|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review显示文摘The natural history of hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT)is dismal(approximately 2-4 mo),and PVTT is reportedly found in 10%-40%of HCC patients at diagnosis.According to the Barcelona Clinic Liver Cancer(BCLC)Staging System(which is the most widely adopted HCC management guideline),sorafenib is the standard of care for advanced HCC(i.e.,BCLC stage C)and the presence of PVTT is included in this category.However,sorafenib treatment only marginally prolongs patient survival and,notably,its therapeutic efficacy is reduced in patients with PVTT.In this context,there have been diverse efforts to develop alternatives to current standard systemic chemotherapies or combination treatment options.To date,many studies on transarterial chemoembolization,3-dimensional conformal radiotherapy,hepatic arterial chemotherapy,and transarterial radioembolization report better overall survival than sorafenib therapy alone,but their outcomes need to be verified in future prospective,randomized controlled studies in order to be incorporated into current treatment guidelines.Additionally,combination strategies have been applied to treat HCC patients with PVTT,with the hope that the possible synergistic actions among different treatment modalities would provide promising results.This narrative review describes the current status of the management options for HCC with PVTT,with a focus on overall survival. | Kichang Han Jin Hyoung Kim Gi-Young Ko Dong Il Gwon Kyu-Bo Sung | 2016 | World Journal of Gastroenterology2016，22，1： | 29 |
| 2 | Sequential transcatheter arterial chemoembolization and portal vein embolization before right hemihepatectomy in patients with hepatocellular carcinoma显示文摘Background:Recent studies showed that sequential selective transcatheter arterial chemoembolization(TACE)and portal vein embolization(PVE)provided better future liver remnant(FLR)regeneration rate and disease-free survival following surgery compared with PVE alone.The present study aimed to clarify whether preoperative sequential TACE and PVE before right hemihepatectomy can reduce postoperative hepatocellular carcinoma(HCC)recurrence and improve long-term disease-free and overall survival.Methods:Recurrence and survival outcomes were retrospectively evaluated in 205 patients with HCC who underwent right hemihepatectomy by a single surgeon from November 1993 to November 2017.Patients were divided into four groups according to the procedure performed before the surgery:sequential TACE and PVE(TACE-PVE),PVE-only,TACE-only,or na?ve control groups.The baseline patient and tumor characteristics,postoperative outcomes,recurrence-free survival and overall survival were analyzed.Results:Baseline patient and tumor characteristics upon diagnosis were similar in all four groups,while sequential TACE and PVE were well tolerated.The TACE-PVE group had a higher mean increase in percentage FLR volume compared with that of the PVE-only group(17.46%±6.63%vs.12.14%±5.93%;P=0.001).The TACE-PVE group had significantly better overall and disease-free survival rates compared with the other groups(both P<0.001).Conclusions:Sequential TACE and PVE prior to surgery can be an effective therapeutic strategy for patients with HCC scheduled for major hepatic resection.The active application of preoperative sequential TACE and PVE for HCC would allow more patients with marginal FLR volume to become candidates for major hepatic resection by promoting compensatory FLR hypertrophy without the deterioration of basal hepatic functional reserve or tumor progression. | Gil Chun Park Sung Gyu Lee Young In Yoon Kyu Bo Sung Gi Young Ko Dong Il Gwon Dong Hwan Jung Yong Kyu Jung | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，3： | 9 |
| 3 | SnO_(2)/Graphene Composite with High Lithium Storage Capability for Lithium Rechargeable Batteries显示文摘SnO_(2)/graphene nanocomposites have been fabricated by a simple chemical method.In the fabrication process,the control of surface charge causes echinoid-like SnO_(2)nanoparticles to be formed and uniformly decorated on the graphene.The electrostatic attraction between a graphene nanosheet(GNS)and the echinoid-like SnO_(2)particles under controlled pH creates a unique nanostructure in which extremely small SnO_(2)particles are uniformly dispersed on the GNS.The SnO_(2)/graphene nanocomposite has been shown to perform as a high capacity anode with good cycling behavior in lithium rechargeable batteries.The anode retained a reversible capacity of 634 mA·h·g^(–1)with a coulombic efficiency of 98%after 50 cycles.The high reversibility can be attributed to the mechanical buffering by the GNS against the large volume change of SnO_(2)during delithiation/lithiation reactions.Furthermore,the power capability is significantly enhanced due to the nanostructure,which enables facile electron transport through the GNS and fast delithiation/lithiation reactions within the echinoid-like nano-SnO_(2).The route suggested here for the fabrication of SnO_(2)/graphene hybrid materials is a simple economical route for the preparation of other graphene-based hybrid materials which can be employed in many different fields. | Haegyeom Kim Sung-Wook Kim Young-Uk Park Hyeokjo Gwon Dong-Hwa Seo Yuhee Kim Kisuk Kang | 2010 | Nano Research2010，3，11： | 8 |
| 4 | Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era (from KAMIR-NIH registry)显示文摘ObjectivesTo 评估年龄相关的一个年专业在在尖锐心肌的梗塞(AMI ) 的经皮的冠的干预(一种总线标准) 以后的不利 cardiocerebrovascular 事件(MACCE ) 。我们从在 2011 年 11 月之间的健康(KAMIR-NIH ) 的朝鲜尖锐心肌的梗塞登记公民 Institue 在 13,104 个 AMI 病人全部的 AMI.MethodsA 以后分析了在年龄和一个年 MACCE 之间的协会, 2015 年 12 月根据年龄被分类进四个组(组我, < 60 年, n = 4199;组 II, 60-70 年, n = 2577;组织 III;70-80 年, n = 2774;组 IV, 80 年, n = 1018 ) 。病人们为 MACCE 合成的一个年被分析(心脏的死亡,心肌的梗塞,目标容器 revascularization,脑血管的事件) 在 AMI.ResultsThe 一个年以后,在 AMI 的 MACCE 是 3.5%( 组我) , 6.3%( 组 II ) , 9.6%( 组 III ) 并且 17.6%( 组 IV ) 。在为使参数惊讶的调整以后,分析结果证明有 AMI 的病人有一个年 MACCE 的增长风险[组 II,调整危险比率(aHR )= 1.224, 95% CI:0.965-1.525, P = 0.096;组 III, aHR = 1.316, 95% CI:1.037-1.671, P = 0.024;组 IV, aHR = 1.975, 95% CI:1.500-62.601, P < 0.001 ) 与相比组我。特别,心脏的死亡在玩的主要结束点合成在这效果的一个主要角色(组 II, aHR = 1.335, 95% CI:0.941-1.895, P = 0.106;组 III, aHR = 1.575, 95% CI:1.122-2.210, P = 0.009;组 IV, aHR = 2.803, 95% CI:1.937-4.054, P < 0.001 ).ConclusionsDespite 在 AMI 为一种总线标准推进了技术和药,年龄仍然在临床的结果施加强大的影响。小心的途径,甚至在发达心病学的现代时代被需要为在 AMI 干预年老人口。 | Dae-Won Kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung Chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung | 2018 | Journal of Geriatric Cardiology2018，15，9： | 4 |
| 5 | Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry显示文摘Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up. | Myunhee Lee Dae-Won Kim Mahn-Won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-Hoon Jung 无 KAMIR-NIH registry investigators | 2020 | Journal of Geriatric Cardiology2020，17，11： | 3 |
| 6 | Bioactive hydrogel microcapsules for guiding stem cell fate decisions by release and reloading of growth factors显示文摘Human pluripotent stem cells(hPSC)hold considerable promise as a source of adult cells for treatment of diseases ranging from diabetes to liver failure.Some of the challenges that limit the clinical/translational impact of hPSCs are high cost and difficulty in scaling-up of existing differentiation protocols.In this paper,we sought to address these challenges through the development of bioactive microcapsules.A co-axial flow focusing microfluidic device was used to encapsulate hPSCs in microcapsules comprised of an aqueous core and a hydrogel shell.Importantly,the shell contained heparin moieties for growth factor(GF)binding and release.The aqueous core enabled rapid aggregation of hPSCs into 3D spheroids while the bioactive hydrogel shell was used to load inductive cues driving pluripotency maintenance and endodermal differentiation.Specifically,we demonstrated that one-time,1 h long loading of pluripotency signals,fibroblast growth factor(FGF)-2 and transforming growth factor(TGF)-β1,into bioactive microcapsules was sufficient to induce and maintain pluripotency of hPSCs over the course of 5 days at levels similar to or better than a standard protocol with soluble GFs.Furthermore,stem cell-carrying microcapsules that previously contained pluripotency signals could be reloaded with an endodermal cue,Nodal,resulting in higher levels of endodermal markers compared to stem cells differentiated in a standard protocol.Overall,bioactive heparin-containing core-shell microcapsules decreased GF usage five-fold while improving stem cell phenotype and are well suited for 3D cultivation of hPSCs. | Kihak Gwon Hye Jin Hong Alan M.Gonzalez-Suarez Michael Q.Slama Daheui Choi Jinkee Hong Harihara Baskaran Gulnaz Stybayeva Quinn P.Peterson Alexander Revzin | 2022 | Bioactive Materials2022，7，9： | 3 |
| 7 | Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions: volumetric intravascular ultrasound analysis显示文摘 | XU Jian-qiang Young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Jin-Ho Choi LU Cheng-zhi Sang Hoon Lee Kyung Pyo Hong Jeung Euy Park Hyeon-Cheol Gwon | 2013 | Chinese Medical Journal2013，，18： | 3 |
| 8 | Superhydrophobic and antireflective nanograss-coated glass for high performance solar cells显示文摘我们在场为生产 superhydrophobic 的一个灵巧的方法 nanograss 涂(SNGC ) 在空气 / 眼镜拥有两个都减少的反射率和自我清洗的性质的玻璃表面连接。CaF 的折射索引 < 潜水艇 class= “ a-plus-plus ” > 玻璃底层上的 2 nanograss (NG ) 层,由看一眼的角度蒸汽免职扔了,在 500 nm 是 1.04,它是到目前为止曾经报导的秒低的价值。氟化的 NG 层产生一个高水位线接触角度(> 150 ????? | Hyo Jin Gwon Yensil Park Cheon Woo Moon Sahn Nahm Seok-Jin Yoon Soo Young Kim Ho Won Jang | 2014 | Nano Research2014，7，5： | 3 |
| 9 | Therapeutic strategies of three-dimensional stem cell spheroids and organoids for tissue repair and regeneration显示文摘Three-dimensional(3D)stem cell culture systems have attracted considerable attention as a way to better mimic the complex interactions between individual cells and the extracellular matrix(ECM)that occur in vivo.Moreover,3D cell culture systems have unique properties that help guide specific functions,growth,and processes of stem cells(e.g.,embryogenesis,morphogenesis,and organogenesis).Thus,3D stem cell culture systems that mimic in vivo environments enable basic research about various tissues and organs.In this review,we focus on the advanced therapeutic applications of stem cell-based 3D culture systems generated using different engineering techniques.Specifically,we summarize the historical advancements of 3D cell culture systems and discuss the therapeutic applications of stem cell-based spheroids and organoids,including engineering techniques for tissue repair and regeneration. | Woochan Kim Yonghyun Gwon Sunho Park Hyoseong Kim Jangho Kim | 2023 | Bioactive Materials2023，，1： | 3 |
| 10 | Prevalence and Risk Factors of Silent Cerebral Infarction in Apparently Normal Adults显示文摘 | Sang-Chol Lee Sang-Joon Park Hyun-Kyun Ki Hyeon-Cheol Gwon Chin-Sang Chung Hong Sik Byun Kyung-Ja Shin Myung-Hee Shin Won Ro Lee | 2000 | Hypertension: Journal of the American Heart Association2000，，1： | 2 |
| 11 | 应用Amplatzer血管栓塞物行术前门静脉栓塞显示文摘目的是评估应用Amplatzer血管栓塞物(AVP)行术前门静脉栓塞术(PVE)的安全性和有效性。41例病人应用明胶海绵颗粒和AVP行PVE。应用5F导管以明胶海绵颗粒(1~8mm^3)栓塞门静脉右支,然后将AVP在门静脉右支的一级或二级分支内展开。评价指标包括技术操作的成功率、并发症、血管再通、肝体积总体估计值(TELV)的改变、未来肝残留(FLR)以及FLR/TELV。41例病人中PVE技术成功40例,并在治疗后6~43d(中位数16d)行CT随访观察。2例出现严重并发症, | H. Yoo G.Y. Ko D.I. Gwon J.H. Kim H.K. Yoon K.B. Sung 李靖(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 2 |
| 12 | Improvement of Kalman filters for WLAN based indoor tracking显示文摘 | Jaegeol Yim Seunghwan Jeong Kiyoung Gwon Jaehun Joo | 2009 | Expert Systems With Applications2009，，1： | 2 |
| 13 | Effects of rigidity of an internal fixation device:a comprehensive biomechanical investigation显示文摘 | Goel VK Lim TH Gwon J | 1991 | Spine1991，16，3： | 1 |
| 14 | Effects of rigidity of an internal fixation device:a comprehensive biomechanical investigation 显示文摘 | Goel VK Lim TH Gwon J | 1991 | Spine1991，16，3： | 1 |
| 15 | Improvement of Kalman filters for WLAN based indoor tracking显示文摘 | Jaegeol Yim Seunghwan Jeong Kiyoung Gwon Jaehun Joo | 2010 | Expert Systems with Applications2010，37，1： | 1 |
| 16 | Wafer-scale nanoconical frustumarray crystalline silicon solar cells: promising candidates for ultrathindevice applications 显示文摘 | CHO Y GWON M PARK H H | 2014 | Nanoscale2014，6，16： | 1 |
| 17 | Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia显示文摘 | Gwon C Iwaguro H | 2001 | Circulation2001，103，63： | 1 |
| 18 | Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia 显示文摘 | Kawamoto A Gwon HC Iwaguro H | 2001 | Circulation2001，103，： | 1 |
| 19 | Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia显示文摘 | Kawamoto A Gwon HC Iwaguro H | 2001 | Circulation2001，103，5： | 1 |
| 20 | Hepatocellular carcinoma associated with membranous obstruction of the inferior vena cava:incidence,characteristics,and risk factors and clinical efficacy of TACE显示文摘 | Gwon D 2nd Ko G Y Yoon H K | 2010 | Radiology2010，254，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员