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| 1 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 2 | Breast cancer-specific serum peptide profiles显示文摘Early detection of breast cancer is paramount to successful clinical therapy. Yet, early-stage breast cancer lacks specific symptoms or biomarkers. With the emerging of the mass spectrometric (MS) -based signatures as biomarkers, we investigated breast cancer-related serum profile pattern through class prediction and independent validation, and used Fourier transfer MS to identify breast cancer signature. We now show a distinctive serum peptide pattern that discriminates breast cancer from healthy controls with 93.2% sensitivity and 95.4% specificity. m/z 5901.70 and 4465.74 of ion fragment of FPA and alpha1-antichymotrypsin are found in the signatures that predominantly discriminate breast cancer from healthy individuals. These novel findings identify an MS-based serum peptide pattern of breast cancer that may have direct clinical utility in future. | WANG Na WEN XinYu WANG Jie LI AiLing LI WeiHua LI Tao Li Yan ZHANG XueMin WANG HongXia YANG SongCheng ZHOU Tao GONG WeiLi TIAN YaPing HE Kun | 2009 | Chinese Science Bulletin2009，54，3： | 4 |
| 3 | Design of Fault Detection Observer Based on Hyper Basis Function显示文摘In this paper, we propose the Hyper Basis Function(HBF) neural network on the basis of Radial Basis Function(RBF) neural network. Compared with RBF, HBF neural networks have a more generalized ability with different activation functions. A decision tree algorithm is used to determine the network center. Subsequently, we design an adaptive observer based on HBF neural networks and propose a fault detection and diagnosis method based on the observer for the nonlinear modeling ability of the neural network. Finally, we apply this method to nonlinear systems. The sensitivity and stability of the observer for the failure of the nonlinear systems are proved by simulation, which is beneficial for real-time online fault detection and diagnosis. | Xin Wen Xingwang Zhang Yaping Zhu | 2015 | Tsinghua Science and Technology2015，20，2： | 4 |
| 4 | Electroacupuncture improves neuropathic pain Adenosine, adenosine 5'-triphosphate disodium and their receptors perhaps change simultaneously显示文摘Applying a stimulating current to acupoints through acupuncture needles-known as electroacupuncture-has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 (P2X3) receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain. | Wen Ren Wenzhan Tu Songhe Jiang Ruidong Cheng Yaping Du | 2012 | Neural Regeneration Research2012，7，33： | 3 |
| 5 | A fast synthetic strategy for high-quality atomically thin antimonene with ultrahigh sonication power显示文摘Recent theoretical studies revealed that two-dimensional (2D) antimonene hasattractive characteristics, such as superior photothermal conductivity, absorptionover a wide range, high mobility, and good spintronic properties. Herein, we reporta reliable liquid phase exfoliation (LPE) route for the preparation of high-qualityhigh-stability atomically thin (AT) antimonene via high ultrasonic power. TheAT antimonene delivers a high specific capacity of up to 860 mA.h.g-1, with highrate capability and good cycling stability as an anode of a sodium ion battery(SIB). The good conductivity and 2D structure endow AT antimonene with moreactive sites for sodium storage, a facilitated pathway for electron transfer andmass transport, and the capability to reduce the volume expansion during thedischarge-charge process. | Wanzhen Lin Yaping Lian Guang Zeng Yanyan Chen Zhenhai Wen Huanghao Yang | 2018 | Nano Research2018，11，11： | 2 |
| 6 | Multiplexed cytokine profiling of serum for detection of colorectal cancer显示文摘 | Zhang Pengjun Wen Xinyu Gu Feng Deng Xinxin Liu Yulan Li Juan Jia Xingwang Dong Zhennan Tian Yaping | 2013 | Future Oncol2013，，7： | 2 |
| 7 | The characteristics and performance of a multi-functional nanoassembly system for the co-delivery of docetaxel and iSur-pDNA in a mouse hepatocellular carcinoma model显示文摘 | Zhenghong Xu Zhi wen Zhang Yi Chen Lingli Chen Liping Lin Yaping Li | | 0，，： | 1 |
| 8 | LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma显示文摘 | Xu Wen Zhang Yaping Yang Ming | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，45，： | 1 |
| 9 | Phylogenetic study of complete cytochrome b genes in musk deer(Genus Moschus) using museum amples显示文摘 | Bing Su Ying-xiang Wang Hong Lan Wen Wang Yaping Zhang | 1999 | Molecular Phylogenetics and Evolution1999，12，3： | 1 |
| 10 | Amperometric biosensor for NADH and ethanol based on electroreduced graphene oxide–polythionine nanocomposite film显示文摘 | Zou Li Yi Huang Li Chen Xiaoli Qin Zhao Huang Yaping Zhou Yue Meng Jing Li Siyu Huang Yan Liu Wen Wang Qingji Xie Shouzhuo Yao | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 11 | Simultaneous determination of five main active bufadienolides of Glum Su in rat plasma by liquid chromatography tandem mass spectrometry显示文摘 | Xu Wen Luo Heng Zhang Yaping | 2007 | J Chromatogr B2007，859，： | 1 |
| 12 | Lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein for combinational immunochemotherapy of metastatic triple-negative breast cancer显示文摘Metastatic triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Combination of systemic chemotherapy and immune checkpoint blockade is effective but of limited benefit due to insufficient intratumoral infiltration of cytotoxic T lymphocytes(CTLs)and the accumulation of immunosuppressive cells.Herein,we designed a lenvatinib-and vadimezan-loaded synthetic high-density lipoprotein(LV-sHDL)for combinational immunochemotherapy of metastatic TNBC.The LV-sHDL targeted scavenger receptor class B type 1-overexpressing 4T1 cells in the tumor after intravenous injection.The multitargeted tyrosine kinase inhibitor(TKI)lenvatinib induced immunogenic cell death of the cancer cells,and the stimulator of interferon genes(STING)agonist vadimezan triggered local inflammation to facilitate dendritic cell maturation and antitumor macrophage differentiation,which synergistically improved the intratumoral infiltration of total and active CTLs by 33-and 13-fold,respectively.LV-sHDL inhibited the growth of orthotopic 4T1 tumors,reduced pulmonary metastasis,and prolonged the survival of animals.The efficacy could be further improved when LV-sHDL was used in combination with antibody against programmed cell death ligand 1.This study highlights the combination use of multitargeted TKI and STING agonist a promising treatment for metastatic TNBC. | Chao Zheng Wen Zhang Jinming Wang Yihui Zha Fengqin Xiong Ying Cai Xiang Gong Binyu Zhu Helen He Zhu Hao Wang Yaping Li Pengcheng Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，9： | 1 |
| 13 | Prognostic value of serum leptin in advanced lung adenocarcinoma patientswith cisplatin/pemetrexed chemotherapy显示文摘 | Wenjun Mou Hui Xue Hongli Tong Shengjie Sun Zhuhong Zhang Chunyan Zhang Qiyu Sun Jing Dong Xinyu Wen Guangtao Yan Yaping Tian | 2014 | Oncology Letters2014，，6： | 1 |
| 14 | Serological AFP/Golgi protein 73 could be a new diagnostic parameter of hepatic diseases显示文摘 | Liyuan Tian Yu Wang Dabin Xu Junhao Gui Xingwang Jia Hongli Tong Xinyu Wen Zhennan Dong Yaping Tian | 2011 | Int J Cancer2011，，8： | 1 |
| 15 | Isolation and identification of duck Tembusu virus strain LH and devel-opment of latex-agglutination diagnostic method for rapid detection of antibodies 显示文摘 | Quanxi Wang Yaping Wen Yifan Huang | 2014 | Avian diseases2014，58，4： | 1 |
| 16 | Phase Regulation and Defect Passivation Enabled by Phosphoryl Chloride Molecules for Efficient Quasi‑2D Perovskite Light‑Emitting Diodes显示文摘Quasi-2D perovskites have attracted tremendous interest for application as lightemission layers in light-emitting diodes(LEDs).However,the heterogeneous n phase and non-uniform distribution still severely limit the further development of quasi-2D perovskite LEDs(Pero-LEDs).Meanwhile,the increased defect density caused by the reduced dimension and grain size induces non-radiative recombination and further deteriorates the device performance.Here,we found that a series of molecules containing phosphoryl chloride functional groups have noticeable enhancement effects on the device performance of quasi-2D Pero-LEDs.Then,we studied the modification mechanism by focusing on the bis(2-oxo-3-oxazolidinyl)phosphinic chloride(BOPCl).It is concluded that the BOPCl can not only regulate the phase distribution by decreasing the crystallization rate but also remain in the grain boundaries and passivate the defects.As a result,the corresponding quasi-2D Pero-LEDs obtained a maximum external quantum efficiency(EQE_(max))of 20.82%and an average EQE(EQE_(ave))of around 20%on the optimal 50 devices,proving excellent reproducibility.Our work provides a new selection of molecular types for regulating the crystallization and passivating the defects of quasi-2D perovskite films. | Mingliang Li Yaping Zhao Jia Guo Xiangqian Qin Qin Zhang Chengbo Tian Peng Xu Yuqing Li Wanjia Tian Xiaojia Zheng Guichuan Xing Wen‑Hua Zhang Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 17 | Runoff and water erosion on road side-slopes: effects of rainfall characteristics and slope length 显示文摘 | Xu Xianli Liu Wen Kong Yaping | 2009 | Transportation Re- search Part D: Transport and Environment2009，14，7： | 1 |
| 18 | Aristolochic acids exposure was not the main cause of liver tumorigenesis in adulthood显示文摘Aristolochic acids(AAs) have long been considered as a potent carcinogen due to its nephrotoxicity. Aristolochic acid I(AAI) reacts with DNA to form covalent aristolactam(AL)-DNA adducts,leading to subsequent A to T transversion mutation, commonly referred as AA mutational signature. Previous research inferred that AAs were widely implicated in liver cancer throughout Asia. In this study, we explored whether AAs exposure was the main cause of liver cancer in the context of HBV infection in China's Mainland. Totally 1256 liver cancer samples were randomly retrieved from 3 medical centers and a refined bioanalytical method was used to detect AAI-DNA adducts. 5.10% of these samples could be identified as AAI positive exposure. Whole genome sequencing suggested 8.41% of 107 liver cancer patients exhibited the dominant AA mutational signature, indicating a relatively low overall AAI exposure rate. In animal models, long-term administration of AAI barely increased liver tumorigenesis in adult mice, opposite from its tumor-inducing role when subjected to infant mice. Furthermore, AAI induced dose-dependent accumulation of AA-DNA adduct in target organs in adult mice, with the most detected in kidney instead of liver. Taken together, our data indicate that AA exposure was not the major threat of liver cancer in adulthood. | Shuzhen Chen Yaping Dong Xinming Qi Qiqi Cao Tao Luo Zhaofang Bai Huisi He Zhecai Fan Lingyan Xu Guozhen Xing Chunyu Wang Zhichao Jin Zhixuan Li Lei Chen Yishan Zhong Jiao Wang Jia Ge Xiaohe Xiao Xiuwu Bian Wen Wen Jin Ren Hongyang Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 19 | Research progress on space charge layer effect in lithium-ion solid-state battery显示文摘The development of lithium-ion solid electrolyte provides new ideas for solving the safety problems of secondary lithium-ion batteries(LIB) and, at the same time, the improvement of energy density. However, the consequent solid-solid interfacial problems have become a typical bottleneck to the performance. It has been considered that the space charge layer(SCL) formed at the interface to balance the sharp electrochemical inherent difference of properties is one of the most important factors that affect the ion transportation along and across the interface. Its existence may hinder ion transportation and increase the interfacial impedance but may also help to provide a new percolation path for lithium ion and so to enhance the ion migration. However the mechanism of SPL formation and its regulation on ion transport is not very clear, so it has raised a lot of attention and interest from LIB researchers. The purpose of this article is to try to gain some knowledge of SCL and, at the same time to browse through the related research in recent years. Hopefully, it may help those interested in solid electrolyte development for all-solidstate lithium-ion batteries(ASSB) in the future. | ZHANG Qian KONG YaQi GAO KeXin WEN YaJing ZHANG Qi FANG HuaYi MA ChunJie DU YaPing | 2022 | Science China(Technological Sciences)2022，65，10： | 1 |
| 20 | Se-Ni Se_(2) hybrid nanosheet arrays with self-regulated elemental Se for efficient alkaline water splitting显示文摘Understanding the catalytic mechanism of non-noble transition metal electrocatalysts is crucial to designing high-efficiency,low-cost,and durable alternative electrocatalysts for water splitting which comprises the hydrogen evolution reaction(HER) and oxygen evolution reaction(OER).In this work,Se-NiSe_(2) hybrid nanosheets with a self-regulated ratio of ionic Se(I-Se) to elemental Se(E-Se) are designed on carbon cloth by solution synthesis and hydrothermal processing.The effects of the I-Se/E-Se ratios on the electrocatalytic characteristics in HER and OER are investigated systematically both experimentally and theoretically.The optimized bifunctional electrocatalyst needs overpotentials of only 133 mV to deliver an HER current density of 10 mA cm^(-2) and 350 mV to generate an OER current density of 100 mA cm^(-2) in1.0 mol L^(-1) KOH.Based on the density-functional theory calculation,surface-adsorbed E-Se is beneficial to optimizing the electron environment and the adsorption/desorption free energy of hydrogen/water of the hybrid catalyst,consequently facilitating the electrocatalytic water splitting process.There is a proper I-Se/E-Se ratio to improve the catalytic activity and kinetics of the reaction and the optimized E-Se adsorption amount can balance the interactions between I-Se and E-Se,so that the catalyst can achieve appropriate Se-H binding and active site exposure for the excellent electrocatalytic activity.To demonstrate the practicality,the assembled symmetrical device can be powered by an AA battery to produce hydrogen and oxygen synchronously.Our results provide a deeper understanding of the catalytic mechanism of transition metal selenides in water splitting and insights into the design of high-efficiency and low-cost electrocatalysts in energy-related applications. | Xiang Peng Yujiao Yan Shijian Xiong Yaping Miao Jing Wen Zhitian Liu Biao Gao Liangsheng Hu Paul K.Chu | 2022 | Journal of Materials Science & Technology2022，，23： | 1 |
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