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| 1 | L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway显示文摘As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute ischemic stroke. The activated Akt kinase pathway can prevent the death of nerve cells and exhibit neuroprotective effects in the brain after stroke. This study provides the hypothesis that l-3-n-butylphthalide has a certain therapeutic effect on vascular dementia, and its mechanism depends on the activation of the Akt kinase pathway. A vascular dementia mouse model was established by cerebral repetitive ischemia/reperfusion, and intragastrically administered l-3-n-butylphthalide daily for 28 consecutive days after ischemia/reperfusion, or 7 consecutive days before ischemia/reperfusion. The Morris water maze test showed significant impairment of spatial learning and memory at 4 weeks after operation, but intragastric administration of l-3-n-butylphthalide, especially pretreatment with l-3-n-butylphthalide, significantly reversed these changes. Thionine staining and western blot analylsis showed that preventive and therapeutic application of l-3-n-butylphthalide can reduce loss of pyramidal neurons in the hippocampal CA1 region and alleviate nerve damage in mice with vascular demen-tia. In addition, phosphorylated Akt expression in hippocampal tissue increased significantly after l-3-n-butylphthalide treatment. Experimental findings demonstrate that l-3-n-butylphthalide has preventive and therapeutic effects on vascular dementia, and its mechanism may be mediated by upregulation of phosphorylated Akt in the hippocampus. | Yaping Huai Yanhong Dong Jing Xu Nan Meng Chunfeng Song Wenbin Li Peiyuan Lv | 2013 | Neural Regeneration Research2013，8，19： | 17 |
| 2 | Genetic and biological characteristics of the globally circulating H5N8 avian influenza viruses and the protective efficacy offered by the poultry vaccine currently used in China显示文摘The H5N8 avian influenza viruses have been widely circulating in wild birds and are responsible for the loss of over 33 million domestic poultry in Europe, Russia, Middle East, and Asia since January 2020. To monitor the invasion and spread of the H5N8 virus in China, we performed active surveillance by analyzing 317 wild bird samples and swab samples collected from 41,172 poultry all over the country. We isolated 22 H5N8 viruses from wild birds and 14 H5N8 viruses from waterfowls. Genetic analysis indicated that the 36 viruses formed two different genotypes: one genotype viruses were widely detected from different wild birds and domestic waterfowls;the other genotype was isolated from a whopper swan. We further revealed the origin and spatiotemporal spread of these two distinct H5N8 virus genotypes in 2020 and 2021. Animal studies indicated that the H5N8 isolates are highly pathogenic to chickens, mildly pathogenic in ducks, but have distinct pathotypes in mice. Moreover, we found that vaccinated poultry in China could be completely protected against H5N8 virus challenge. Given that the H5N8 viruses are likely to continue to spread in wild birds, vaccination of poultry is highly recommended in high-risk countries to prevent H5N8 avian influenza. | Pengfei Cui Xianying Zeng Xuyong Li Yanbing Li Jianzhong Shi Conghui Zhao Zhiyuan Qu Yanwen Wang Jing Guo Wenli Gu Qi Ma Yuancheng Zhang Weipeng Lin Minghui Li Jingman Tian Dongxue Wang Xin Xing Yanjing Liu Shuxin Pan Yaping Zhang Hongmei Bao Liling Liu Guobin Tian Chengjun Li Guohua Deng Hualan Chen | 2022 | Science China(Life Sciences)2022，65，4： | 12 |
| 3 | Matrilineal History of the Rana longicrus Species Group(Rana,Ranidae,Anura) and the Description of a New Species from Hunan,southern China显示文摘Fieldwork in Jiemuxi National Nature Reserve,Hunan,China,discovered morphologically indistinguishable groups of brown frogs that bred at different,exclusive times of the year.A principal components analysis of morphometric data,molecular analyses,and the exclusive breeding season suggested the occurrence of two species.The population that breeds during the winter was found to be an undescribed species and was subsequently described as Rana jiemuxiensis sp.nov.The new cryptic species can be identified from its congeners at the same locality by having a different breeding season and a divergent DNA barcode.Six major lineages of brown frogs were resolved with high nodal support.Rana japonica,R.chaochiaoensis,R.omeimontis,and R.jiemuxiensis have independent maternal lineages.Rana hanlunica and R.maoershanensis have essentially identical maternal lineages and they appear to represent the same species.The validity of the species R.longicrus,R.zhenhaiensis,and R.culaiensis and their genealogical relationships are not resolved and deserve further study.The genealogy indicates that sympatric cryptic lineages probably widely exist in the R.longicrus group.This highlights the importance of future more fine-scaled samplings and the inclusion of nuclear genes. | Fang YAN Ke JIANG Hongman CHEN Ping FANG Jieqiong JIN Yi LI Shaoneng WANG Robert W.MURPHY Jing CHE Yaping ZHANG | 2011 | Asian Herpetological Research2011，2，2： | 8 |
| 4 | DNA Barcoding and the International Barcode of Life Project in China显示文摘1.Scientific and Social Benefits of DNA Barcoding Along with the accelerated global trade and climate change,the needs for sustainable development and for understanding biodiversity are increasing.Rapid and accurate species identification and sustainable utility of biodiversity resources have become a great need for the world. | CHE Jing HUANG Dawei LI Dezhu MA Juncai ZHANG Yaping | 2010 | Bulletin of the Chinese Academy of Sciences2010，24，4： | 6 |
| 5 | Variations of Stable Carbon Isotopes of CH4 Emission from Three Typical Rice Fields in China显示文摘Little is known about the stable carbon isotopes of methane(CH4) emitted(δ^(13)CH_(4emitted)) from permanently flooded rice fields and double rice-cropping fields.The CH4 emission and corresponding δ^(13)CH_(4emitted) under various field managements(mulching,water regime,tillage,and nitrogen(N) fertilization) were simultaneously measured in three typical Chinese rice fields,a permanently flooded rice field in Ziyang City,Sichuan Province,Southwest China,a double-rice cropping field in Yingtan City,Jiangxi Province,Southeast China,and a rice-wheat rotation field in Jurong City,Jiangsu Province,East China,from 2010 to 2012.Results showed different seasonal variations of δ^(13)CH_(4emitted) among the three fields during the rice-growing season.The values of δ^(13)CH_(4emitted) were negatively correlated with corresponding CH4 emissions in seasonal variation and mean,indicating the importance of CH_4 production,oxidation,and transport associated with isotopic fractionation effects to the δ^(13)CH_(4emitted).Seasonal variations of δ^(13)CH_(4emitted) were slightly impacted by mulching cultivation,tillage,and N application,but highly controlled by drainage.Meanwhile,tillage,N application,and especially mulching cultivation had important effects on seasonal mean CH4 emissions and corresponding δ^(13)CH_(4emitted) with low emissions accompanied by high values of δ^(13)CH_(4emitted).Seasonal mean values of δ^(13)CH_(4emitted) from the three fields were similar,mostly ranging from —60‰ to — 50‰,which are well in agreement with previously published data.These demonstrated that seasonal variations of δ^(13)CH_(4emitted) mainly depended on the changes in CH4 emission from rice fields and further indicated the important effects of methanogenic pathways,CH4 oxidation,and CH4 transport associated with isotope fractionation effects influenced by field managements on δ^(13)CH_(4emitted). | ZHANG Guangbin MA Jing YANG Yuting YU Haiyang SHI Yaping XU Hua | 2017 | Pedosphere2017，27，1： | 6 |
| 6 | Invading cord grass vegetation changes analyzed from Landsat-TM imageries: a case study from the Wanggang area, Jiangsu coast, eastern China显示文摘Cord grass colonization on the Jiangsu coast, eastern China, modifies the native salt marshes in terms of ecosystem structure. The Landsat TM images from 1992 to 2003 were analyzed to identify salt-marsh vegetation distribution patterns and their changes over this coastal region, in order to evaluate the effects of the spreading of the artificially introduced halophyte Spartina. Supervised classification was performed using Bands 3, 4 and 5 in conjunction with in situ training samples, to derive the distribution pattern of the vegetation in the study area. Further, in order to identify the intertidal areas with different tidal elevations, a data treatment procedure was designed to combine regional water level data using harmonic analysis with the waterlines on the TM images extracted by density slice. The results show that: (1) the Spartina alterniflora area has been expanding towards the sea rapidly since it was introduced, especially at initial stages; (2) in the upper part of the inter-tidal zone, the local marsh plant Suaeda salsa and the exotic species Spartina anglica were present only near the sea dyke, occupying only a small part of the entire salt marsh, and the area of these two species has been reduced by land reclamation; (3) there has been a trend for Spartina alterniflora to become the dominant species in the salt marshes in the study area; and (4) the elevation of Spartina alterniflora’s seaward fringe was close to mean high water on neaps, and its landward boundary was slightly higher than mean high water. The salt marsh environment of the study area has been modified rapidly by the Spartina vegetation for the last 12 years. | LI Jing GAO Shu WANG Yaping | 2010 | Acta Oceanologica Sinica2010，29，3： | 6 |
| 7 | A β-glucosidase-producing M-2 strain: Isolation from cow dung and fermentation parameter optimization for flaxseed cake显示文摘Flaxseed cake contains cyanogenic glucosides, which can be metabolized into hydrocyanic acid in an animal's body, leading to asphyxia poisoning in cells. Beta-glucosidase is highly efficient in degrading cyanogenic glucosides. The Cattle may have b-glucosidase-producing strains in the intestinal tract after eating small amounts of flaxseed cake for a long time. This study aimed to isolate of a strain from cow dung that produces b-glucosidase with high activity and can significantly reduce the amount of cyanogenic glucosides. We used cow dung as the microflora source and an esculin agar as the selective medium. After screening with 0.05% esculin and 0.01% ferric citrate, we isolated 5 strains producing high amounts of b-glucosidase. In vitro flaxseed cake fermentation was fermented by these 5 strains, in which the strain M-2 exerted the best effect(P < 0.05). The strain M-2 was identified as Lichtheimia ramosa and used as the fermentation strain to optimize the fermentation parameters by a single factor analysis and orthogonal experimental design. The optimum condition was as follows: inoculum size3%, water content 60%, time 144 h, and temperature 32℃. Under this condition, the removal rate of cyanogenic glucosides reached 89%, and crude protein increment reached 44%. These results provided a theoretical basis for the removal of cyanogenic glucosides in flaxseed and the comprehensive utilization of flaxseed cake. | Chenhui Li Junshu Wei Yaping Jing Baoxia Teng Pingrong Yang Xinjun Chen Haiying Huang Tang Zhao Tuanjie Che Chunjiang Zhang | 2019 | Animal Nutrition2019，，1： | 5 |
| 8 | ATF4 is directly recruited by TLR4 signaling and positively regulates TLR4-trigged cytokine production in human monocytes显示文摘像使用费的受体(TLR ) 是主人防卫系统的哨兵,它认出很多微生物引起的病原体。主机防卫系统可能是低效的或如果由 TLR 和随后的被触发 TLR 的 cytokine 生产的微生物引起的识别是 deregulated,煽动性的疾病可以发展。激活抄写因素 4 (ATF4 ) , ATF/CREB 抄写因素家庭的一个成员,是参予几个 pathophysiological 过程的一个重要因素。在这份报告,我们发现 ATF4 也涉及调停 TLR 的天生的有免疫力的反应,它参予 TLR4 信号 transduction 并且调停许多 cytokines 的分泌物。我们观察到 ATF4 被激活并且 translocates 到经由 TLR4-MyD88-dependent 小径跟随 lipopolysaccharide (LPS ) 刺激的原子核。另外, cytokine 数组试金证明某关键煽动性的 cytokines 例如 IL-6, IL-8 和 RANTES,被 ATF4 断然调整。我们也证明 c6 月直接绑在 ATF4,从而支持煽动性的 cytokines 的分泌物。一起拿,这些结果显示 ATF4 在被触发 TLR4 的 cytokine 充当一个积极管理者生产。 | Chunyan Zhang Nan Bai Antao Chang Zhuhong Zhang Jing Yin Wenzhi Shen Yaping Tian RongXiang Chenghu Liu | 2013 | Cellular & Molecular Immunology2013，10，1： | 5 |
| 9 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 10 | Delineating suspended sediment concentration patterns in surface waters of the Changjiang Estuary by remote sensing analysis显示文摘Three Landsat TM imageries (taken on 18 May 1987,4 August 1998 and 28 July 2007) were used as the data source to identify the spatial and temporal variations of the suspended sediment concentration (SSC) in surface waters of the Changjiang Estuary.Atmospheric correction was carried out to determine the water-leaving reflectance using the FLAASH module.A regression equation between surveyed SSC and suspended sediment index was chosen to retrieve the SSC from the Landsat TM images.In addition,tidal harmonic analysis was performed to calculate tidal conditions corresponding to the acquisition time of satellite images.The results show that the SSC spatial patterns are similar to the in situ observation results,which show the highest SSC in the region of turbidity maximum zone in the Changjiang Estuary.For the period of 1987 to 2007,the SSC pattern is controlled mainly by tidal dynamic conditions and wind speeds,rather than sediment discharges from the river. | LI Jing GAO Shu WANG Yaping | 2010 | Acta Oceanologica Sinica2010，29，4： | 3 |
| 11 | Amperometric biosensor for NADH and ethanol based on electroreduced graphene oxide–polythionine nanocomposite film显示文摘 | Zou Li Yi Huang Li Chen Xiaoli Qin Zhao Huang Yaping Zhou Yue Meng Jing Li Siyu Huang Yan Liu Wen Wang Qingji Xie Shouzhuo Yao | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 12 | An iridium(Ⅲ)-palladium(Ⅱ) metal-organic cage for efficient mitochondria-targeted photodynamic therapy显示文摘An Ir8 Pd4-heteronuclear metal-organic cage(MOC-51)was assembled from bipodal metalloligand[Ir(ppy)2(qpy)(BF4)](qpy=4,4′:2′,2″:4″,4′′′-quaterpyridine;ppy-2-phenylpridine)with Pd(Ⅱ)salt.The cubic barrel shaped MOC shows one-photon and two-photon excited deep-red emission,as well as large singlet oxygen quantum yields under visible light irradiation,therefore exhibiting great potentials in organelles-targeted cell imaging and photodynamic therapy(PDT).Compared with the Ir(Ⅲ)metalloligand,the Ir8 Pd4-MOC showed less dark toxicity and higher mitochondria-targeting efficiency.The localization in mitochondria overco mes the limitation of short lifetime and diffusion distance of ROS in cell,thus improved PDT effect can be obtained in low light dose usage of the MOC.This study presents the first case of Ir-based metal-organic cages for bio-applications in successful integration of imaging diagnosis and photodynamic therapy. | Chaojie Li Yaping Wang Yulin Lu Jing Guo Chengyi Zhu Haozhe He Xiaohui Duan Mei Pan Chengyong Su | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 13 | Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice显示文摘Differentially expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The results showed that 21 peptides were down-regulated,with peptides of mass-to-charge ratio 758.772 5 and mass-to-charge ratio 5 432.206 9,demonstrating the most significant decreases.These finding suggest that these peptides are candidate biomarkers and may play an important role in the pathogenesis of prion disease. | Xiangyu Liao Jiayu Wan Wensen Liu Xin Tang Wufei Zhu Na XU Jing Xu Nan Li Yaping Chang Chuanjing Ju | 2011 | Neural Regeneration Research2011，6，23： | 1 |
| 14 | Prognostic value of serum leptin in advanced lung adenocarcinoma patientswith cisplatin/pemetrexed chemotherapy显示文摘 | Wenjun Mou Hui Xue Hongli Tong Shengjie Sun Zhuhong Zhang Chunyan Zhang Qiyu Sun Jing Dong Xinyu Wen Guangtao Yan Yaping Tian | 2014 | Oncology Letters2014，，6： | 1 |
| 15 | Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma显示文摘 | Zhuhong Zhang Jing Yin Chunyan Zhang Ning Liang Nan Bai Antao Chang Yanhua Liu Zongjin Li Xiaoyue Tan Na Li Dan Lv Rong Xiang Yaping Tian Chenghu Liu | 2012 | Cancer Biology & Therapy2012，，6： | 1 |
| 16 | Polyploidization and epigenetics显示文摘The occurrence of polyploidy,or whole genome duplication,can result in instantaneous speciation.Because new polyploids are immediately reproductively isolated from their non-polyploid congeners,polyploidization has played an important role in the diversification of flowering plants and some vertebrates.Newly formed polyploids must respond to this instantaneous genomic change,which resembles 'genome shock' syndrome to survive and reproduce successfully.Epigenetic changes,which do not cause changes to the sequence of DNA,can significantly contribute to the survival of and ultimately to the evolutionary success of new polyploids.Epigenetic regulation,both transcriptional and post-transcriptional,entails changes in DNA methylation,gene status and/or nucleolus dominance.These changes provide effective and flexible ways for a new polyploid to respond quickly to the enormous change in genetic material,to survive and potentially reproduce.We examine and assess certain epigenetic phenomena and possible pathways that may facilitate the evolutionary success of polyploid organisms. | LI ZhiHui LU Xiang GAO Yun LIU ShaoJun TAO Min XIAO Heng QIAO YunQian ZHANG YaPing LUO Jing | 2011 | Chinese Science Bulletin2011，56，3： | 1 |
| 17 | Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics显示文摘White blood cells(WBCs)play essential roles against inflammatory disorders,bacterial infections,and cancers.Inspired by nature,WBC membrane-camouflaged nanocarriers(WBC-NCs)have been developed to mimic the“dynamic”functions of WBCs,such as transendothelial migration,adhesion to injured blood vessels,etc,which make them promising for diverse medical applications.WBC-NCs inherit the cell membrane antigens of WBCs,while still exhibiting the robust inflammation-related therapeutic potential of synthetic nanocarriers with excellent(bio)physicochemical performance.This review summarizes the proposed concept of cell membrane engineering,which utilizes physical engineering,chemical modification,and biological functionalization technologies to endow the natural cell membrane with abundant functionalities.In addition,it highlights the recent progress and applications of WBC-NCs for inflammation targeting,biological neutralization,and immune modulation.Finally,the challenges and opportunities in realizing the full potential of WBC-NCs for the manipulation of inflammation-related therapeutics are discussed. | Wanli Song Pengfei Jia Yaping Ren Junmiao Xue Bingqian Zhou Xinkai Xu Yansheng Shan Jing Deng Qihui Zhou | 2023 | Bioactive Materials2023，，5： | 1 |
| 18 | Isolation of human neuronal cells resistant to toxicity by the Prion protein peptide 106-126显示文摘 | Gu Yaping Yi Jing Kumar A | 2001 | J Alzheimer''s Disease2001，3，2： | 1 |
| 19 | Effects of Nd^(3+) and Sm^(3+) on the proliferation,differentiation and mineralization function of primary osteoblasts in vitro显示文摘A series of experimental methods including 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide (MTT) test,alkaline phosphatase (ALP) activity measurement,Oil Red O stain and measurement,mineralized function expression and quantitive real time RT-PCR (qRT-PCR) were employed to assess the effect of Nd3+ and Sm3+ on the proliferation,differentiation and mineralization function of primary osteoblasts (OBs) in vitro at cell and molecular levels.The experimental results suggest that concentration,culture time and ion species are pivotal factors for switching the biological effects of rare earth ions from toxicity to activity,from damage to protection,or from down-regulation to up-regulation. | ZHANG JinChao SHANG MiQin ZHANG DaWei LI YaPing SUN Jing CHEN Hang | 2010 | Chinese Science Bulletin2010，55，23： | 1 |
| 20 | Isolation of human neuronalcells resistant to toxicity by the Prion protein peptide 106-126显示文摘 | Yaping Gu Yi Jing Anil Kumar | 2001 | J Alzheimer''s Dis2001，3，： | 1 |
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