|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A journey to understand wheat Fusarium head blight resistance in the Chinese wheat landrace Wangshuibai显示文摘Fusarium head blight(FHB) or scab caused by Fusarium graminearum is a major threat to wheat production in China as well as in the world. To combat this disease, multiple efforts have been carried out internationally. In this article, we review our long-time effort in identifying the resistance genes and dissecting the resistance mechanisms by both forward and reverse genetics approaches in the last two decades. We present recent progress in resistance QTL identification, candidate functional gene discovery, marker-assisted improvement of FHB resistant varieties, and findings in investigating association of signal molecules, such as Ca^(++),SA, JA, and ET, with FHB response, with the assistance from rapidly growing genomics platforms. The information will be helpful for designing novel and efficient approaches to curb FHB. | Haiyan Jia Jiyang Zhou Shulin Xue Guoqiang Li Haisheng Yan Congfu Ran Yiduo Zhang Jinxing Shi Li Jia Xin Wang Jing Luo Zhengqiang Ma | 2018 | The Crop Journal2018，6，1： | 24 |
| 2 | Actin cytoskeleton-dependent pathways for ADMA-induced NF-κB activation and TGF-β high expression in human renal glomerular endothelial cells显示文摘不对称的 dimethylarginine (ADMA ) ,一个内长的氮的氧化物 synthase 禁止者,被认为是在长期的肾疾病(CKD ) 的前进的一个独立风险因素。它能由增加转变生长因素(TGF )-1 表示导致肾纤维变性,但是它的分子的机制是不清楚的。现在的学习的目的是在人的肾的 glomerular endothelial 房间(HRGEC ) 在导致 ADMA 的 TGF-1 高表示调查肌动朊细胞骨架的角色。压力纤维的结构被 immunofluorescence 设想,原子 factor-B (NF-B )DNA 有约束力的活动被 electrophoretic 活动性移动试金估计, TGF-1 表示被西方的污点分析估计。结果证明 ADMA 导致了压力纤维, NF-B 的 DNA 绑定,和 TGF-1 的增加的表示的汇编。当肌动朊细胞骨架的动力学被使解聚肌动朊的代理人 cytochalasin 使不安时, D 和稳定肌动朊的代理人 jasplakinolide,或压力纤维的脱离由 nicotineamide 腺嘌 dinucleotide 磷酸盐 oxidase 禁止者 apocynin 和 p38 绑激活 mitogen 的蛋白质 kinase 禁止者 SB203580, NF-B 的导致 ADMA 的 DNA 绑定和 TGF-1 表示被禁止。这些结果在 HRGEC 在导致 ADMA 的 NF-B 激活和 TGF-1 高表示揭示了肌动朊细胞骨架依赖者机制。肌动朊细胞骨架的特定的指向可以是有用策略在 CKD 阻止激活 ADMA 的肾纤维变性。 | Liyan Wang Dongliang Zhang Junfang Zheng Yiduo Feng Yu Zhang Wenhu Liu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 9 |
| 3 | Polyphase coded signal design for MIMO radar using MO-MicPSO显示文摘A novel modified optimization technique known as the multi-objective micro particle swarm optimization(MO-MicPSO) is proposed for polyphase coded signal design.The proposed MO-MicPSO requires only a small population size compared with the standard particle swarm optimization that uses a larger population size.This new method is guided by an elite archive to finish the multi-objective optimization.The orthogonal polyphase coded signal(OPCS) can fundamentally improve the multiple input multiple output(MIMO) radar system performance,with which the radar system has high resolution and abundant signal channels.Simulation results on the polyphase coded signal design show that the MO-MicPSO can perform quite well for this high-dimensional multi-objective optimized problem.Compared with particle swarm optimization or genetic algorithm,the proposed MO-MicPSO has a better optimized efficiency and less time consumption. | Xiangneng Zeng Yongshun Zhang Yiduo Guo | 2011 | Journal of Systems Engineering and Electronics2011，22，3： | 8 |
| 4 | Effect of Recql5 deficiency on the intestinal tumor susceptibility of Apc^(min) mice显示文摘AIM:To investigate whether Recql5,a DNA helicase that plays an important role in the maintenance of genome integrity,is a tumor suppressor in the gastrointestinal tract in mice.METHODS:We generated cohorts of both Recql5-proficient and Recql5-deficient Apcmin/+mice and compared the tumor susceptibility in their gastrointestinal tracts.RESULTS:Recql5 deficiency in Apcmin/+mice resulted in a significant increase in the tumor incidence in both the colon(P=0.0162)and the small intestine(P<0.01).These findings have provided the first genetic evidence for a tumor suppression role of Recql5 in the gastrointestinal tract of mice.Importantly,since mouse Recql5 and human RECQL5 are highly conserved,these findings also suggest that RECQL5 may be a tu-mor suppressor for human colon cancer.CONCLUSION:Recql5 has a tumor suppression role in the mouse gastrointestinal tract. | Yiduo Hu,Xincheng Lu,Guangbin Luo,Department of Genetics,Case Comprehensive Cancer Center and University Hospitals of Cleveland,Case Western Reserve University,Cleveland,OH 44106,United States Yiduo Hu,Department of Cancer Biology,Dana-Farber Cancer Institute,Boston,MA 02115,United States | 2010 | World Journal of Gastroenterology2010，16，12： | 6 |
| 5 | RhoB regulates the function of macrophages in the hypoxia-induced inflammatory response显示文摘有免疫力的房间,特别地巨噬细胞,在导致组织缺氧的煽动性的反应起关键作用。小 GTPase RhoB 被许多刺激很快通常导致并且被描述了为细胞骨架组织和泡和膜受体 trafficking 的一个重要管理者。然而, RhoB 是否涉及导致组织缺氧的煽动性的反应,是未知的。这里,我们在巨噬细胞在 RhoB 表示的 RhoB 和机制和意义的表示上调查了组织缺氧的效果。我们显著地发现了那组织缺氧 upregulated 在老鼠的 RAW264.7 房间,鼠标腹巨噬细胞,和怒气的 RhoB 的表达式。RhoB 的导致组织缺氧的表示被组织缺氧可诱导的 factor-1 (HIF-1 ) 的一个特定的禁止者显著地堵住, c6 月 N 终端 kinase (JNK ) ,或细胞外信号的调整蛋白质 kinase (英皇家空军之阶级最低之兵) ,显示那激活组织缺氧的 HIF-1, JNK,和英皇家空军之阶级最低之兵被组织缺氧涉及 RhoB 的 upregulation。RhoB 表示击倒不仅 interleukin-1 贝它(IL-1 ) 的显著地压制的基础生产, interleukin 6 (IL-6 ) ,并且在 normoxia 而且更多的肿瘤坏死因素 alpha (TNF-) 显著地减少了这些 cytokines 的刺激组织缺氧的生产。而且,我们证明 RhoB 增加了 NF-B transcriptional 的原子 factor-kappa B (NF-B ) 活动,和抑制活动显著地减少了 IL-1, IL-6,和 TNF- 的增加 RhoB 的 mRNA 层次。最后,我们证明 RhoB 提高了房间粘附并且在 normoxia 和组织缺氧禁止了房间移植。一起拿,这些结果建议 RhoB 在巨噬细胞和煽动性的反应的导致组织缺氧的激活起一个重要作用。 | Gaoxiang Huang Jie Su Mingzhuo Zhang Yiduo Jin Yan Wang Peng Zhou Jian Lu | 2017 | Cellular & Molecular Immunology2017，14，3： | 3 |
| 6 | A synthetic aperture radar sea surface distribution estimation by n-order Bézier curve and its application in ship detection显示文摘To dates,most ship detection approaches for single-pol synthetic aperture radar(SAR) imagery try to ensure a constant false-alarm rate(CFAR).A high performance ship detector relies on two key components:an accurate estimation to a sea surface distribution and a fine designed CFAR algorithm.First,a novel nonparametric sea surface distribution estimation method is developed based on n-order Bézier curve.To estimate the sea surface distribution using n-order Bézier curve,an explicit analytical solution is derived based on a least square optimization,and the optimal selection also is presented to two essential parameters,the order n of Bézier curve and the number m of sample points.Next,to validate the ship detection performance of the estimated sea surface distribution,the estimated sea surface distribution by n-order Bézier curve is combined with a cell averaging CFAR(CA-CFAR).To eliminate the possible interfering ship targets in background window,an improved automatic censoring method is applied.Comprehensive experiments prove that in terms of sea surface estimation performance,the proposed method is as good as a traditional nonparametric Parzen window kernel method,and in most cases,outperforms two widely used parametric methods,K and G0 models.In terms of computation speed,a major advantage of the proposed estimation method is the time consuming only depended on the number m of sample points while independent of imagery size,which makes it can achieve a significant speed improvement to the Parzen window kernel method,and in some cases,it is even faster than two parametric methods.In terms of ship detection performance,the experiments show that the ship detector which constructed by the proposed sea surface distribution model and the given CA-CFAR algorithm has wide adaptability to different SAR sensors,resolutions and sea surface homogeneities and obtains a leading performance on the test dataset. | LANG Haitao ZHANG Jie WANG Yiduo ZHANG Xi MENG Junmin | 2016 | Acta Oceanologica Sinica2016，35，9： | 3 |
| 7 | Exploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators显示文摘Allatostatins(ASTs), a family of insect neuropeptide, can inhibit juvenile hormone(JH) biosynthesis by the corpora allata(CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators(IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro(IC_(50): 0.09 mmol/L) in our previous studies. In the present work, two series of B1 analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with log P value over 2.0 exhibited good activity,which indicated the hydrophobicity is important to the bioactivity. Three dimension quantitative structure-activity relationship(3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog Ⅱ12(IC_(50): 0.08 mmol/L) exhibited similar inhibitory activity to the lead B1,but its synthetic route was simpler than B1. Therefore, Ⅱ12 could be used as a new lead compound for the discovery eco-friendly IGRs. | Meizi Wang Li Zhang Xianwei Wang Yun Ling Xiaoqing Wu Xinlu Li Yiduo Mi Xinling Yang | 2018 | Chinese Chemical Letters2018，29，9： | 2 |
| 8 | Association between hsa-miR-34b/c rs4938723 T>C promoter polymorphism and cancer risk: a meta-analysis based on 6,036 cases and 6,204 controls显示文摘Objective: Emerging evidence shows that microRNAs(miRNAs) function as tumor suppressors or oncogenes in human carcinogenesis. A single nucleotide polymorphism(SNP) located in the pri-miRNA promoter may affect the processing and expression of mature miRNA. However, previous studies showed conflicting results regarding the association of hsa-miR-34b/c rs4938723 T > C promoter polymorphism with cancer. Therefore, we conducted a meta-analysis to determine the association of polymorphism with cancer risk.Methods: A computerized search of PubMed, Web of Science, and Chinese National Knowledge Infrastructure(CNKI) for publications on hsa-miR-34b/c rs4938723 T > C promoter polymorphism and cancer risk was performed and the genotype data were analyzed in a meta-analysis. Odds ratios(ORs) with 95% confidence intervals(CIs) were estimated to assess the association. Test of heterogeneity, cumulative meta-analysis, sensitivity analysis and assessment of bias were performed in our meta-analysis by STATA software 12.0.Results: There was no significant association between hsa-miR-34b/c rs4938723 polymorphism and overall cancer risk in the comparison models. Moreover, subgroup analysis revealed that the variant CT(OR =1.19, 95% CI: 1.03-1.37) and CC/CT(OR =1.18, 95% CI: 1.03-2.35) genotypes were associated with an increased risk of hepatocellular carcinoma(HCC) compared with wild-type TT genotype. However, a decreased risk of colorectal cancer(CRC) was found in the genetic model of CC/TT(OR =0.66, 95% CI: 0.47-0.92) and CC/CTTT(OR =0.67, 95% CI: 0.49-0.93). Conclusions: The results suggest that hsa-miR-34b/c rs4938723 polymorphism may play an opposite role in different types of cancer based on current studies, which is the main origin of heterogeneity in this metaanalysis. Further large-scale studies and functional studies between this polymorphism and cancer risk are warranted. | Tao Tao Shuqiu Chen Bin Xu Chunhui Liu Yiduo Wang Yeqing Huang Ming Chen | 2014 | Chinese Journal of Cancer Research2014，26，3： | 2 |
| 9 | 一种适用于欠压实成因的地层孔隙流体压力预测技术显示文摘为了提高基于欠压实成因机制的地层孔隙流体压力预测的准确性,这里从提高地震层速度场的计算精度的角度出发,提出了一种高精度地层孔隙流体压力预测技术。①该技术针对浅部地层(无测井曲线的地层段)采用三维约束DIX反演方法和叠加速度体、层位数据计算浅部地层的地震层速度体;②针对中深层地层(有测井曲线的地层段)采用叠后波阻抗反演方法和叠后三维地震数据体、测井数据、层位数据计算中深层地层的地震层速度;③沿着研究区的某一浅部地层分界面将浅部地层与中深层地层的地震层速度体进行拼接处理,得到一个完整的地震层速度体;④采用'Fillippone方法+Eaton方法'的组合方法进行三维地层孔隙流体压力预测。某区页岩气地层的实际计算结果验证了该技术的正确性与可靠性,其预测的地层孔隙流体压力与实钻井一致,且目的层的地层孔隙压力平面分布特征与地质认识一致,有助于指导研究区后续的勘探与开发。 | 熊晓军 黄劲 陈容 LIAO Yiduo 袁野 | 2019 | 物探化探计算技术2019，41，1： | 2 |
| 10 | A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers显示文摘 | Siwanon Jirawatnotai Yiduo Hu Wojciech Michowski | | 0，，： | 1 |
| 11 | Efficacy of real-time PCR-based detection of Helicobacter pylori infection and genotypic resistance-guided quadruple therapy as the first-line treatment for functional dyspepsia with Helicobacter pylori infection显示文摘 | Qian Liu Dongdong Qi Jiarui Kang Yiduo Jin Wenxiang Liu Wenbin Gao Peng Hou Jiangyang Lu | 2015 | European Journal of Gastroenterology & Hepatology2015，，3： | 1 |
| 12 | Hybrid Tandem Solar Cell for Concurrently Converting Light and Heat Energy With Utilization of Full Solar Spectrum 显示文摘 | Guo Xiaozhi Zhang Yiduo Qin Da | 2010 | Journal of Power Sources2010，195，22： | 1 |
| 13 | Experi- mental study of pre-stressed concrete beams with fa- tigue subjoining freezing-thawing circle 显示文摘 | Zhang Yiduo Liu Ronggui Chen Yu | 2012 | Ad- vanced Materials Research2012，，10： | 1 |
| 14 | Alpha-fetoprotein-thymidine kinase–luciferase knockin mice: A novel model for dual modality longitudinal imaging of tumorigenesis in liver显示文摘 | Xincheng Lu Hong Guo Joseph Molter Hui Miao Lizabeth Gerber Yiduo Hu Ellen L. Barnes Hannes Vogel Zhenghong Lee Guangbin Luo Bingcheng Wang | 2010 | Journal of Hepatology2010，，1： | 1 |
| 15 | Preparation and Ammonia Adsorption Performance of Titanium Phosphonate Adsorbent Materials with Hierarchically Porous Structure显示文摘Titanium phosphonate adsorbent materials with hierarchically porous structure were fabricated using the hydrolysis of tetrabutyl titanate in different organophosphonic acids solutions. Based on the macroporous structure of 100-2000 nm in size, a worm-hole like mesostructure was in the macropore walls, which was supported by the scanning electron microscopy(SEM), transmission electron microscopy(TEM), and N_2 sorption analysis. Fourier transform infrared spectroscopy(FT-IR) data indicated the organic groups inside the solid materials framework. NH_3 adsorption detection was performed using titanium phosphonate adsorbent materials and some significant results were obtained. The adsorption mechanism was also discussed in this study. Large adsorption amount(75.2 mg/g) was mainly attributed to the acid site via acid-base reactions and the physical adsorption site via Van der Waals forces. Resultant materials could effectively restrain the desorption of adsorbent NH_3 back into air causing secondary pollution, so it could make a promising potential use in decontamination of gas pollutants in the future. | 邵高耸 lu lingang qian xiaodong zhang yiduo | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，4： | 1 |
| 16 | A function for cyelin D1 in DNA repair uncovered by protein interactome analyses in human cancers 显示文摘 | Siwanon J Yiduo H Wojeiech M | 2011 | Nature2011，474，： | 1 |
| 17 | Revealing the intrinsic nonlinear optical response of a single MoS_(2) nanosheet in a suspension based on spatial self-phase modulation显示文摘The reorientation of 2D materials caused by nonlocal electron coherence is the formation mechanism of 2D material spatial self-phase modulation under laser irradiation,which is widely known as the“wind-chime”model.Here,we present a method that provides strong evidence for the reorientation of 2D-material-induced spatial self-phase modulation.The traditional“wind-chime”model was modified by taking into account the attenuation,i.e.,damping of the incident light beam in the direction of the optical path.Accordingly,we can extract the nonlinear refractive index of a single MoS2 nanosheet,instead of simply obtaining the index from an equivalent MoS2 film that was constructed by all nanosheets.Our approach introduces a universal and accurate method to extract intrinsic nonlinear optical parameters from 2D material systems. | Si Xiao Ying Ma Yilin He Yiduo Wang Hao Xin Qi Fan Jingdi Zhang Xiaohong Li Yu Zhang Jun He Yingwei Wang | 2020 | Photonics Research2020，8，11： | 0 |
| 18 | Reconfigurable memristor based on SrTiO_(3) thin-film for neuromorphic computing显示文摘Neuromorphic computing aims to achieve artificial intelligence by mimicking the mechanisms of biological neurons and synapses that make up the human brain.However,the possibility of using one reconfigurable memristor as both artificial neuron and synapse still requires intensive research in detail.In this work,Ag/SrTiO_(3)(STO)/Pt memristor with low operating voltage is manufactured and reconfigurable as both neuron and synapse for neuromorphic computing chip.By modulating the compliance current,two types of resistance switching,volatile and nonvolatile,can be obtained in amorphous STO thin film.This is attributed to the manipulation of the Ag conductive filament.Furthermore,through regulating electrical pulses and designing bionic circuits,the neuronal functions of leaky integrate and fire,as well as synaptic biomimicry with spike-timing-dependent plasticity and paired-pulse facilitation neural regulation,are successfully realized.This study shows that the reconfigurable devices based on STO thin film are promising for the application of neuromorphic computing systems. | Xiaobing Yan Xu Han Ziliang Fang Zhen Zhao Zixuan Zhang Jiameng Sun Yiduo Shao Yinxing Zhang Lulu Wang Shiqing Sun Zhenqiang Guo Xiaotong Jia Yupeng Zhang Zhiyuan Guan Tuo Shi | 2023 | Frontiers of physics2023，18，6： | 0 |
| 19 | Visualization Analysis of Research on Student Classroom Engagement by Knowledge Mapping显示文摘The aim of the paper is to identify and explore leading development situation within the research field related to student classroom engagement.Using knowledge mapping tools,this paper conducted the visualization analysis on internationalliteraturein relation to student classroom engagementfrom the Web of Science databases.By combination of the statistical data and visualizationmapping,this paper studied on the research relationship networks and status for the co-authors'countries/institutions,co-citation documents/journalsand co-occurring keywordsbased on the sample datafromliterature.The results indicate that the number ofpublished papershasincreased obviously and expanded graduallysince 2000.Main countries and institutions of researches were the UnitedStates,Australia,United Kingdom,Canada and China in order,and these countries had intense collaboration.The theoretical basis of the research come from education and teaching,psychology.The hotspots of researches fromthe global literature coveredvarious fields including achievement,motivation,behavior,education,performance.As a result of the multidisciplinary integration,many relevant internationalresearch constantly expanded the research scopes,which promoted the combination and development of theories. | Pengbin Gao Yiyuan Zhang Yan Xiang Yiduo Song | 2021 | 教育研究前沿(中英文版)2021，11，3： | 0 |
| 20 | A high-speed true random number generator based on Ag/SiNx/n-Si memristor显示文摘The intrinsic variability of memristor switching behavior can be used as a natural source of randomness,this variability is valuable for safe applications in hardware,such as the true random number generator(TRNG).However,the speed of TRNG is still be further improved.Here,we propose a reliable Ag/SiNx/n-Si volatile memristor,which exhibits a typical threshold switching device with stable repeat ability and fast switching speed.This volatile-memristor-based TRNG is combined with nonlinear feedback shift register(NFSR)to form a new type of high-speed dual output TRNG.Interestingly,the bit generation rate reaches a high speed of 112 kb/s.In addition,this new TRNG passed all 15 National Institute of Standards and Technology(NIST)randomness tests without post-processing steps,proving its performance as a hardware security application.This work shows that the SiNx-based volatile memristor can realize TRNG and has great potential in hardware network security. | Xiaobing Yan Zixuan Zhang Zhiyuan Guan Ziliang Fang Yinxing Zhang Jianhui Zhao Jiameng Sun Xu Han Jiangzhen Niu Lulu Wang Xiaotong Jia Yiduo Shao Zhen Zhao Zhenqiang Guo Bing Bai | 2024 | Frontiers of physics2024，19，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员