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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Fields of applications,diagnostic yields and findings of OMOM capsule endoscopy in 2400 Chinese patients显示文摘AIM:To retrospectively analyze the fields of application,diagnostic yields and findings of OMOM capsule endoscopy in Chinese patients.METHODS:A database including 2400 Chinese patients who received OMOM capsule endoscopy in 27 endoscopy centers in China was retrieved from the Jianshan Science and Technology Ltd.OMOM capsule endoscopy database.The patient's age,gender,fields of application,the potentially relevant findings,pyloric transit time(PTT),small bowel transit time(SBTT),and complete small-bowel examination rate(CSER) were recorded and analyzed.RESULTS:Two thousand four hundred patients aged 9-91 years(mean,49 years),of whom 1510 were males(62.9%),underwent 2400 OMOM capsule endoscopy procedures.One thousand two hundred and thirty two(51.3%) were referred with obscure gastrointestinal bleeding(OGIB),642(26.8%) with abdominal pain,and 223(9.3%) with chronic diarrhea.The overall diagnostic yield was 47.7%(1144/2400).The diagnostic yield of OMOM capsule endoscopy in OGIB subgroup was much higher than in the non-OGIB subgroup(62.4% vs 32.1%,P<0.001).The most common findings of the small bowel in Chinese patients with OGIB were arteriovenous malformation(28.1%) and tumors(18.9%).There was no significant difference in the diagnostic yield between the male and female patients with OGIB.However,the diagnostic yield in patients aged more than 60 was higher than in patients aged less than 60(69.8% vs 58.9%,P<0.001).The median PTT was 41 min(range:1-544 min) and the mean SBTT was 247.2 ± 88.9 min.The overall CSER was 86.8%.CONCLUSION:The OMOM capsule endoscopy is a valuable tool for small bowel evaluation with good overall diagnostic yield and CSER. | Liao, Zhuan Gao, Rui Li, Feng Xu, Can Zhou, Yi Wang, Jin-Shan Li, Zhao-Shen | 2010 | World Journal of Gastroenterology2010，16，21： | 35 |
| 3 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for PDAC progression, we employed single-cell RNA-seq (scRNA-seq) to acquire the transcriptomic atlas of 57,530 individual pancreatic cells from primary PDAC tumors and control pancreases, and identified diverse malignant and stromal cell types, including two ductal subtypes with abnormal and malignant gene expression profiles respectively, in PDAC. We found that the heterogenous malignant subtype was composed of several subpopulations with differential proliferative and migratory potentials. Cell trajectory analysis revealed that components of multiple tumor-related pathways and transcription factors (TFs) were differentially expressed along PDAC progression. Furthermore, we found a subset of ductal cells with unique proliferative features were associated with an inactivation state in tumor-infiltrating T cells, providing novel markers for the prediction of antitumor immune response. Together, our findings provide a valuable resource for deciphering the intra-tumoral heterogeneity in PDAC and uncover a connection between tumor intrinsic transcriptional state and T cell activation, suggesting potential biomarkers for anticancer treatment such as targeted therapy and immunotherapy. | Junya Peng Bao-Fa Sun Chuan-Yuan Chen Jia-Yi Zhou Yu-Sheng Chen Hao Chen Lulu Liu Dan Huang Jialin Jiang Guan-Shen Cui Ying Yang Wenze Wang Dan Guo Menghua Dai Junchao Guo Taiping Zhang Quan Liao Yi Liu Yong-Liang Zhao Da-Li Han Yupei Zhao Yun-Gui Yang Wenming Wu | 2019 | Cell Research2019，29，9： | 24 |
| 4 | Clinical experience of airway management and tracheal intubation under general anesthesia in patients with scar contracture of the neck显示文摘背景因为有颈的疤挛缩的病人在航线的损失的高风险,在麻醉正式就职以后控制,醒着 intubation 通常被推荐。这回顾的临床的研究被设计在这回顾的研究包括了的如此的 patients.Methods 在一般麻醉下面评估航线管理和气管的 intubation 的可能性,安全和功效从1994年1月的 1683 个病人到有颈的疤挛缩的2006年12月 1.5-67.0 年,谁在整形外科医院,医药科学的中国学院和北京联合医学院里在一般麻醉下面为选任的整形外科被安排。基于外科手术前的航线评价的结果,病人被分类进组 1 (包括有 20 的 atlanto 枕骨的延期的 1375 个病人吗?? | XUE Fu-shan LIAO Xu LI Cheng-wen XU Ya-chao YANG Quan-yong LIU Yi LIU Jian-hua LUO Mao-ping ZHANG Yan-ming | 2008 | Chinese Medical Journal2008，，11： | 23 |
| 5 | Ion Channel Genes and Epilepsy:Functional Alteration,Pathogenic Potential,and Mechanism of Epilepsy显示文摘Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy. Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed. In this paper, we analyzed the genotypes, functional alterations(funotypes), and phenotypes of these mutations. Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes, among which a distinct funotype-phenotype correlation was found in SCN1A. These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene. | Feng Wei Li-Min Yan Tao Su Na He Zhi-Jian Lin Jie Wang Yi-Wu Shi Yong-Hong Yi Wei-Ping Liao | 2017 | Neuroscience Bulletin2017，33，4： | 21 |
| 6 | Electromagnetic wave absorption in reduced graphene oxide functionalized with Fe3O4/Fe nanorings显示文摘我们与嵌入的 Fe 3 由化学热水的生长的 O 4/Fe nanorings (FeNR@rGO ) 。我们作为吸收材料的新奇电磁波说明这些 nanocomposites 的使用。有不同作文的 nanocomposites 的电磁波吸收性质被调查。准备过程和 nanocomposite 作文被优化完成最好的电磁波吸收性质。有 GO:-Fe 2 为 3 h 在 H 2/Ar 退火准备的 1:1 的 O 3 团比率展出了最好的性质。这件 nanocomposite 样品(厚度 = 4.0 公里) 在 9.16 GHz 显示出最小的反射率 of-23.09 dB。当反射率是更少的 than-10 dB,光谱宽度直到 3.9 GHz 时,乐队范围是 7.4-11.3 GHz。当时,优点的这些数字典型地具有一样的数量级与传统的铁的氧化物材料显示出的价值相比。然而, FeNR@rGO 能乐意地作为因为我们建议的生产方法与大量生产标准高度兼容,吸收材料的微波被使用。 | Yi Ding Long Zhang Qingliang Liao Guangjie Zhang Shuo Liu Yue Zhang | 2016 | Nano Research2016，9，7： | 17 |
| 7 | Intercropping with Solanum nigrum and Solanum photeinocarpum from Two Ecoclimatic Regions Promotes Growth and Reduces Cadmium Uptake of Eggplant Seedlings显示文摘Soil contamination by heavy metals is a serious environmental problem worldwide, and reduction of heavy metal accumulation in vegetables grown on contaminated land is a matter of urgency. A pot experiment was conducted to study the effects of intercropping with the Cd hyperaccumulators Solanum nigrum and Solanum photeinocarpum from two ecoclimatic regions, Ya'an and Chengdu,Sichuan Province, China, on the growth and cadmium(Cd) uptake of eggplant(Solanum melongena L.). The biomass, photosynthetic pigment contents, and activities of antioxidant enzymes of eggplant were enhanced by intercropping. The biomass of eggplant was the highest after intercropping with S. photeinocarpum from Ya'an, but did not differ significantly from that after intercropping with S. nigrum from Chengdu. The shoot Cd content of eggplant was significantly reduced by intercropping with the hyperaccumulators,which ranked as follows: S. nigrum from Chengdu > S. nigrum from Ya'an > S. photeinocarpum from Chengdu > S. photeinocarpum from Ya'an, with the decreases being 19.60%, 14.36%, 9.66%, and 6.42%, respectively, as compared with the control. The lowest shoot Cd content and translocation factor of eggplant were attained after intercropping with S. nigrum from Chengdu. Therefore, it was feasible to intercrop eggplant with S. nigrum and S. photeinocarpum on Cd-contaminated soil. | TANG Yi HE Juan YU Xuena XIE Yongdong LIN Lijin SUN Guochao LI Huanxiu LIAO Mingan LIANG Dong XIA Hui WANG Xun ZHANG Jing LIU Zejing TU Lihua LIU Li | 2017 | Pedosphere2017，27，3： | 17 |
| 8 | Binding characteristics of perylene, phenanthrene and anthracene to different DOM fractions from lake water显示文摘Six hydrophobic and hydrophilic fractions were isolated using XAD-8 and XAD-4 resins, and were extensively characterized. Partition coefficients of perylene, phenanthrene and anthracene binding to the six fractions were determined by fluorescence quenching titration. The Kdoc values obtained for the polycyclic aromatic hydrocarbons (PAHs) binding to the hydrophobic fractions were larger than those to the hydrophilic fractions. Nonlinear Stern-Volmer plots were observed when binding phenanthrene and anthracene to some hydrophilic fraction samples, suggesting saturation of polar interaction binding sites. A significant correlation of logKdoc values with molecular weights and molar absorptivities at 280 nm was observed, while atomic ratio of C/H was found to be a poor indicator for aromaticity. Other structural descriptors such as paraffinic carbon and polarity influenced the DOM-fraction ability to bind PAHs. Different interaction mechanisms underlying binding of the different fractions to the PAHs were also discussed. | MEI Yi WU Fengchang WANG Liying BAI Yingchen LI Wen LIAO Haiqing | 2009 | Journal of Environmental Sciences2009，21，4： | 16 |
| 9 | Investigation on the broadband electromagnetic wave absorption properties and mechanism of Co3O4- nanosheets/reduced-graphene-oxide composite显示文摘cobaltosic-oxide-nanosheets/reduced-graphene-oxide 合成(CoNSs@RGO ) 成功地作为一个小宽带电磁波吸收器被准备。样品厚度的效果和数量合成在吸收上补充说性质彻底地被调查到石蜡样品。由于公司 3 O 4, 很高,波浪吸收材料的 surface-to-volume 比率在吸收性质正在导致大改进。为 3.6 公里的厚度的 CoNSs@RGO 合成 was-45.15 dB 的最大的茶点损失,和有思考损失 below-10 dB 的最好的吸收带宽是有 2.9 公里的厚度的 7.14 GHz。另外,微波吸收的山峰与增加吸收涂层的厚度向低频率区域变了。电磁波吸收的机制被归因于阻抗象 RGO 的绝缘的松驰和极化一样匹配 CoNSs@RGO。比作以前报导的吸收材料, CoNSs@RGO 在高频率乐队为申请作为一个无足轻重的人和高度有效的吸收材料显示出更好的性能。 | Yi Ding Zheng Zhang Baohe Luo Qingliang Liao Shuo Liu Yichong Liu Yue Zhang | 2017 | Nano Research2017，10，3： | 16 |
| 10 | Ischemic preconditioning produces more powerful anti- inflammatory and cardioprotective effects than limb remote ischemic postconditioning in rats with myocardial ischemia-reperfusion injury显示文摘 | Zhang Jia-qiang Wang Qiang Xue Fu-shan Li Rui-ping Cheng Yi Cui Xin-long Liao Xu Meng Fan-min | 2013 | Chinese Medical Journal2013，，20： | 15 |
| 11 | Threat Assessment Method Based on Intuitionistic Fuzzy Similarity Measurement Reasoning with Orientation显示文摘The aim of this paper is to propose a threat assessment method based on intuitionistic fuzzy measurement reasoning with orientaion to deal with the shortcomings of the method proposed in [Ying-Jie Lei et al., Journal of Electronics and Information Technology 29(9)(2007)2077-2081] and [Dong-Feng Chen et al., Procedia Engineering 29(5)(2012)3302-3306] the ignorance of the influence of the intuitionistic index's orientation on the membership functions in the reasoning, which caused partial information loss in reasoning process. Therefore, we present a 3D expression of intuitionistic fuzzy similarity measurement, make an analysis of the constraints for intuitionistic fuzzy similarity measurement, and redefine the intuitionistic fuzzy similarity measurement. Moreover, in view of the threat assessment problem, we give the system variables of attribute function and assessment index, set up the reasoning system based on intuitionistic fuzzy similarity measurement with orientation, and design the reasoning rules, reasoning algorithms and fuzzy-resolving algorithms. Finally, through the threat assessment, some typical examples are cited to verify the validity and superiority of the method. | WANG Yi LIU Sanyang NIU Wei LIU Kai LIAO Yong | 2014 | China Communications2014，11，6： | 15 |
| 12 | Distribution of the COVID-19 epidemic and correlation with population emigration from Wuhan,China显示文摘Background:The ongoing new coronavirus pneumonia(Corona Virus Disease 2019,COVID-19)outbreak is spreading in China,but it has not yet reached its peak.Five million people emigrated from Wuhan before lockdown,potentially representing a source of virus infection.Determining case distribution and its correlation with population emigration from Wuhan in the early stage of the epidemic is of great importance for early warning and for the prevention of future outbreaks.Methods:The official case report on the COVID-19 epidemic was collected as of January 30,2020.Time and location information on COVID-19 cases was extracted and analyzed using ArcGIS and WinBUGS software.Data on population migration from Wuhan city and Hubei province were extracted from Baidu Qianxi,and their correlation with the number of cases was analyzed.Results:The COVID-19 confirmed and death cases in Hubei province accounted for 59.91%(5806/9692)and 95.77%(204/213)of the total cases in China,respectively.Hot spot provinces included Sichuan and Yunnan,which are adjacent to Hubei.The time risk of Hubei province on the following day was 1.960 times that on the previous day.The number of cases in some cities was relatively low,but the time risk appeared to be continuously rising.The correlation coefficient between the provincial number of cases and emigration from Wuhan was up to 0.943.The lockdown of 17 cities in Hubei province and the implementation of nationwide control measures efficiently prevented an exponential growth in the number of cases.Conclusions:The population that emigrated from Wuhan was the main infection source in other cities and provinces.Some cities with a low number of cases showed a rapid increase in case load.Owing to the upcoming Spring Festival return wave,understanding the risk trends in different regions is crucial to ensure preparedness at both the individual and organization levels and to prevent new outbreaks. | Ze-Liang Chen Qi Zhang Yi Lu Zhong-Min Guo Xi Zhang Wen-Jun Zhang Cheng Guo Cong-Hui Liao Qian-Lin Li Xiao-Hu Han Jia-Hai Lu | 2020 | Chinese Medical Journal2020，，9： | 15 |
| 13 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 14 | COVID-19: Challenges to GIS with Big Data显示文摘The outbreak of the 2019 novel coronavirus disease(COVID-19)has caused more than 100,000 people infected and thousands of deaths.Currently,the number of infections and deaths is still increasing rapidly.COVID-19 seriously threatens human health,production,life,social functioning and international relations.In the fight against COVID-19,Geographic Information Systems(GIS)and big data technologies have played an important role in many aspects,including the rapid aggregation of multi-source big data,rapid visualization of epidemic information,spatial tracking of confirmed cases,prediction of regional transmission,spatial segmentation of the epidemic risk and prevention level,balancing and management of the supply and demand of material resources,and socialemotional guidance and panic elimination,which provided solid spatial information support for decision-making,measures formulation,and effectiveness assessment of COVID-19 prevention and control.GIS has developed and matured relatively quickly and has a complete technological route for data preparation,platform construction,model construction,and map production.However,for the struggle against the widespread epidemic,the main challenge is finding strategies to adjust traditional technical methods and improve speed and accuracy of information provision for social management.At the data level,in the era of big data,data no longer come mainly from the government but are gathered from more diverse enterprises.As a result,the use of GIS faces difficulties in data acquisition and the integration of heterogeneous data,which requires governments,businesses,and academic institutions to jointly promote the formulation of relevant policies.At the technical level,spatial analysis methods for big data are in the ascendancy.Currently and for a long time in the future,the development of GIS should be strengthened to form a data-driven system for rapid knowledge acquisition,which signifies ts that GIS should be used to reinforce the social operation parameterization of models and methods,especially when providing support for social management. | Chenghu Zhou Fenzhen Su Tao Pei An Zhang Yunyan Du Bin Luo Zhidong Cao Juanle Wang Wen Yuan Yunqiang Zhu Ci Song Jie Chen Jun Xu Fujia Li Ting Ma Lili Jiang Fengqin Yan Jiawei Yi Yunfeng Hu Yilan Liao Han Xiao | 2020 | Geography and Sustainability2020，1，1： | 13 |
| 15 | Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018显示文摘Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more serious.This study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and 2018.Methods:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this study.Viral RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)protocol.The Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral drugs.Results:The prevalence of TDR was not significantly increased over time.The prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,respectively.Conclusions:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance. | Jingjing Hao Shan Zheng Mengze Gan Aobo Dong Ruihua Kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing | 2021 | China CDC weekly2021，3，53： | 13 |
| 16 | Median effective dose of remifentanil for awake laryngoscopy and intubation显示文摘 | XU Ya-chao XUE Fu-shan LUO Mao-ping YANG Quan-yong LIAO Xu LIU Yi ZHANG Yan-ming | 2009 | Chinese Medical Journal2009，，13： | 13 |
| 17 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 18 | Grey matter volume abnormalities in patients with bipolar I depressive disorder and unipolar depressive disorder:a voxelbased morphometry study显示文摘Bipolar disorder and unipolar depressive disorder(UD) may be different in brain structure. In the present study,we performed voxel-based morphometry(VBM) to quantify the grey matter volumes in 23 patients with bipolar I depressive disorder(BP1) and 23 patients with UD,and 23 age-,gender-,and educationmatched healthy controls(HCs) using magnetic resonance imaging. We found that compared with the HC and UD groups,the BP1 group showed reduced grey matter volumes in the right inferior frontal gyrus and middle cingulate gyrus,while the UD group showed reduced volume in the right inferior frontal gyrus compared to HCs. In addition,correlation analyses revealed that the grey matter volumes of these regions were negatively correlated with the Hamilton depression rating scores. Taken together,the results of our study suggest that decreased grey matter volume of the right inferior frontal gyrus is a common abnormality in BP1 and UD,and decreasedgrey matter volume in the right middle cingulate gyrus may be specifi c to BP1. | Yi Cai Jun Liu Li Zhang Mei Liao Yan Zhang Lifeng Wang Hongjun Peng Zhong He Zexuan Li Weihui Li Shaojia Lu Yuqiang Ding Lingjiang Li | 2015 | Neuroscience Bulletin2015，31，1： | 11 |
| 19 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 20 | Comparison of bolus remifentanil versus bolus fentanyl for blunting cardiovascular intubation responses in children: a randomized, double-blind study显示文摘作者没发现学习比较在孩子弄钝心血管的 intubation 反应的大丸药剂量芬太奴和 remifentanil 的功效的背景,他们因此设计了这使随机化,双窗帘估计 remifentanil 的效果的临床的学习 2 ug/kg 和芬太奴由在健康 children.Methods 的心血管的 intubation 反应上的大丸药注射的 2 ug/kg 102 个孩子,麻醉学者( ASA )的美国社会物理地位 1-2 并且为选任的原浆安排了remifentanil 2 ug/kg (组 R ) 和芬太奴 2 ug/kg (组 F ) 当麻醉与 propofol 和 vecuronium 被导致时。orotracheal intubation 用直接喉镜被执行。血压(BP ) 和心率(HR ) 在麻醉正式就职(基线价值) 前被记录,立即在 intubation 前,在为在 intubation 以后的 5 分钟的 intubation 和每分钟。收缩血压(SBP ) 和相对在每个观察的点的基线价值和率压力产品(RPP ) 的 HR 的百分比变化是计算的。SBP 和 HR 百分比变化的发生 >30% 基线价值和 RPP > 22 000 在观察期间被记录。在那里的结果不是在人口统计的数据的组之间的重要差别, BP 和 HR 和 intubation 的基线价值预定。作为与基线价值相比,在在观察期间的 intubation 和他们的最大的价值的 BP, HR 和 RPP 在组 F 显著地增加了,但是他们都在组 R 显著地减少了。BP, HR 和 RPP 根本在观察期间遵守了点,和他们的最大的价值,在组之间是显著地不同的。也在 SBP 的百分比变化的组之间有重要差别,相对基线价值的 HR 根本在观察期间遵守了点和他们的最大的百分比变化。 SBP 和 HR 百分比的发生增加了>30%基线价值和 RPP > 22 000 在观察期间,比在组 R 在组 F 是显著地更高的,但是 SBP 和 HR 百分比的发生减少了>30%基线价值与组 R 相比在组 F 是显著地更低的。结论当在孩子用作与 propofol 和 vecuronium 感应的平淡的麻醉的部分时,由大丸药注射的芬太奴 2 IJg/kg 没能有效地压抑心血管的 intubation 反应。由大丸药注射的 Remifentanil 2 ug/kg 能完全废除心血管的 intubation 反应,而且引起暂时的重要心血管的消沉的更不利的复杂并发症。 | YANG Quan-yong XUE Fu-shan LIAO Xu LIU He-ping LUO Mao-ping XU Ya-chao LIU Yi ZHANG Yan-ming | 2009 | Chinese Medical Journal2009，，1： | 8 |
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