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| 1 | Potentiating CD8^(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling显示文摘Metabolic regulation has been proven to play a critical role in T cell antitumor immunity.However,cholesterol metabolism as a key component of this regulation remains largely unexplored.Herein,we found that the low-density lipoprotein receptor(LDLR),which has been previously identified as a transporter for cholesterol,plays a pivotal role in regulating CD8+T cell antitumor activity.Besides the involvement of cholesterol uptake which is mediated by LDLR in T cell priming and clonal expansion,we also found a non-canonical function of LDLR in CD8+T cells:LDLR interacts with the T-cell receptor(TCR)complex and regulates TCR recycling and signaling,thus facilitating the effector function of cytotoxic T-lymphocytes(CTLs).Furthermore,we found that the tumor microenvironment(TME)downregulates CD8+T cell LDLR level and TCR signaling via tumor cell-derived proprotein convertase subtilisin/kexin type 9(PCSK9)which binds to LDLR and prevents the recycling of LDLR and TCR to the plasma membrane thus inhibits the effector function of CTLs.Moreover,genetic deletion or pharmacological inhibition of PCSK9 in tumor cells can enhance the antitumor activity of CD8+T cells by alleviating the suppressive effect on CD8+T cells and consequently inhibit tumor progression.While previously established as a hypercholesterolemia target,this study highlights PCSK9/LDLR as a potential target for cancer immunotherapy as well. | Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun Wu Zhenhai Zhang Yanqing Ding Wei Yang | 2021 | Protein & Cell2021，12，4： | 12 |
| 2 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 3 | Short-working-distance optical imaging system and method for surface detection of underwater structures显示文摘In the surface imaging of underwater structures, long working distance will reduce image quality due to the turbidity of water. To acquire high definition and large field of view(FOV) images for surface detection, a short-working-distance underwater imaging system is proposed based on camera array. A multi-view calibration and rectification method is developed. A look-up table(LUT) method and a multi-resolution spline(MRS) method are applied to stitch array images real-time and seamlessly.Experiments both in the air and in the water are conducted. Strength and weakness of the LUT and MRS methods are discussed.Based on the results, the effectiveness in surface detection of underwater structures is verified. | LIU Cong WANG ChengFei XU YingJun LI Xu LUO ChunHao DAI MeiLing SHAO XinXing HE XiaoYuan | 2018 | Science China(Technological Sciences)2018，61，5： | 4 |
| 4 | MicroRNA-activated hydrogel scaffold generated by 3D printing accelerates bone regeneration显示文摘Bone defects remain a major threat to human health and bone tissue regeneration has become a prominent clinical demand worldwide.The combination of microRNA(miRNA)therapy with 3D printed scaffolds has always posed a challenge.It can mimic physiological bone healing processes,in which a biodegradable scaffold is gradually replaced by neo-tissue,and the sustained release of miRNA plays a vital role in creating an optimal osteogenic microenvironment,thus achieving promising bone repair outcomes.However,the balance between two key factors-scaffold degradation behavior and miRNA release profile-on osteogenesis and bone formation is still poorly understood.Herein,we construct a series of miRNA-activated hydrogel scaffolds(MAHSs)generated by 3D printing with different crosslinking degree to screened the interplay between scaffold degradation and miRNA release in the osteoinduction activity both in vitro and in vivo.Although MAHSs with a lower crosslinking degree(MAHS-0 and MAHS-0.25)released a higher amount of miR-29b in a sustained release profile,they degraded too fast to provide prolonged support for cell and tissue ingrowth.On the contrary,although the slow degradation of MAHSs with a higher crosslinking degree(MAHS-1 and MAHS-2.5)led to insufficient release of miR-29b,their adaptable degradation rate endowed them with more efficient osteoinductive behavior over the long term.MAHS-1 gave the most well-matched degradation rate and miR-29b release characteristics and was identified as the preferred MAHSs for accelerated bone regeneration.This study suggests that the bio-adaptable balance between scaffold degradation behavior and bioactive factors release profile plays a critical role in bone regeneration.These findings will provide a valuable reference about designing miRNAs as well as other bioactive molecules activated scaffold for tissue regeneration. | Ting Pan Wenjing Song Hongbao Xin Haiyue Yu He Wang Dandan Ma Xiaodong Cao Yingjun Wang | 2022 | Bioactive Materials2022，7，4： | 2 |
| 5 | Dynamic dispersion stability of graphene oxide with metal ions显示文摘Graphene oxide(GO),an important chemical precursor of graphene,can stably disperse in aqueous surrounding and undergo aggregation as metal cations introduced.The usual instability of GO with ions is caused by the shielding effect of ions and crosslinking between GO and ions.However,the dynamic stability of GO under ions exchange still remains unclear.Here,we investigated the dynamic dispersion stability of GO with metal ions and observed a redispersion behavior in concentrated Fe3+solution,other than permanent aggregation.The exchange with Fe3+ions drives the reversion of zeta(ζ)potential and enables the redispersion to individual GO-Fe3+complex sheets,following a dynamic electric double layer(EDL)mechanism.It is found that the specifically strong electrostatic shielding effect and coordination attraction between Fe3+and functional oxygen groups allows the selective redispersion of GO in concentrated Fe3+solution.The revealed dynamic dispersion stability complements our understanding on the dispersive stability of GO and can be utilized to fabricate graphene-metal hybrids for rich applications. | Yinghui He Yingjun Liu Fan Guo Kai Pang Bo Fang Ya Wang Dan Chang Zhen Xu Chao Gao | 2020 | Chinese Chemical Letters2020，31，6： | 2 |
| 6 | Kinematic-parameter identification for serial-robot calibration based on POE formula显示文摘 | HE Ruibo ZHAO Yingjun YANG Shunian | 2010 | IEEE Transactions on Robotics2010，26，3： | 1 |
| 7 | Kinematic-parameter identification for serial-robot calibration based on POE formula显示文摘 | HE Ruibo ZHAO Yingjun YANG Shunian | | 0，，3： | 1 |
| 8 | Determination of Diosgenin Content in Medicinal Plants with Enzyme-Linked Immunosorbent Assay显示文摘 | Jiaru Li Dingyu Yang Kun Yu Ji He Yingjun Zhang | 2010 | Planta Med2010，，16： | 1 |
| 9 | Biomineralization of large hydroxyapatite particles using ovalbumin as biosurfactant Materials 显示文摘 | Hongshi Zhao Wen He Yingjun Wang | 2008 | Letters2008，62，7： | 1 |
| 10 | Expression of metallothionein of freshwater crab ( Sinopotamon henanense ) in Escherichia coli enhances tolerance and accumulation of zinc, copper and cadmium显示文摘 | Yongji He Wenli Ma Yingjun Li Jinping Liu Weixin Jing Lan Wang | 2014 | Ecotoxicology2014，，1： | 1 |
| 11 | Kinematic parameter identification for serial-robot calibration based on POE formula显示文摘 | He Ruibo Zhao Yingjun Yang Shunian | 2010 | IEEE Transactions on Robotics2010，26，3： | 1 |
| 12 | Synthesis of mesoporous structured hydroxyapatite particles using yeast cells as the template 显示文摘 | HE Wen LI Zhengmao WANG Yingjun | 2010 | Journal of Materials Sci- ence: Materials in Medicine2010，21，1： | 1 |
| 13 | The preparation of nanoparticle zirconium phosphate显示文摘 | Feng Yingjun He Wen Zhang Xudong | 2007 | Mater Lett2007，61，1415： | 1 |
| 14 | Rainfall forecast errors in different landfall stages of Super Typhoon Lekima (2019)显示文摘The rainfall forecast performance of the Tropical Cyclone(TC)version Model of Global and Regional Assimilation PrEdiction System(GRAPESTCM)of the China Meteorological Administration for landfalling Super Typhoon Lekima(2019)is studied by using the object-oriented verification method of contiguous rain area(CRA).The major error sources and possible reasons for the rainfall forecast uncertainties in different landfall stages(including near landfall and moving further inland)are compared.Results show that different performance and errors of rainfall forecast exist in the different TC stages.In the near landfall stage the asymmetric rainfall distribution is hard to be simulated,which might be related to the too strong forecasted TC intensity and too weak vertical wind shear accompanied.As Lekima moves further inland,the rain pattern and volume errors gradually increase.The Equitable Threat Score of the 24 h forecasted rainfall over 100 mm declines quickly with the time-length over land.The diagnostic analysis shows that there exists an interaction between the TC and the mid-latitude westerlies,but too weak frontogenesis is simulated.The results of this research indicate that for the current numerical model,the forecast ability of persistent heavy rainfall is very limited,especially when the weakened landing TC moves further inland. | Bin HE Zifeng YU Yan TAN Yan SHEN Yingjun CHEN | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 15 | Coordinative regulation of plants growth and development by light and circadian clock显示文摘The circadian clock,known as an endogenous timekeeping system,can integrate various cues to regulate plant physiological functions for adapting to the changing environment and thus ensure optimal plant growth.The synchronization of internal clock with external environmental information needs a process termed entrainment,and light is one of the predominant entraining signals for the plant circadian clock.Photoreceptors can detect and transmit light information to the clock core oscillator through transcriptional or post-transcriptional interactions with core-clock components to sustain circadian rhythms and regulate a myriad of downstream responses,including photomorphogenesis and photoperiodic flowering which are key links in the process of growth and development.Here we summarize the current understanding of the molecular network of the circadian clock and how light information is integrated into the circadian system,especially focus on how the circadian clock and light signals coordinately regulate the common downstream outputs.We discuss the functions of the clock and light signals in regulating photoperiodic flowering among various crop species. | Chen Su Yan Wang Yingjun Yu Yuqing He Lei Wang | 2021 | aBIOTECH2021，2，2： | 1 |
| 16 | Choline Transporters in Human Lung Adenocarcinoma: Expression and Functional Implications显示文摘然而,胆碱是为房间幸存和增长的必要营养素胆碱运输 ers 的表示和功能很好没在癌症被识别。在这研究,我们检测了 mRNA 和器官的阳离子 transporter 的蛋白质表示 OCT3,肉毒碱 / 阳离子运输 ers OCTN1 和 OCTN2,和在人的肺腺癌房间的像运输的 proteinCTL1 衬里的胆碱 A549, H1299 和 SPC-A-1.Their 表示模式是进一步的在 25 人的主要腺癌纸巾证实了。在这些房间线的胆碱举起被 CTL1 禁止者显著地堵住,但是仅仅部分在房间增长上由 10 月或这些禁止者的 OCTNinhibitors.The 功效禁止了密切与他们堵住胆碱运输的能力被相关。在这些运输 ers 的本国的表示下面,全部的胆碱举起被特定的 PI3K/AKT 禁止者显著地堵住。这些结果在人的肺腺癌的房间增长描述胆碱运输 ers 和他们的相关功能的表示,因此提供潜在的“胆碱饥饿”通过指向胆碱运输 ers 的癌症干扰的策略,特别 CTL1。 | Tao WANG Jinjun LI Fei CHEN Yingjun ZHAO Xianghuo HE Dafang WAN Jianren GU | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 1 |
| 17 | Study on Tissue Culture and Rapid Propagation of Tilia amurensis显示文摘To explore the establishment of a tissue culture and rapid propagation system of Tilia amurensis,the effects of basic medium and concentrations and ratios of plant growth regulators on tissue culture and rapid propagation of T.amurensis were studied.The results showed that 1/2 MS medium was the most suitable proliferation medium,and the proliferation coefficient could reach 13.5 after adding 0.05 mg/L 6-BA and 0.03 mg/L IBA;MS medium was the most suitable medium for strong plantlets and rooting,and the best medium for strong plantlets was MS+0.1 mg/L 6-BA+0.1 mg/L IBA+0.03 mg/L GA_(3),with which the average plantlet height reached 5.15 cm;and the best rooting medium was MS+1.0 mg/L6-BA+0.05 mg/L NAA,with which the rooting rate was 93.3%and the number of roots was 5.7 roots. | Yinhua WANG Yuguang KONG Yingjun HE Liping YAN Dejun WU | 2022 | Agricultural Biotechnology2022，11，3： | 0 |
| 18 | A novel grey wolf optimizer and its applications in 5G frequency selection surface design显示文摘In fifth-generation wireless communication system(5G),more connections are built between metaheuristics and electromagnetic equipment design.In this paper,we propose a self-adaptive grey wolf optimizer(SAGWO)combined with a novel optimization model of a 5G frequency selection surface(FSS)based on FSS unit nodes.SAGWO includes three improvement strategies,improving the initial distribution,increasing the randomness,and enhancing the local search,to accelerate the convergence and effectively avoid local optima.In benchmark tests,the proposed optimizer performs better than the five other optimization algorithms:original grey wolf optimizer(GWO),genetic algorithm(GA),particle swarm optimizer(PSO),improved grey wolf optimizer(IGWO),and selective opposition based grey wolf optimization(SOGWO).Due to its global searchability,SAGWO is suitable for solving the optimization problem of a 5G FSS that has a large design space.The combination of SAGWO and the new FSS optimization model can automatically obtain the shape of the FSS unit with electromagnetic interference shielding capability at the center operating frequency.To verify the performance of the proposed method,a double-layer ring FSS is designed with the purpose of providing electromagnetic interference shielding features at28 GHz.The results show that the optimized FSS has better electromagnetic interference shielding at the center frequency and has higher angular stability.Finally,a sample of the optimized FSS is fabricated and tested. | Zhihao HE Gang JIN Yingjun WANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，9： | 0 |
| 19 | Risk stratification system for skin and soft tissue infections after allogeneic hematopoietic stem cell transplantation:PAH risk score显示文摘Skin and soft tissue infections(SSTIs)refer to infections involving the skin,subcutaneous tissue,fascia,and muscle.In transplant populations with hematological malignancies,an immunocompromised status and the routine use of immunosuppressants increase the risk of SSTIs greatly.However,to date,the profiles and clinical outcomes of SSTIs in hematopoietic stem cell transplantation(HSCT)patients remain unclear.This study included 228 patients(3.67%)who developed SSTIs within 180 days after allogeneic HSCT from January 2004 to December 2019 in Peking University People’s Hospital.The overall annual survival rate was 71.5%.We compared the differences between survivors and non-survivors a year after transplant and found that primary platelet graft failure(PPGF),comorbidities of acute kidney injury(AKI),and hospital-acquired pneumonia(HAP)were independent risk factors for death in the study population.A PPGF-AKI-HAP risk stratification system was established with a mortality risk score of 1×PPGF+1×AKI+1×HAP.The areas under the curves of internal and external validation were 0.833(95%CI 0.760–0.906)and 0.826(95%CI 0.715–0.937),respectively.The calibration plot revealed the high consistency of the estimated risks,and decision curve analysis showed considerable net benefits for patients. | Shan Chong Yun He Yejun Wu Peng Zhao Xiaolu Zhu Fengrong Wang Yuanyuan Zhang Xiaodong Mo Wei Han Jingzhi Wang Yu Wang Huan Chen Yuhong Chen Xiangyu Zhao Yingjun Chang Lanping Xu Kaiyan Liu Xiaojun Huang Xiaohui Zhang | 2022 | Frontiers of Medicine2022，16，6： | 0 |
| 20 | Solid-liquid contact TENG using a melting near-field direct writing PCL nano-fiber structure显示文摘Recently,the triboelectric nanogenerator(TENG)has been widely studied for the development of flexible and wearable electronics.Among the various methods for TENG modification,melting nearfield direct writing is a new method to fabricate solid-liquid TENG.Here,the electrospun PCL was introduced with traditional polymers to fabricate the compound solid triboelectric layer,and water,dimethicone and GaIn were chosen as the liquid triboelectric layers.In this paper,the solid substrate effect,temperature gradient effect,and the liquid substrate effect were compared in terms of TENGs.A free-standing model of TENG is employed in this paper,and the charge generated by the PCL-PI composite solid triboelectrical solid layer is more than 10 times higher than the pristine one,showing the high charge generating ability to melt near-field direct written microfibers.Furthermore,detailed investigation will be discussed how we can get a high the out-circuit voltage and short-circuit current. | Shuye Zhang Yingjun Chen Dayin Wang Peng He | 2023 | International Journal of Smart and Nano Materials2023，14，1： | 0 |
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