化。在调整了年龄、季节、体重指数、身体成分、慢性疾病、吸烟以及饮酒等因素之后,维生素D缺乏[25(OH)D〈20ngml-1]与总睾酮水平缺乏(〈2.30ngml-1)的风险增高(风险率[OR]:2.65;95%可信区间:1.21—5.78,P=0.014)以及游离睾酮水平缺乏(〈6.50Pgml-1)的风险增高(OR:1.44;95%可信区间:1.01-2.06,P=O.048)相关。综上所述,我们证明了韩国男性血清25.羟维生素D与睾酮水平之间的正相关,并呈现季节性波动。 | Young Jin Tak Jeong Gyu Lee Yun Jin Kim Nam Cheol Park Sang Soo Kim Sangyeoup Lee Byung Mann Cho Eun Hee Kong Dong Wook Jung Yu Hyeon Yi | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 6 | Effect of two different doses of intravitreal bevacizumab with temporal retina-sparing laser photocoagulation for retinopathy of prematurity显示文摘This study aims to compare the efficacy and safety between two different doses of intravitreal bevacizumab(IVB) injection with temporal retina-sparing laser(TRSL) photocoagulation for retinopathy of prematurity(ROP). We retrospectively evaluated 22 eyes of ROP infants who underwent IVB combined with partial TRSL for stage 3+ zone I or posterior zone II ROP. Laser photocoagulation was applied on the avascular retina, sparing two-discdiameter width temporal avascular area anterior to ridge. A half dose(0.625 mg) or minimal dose(0.25 mg) of IVB was conducted. Four eyes in minimal dose group were retreated with IVB and laser photocoagulation on the spared retina. Of those 4 retreated eyes, three developed preretinal hemorrhage around the ridge after the first treatment, resulting in fibrotic macular dragging. A half dose of IVB may be more effective than a minimal dose with partial TRSL for ROP. Preretinal hemorrhage may be a harbinger of poor prognosis. | A Young Choi Hochan Cho Yu Cheol Kim | 2018 | International Journal of Ophthalmology(English edition)2018，11，1： | 3 |
| 7 | 降低早产儿视网膜病变的氧饱和度对新生儿呼吸窘迫综合征的影响(英文)显示文摘目的:研究降低早产儿视网膜病变( ROP)的氧饱和度及其危险因素对呼吸窘迫综合症( RDS)的影响。 方法:回顾性分析2009-01/2012-12期间确诊为呼吸窘迫综合症的早产儿( N=252)的医疗记录。根据氧饱和度范围将患者分为高饱和度组(90%-97%; n=116)和低饱和度组(85%-93%, n=136)。并对早产儿视网膜病变的严重程度及其相关参数进行评估。 结果:早产儿视网膜病变的发生率,激光治疗的需求和进展性早产儿视网膜病变比例两组无显著差异,但低饱和度组存活率较高(P=0.005)。早产儿患者在恒温箱内多护理1 d患视网膜病变几率减少1.041倍( OR=1.041;95%CI=1.003-2.275; P=0.002),而5 min内Apgar评分每多1分患病可能性降低24.7%( OR=0.753;95% CI=0.152-0.965;P=0.033)。 结论:85%-93%的氧饱和度可提高早产儿存活率,且不影响早产儿视网膜病变伴随呼吸窘迫综合症的发生。相关风险因素与恒温箱内护理的持续时间和5 min内Apgar评分的情况有关。 | Youhyun Lee Sanglak Lee Yu Cheol Kim | 2016 | 国际眼科杂志2016，16，11： | 3 |
| 8 | Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial显示文摘 | Sung Hoon Noh Sook Ryun Park Han-Kwang Yang Hyun Cheol Chung Ik-Joo Chung Sang-Woon Kim Hyung-Ho Kim Jin-Hyuk Choi Hoon-Kyo Kim Wansik Yu Jong Inn Lee Dong Bok Shin Jiafu Ji Jen-Shi Chen Yunni Lim Stella Ha Yung-Jue Bang | 2014 | Lancet Oncology2014，，12： | 3 |
| 9 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 10 | Usefulness of continuous renal replacement therapy for correcting hypernatremia in a patient with severe congestive heart failure显示文摘 | Hoon Suk Park Yu Ah Hong Hyun Gyung Kim Sun Ryoung Choi In O. Sun Byung Ha Chung Cheol Whee Park Chul Woo Yang Yong Soo Kim Bum Soon Choi | 2012 | Hemodial Int2012，，4： | 1 |
| 11 | Seroprevalence of anti-HAV among patients with chronic viral liver disease显示文摘AIM:To investigate the current seroprevalence of hepatitis A virus(HAV) antibodies in patients with chronic viral liver disease in Korea.We also tried to identify the factors affecting the prevalence of HAV antibodies. METHODS:We performed an analysis of the clinical records of 986 patients(mean age:49±9 years,714 males/272 females) with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection who had undergone HAV antibody testing between January 2008 and December 2009.RESULTS:The overall prevalence of IgG anti-HAV was 86.61%(854/986) in patients with chronic liver disease and was 88.13%(869/986) in age-and gendermatched patients from the Center for Health Promotion.The anti-HAV prevalence was 80.04%(405/506) in patients with chronic hepatitis B,86.96%(20/23) in patients with chronic hepatitis C,93.78%(422/450) in patients with HBV related liver cirrhosis,and 100%(7/7) in patients with HCV related liver cirrhosis.The anti-HAV prevalence according to the decade of age was as follows:20s(6.67%) ,30s(50.86%) ,40s(92.29%) ,50s(97.77%) ,and 60s(100%) .The antiHAV prevalence was significantly higher in patients older than 40 years compared with that in patients younger than 40 years of age.Multivariable analysis showed that age≥40 years,female gender and metropolitan cities as the place of residence were independent risk factors for IgG anti-HAV seropositivity. CONCLUSION:Most Korean patients with chronic liver disease and who are above 40 years of age have already been exposed to hepatitis A virus. | Hyun Chin Cho Seung Woon Paik Yu Jin Kim Moon Seok Choi Joon Hyeok Lee Kwang Cheol Koh Byung Chul Yoo Hee Jung Son Seon Woo Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 1 |
| 12 | Ischemic Postconditioning During Primary Percutaneous Coronary Intervention: The Effects of Postconditioning on Myocardial Reperfusion in Patients With ST-Segment Elevation Myocardial Infarction (POST) Randomized Trial显示文摘 | Joo-Yong Hahn Young Bin Song Eun Kyoung Kim Cheol Woong Yu Jang-Whan Bae Woo-Young Chung Seung-Hyuk Choi Jin-Ho Choi Jang-Ho Bae Kyung Joo An Jong-Seon Park Ju Hyeon Oh Sang-Wook Kim Jin-Yong Hwang Jae Kean Ryu Hun Sik Park Do-Sun Lim Hyeon-Cheol Gwon | 2013 | Circulation2013，，17： | 1 |
| 13 | Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses显示文摘 | Yanyan Yang Seung Cheol Kim Tao Yu Young-Su Yi Man Hee Rhee Gi-Ho Sung Byong Chul Yoo Jae Youl Cho Pham My-Chan Dang | 2014 | Mediators of Inflammation2014，，： | 1 |
| 14 | Aberrant CpG island methylation in early-onset sporadic gastric carcinoma显示文摘 | Hee Cheol Kim Jin Cheon Kim Sun Ae Roh Chang Sik Yu Jeong Hwan Yook Sung Tae Oh Byung Sik Kim Kun Choon Park Rin Chang | 2005 | Journal of Cancer Research and Clinical Oncology2005，，11： | 1 |
| 15 | Effect of Adjuvant Radiotherapy on Local Recurrence in Stage II Rectal Cancer显示文摘 | In Ja Park MD PhD Hee Cheol Kim MD PhD Chang Sik Yu MD PhD Tae Won Kim MD PhD Se Jin Jang MD PhD Jin Cheon Kim MD PhD | 2008 | Annals of Surgical Oncology2008，，2： | 1 |
| 16 | Assessment of posterior vitreous detachment on enhanced high density line optical coherence tomography显示文摘Dear Editor,The state of the vitreo-retinal interface affects various retinal diseases,and the presence or absence of a posterior vitreous detachment(PVD)is one of the most important factors^([1-5]).As such,various studies studying PVD in relation to retinal disease have been performed^([1-5]). | Yu Cheol Kim Mariana Harasawa Frank S Siringo Hugo Quiroz-Mercado | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 1 |
| 17 | Efficacy of veno-arterial extracorporeal membrane oxygenation in acute myocardial infarction with cardiogenic shock显示文摘 | Hyungtae Kim Sang-Hyun Lim Joonhwa Hong You-Sun Hong Cheol Joo Lee Joon-Ho Jung Saehwan Yu | 2012 | Resuscitation2012，，： | 1 |
| 18 | Risk Factors and Oncologic Impact of Anastomotic Leakage after Rectal Cancer Surgery显示文摘 | Sang Hun Jung M.D. Chang Sik Yu M.D. Pyong Wha Choi M.D. Dae Dong Kim M.D. In Ja Park M.D. Hee Cheol Kim M.D. Jin Cheon Kim M.D | 2008 | Diseases of the Colon & Rectum2008，，6： | 1 |
| 19 | Risk Factors and Oncologic Impact of Anastomotic Leakage after Rectal Cancer Surgery显示文摘 | Sang Hun Jung M.D. Chang Sik Yu M.D. Pyong Wha Choi M.D. Dae Dong Kim M.D. In Ja Park M.D. Hee Cheol Kim M.D. Jin Cheon Kim M.D | 2008 | Diseases of the Colon & Rectum2008，，6： | 1 |
| 20 | Risk Factors and Oncologic Impact of Anastomotic Leakage after Rectal Cancer Surgery显示文摘 | Sang Hun Jung M.D. Chang Sik Yu M.D. Pyong Wha Choi M.D. Dae Dong Kim M.D. In Ja Park M.D. Hee Cheol Kim M.D. Jin Cheon Kim M.D | 2008 | Diseases of the Colon & Rectum2008，，6： | 1 |
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