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| 1 | Neuroinflammation in Parkinson’s disease and its potential as therapeutic target显示文摘Parkinson’s disease(PD),the second most common age-associated neurodegenerative disorder,is characterized by the loss of dopaminergic(DA)neurons and the presence ofα-synuclein-containing aggregates in the substantia nigra pars compacta(SNpc).Chronic neuroinflammation is one of the hallmarks of PD pathophysiology.Postmortem analyses of human PD patients and experimental animal studies indicate that activation of glial cells and increases in pro-inflammatory factor levels are common features of the PD brain.Chronic release of proinflammatory cytokines by activated astrocytes and microglia leads to the exacerbation of DA neuron degeneration in the SNpc.Besides,peripheral immune system is also implicated in the pathogenesis of PD.Infiltration and accumulation of immune cells from the periphery are detected in and around the affected brain regions of PD patients.Moreover,inflammatory processes have been suggested as promising interventional targets for PD and even other neurodegenerative diseases.A better understanding of the role of inflammation in PD will provide new insights into the pathological processes and help to establish effective therapeutic strategies.In this review,we will summarize recent progresses in the neuroimmune aspects of PD and highlight the potential therapeutic interventions targeting neuroinflammation. | Qinqin Wang Yingjun Liu Jiawei Zhou | 2015 | Translational Neurodegeneration2015，4，1： | 25 |
| 2 | The estimate of sea ice resources quantity in the Bohai Sea based on NOAA/AVHRR data显示文摘The research on sea ice resources is the academic base of sea ice exploitation in the Bohai Sea. According to the ice-water spectrum differences and the correlation between ice thickness and albedo, this paper comes up with a sea ice thickness inversion model based on the NOAA/AVHRR data. And then a sea ice resources quantity (SIQ) time series of Bohai Sea is established from 1987 to 2009. The results indicate that the average error of inversion sea ice thickness is below 30%. The maximum sea ice resources quantity is about 6 × 10 9 m 3 and the minimum is 1.3 × 10 9 m 3 . And a preliminary analysis has been made on the errors of the estimate of sea ice resources quantity (SIQ). | YUAN Shuai GU Wei XU Yingjun WANG Ping HUANG Shuqing LE Zhangyan CONG Jianou | 2012 | Acta Oceanologica Sinica2012，31，1： | 15 |
| 3 | Geometrically constrained isogeometric parameterizedlevel-set based topology optimization via trimmed elements显示文摘In this paper, an approach based on the fastpoint-in-polygon (PIP) algorithm and trimmed elements isproposed for isogeometric topology optimization (TO)with arbitrary geometric constraints. The isogeometricparameterized level-set-based TO method, which directlyuses the non-uniform rational basis splines (NURBS) forboth level set function (LSF) parameterization andobjective function calculation, provides higher accuracyand efficiency than previous methods. The integration oftrimmed elements is completed by the efficient quadraturerole that can design the quadrature points and weights forarbitrary geometric shape. Numerical examples demon-strate the efficiency and flexibility of the method. | Yingjun WANG David J. BENSON | 2016 | Frontiers of Mechanical Engineering2016，11，4： | 13 |
| 4 | Preparation and evaluation of biomimetric nano-hydroxyapatite-based composite scaffolds for bone-tissue engineering显示文摘In the present study,novel biomimetic composite scaffolds with a composition similar to that of natural bone were prepared,using nano-hydroxyapatite,collagen,and phosphatidylserine.The scaffolds possess an interconnected porous structure with a porosity of 84%.The pore size ranges from several micrometers up to about 400 m.In-vitro studies in simulated body fluids showed that the morphologies of the products derived from mineralization can be regulated by the extracellular matrix components of the scaffolds;this in turn leads to creation of a large number of hydroxyapatite crystals on the scaffold surface.The regulatory properties of collagen and phosphatidylserine also influenced the cell response to the composite scaffolds.MC3T3-E1 cells attached and spread on the surfaces of the materials and interacted with the substrates;this may be the result of charged groups on the composite materials.Radiological analysis suggested that calluses and bone bridges formed in defects within 12 weeks.These composite scaffolds may therefore be a suitable replacement in bone-tissue engineering. | YANG ChunRong WANG YingJun CHEN XiaoFeng | 2012 | Chinese Science Bulletin2012，57，21： | 9 |
| 5 | Platelet transfusion refractoriness after T-cell-replete haploidentical transplantation is associated with inferior clinical outcomes显示文摘Haploidentical stem cell transplantation (haplo-SCT) has been an alternative source of bone marrow for patients without human leukocyte antigen (HLA)-matched donors. The aim of this study was to investigate the relationships between platelet transfusion refractoriness (PTR) and clinical outcomes in the setting of haplo-SCT. Between May 2012 and March 2014, 345 patients who underwent unmanipulated haplo-SCT were retrospectively enrolled. PTR occurred in 20.6% of all patients. Patients in the PTR group experienced higher transplant-related mortality (TRM, 43.7% vs. 13.5%, P<0.001), lower overall survival (OS, 47.9%vs. 76.3%, P<0.001) and lower leukemia-free survival (LFS, 47.9% vs. 72.3%, P<0.001) compared to patients in the non-PTR group. The multivariate analysis showed that PTR was associated with TRM (P=0.002), LFS (P<0.001), and OS (P<0.001).The cumulative incidences of PTR in patients receiving >12 platelet (PLT) transfusions (third quartile of PLT transfusions) were higher than in patients receiving either >6 (second quartile) or >3 (first quartile) PLT transfusions (56.1% vs. 41.6% vs. 28.2%,respectively; P<0.001). The multivariate analysis also showed that PTR was associated with the number of PLT transfusions(P<0.001). PTR could predict poor transplant outcomes in patients who underwent haploidentical SCT. | Qiang Fu Lanping Xu Xiaohui Zhang Yu Wang Yingjun Chang Kaiyan Liu Xiaojun Huang | 2018 | Science China(Life Sciences)2018，61，5： | 7 |
| 6 | Reduced-rank space-time adaptive detection for airborne radar显示文摘For airborne radar,there are usually insufficient independent and identically distributed(IID)training data because of geometric considerations and terrain variations.The rank reduction technique is one of the most effective approaches to circumvent this problem.In this study,we investigate four reduced-rank spacetime adaptive detectors for airborne radar,namely,the reduced-rank sample-matrix-inversion(RR-SMI),the reduced-rank adaptive matched filter(RR-AMF),the reduced-rank adaptive coherence estimator(RR-ACE),and the reduced-rank generalized likelihood ratio test(RR-GLRT).Their asymptotic analytical probabilities of detection(PD’s)and false alarm(PFA’s)are all derived.These detectors all asymptotically attain a constant false alarm rate(CFAR).It is shown that these four reduced-rank detectors exhibit detection performance which is better than or comparable to that of two existing reduced-rank detectors,proposed by Reed and Gau(RG1and RG2).Moreover,these four reduced-rank detectors are more robust to change in power of clutter and noise than RG1 and RG2. | WANG YongLiang LIU WeiJian XIE WenChong ZHAO YingJun | 2014 | Science China(Information Sciences)2014，57，8： | 7 |
| 7 | Improved clinical outcomes of rhG-CSF-mobilized blood and marrow haploidentical transplantation compared to propensity score-matched rhG-CSF-primed peripheral blood stem cell haploidentical transplantation:a multicenter study显示文摘The effects of haploidentical rhG-CSF-mobilized blood and marrow transplantation(HBMT) on hematological malignances are well established. Previous prospective single-center studies have demonstrated better survival after HBMT versus haploidentical rhG-CSF-mobilized peripheral blood stem cell transplantation(HPBSCT) for acute leukemia(AL) not in remission(NR) or in more than the second complete remission(>CR2). To test the hypothesis that HBMT is still superior to HPBSCT for patients with AL, multiple myeloma(MM), or non-Hodgkin lymphoma(NHL) in CR1/CR2 and for patients with chronic myeloid leukemia in the first and second chronic phase lacking a matched donor, we designed a propensity score method-based multicenter study.Hematopoietic recovery, acute graft-versus-host disease(aGVHD), and chronic GVHD were comparable between the HBMT group(n=168) and the HPBSCT group(n=42). No significant differences were found in non-relapse mortality rate(20.17%±3.58%and 27.24%±7.16%, P=0.18) or relapse rate(19.96%±3.72% and 28.49%±8.25%, P=0.32) between the HBMT group and the HPBSCT group. HBMT recipients had better overall survival(65.0%±4.2% and 54.2%±8.3%, P=0.037) and disease-free survival(59.9%±4.6% and 44.3%±8.7%, P=0.051). Multivariate analysis showed that HPBSCT was associated with poorer DFS(HR(95%CI), 1.639(0.995–2.699), P=0.052). Our comparisons showed that HBMT was superior to HPBSCT as a post-remission treatment for patients lacking an identical donor. | Xiangyu Zhao Feng Gao Xiaohui Zhang Yu Wang Lanping Xu Kaiyan Liu Xiaosu Zhao Yingjun Chang Han Wei Huan Chen Yuhong Chen Zhengfan Jiang Xiaojun Huang | 2016 | Science China(Life Sciences)2016，59，11： | 7 |
| 8 | Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication显示文摘Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement results.Therefore, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing equalization.As far as we know, this is the highest data rate for an LED-based UVLC system. | YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU JUNLIN LIU FENGYI JIANG NAN CHI | 2019 | Photonics Research2019，7，9： | 7 |
| 9 | The enhanced permeability and retention effect based nanomedicine at the site of injury显示文摘The enhanced permeability retention(EPR)effect based nanomedicine has been widely used for tumor targeting during the past decades.Here we unexpectedly observed the similar'EPR effect'at the site of iniury.We found that the temporary dilated and leaky blood vessels caused by the potent vasodilator histamine in response to injury allowed the injected nanoparticles to pass through the vasculature and reached the injured tissue.Our finding shows the potential underline mechanism of'EPR effect'at the injured site.By loading with antibiotics,we further demonstrated a new strategy for prevention of infection at the site of injury. | Yingjun Liu Dongdong Sun Qin Fan Qingle Ma Ziliang Dong Weiwei Tao Huiquan Tao Zhuang Liu Chao Wang | 2020 | Nano Research2020，13，2： | 6 |
| 10 | Bioadaptability:An Innovative Concept for Biomaterials显示文摘Biocompatibility is the basic requirement of biomaterials for tissue repair. However, the present concept of biocompatibility has a certain limitation in explaining the phenomena involved in biomaterial-based tissue repair. New materials, in particular those for tissue engineering and regeneration, have been developed with common characteristics, i.e. they participate deeply into important chemical and biological processes in the human body and the interaction between the biomaterials and tissues is far more complex.Understanding the interplay between these biomaterials and tissues is vital for their development and functionalization. Herein, we suggest the concept of bioadaptability of biomaterials. This concept describes the three most important aspects that can determine the performance of biomaterials in tissue repair: 1) the adaptability of the micro-environment created by biomaterials to the native microenvironment in situ; 2) the adaptability of the mechanical properties of biomaterials to the native tissue;3) the adaptability of the degradation properties of biomaterials to the new tissue formation. The concept of bioadaptability emphasizes both the material's characteristics and biological aspects within a certain micro-environment and molecular mechanism. It may provide new inspiration to uncover the interaction mechanism of biomaterials and tissues, to foster the new ideas of functionalization of biomaterials and to investigate the fundamental issues during the tissue repair process by biomaterials. Furthermore, designing biomaterials with such bioadaptability would open a new door for repairing and regenerating organs or tissues. In this review, we summarized the works in recent years on the bioadaptability of biomaterials for tissue repair applications. | Yingjun Wang | 2016 | Journal of Materials Science & Technology2016，32，9： | 5 |
| 11 | Fabrication of a hydroxyapatite-PDMS microfluidic chip for bone-related cell culture and drug screening显示文摘Bone is an important part of the human body structure and plays a vital role in human health.A microfluidic chip that can simulate the structure and function of bone will provide a platform for bone-related biomedical research.Hydroxyapatite(HA),a bioactive ceramic material,has a similar structure and composition to bone mineralization products.In this study,we used HA as a microfluidic chip component to provide a highly bionic bone environment.HA substrates with different microchannel structures were printed by using ceramic stereolithography(SLA)technology,and the minimum trench width was 50μm.The HA substrate with microchannels was sealed by a thin polydimethylsiloxane(PDMS)layer to make a HA-PDMS microfluidic chip.Cell culture experiments demonstrated that compared with PDMS,HA was more conducive to the proliferation and osteogenic differentiation of the human foetal osteoblast cell line(hFOB).In addition,the concentration gradient of the model drug doxorubicin hydrochloride(DOX)was successfully generated on a Christmas tree structure HA-PDMS chip,and the half maximal inhibitory concentration(IC50)of DOX was determined.The findings of this study indicate that the HA-PDMS microfluidic chip has great potential in the field of high-throughput bonerelated drug screening and bone-related research. | Qiangqiang Tang Xiaoyu Li Chen Lai Lei Li Hongkai Wu Yingjun Wang Xuetao Shi | 2021 | Bioactive Materials2021，6，1： | 5 |
| 12 | Characterization of bioactive ceramic coatings prepared on titanium implants by micro-arc oxidation显示文摘微弧的氧化(毛) 是在电解质媒介的提高的化学工艺在阀门金属表面上获得涂层结构。毛在磷酸钠电解质获得的三氧化钛电影被调查。这些电影主要由在锐钛矿和金红石形式的 TiO_2 阶段组成并且在表面与 Na 和 P 元素充实。他们的导致磷灰石的能力在模仿的身体液体(SBF ) 被评估。在为超过 30 d 的 SBF 的 Whenimmersing,优先的 carbonated-hydroxyapatite 在这些电影的表面上被形成,它建议对待 MAO 的钛有有希望的积极生物回答。 | WANG Yingjun NAN Kaihui CHEN Xiaofeng NING Chengyun WANG lingyu ZHAO Naru | 2006 | Rare Metals2006，25，1： | 5 |
| 13 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 14 | Signaling pathways in cancer-associated fibroblasts:recent advances and future perspectives显示文摘As a critical component of the tumor microenvironment(TME),cancerassociated fibroblasts(CAFs)play important roles in cancer initiation and progression.Well-known signaling pathways,including the transforming growth factor-β(TGF-β),Hedgehog(Hh),Notch,Wnt,Hippo,nuclear factor kappa-B(NF-κB),Janus kinase(JAK)/signal transducer and activator of transcription(STAT),mitogen-activated protein kinase(MAPK),and phosphoinositide 3-kinase(PI3K)/AKT pathways,as well as transcription factors,including hypoxia-inducible factor(HIF),heat shock transcription factor 1(HSF1),P53,Snail,and Twist,constitute complex regulatory networks in theTMEtomodulate the formation,activation,heterogeneity,metabolic characteristics and malignant phenotype of CAFs.Activated CAFs remodel the TME and influence the malignant biological processes of cancer cells by altering the transcriptional and secretory characteristics,and this modulation partially depends on the regulation of signaling cascades.The results of preclinical and clinical trials indicated that therapies targeting signaling pathways in CAFs demonstrated promising efficacy but were also accompanied by some failures(e.g.,NCT01130142 and NCT01064622).Hence,a comprehensive understanding of the signaling cascades in CAFs might help us better understand the roles of CAFs and the TME in cancer progression and may facilitate the development of more efficient and safer stroma-targeted cancer therapies.Here,we review recent advances in studies of signaling pathways in CAFs and briefly discuss some future perspectives on CAF research. | Zengli Fang Qingcai Meng Jin Xu Wei Wang Bo Zhang Jiang Liu Chen Liang Jie Hua Yingjun Zhao Xianjun Yu Si Shi | 2023 | Cancer Communications2023，43，1： | 5 |
| 15 | Insight into vitronectin structural evolution on material surface chemistries: The mediation for cell adhesion显示文摘Biomaterial surface chemistry engenders profound consequences on cell adhesion and the ultimate tissue response by adsorbing proteins from extracellular matrix,where vitronectin(Vn)is involved as one of the crucial mediator proteins.Deciphering the adsorption behaviors of Vn in molecular scale provides a useful account of how to design biomaterial surfaces.But the details of structural dynamics and consequential biological effect remain elusive.Herein,both experimental and computational approaches were applied to delineate the conformational and orientational evolution of Vn during adsorption onto self-assembled monolayers(SAMs)terminating with-COOH,-NH2,-CH3 and-OH.To unravel the interplay between cell binding and the charge and wettability of material surface,somatomedin-B(SMB)domain of Vn holding the RGD cell-binding motif was employed in molecular dynamics(MD)simulations,with orientation initialized by Monte Carlo(MC)method.Experimental evidences including protein adsorption,cell adhesion and integrin gene expressions were thoroughly investigated.The adsorption of Vn on different surface chemistries showed very complex profiles.Cell adhesion was enabled on all Vn-adsorbed surfaces but with distinct mechanisms mostly determined by conformational change induced reorientation.Higher amount of Vn was observed on negatively charged surface(COOH)and hydrophobic surface(CH3).However,advantageous orientations defined by RGD loop conditions were only obtained on the charged surfaces(COOH and NH2).Specifically,COOH surface straightened up the Vn molecules and accumulated them into a higher density,whereas CH3 surface squashed Vn and stacked them into higher density multilayer by tracking adsorption but with the RGD loops restrained.These findings may have a broad implication on the understanding of Vn functionality and would help develop new strategies for designing advanced biomaterials. | Tianjie Li Lijing Hao Jiangyu Li Chang Du Yingjun Wang | 2020 | Bioactive Materials2020，5，4： | 4 |
| 16 | Theoretical and simulation research of hydrodynamic instabilities in inertial-confinement fusion implosions显示文摘Inertial fusion energy(IFE)has been considered a promising,nearly inexhaustible source of sustainable carbon-free power for the world's energy future.It has long been recognized that the control of hydrodynamic instabilities is of critical importance for ignition and high-gain in the inertial-confinement fusion(ICF)hot-spot ignition scheme.In this mini-review,we summarize the progress of theoretical and simulation research of hydrodynamic instabilities in the ICF central hot-spot implosion in our group over the past decade.In order to obtain sufficient understanding of the growth of hydrodynamic instabilities in ICF,we first decompose the problem into different stages according to the implosion physics processes.The decomposed essential physics processes that are associated with ICF implosions,such as Rayleigh-Taylor instability(RTI),Richtmyer-Meshkov instability(RMI),Kelvin-Helmholtz instability(KHI),convergent geometry effects,as well as perturbation feed-through are reviewed.Analytical models in planar,cylindrical,and spherical geometries have been established to study different physical aspects,including density-gradient,interface-coupling,geometry,and convergent effects.The influence of ablation in the presence of preheating on the RTI has been extensively studied by numerical simulations.The KHI considering the ablation effect has been discussed in detail for the first time.A series of single-mode ablative RTI experiments has been performed on the Shenguang-Ⅱlaser facility.The theoretical and simulation research provides us the physical insights of linear and weakly nonlinear growths,and nonlinear evolutions of the hydrodynamic instabilities in ICF implosions,which has directly supported the research of ICF ignition target design.The ICF hot-spot ignition implosion design that uses several controlling features,based on our current understanding of hydrodynamic instabilities,to address shell implosion stability,has been briefly described,several of which are novel. | LiFeng Wang WenHua Ye XianTu He JunFeng Wu ZhengFeng Fan Chuang Xue HongYu Guo WenYong Miao YongTeng Yuan JiaQin Dong Guo Jia Jing Zhang YingJun Li Jie Liu Min Wang YongKun Ding WeiYan Zhang | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，5： | 4 |
| 17 | Effects of yttrium and phosphorus on growth and physiological characteristics of Microcystis aeruginosa显示文摘Yttrium is a main kind of rare earth elements(REEs) with wide applications in modern industry and farming. Phosphorus, an essential element of algae, is used as the nutrients and also one of the main factors of eutrophication. To investigate the effects of yttrium and phosphorus on Microcystis aeruginosa(M. aeruginosa), the growth and physiological changes were studied by lab cultured experiments. In the experiment, exogenous yttrium was tested by a concentration gradient(0.0, 0.1, 0.3, 0.5, 1.0 mg/L),meanwhile, phosphorus was tested by three concentrations(0.0, 0.02, 0.2 mg/L). The results show that the contents of chlorophyll a(chl-a) and soluble protein increase compared with the control and they have certain correlation with algal cells density. The growth status of algae is stimulated by initial yttrium concentration <0.3 and 0.2 mg/L phosphorus, while it is inhabited by 0.5 and 1.0 mg/L yttrium. Besides,the activity of superoxide dismutase(SOD) of algae increases with addition of yttrium dose(0-0.3 mg/L)when phosphorus dose is 0.2 mg/L. Furthermore, when yttrium dose is 0.5 and 1.0 mg/L, the vitality of SOD presents a sharp decline. The malondialdehyde(MDA) contents increase with time and addition of yttrium dose, 0.2 mg/L phosphorus weakens the accumulation of MDA. | Yingjun Wang Yuanwei Li Xiaoyu Luo Yin'an Ren En'guang Gao Haojie Gao | 2018 | Journal of Rare Earths2018，36，7： | 4 |
| 18 | Effects of Rat Cytomegalovirus on the Nervous System of the Early Rat Embryo显示文摘The purpose of the study was to investigate the impact of rat cytomegalovirus(RCMV) infection on the development of the nervous system in rat embryos,and to evaluate the involvement of Wnt signaling pathway key molecules and the downstream gene neurogenin 1(Ngn1) in RCMV infected neural stem cells(NSCs).Infection and control groups were established,each containing 20 pregnant Wistar rats.Rats in the infection group were inoculated with RCMV by intraperitoneal injection on the first day of pregnancy.Rat E20 embryos were taken to evaluate the teratogenic rate.NSCs were isolated from E13 embryos,and maintained in vitro.We found:1) Poor fetal development was found in the infection group with low survival and high malformation rates.2) The proliferation and differentiation of NSCs were affected.In the infection group,NSCs proliferated more slowly and had a lower neurosphere formation rate than the control.The differentiation ratio from NSCs to neurons and glial cells was significantly different from that of the control,showed by immunofluorescence staining.3) Ngn1 mRNA expression and the nuclear β-catenin protein level were significantly lower than the control on day 2 when NSCs differentiated.4) The Morris water maze test was performed on 4-week pups,and the infected rats were found worse in learning and memory ability.In a summary,RCMV infection caused abnormalities in the rat embryonic nervous system,significantly inhibited NSC proliferation and differentiation,and inhibited the expression of key molecules in the Wnt/β-catenin signaling pathway so as to affect NSCs differentiation.This may be an important mechanism by which RCMV causes embryonic nervous system abnormalities. | Xiuning Sun YingJun Guan Fengjie Li Xutong Li Xiaowen Wang Zhiyu Guan Kai Sheng Li Yu Zhijun Liu | 2012 | Virologica Sinica2012，27，4： | 4 |
| 19 | Rh-doped PdAg nanoparticles as efficient methanol tolerance electrocatalytic materials for oxygen reduction显示文摘Direct methanol fuel cells(DMFCs)have received extensive attention on their high efficiency,high reliability,and no carbon emission.Unfortunately,the poor methanol tolerance and sluggish oxygen reduction reaction(ORR)at cathode have seriously hindered their further development.Herein we report the synthesis of a new class of Rh-doped PdAg alloy nanoparticles(NPs)for boosting ORR activity with high methanol tolerance capacity concurrently.The ORR mass activity of typical Rh_4Pd_(40)Ag_(56)NPs is 4.2 times higher than that of commercial Pt catalyst.Moreover,it shows a great methanol tolerance capability by maintaining 92.4%in ORR mass activity in alkaline solution with 0.1 mol L^(à1)methanol,against a big decrease of almost 100%for commercial Pt.Even after 30,000 potential cycles with 1.0 mol L^(à1)methanol,Rh_4Pd_(40)Ag_(56)NPs still retain ORR mass activity of up to 68.3%.DFT calculations reveal that excellent ORR performance with excellent methanol tolerance originates the active d-band-pinning engineering for an efficient site-independent electron-transfer.A generalized d-band mediated fine electron-transfer tuning path has blueprinted for effectively minimizing intrinsic ORR barriers with high current density.The present work highlights the key role of Rh doping in enhancing the ORR activity and methanol tolerance ability of PdAg NPs for future high-performance DMFCs. | Yingjun Sun Bolong Huang Nuoyan Xu Yingjie Li Mingchuan Luo Chunji Li Yingnan Qin Lei Wang Shaojun Guo | 2019 | Science Bulletin2019，64，1： | 4 |
| 20 | Data-Driven Structural Design Optimization for Petal-Shaped Auxetics Using Isogeometric Analysis显示文摘Focusing on the structural optimization of auxetic materials using data-driven methods,a back-propagation neural network(BPNN)based design framework is developed for petal-shaped auxetics using isogeometric analysis.Adopting a NURBSbased parametric modelling scheme with a small number of design variables,the highly nonlinear relation between the input geometry variables and the effective material properties is obtained using BPNN-based fitting method,and demonstrated in this work to give high accuracy and efficiency.Such BPNN-based fitting functions also enable an easy analytical sensitivity analysis,in contrast to the generally complex procedures of typical shape and size sensitivity approaches. | Yingjun Wang Zhongyuan Liao Shengyu Shi Zhenpei Wang Leong Hien Poh | 2020 | Computer Modeling in Engineering & Sciences2020，，2： | 4 |
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