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| 1 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 2 | Toona sinensis extracts induces apoptosis via reactive oxygen species in human premyelocytic leukemia cells 显示文摘 | Yang Hsinling Chang Wenhuei Chia Yichen | 2006 | Food and Chemical Toxicology2006，，44： | 1 |
| 3 | Why firms use convertibles: A further test of the sequential-financing hypothesis 显示文摘 | Shao-Chi Chang Sheng-Syan Chen Yichen Liu | 2004 | Journal of Banking & Finance2004，，28： | 1 |
| 4 | Roles of thymosins in cancers and other organ systems显示文摘 | Chang Yichen Li Min Yang Hui | 2005 | World J Surg2005，29，3： | 1 |
| 5 | Why firms use convertibles: A further test of the sequentialfinancing hypothesis 显示文摘 | Chang Shao-Chi Sheng-Syan Chen and Yichen Liu | 2004 | Journal of Banking & Finance2004，28，： | 1 |
| 6 | Roles of thymosins in cancers and other organ systems显示文摘 | Chang Yichen Li Min Yang Hni | 2005 | World J Surg2005，29，3： | 1 |
| 7 | Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats显示文摘 | Wen Zhihong Chang Yichen Cherng ChenHhwan | 2004 | Brain Res2004，995，2： | 1 |
| 8 | Why Firms Use Convertibles: A Further Test of the Sequential -financing Hypothesis显示文摘 | Shan- Chi Chang Sheng- Syan Chen Yichen Liu | 2004 | Journal of Banking &Finance2004，28，： | 1 |
| 9 | Roles ofthymosinsin cancers and other organ systems显示文摘 | Chang Yichen LiMin YangHui | 2005 | World J Surg2005，29，3： | 1 |
| 10 | Solid particle size characterization by a high-frequency collision response in pneumatic particulate flow显示文摘A novel triaxial vibration method is developed for the real-time characterization of the solid particle size distribution(PsD)in pneumatic particulate flow,which is critical for chemical industry.In this work,the particle-wall collision and friction behaviours were analysed by the time-domain statistical and timefrequency joint methods to narrow the high-frequency response range by the initial experiment of free fall for a single particle,interparticle,and multiple particles.Subsequently,verification experiments of PSD characterization in pneumatic flow were performed.First,the quantitative triaxial energy response model that considers the particle size,shape,and mass factors were established.Second,a good agreement of the particle number identification was found between the triaxial vibration energy and mean particle size of 150-550μm.Moreover,the performance with the best accuracy was focused on a range of 42-43 kHz in the x-axis and z-axis and 36.8-38.8 kHz in the y-axis.Finally,the individual particle energy was inversely analysed by the triaxial vibration response within the optimized frequency bands,and the PSD was characterized in real-time by a low error rate,that is,5.2% from the XZ-axis direction of sand(42-43 kHz)and 5.6% from the XYZ-axis of glass(30.9-33.9 kHz,46.2-47.2 kHz,38.3-41.3 kHz for each axis response).Therefore,this research complements the existing approaches for PsD characterization in particulate multiphase flow. | Kai Wang Yichen Li Ziang Chang Min Qin Guangming Fu Bangtang Yin Gang Wang jiaqi Tian | 2024 | Particuology2024，86，3： | 0 |
| 11 | CAV driving safety monitoring and warning via V2X-based edge computing system显示文摘Driving safety and accident prevention are attracting increasing global interest.Current safety monitoring systems often face challenges such as limited spatiotemporal coverage and accuracy,leading to delays in alerting drivers about potential hazards.This study explores the use of edge computing for monitoring vehicle motion and issuing accident warnings,such as lane departures and vehicle collisions.Unlike traditional systems that depend on data from single vehicles,the cooperative vehicle-infrastructure system collects data directly from connected and automated vehicles(CAVs)via vehicle-to-everything communication.This approach facilitates a comprehensive assessment of each vehicle’s risk.We propose algorithms and specific data structures for evaluating accident risks associated with different CAVs.Furthermore,we examine the prerequisites for data accuracy and transmission delay to enhance the safety of CAV driving.The efficacy of this framework is validated through both simulated and real-world road tests,proving its utility in diverse driving conditions. | Cheng CHANG Jiawei ZHANG Kunpeng ZHANG Yichen ZHENG Mengkai SHI Jianming HU Shen LI Li LI | 2024 | Frontiers of Engineering Management2024，11，1： | 0 |
| 12 | Efficacy of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for the treatment of poor sleep quality:a multi-center,randomized controlled,superiority trial显示文摘OBJECTIVE:To evaluate the efficacy and safety of Zhumian Tang formula granules(助眠汤配方颗粒)combined with eszopiclone for treating poor sleep quality.METHODS:This multi-center,dynamic blockrandomized,parallel-group superiority clinical trial included 130 patients.The combined treatment group received Zhumian Tang formula granules combined with eszopiclone treatment,and the control group received eszopiclone treatment only.The group allocation ratio was 1∶1.The duration of treatment was 2 weeks.Participants were asked to complete questionnaires before treatment,after 1 week of the intervention,after 2 weeks of the intervention,and at the follow-up on week 3.The primary outcomes were the Pittsburgh Sleep Quality Index(PSQI)score and the total effective rate of treatment.The secondary outcome was the rate of adverse effects.RESULTS:Compared with the eszopiclone treatment group,the PSQI score of the combined treatment group was significantly lower after 2 weeks of the intervention(6.98 vs 8.26,P<0.05).However,there was no significant difference in the mean PSQI score after 1 week of the intervention(9.89 vs 9.15,P=0.124).After the follow-up on week 3,the PSQI score of the combined treatment group remained significantly lower than that of the eszopiclone treatment group(6.12 vs 8.31,P<0.001).The total effective rates of treatment of the combined group and the eszopiclone group were 36.92%vs 35.38%(Z=0.033,P=0.855)after 1 week of the intervention,83.08%vs 58.46%(Z=9.519,P<0.05)after 2 weeks of the intervention,and 83.08%vs 61.54%(Z=7.530,P<0.05)and after the follow-up on week 3,respectively.There was no significant difference in the overall rate of adverse reactions between the combined and eszopiclone treatment groups(21.53%vs 31.8%,P=0.318).CONCLUSION:The combination of Zhumian Tang formula granules with eszopiclone was found to be safe and more effective in improving sleep quality than eszopiclone alone.Traditional Chinese medicine can enhance the effectiveness of Western medicine in the treatment of insomnia. | WANG Yichen WU Shiyi WANG Zhengyan CHANG Wenling XIE Zhihao TANG Xing ZHAO Songmei ZHOU Jing CHEN Zehong WANG Chao() YANG Chunxia | 2024 | Journal of Traditional Chinese Medicine2024，44，1： | 0 |
| 13 | Comparative Analysis of Epidemiological Features of HIV/AIDS Cases Aged Over and Under 50 Years Old—China,2010-2022显示文摘Introduction:Recent data indicate a year-on-year increase in the proportion of human immunodeficiency virus/acquired immunodeficiency syndrome(HIV/AIDS)cases reported among individuals aged≥50 in China.This study compares the epidemiological characteristics of HIV/AIDS cases in populations above and below 50 years of age.By doing so,it seeks to scrutinize the current epidemiological landscape of HIV within these distinct age cohorts and suggest tailored interventions for each group.Methods:We utilized data from the Chinese HIV/AIDS Comprehensive Response Information Management System for our comparative analysis.Joinpoint regression analysis was employed to assess the trends in standardized detection rates.Results:In China,the number of newly reported HIV/AIDS cases in the 15-49 age group increased from 51,436 in 2010 to 55,397 in 2022,while it increased from 11,751 in 2010 to 51,856 in 2022 in the group aged≥50 years.Recent years have seen a greater proportion and detection rate of HIV/AIDS cases among the≥50 age demographic compared to the 15-49 age group.In 2022,significant statistical differences were observed between males and females in both age cohorts with respect to education,marital status,occupation,mode of transmission,location of diagnosis,and region.Conclusions:The observed trend of a rising proportion of HIV/AIDS cases in individuals aged 50 years and older necessitates heightened attention.It is imperative that we develop and implement interventions specifically designed to prevent and control the transmission of HIV within this demographic. | Yushan Hou Yichen Jin Chang Cai Qianqian Qin Houlin Tang Fan Lyu | 2023 | China CDC weekly2023，5，48： | 0 |
| 14 | An updated constraint on the local stratigraphy at the Chang'E-4 landing site显示文摘The Chang’E-4 mission has been exploring the lunar farside.Two scientific targets of the rover onboard are(1)resolving the possible mineralogy related to the South Pole-Aitken basin and(2)understanding the subsurface processes at the lunar farside.Publications to date that are based on the reflectance spectra and radar data obtained by the rover have shown a persistent inconsistency about the local stratigraphy.To explain both the abnormal surface topography at the landing site and the unexpected radargram observed by the rover,the Alder crater has been frequently reported to be older than the mare basalts at that landing site.However,this argument is not supported by earlier geological mapping nor recent crater statistics.Resolving this controversy is critical for a full understanding of the geological history of the landing area and for correct interpretations of the scientific data returned.Employing detailed crater statistics,rigorous statistical analyses,and an updated crater chronology function,this study is determined to resolve the relative ages of the Alder crater,Finsen crater,and the mare basalts on the floor of Von Kármán.Our results reveal that while background secondaries and local resurfacing have widely occurred in the study area,affecting age determinations,the statistics are significant enough to conclude that the Alder crater is the oldest among the three targets.This independent constraint is consistent with both the crosscutting relationships of different terrains in this area and global stratigraphic mapping.Our results exclude Alder as a possible contributor of the post-mare deposits at the landing site,appealing for a more systematic stratigraphy study to resolve the provenances of these deposits. | YiRen Chang ZhiYong Xiao YiChen Wang ChunYu Ding Jun Cui YuZhen Cai | 2021 | Earth and Planetary Physics2021，5，1： | 0 |
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