|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Modeling mechanism and extension of GM (1,1)显示文摘Firstly,the research progress of grey model GM(1,1) is summarized,which is divided into three development stages: assimilation,alienation and melting stages.Then,the matrix analysis theory is used to study the modeling mechanism of GM(1,1),which decomposes the modeling data matrix into raw data transformation matrix,accumulated generating operation matrix and background value selection matrix.The changes of these three matrices are the essential reasons affecting the modeling and the accuracy of GM(1,1).Finally,the paper proposes a generalization grey model GGM(1,1),which is a extended form of GM(1,1) and also a unified form of model GM(1,1),model GM(1,1,α),stage grey model,hopping grey model,generalized accumulated model,strengthening operator model,weakening operator model and unequal interval model.And the theory and practical significance of the extended model is analyzed. | Xinping Xiao Yichen Hu Huan Guo | 2013 | Journal of Systems Engineering and Electronics2013，24，3： | 16 |
| 2 | Rapid determination of pesticide residues in Chinese materia medica using QuEChERS sample preparation followed by gas chromatography-mass spectrometry显示文摘Pesticide residue analysis plays an important role in the quality control of Chinese materia medica.This paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of Chinese materia medica.Sample preparation utilized the QuEChERS method with acetonitrile:1% aqueous acetic acid(9:1,v/v)as extraction solvent followed by sample clean-up by dispersive solid phase extraction using primary secondary amine sorbent and graphitized carbon black.Extracts were then analysed by gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring mode.Limit of detection(LOD)and limit of quantitation(LOQ)values were in the ranges 0.5-50 ng/g and 1-100 ng/g,respectively.The recoveries of the 39 pesticides were in the range 75-112% with precision(as relative standard deviation,RSD)<15%.The results show that the modified QuEChERS method allows rapid and sensitive analysis of multiple pesticide residues in Chinese materia medica. | Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang Cao | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 11 |
| 3 | Alterations in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats during hypobaric hypoxia challenge显示文摘The gut microbiota is involved in host responses to high altitude.However,the dynamics of intestinal microecology and their association with altitude-related illness are poorly understood.Here,we used a rat model of hypobaric hypoxia challenge to mimic plateau exposure and monitored the gut microbiome,short-chain fatty acids(SCFAs),and bile acids(BAs)over 28 d.We identified weight loss,polycythemia,and pathological cardiac hypertrophy in hypoxic rats,accompanied by a large compositional shift in the gut microbiota,which is mainly driven by the bacterial families of Prevotellaceae,Porphyromonadaceae,and Streptococcaceae.The aberrant gut microbiota was characterized by increased abundance of the Parabacteroides,Alistipes,and Lactococcus genera and a larger Bacteroides to Prevotella ratio.Trans-omics analyses showed that the gut microbiome was significantly correlated with the metabolic abnormalities of SCFAs and BAs in feces,suggesting an interaction network remodeling of the microbiome-metabolome after the hypobaric hypoxia challenge.Interestingly,the transplantation of fecal microbiota significantly increased the diversity of the gut microbiota,partially inhibited the increased abundance of the Bacteroides and Alistipes genera,restored the decrease of plasma propionate,and moderately ameliorated cardiac hypertrophy in hypoxic rats.Our results provide an insight into the longitudinal changes in intestinal microecology during the hypobaric hypoxia challenge.Abnormalities in the gut microbiota and microbial metabolites contribute to the development of high-altitude heart disease in rats. | Zhiyuan Pan Yichen Hu Zongyu Huang Ni Han Yan Li Xiaomei Zhuang Jiye Yin Hui Peng Quansheng Gao Wenpeng Zhang Yong Huang Yujun Cui Yujing Bi Zhenjiang Zech Xu Ruifu Yang | 2022 | Science China(Life Sciences)2022，65，10： | 5 |
| 4 | ZbAGL11, a class D MADS-box transcription factor of Zanthoxylum bungeanum, is involved in sporophytic apomixis显示文摘Apomixis is a reproductive model that bypasses sexual reproduction,so it does not require the combination of paternal and maternal gametes but instead results in the production of offspring directly from maternal tissues.This reproductive mode results in the same genetic material in the mother and the offspring and has signi fi cant applications in agricultural breeding.Molecular and cytological methods were used to identify the reproductive type of Zanthoxylum bungeanum(ZB).Fluorescence detection of the ampli fi ed products of 12 pairs of polymorphic SSR primers showed consistent fl uorescence signals for mother and offspring,indicating that no trait separation occurred during reproduction.In addition,the cytological observation results showed differentiation of ZB embryos(2n)from nucellar cells(2n)to form inde fi nite embryonic primordia and then form adventitious embryos(2n),indicating that the apomictic type of ZB is sporophytic apomixis.The MADS-box transcription factor ZbAGLll was highly expressed during the critical period of nucellar embryo development in ZB.Unpollinated ZbAGLll-OE Arabidopsis produced fertile offspring and exhibited an apomictic phenotype.The overexpression of ZbAGL11 increased the callus induction rate of ZB tissue.In addition,the results of the yeast two-hybrid experiment showed that ZbAGL11 could interact with the ZbCYP450 and ZbCAD11 proteins.Our results demonstrate that ZbAGL11 can cause developmental disorders of Arabidopsis fl ower organs and result in apomixis-like phenotypes. | Xitong Fei Qianqian Shi Yichen Qi Shujie Wang Yu Lei Haichao Hu Yulin Liu Tuxi Yang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 5 | A Generalized Comfort Function of Subway Systems Based on a Nested Logit Model显示文摘With rapid urbanization, subway systems are widely acknowledged as one of the best solutions to urban transportation problems. The operators or managers of subway systems should pay more attention to passenger's perceptions of service quality to maintain its competitive position. Taking the traffic state, efficiency,and environmental impact into consideration, the concept of generalized comfort is proposed in this paper. Based on a nested logit model, the selection probability for each factor in a generalized comfort function can be estimated using a nested structure. A certain factor is considered to be more significant in a generalized comfort function than others, when the corresponding probability of this factor is higher in value. Using stated preference and revealed preference data about passenger travel behavior obtained from the Beijing subway, the parameters of generalized comfort function are estimated by maximum likelihood techniques. | Yichen Zheng Wei Guo Yi Zhang Jianming Hu | 2014 | Tsinghua Science and Technology2014，19，3： | 1 |
| 6 | Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation显示文摘Dear Editor,TAR DNA-binding protein 43 kDa(TDP-43)undergoes liquid-liquid phase separation(LLPS)and forms reversible,cytoprotective nuclear bodies(NBs)under stress.1 Abnormal liquid-to-solid phase transition condenses TDP-43 into irreversible pathological fibril,which is associated with neurodegenerative disorders including amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD). | Jinge Gu Chen Wang Rirong Hu Yichen Li Shengnan Zhang Yunpeng Sun Qiangqiang Wanq Dan Li Yanshan Fang Cong Liu | 2021 | Cell Research2021，31，9： | 1 |
| 7 | A comprehensive evaluation of flowering plant diversity and conservation priority for national park planning in China显示文摘Establishment of a national park protection system in China,including the latest target proposed to protect at least 30%of the land area,calls for a comprehensive exploration of conservation priorities incorporating multiple diversity facets.We herein evaluate the spatial distribution of Chinese flowering plants from the perspectives of richness,uniqueness,vulnerability,and evolutionary history,by integrating three mega-phylogenies and comprehensive distribution data.We detect significantly high consistency among hotspots of different diversity measures for Chinese flowering plants,suggesting that multiple facets of evolutionary diversity are concentrically distributed in China.Affording legal protection to these areas is expected to maximize positive conservation outcomes.We propose two integrative diversity indices by incorporating three richness-based and three phylogeny-based measures,respectively.Both methods identify areas with high species richness,but the integrative phylogeny-based index also locates key areas with ancient and unique evolutionary histories(e.g.,Ailao-Wuliang Mts,Dabie Mts,Hainan rainforest,Karst area of Yunnan-Guizhou-Guangxi,Nanling Mts,and southeast coastal regions).Of all the diversity indices explored,phylogenetic endemism maximizes the incidental protection of other indices in most cases,emphasizing its significance for conservation planning.Finally,42 priority areas are identified by combining the 5%-criterion hotspots of two integrative indices and the minimum area to protect all threatened species analyzed.These priorities cover only 13.3%of China's land area,but host 97.1%of species richness(23,394/24,095),96.5%of endemic species(11,841/12,274),100%of threatened species(2,613/2,613),and 99.3%of phylogenetic diversity for flowering plants involved in this study.These frameworks provide a solid scientific basis for national park planning in China. | Limin Lu Lina Zhao Haihua Hu Bing Liu Yuchang Yang Yichen You Danxiao Peng Russell L.Barrett Zhiduan Chen | 2023 | Fundamental Research2023，3，6： | 1 |
| 8 | A leakage particle-wall impingement based vibro-acoustic characterization of the leaked sand-gas pipe flow显示文摘Solid particle leakage detection in double-wall pipes is industrially important,especially in chemical and petroleum engineering.Here,we developed vibration and acoustic sensor approaches for the characterization and comparative study of the applicability of leakage sand particle detection from the flow of gas pipes.A specific wideband vibration sensor and pressure-field microphone were selected to identify the vibro-acoustic characteristics within 50 kHz of the particle leakage.The vibro-acoustic time-behaviours and characteristic frequencies of particle leakage were observed by the time-frequency method.The leakage gas flow noise was verified by coherence analysis and minimized by a digital bandpass and band-elimination filter.Corresponding experiments were performed,and good agreement was found between the release pressures(0.1-0.3 MPa)with different leak sizes(0-8 mm)under different sand masses(120μm)and vibro-acoustic Root-Mean-Square(RMS)levels.In the comparison of the two methods,the vibration method has a better frequency response for the leakage flow and is good for identifying whether there are particle leaks.The acoustic method has a time behaviour response and is good for establishing the relationship between the particle mass and signals.In addition,the acoustic method has frequency shift features with a better signal to noise ratio.The acoustic method lays the foundation for future work of more complex leakage detection combining the advantages of vibration and the acoustic method. | Kai Wang Yinan Hu Min Qin Gang Liu Yichen Li Gang Wang | 2021 | Particuology2021，19，2： | 1 |
| 9 | A social computing method for energy safety显示文摘Information and communication technologies enable the transformation of traditional energy systems into cyber-physical energy systems(CPESs),but such systems have also become popular targets of cyberattacks.Currently,available methods for evaluating the impacts of cyberattacks suffer from limited resilience,efficacy,and practical value.To mitigate their potentially disastrous consequences,this study suggests a two-stage,discrepancy-based optimization approach that considers both preparatory actions and response measures,integrating concepts from social computing.The proposed Kullback-Leibler divergence-based,distributionally robust optimization(KDR)method has a hierarchical,two-stage objective function that incorporates the operating costs of both system infrastructures(e.g.,energy resources,reserve capacity)and real-time response measures(e.g.,load shedding,demand-side management,electric vehicle charging station management).By incorporating social computing principles,the optimization framework can also capture the social behavior and interactions of energy consumers in response to cyberattacks.The preparatory stage entails day-ahead operational decisions,leveraging insights from social computing to model and predict the behaviors of individuals and communities affected by potential cyberattacks.The mitigation stage generates responses designed to contain the consequences of the attack by directing and optimizing energy use from the demand side,taking into account the social context and preferences of energy consumers,to ensure resilient,economically efficient CPES operations.Our method can determine optimal schemes in both stages,accounting for the social dimensions of the problem.An original disaster mitigation model uses an abstract formulation to develop a risk-neutral model that characterizes cyberattacks through KDR,incorporating social computing techniques to enhance the understanding and response to cyber threats.This approach can mitigate the impacts more effectively than several existing methods,even with limited data availability.To extend this risk-neutral model,we incorporate conditional value at risk as an essential risk measure,capturing the uncertainty and diverse impact scenarios arising from social computing factors.The empirical results affirm that the KDR method,which is enriched with social computing considerations,produces resilient,economically efficient solutions for managing the impacts of cyberattacks on a CPES.By integrating social computing principles into the optimization framework,it becomes possible to better anticipate and address the social and behavioral aspects associated with cyberattacks on CPESs,ultimately improving the overall resilience and effectiveness of the system’s response measures. | Pengfei Zhao Shuangqi Li Zhidong Cao Paul Jen-Hwa Hu Daniel Dajun Zeng Da Xie Yichen Shen Jiangfeng Li Tianyi Luo | 2024 | Journal of Safety Science and Resilience2024，5，1： | 0 |
| 10 | CAV driving safety monitoring and warning via V2X-based edge computing system显示文摘Driving safety and accident prevention are attracting increasing global interest.Current safety monitoring systems often face challenges such as limited spatiotemporal coverage and accuracy,leading to delays in alerting drivers about potential hazards.This study explores the use of edge computing for monitoring vehicle motion and issuing accident warnings,such as lane departures and vehicle collisions.Unlike traditional systems that depend on data from single vehicles,the cooperative vehicle-infrastructure system collects data directly from connected and automated vehicles(CAVs)via vehicle-to-everything communication.This approach facilitates a comprehensive assessment of each vehicle’s risk.We propose algorithms and specific data structures for evaluating accident risks associated with different CAVs.Furthermore,we examine the prerequisites for data accuracy and transmission delay to enhance the safety of CAV driving.The efficacy of this framework is validated through both simulated and real-world road tests,proving its utility in diverse driving conditions. | Cheng CHANG Jiawei ZHANG Kunpeng ZHANG Yichen ZHENG Mengkai SHI Jianming HU Shen LI Li LI | 2024 | Frontiers of Engineering Management2024，11，1： | 0 |
| 11 | Synthesis of Cs_(2.5)H_(0.5)PW_(12)O_(40)/TiO_(2) Nanocomposites with Dominant TiO_(2){001}Facets and Related Photocatalytic Properties显示文摘TiO_(2) nanosheets with dominant{001}facets,coupled with Cs_(2.5)H_(0.5)PW_(12)O_(40),were successfully synthesized by a one-step hydrothermal reaction.The photocatalytic activity of nanocatalysts was evaluated by the degradation of Rhodamine B under UV light irradiation.The results showed that both the addition of Cs_(2.5)H_(0.5)PW_(12)O_(40) and the exposed{001}facets of TiO_(2) have a positive effect on the photocatalytic activity.The improved photoactivity of nanocomposites in comparison with that of TiO_(2) nanosheets could be attributed to the synergistic effect between Cs_(2.5)H_(0.5)PW_(12)O_(40) and TiO_(2) which facilitates the separation of photo-induced hole-electron pairs. | Yichen Hu Yuanhang Ren Gangfeng Tang Cheng Wang Min Tang Bin Yue Heyong He | 2014 | Chinese Journal of Chemistry2014，32，11： | 0 |
| 12 | TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma显示文摘Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(P<0.001).The expression of key receptors in the TNF-dependent signaling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC. | Huigang Li Zuyuan Lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng Ren Lang Di Lu Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，1： | 0 |
| 13 | New insights into effects of Kaixin Powder on depression via lipid metabolism related adiponectin signaling pathway显示文摘Objective:To clarify the anti-depressive potential mechanisms of Kaixin Powder(KP),a drug that helps to prevent and treat depression and other mentaldiseases,from genome-wide transcriptome profiling.Methods:Transcriptome and KEGG pathway analysis were conducted on the hippocampus of depressed rats,then the differentially expressed genes were validated and serum concentration of lipid parameters were identified by enzymatic assays.Furthermore,high-fat diets induced depression-like behaviors in Syrian golden hamsters were conducted to verify the predicted molecular mechanisms acquired from the transcriptome analysis.Results:Transcriptome results revealed that the 24 differentially expressed genes(DEGs)in chronic mild stress(CMS)rats could be reversed after two weeks of KP treatment.The mechanisms of KP in treating depression firstly involved the regulation of several pathology modules,including lipid metabolism,synapse function and inflammation.KP could regulate imbalances of lipid homeostasis in high-fat diet induced depressive symptoms.Furthermore,it was validated that cholesterol metabolism dysfunction can be ameliorated by KP,which was correlated with upregulation of the AdipoR1-BDNF(brainderived neurotrophic factor)co-regulatory pathway.Conclusion:Taken together,our results demonstrated that KP not only alleviates depression via traditional mental illness targets,but it may also simulates the cholesterol metabolism and adiponectin signaling with multi-target characteristics. | Wenshan Yang Hong Yin Yichen Wang Yuanbo Wang Xia Li Chaochen Wang Ping Liu Yuan Hu | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
| 14 | Cobalt phthalocyanine-based conjugated polymer as efficient and exclusive electrocatalyst for CO_(2) reduction to ethanol显示文摘Electrocatalytic conversion of carbon dioxide to high value-added chemicals is a promising method for solving the energy crisis and global warming.Electrochemical active metal-containing conjugated polymers have been widely studied for heterogeneous carbon dioxide reduction.In the present contribution,we designed and synthesized a stable cobalt phthalocyanine-based conjugated polymer,named CoPPc-TFPPy-CP,and also explored its electro-catalytic application in carbon dioxide reduction to liquid products in an aqueous solution.In the catalyst,cobalt phthalocyanine acts as building blocks connected with 1,3,6,8-tetrakis(4-formyl phenyl)pyrenes via imine-linkages,leading to mesoporous formation polymers with the pore size centered at 4.1nm.And the central co-balt atoms shifted to a higher oxidation state after condensation.With these chemical and structural natures,the catalyst displayed a remarkable electrocatalytic CO_(2) reduction performance with an ethanol Faradaic efficiency of 43.25%at-1.0V vs RHE.While at the same time,the electrochemical reduction process catalyzed by cobalt phthalocyanine produced only carbon monoxide and hydrogen.To the best of our knowledge,CoPPc-TFPPy-CP is the first example among organic polymers and metal-organic frameworks that produces ethanol from CO_(2) with a remarkable selectivity. | Dong Jiang Ran Bu Wei Xia Yichen Hu Mengchen Zhou Enqing Gao Toru Asahi Yusuke Yamauchi Jing Tang | 2023 | Materials Reports(Energy)2023，3，1： | 0 |
| 15 | Ancient DNA reveals the maternal genetic history of East Asian domestic pigs显示文摘Zoo-archaeological and genetic evidence suggest that pigs were domesticated independently in Central China and Eastern Anatolia along with the development of agricultural communities and civilizations.However,the genetic history of domestic pigs,especially in China,has not been fully explored.In this study,we generate 42 complete mitochondrial DNA sequences from~7500-to 2750-year-old individuals from the Yellow River basin.Our results show that the maternal genetic continuity of East Asian domestic pigs dates back to at least the Early to Middle Neolithic.In contrast,the Near Eastern ancestry in European domestic pigs saw a near-complete genomic replacement by the European wild boar.The majority of East Asian domestic pigs share close haplotypes,and the most recent common ancestor of most branches dates back to less than 20,000 years before present,inferred using new substitution rates of whole mitogenomes or combined protein-coding regions.Two major population expansion events of East Asian domestic pigs coincided with changes in climate,widespread adoption of introduced crops,and the development of agrarian societies.These findings add to our understanding of the maternal genetic composition and help to complete the picture of domestic pig evolutionary history in East Asia. | Ming Zhang Yichen Liu Zhipeng Li Peng Lü Jacob D.Gardner Maolin Ye Jihuai Wang Miaomiao Yang Jing Shao Weilin Wang Qingyan Dai Peng Cao Ruowei Yang Feng Liu Xiaotian Feng Lizhao Zhang Enwei Li Yunzheng Shi Zehui Chen Shilun Zhu Weiwei Zhai Tao Deng Ziyuan Duan E.Andrew Bennett Songmei Hu Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，6： | 0 |
| 16 | MDvT: introducing mobile three-dimensional convolution to a vision transformer for hyperspectral image classification显示文摘Hyperspectral images carry numerous spectral bands,and their wealth of band data is a valuable source of information for the accurate classification of ground objects.Three-dimensional(3D)convolution,although an excellent spectral information extraction method,is limited by its huge number of parameters and long model training time.To allow better integration of 3D convolution with the most popular transformer models currently available,a new architecture called mobile 3D convolutional vision transformer(MDvT)is proposed.The MDvT introduces inverted residual structure to reduce the number of model parameters and balance the data mining efficiency of low-dimensional data input.Simultaneously,a square patch is used to cut the sequence of tokens to accelerate the model operation.Through extensive experiments,we evaluated the classification overall performance of the proposed MDvT on the WHU-Hi and Pavia University datasets,and demonstrated significant improvements in classification accuracy and model runtime compared with classical deep learning models.It is worth noting that compared with directly integrating 3D convolution into the transformer model,the MDvT architecture improves the accuracy while reducing the time to train an epoch by approximately 58.54%.To facilitate the reproduction of the work in this paper,the model code is available at http://gffzz188fe103f8f1460asxq6c9ovpobcp600u.ffgz.tsg.suse.edu.cn/gloryofroad/MDvT. | Xinyao Zhou Wenzuo Zhou Xiaoli Fu Yichen Hu and Jinlian Liu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 17 | Molecular ferroelectric/semiconductor interfacial memristors for artificial synapses显示文摘With the burgeoning developments in artificial intelligence,hardware implementation of artificial neural network is also gaining pace.In this pursuit,ferroelectric devices(i.e.,tunneling junctions and transistors)with voltage thresholds were recently proposed as suitable candidates.However,their development is hindered by the inherent integration issues of inorganic ferroelectrics,as well as poor properties of conventional organic ferroelectrics.In contrast to the conventional ferroelectric synapses,here we demonstrated a two-terminal ferroelectric synaptic device using a molecular ferroelectric(MF)/semiconductor interface.The interfacial resistance can be tuned via the polarization-controlled blocking effect of the semiconductor,owing to the high ferroelectricity and field amplification effect of the MF.Typical synaptic features including spike timing-dependent plasticity are substantiated.The introduction of the semiconductor also enables the attributes of optoelectronic synapse and in-sensor computing with high image recognition accuracies.Such interfaces may pave the way for the hardware implementation of multifunctional neuromorphic devices. | Yichen Cai Jialong Zhang Mengge Yan Yizhou Jiang Husnain Jawad Bobo Tian Wenchong Wang Yiqiang Zhan Yajie Qin Shisheng Xiong Chunxiao Cong Zhi-Jun Qiu Chungang Duan Ran Liu Laigui Hu | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 18 | 畅享自然——让老年人乐享幸福生活的生态社区公园设计显示文摘为了更好地照顾老年人,护理模式正在一步步由家庭护理向社区护理转变。该项目以自然恢复、低影响发展、自我维持的生态社区为设计理念,旨在创造一个健康舒适的户外空间,为老年人提供互动、娱乐和教育服务,加强老年人与家人之间的联系,并完善社区内外的社交网络。项目地址位于安徽省合肥市中心的仙桥社区。该社区占地0.46平方公里,有6个相对独立的居民区。原有社区景观设计陈旧,建筑密度高,仅有一个公共广场和一个袖珍公园,区域内居民很少有接触到绿色和自然的机会。 | Peng Chen Yichen Lou Kun Qian Zhengwei Xing Yunxin Han Wenjun Liu Hongbo Chen Wenqi Chen Xinmiao Zhu Lang Qin Xueying Liu Yu Leng Xinya Hu Suheng Yao | 2023 | 工业设计2023，，9： | 0 |
| 19 | Altered gut microbiome in FUT2 loss-of-function mutants in support of personalized medicine for inflammatory bowel diseases显示文摘The FUT2 loss-of-function mutations are highly prevalent and are associated with inflammatory bowel disease(IBD).To investigate the impact of FUT2 loss-of-function mutation on the gut microbiota in patients with IBD,81 endoscopically confirmed IBD patients were genotyped and divided into 3 groups:homozygous for functional FUT2 genes(SeSe),with one copy of non-functional FUT2 gene(Sese),or homozygous for non-functional FUT2 genes(sese).Escherichia,which attaches to fucosylated glycoconjugates,was the only abundant genus exhibiting decreased abundance in sese patients.Compared with SeSe or Sese patients,sese patients exhibited higher abundance in CD8+inducing Alistipe and Phascolarctobacterium and Th17 inducing Erysipelotrichaceae UCG-003.Counter-intuitively,butyrate-producing bacteria were more abundant in sese patients.Consistently,metabolomics analysis found higher levels of butyrate in sese patients.Our data support the hypothesis that FUT2 loss-of-function mutation participates in the IBD pathogenesis by decreasing binding sites for adherent bacteria and thus altering the gut microbiota.Decreased abundances of adherent bacteria may allow the overgrowth of bacteria that induce inflammatory T cells,leading to intestinal inflammation.As FUT2 loss-of-function mutations are highly prevalent,the identification of T cell inducing bacteria in sese patients could be valuable for the development of personalized microbial intervention for IBD. | Sijing Cheng Jun Hu Xianrui Wu Ji-An Pan Na Jiao Yichen Li Yibo Huang Xutao Lin Yifeng Zou Yuan Chen Lixin Zhu Min Zhi Ping Lan | 2021 | Journal of Genetics and Genomics2021，48，9： | 0 |
| 20 | Infrared Imageries of Human Body Activated by Tea Match the Hypothesis of Meridian System显示文摘Human meridian(Jingluo)system was hypothesized by traditional Chinese medicine(TCM)for thousands of years,suggest-ing 12 normal meridian channels going through respective organs,carrying fluid and energy,and laying thermal effects.Some treatments based on meridians have been proved effective.However,existence of meridians has never been confirmed,let alone the lack of measurement for meridian phenotypes.Thermal effect is one of the major phenotypes of meridian metabo-lism.Infrared photograph was employed to display the picture of meridians since 1970.Unfortunately,no satisfactory results have been obtained.It is possible that only when a certain meridian is activated will there be thermal effect for successful infrared photograph.In this study,13 types of tea were selected out of the herbs to activate the hypothesized 12 meridians for imagery taking.Forty-two volunteers took part in the experiment lasted for 13 days.Different tea was tested in different day.Infrared imageries of the human bodies were taken immediately after each tea was drunk.The highest temperatures of the fingers,palms,and above the organs were derived from the imageries and analyzed.The temperatures of the organs and fingers possibly connected by 12 hypothesized meridians rose together significantly following the meridian hypothesis.Infrared imageries showed quite clear shapes of the organs activated by different kinds of tea,e.g.,heart and kidneys by yel-low tea,etc.Some high temperature lines also matched the hypothetic meridians.Our work displayed the probable imageries of all the 12 hypothetic meridians for the first time,and proved with data that different foods may activate different organs following the meridian hypothesis,shedding light on a possible new method of targeted drug designs.Measurements of meridian phenotypes can be developed based on this method of activation. | Wenli Jin Yichen Tao Chen Wang Lufei Wang Xue Ao Mingjie Su Binwei Hu Yuxiao Ouyang Jiaxing Liu Hui Li | 2023 | Phenomics2023，3，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员