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| 1 | Antimony(V) removal from water by hydrated ferric oxides supported by calcite sand and polymeric anion exchanger显示文摘We fabricated and characterized two hybrid adsorbents originated from hydrated ferric oxides(HFOs) using a polymeric anion exchanger D201 and calcite as host. The resultant adsorbents(denoted as HFO-201 and IOCCS) were employed for Sb(V) removal from water. Increasing solution pH from 3 to 9 apparently weakened Sb(V) removal by both composites, while increasing temperature from 293 to 313 K only improved Sb(V) uptake by IOCCS. HFO-201 exhibited much higher capacity for Sb(V) than for IOCCS in the absence of other anions in solution. Increasing ionic strength from 0.01 to 0.1 mol/L NaNO3would result in a significant drop of the capacity of HFO-201 in the studied pH ranges; however, negligible effect was observed for IOCCS under similar conditions. Similarly, the competing chloride and sulfate pose more negative effect on Sb(V) adsorption by HFO-201 than by IOCCS, and the presence of silicate greatly decreased their adsorption simultaneously, while calcium ions were found to promote the adsorption of both adsorbents. XPS analysis further demonstrated that preferable Sb(V) adsorption by both hybrids was attributed to the inner sphere complexation of Sb(V) and HFO, and Ca(II) induced adsorption enhancement possibly resulted from the formation of HFO-Ca-Sb complexes. Column adsorption runs proved that Sb(V) in the synthetic water could be effectively removed from 30 μg/L to below 5 μg/L(the drinking water standard regulated by China), and the effective treatable volume of IOCCS was around 6 times as that of HFO-201, implying that HFO coatings onto calcite might be a more effective approach than immobilization inside D201. | Yangyang Miao Feichao Han Bingcai Pan Yingjie Niu Guangze Nie Lu Lv | 2014 | Journal of Environmental Sciences2014，26，2： | 20 |
| 2 | Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis显示文摘Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis. | Xiuli Zhang Nannan Han Guoqing Li Haoqing Yang Yangyang Cao Zhipeng Fan Fengqiu Zhang | 2018 | International Journal of Oral Science2018，10，3： | 9 |
| 3 | Typhoon events recorded in coastal lagoon deposits,southeastern Hainan Island显示文摘Coastal lagoon deposits provide evidence for the magnitude and frequency of past tropical cyclones prior to instrumental records and historical documentation.In the present study,we attempt to analyze the sedimentary records containing typhoon information for the northern South China Sea region.For this purpose,sediment cores were collected from two coastal lagoons in the southeastern Hainan Island,and were analyzed in laboratory to derive the data sets about grain size,organic and inorganic carbon contents,and deposition rates.The grain size and organic-inorganic carbon data were used to formulate the proxies of typhoon events.The deposition rates,as calculated using the CRS 210 Pb method,are around 0.5 mm/a for both lagoons,on the basis of which an age model is established.Within the cores,sedimentary layers associated with 35 typhoon events have been identified.On such a basis,a 350 year history of local typhoon activities is reconstructed by incorporating the 210 Pb dating results,typhoon-induced sedimentation patterns and the historical documents.A comparison of the frequency of typhoon occurrence with the regional climate records indicates that the observed changes in tropical cyclone activity patterns,as revealed by the lagoon sedimentary records,may be related to El Ni?o,Pacific Decadal Oscillation(PDO),North Atlantic Oscillation(NAO),sunspot,and other potential climate drivers that affect the tropical cyclone variability.This study demonstrates that the sedimentary record of storms can be analyzed in combination with historical documents,to provide meaningful information on past storm activities and their long-term variability. | ZHOU Liang GAO Shu YANG Yang ZHAO Yangyang HAN Zhuochen LI Gaocong JIA Peihong YIN Yong | 2017 | Acta Oceanologica Sinica2017，36，4： | 6 |
| 4 | Mineral phase and structure changes during roasting of fine-grained carbonaceous gold ores and their effects on gold leaching efficiency显示文摘While roasting has been widely applied to reduce the negative effect of carbonaceous matters on gold extraction from fine-grained carbonaceous gold ores, the phase and structure changes of minerals during roasting and their in fluences on the leachi ng rate of gold have not been fully understood. This limits the extraction of carbonaceous gold deposits. The current work examines the oxidation process of a fine-grained carbonaceous gold ore during roasting using a range of techniques including X-ray diffraction (XRD), seanning electron microscopy (SEM), Energy Dispersive Spectrometer (EDS) analysis and pore structure analysis together with gold leaching tests. The results show that during the process of oxidative roasting, the carbonaceous matters (organic carbon and graphitic carbon) and pyrite were completely decomposed at 600 ℃ with the carbonaceous components burned and pyrite oxidized into hematite. At 650 ℃, while dolomite was decomposed into calcia, magnesia, calcium sulfate etc., the calcine structure became loose and porous, leading to a high gold leaching rate from the roasted product. Above 750 ℃, the porous calcite structure started to collapse along with the agglomeration, leading to the secondary encapsulation of gold particles, which contributed to the sharp drop in the gold leaching rate of the roasted product. This study suggests optimum phase and structure changes of minerals during roasting to achieve maximum gold extraction from fine-grained carbonaceous gold deposits. | Jianping Jin Yuexin Han Hui Li Yangyang Huai Yongjun Peng Xiaotian Gu Wei Yang | 2019 | Chinese Journal of Chemical Engineering2019，27，5： | 4 |
| 5 | A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease显示文摘Chronic kidney disease(CKD)poses a great burden to global public health as current therapies are generally ineffective.Early detection and effective therapy are crucial for the future prevention and progression of CKD.Nanoparticles(NPs)vary by particle size,charge,shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties,targetability,or the bioavailability of drugs.Thus,the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD.This review describes the current experimental research,clinical applications of NPs,the current challenges,and upcoming opportunities in the diagnosis and treatment of CKD. | Yanhong Ma Fanghao Cai Yangyang Li Jianghua Chen Fei Han Weiqiang Lin | 2020 | Bioactive Materials2020，5，3： | 3 |
| 6 | Differential equation dynamical system based assessment model in GNSS interoperability显示文摘With the development of Global Navigation Satellite System (GNSS),the idea of GNSS interoperability is born and has become the focus of study in the field of satellite navigation.The popularity for GNSS to augment the interoperability with the existing ones necessitates the study of the assessment algorithm of this idea.In this paper,an assessment algorithm for interoperability comprehensive benefits based on the differential equation dynamical system is discussed.There are two important aspects in GNSS that interoperability will affect:one is the performance advancement;the other one is the cost of adopting interoperability.While researching the complex relationship between the performance and cost,we found this relationship is similar as what between prey and predator in biomathematics,so the Lotka-Volterra model used to depict the prey-predator relationship is a felicitous tool.After building a differential dynamical model,we analyze the existence and stability of the positive equilibrium in the model.Then a Cost-Effective Function of GNSS is constructed based on the positive equilibrium,which is employed to assess the interoperability,qualitatively and quantitatively.Finally,the paper demonstrates the significance of the model and its application by citing a numerical example. | HAN Tao LU XiaoChun WANG Xue RAO YongNan ZOU DeCai YANG JianFei WU YangYang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，6： | 3 |
| 7 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 8 | Reconstructing Environmental Changes of a Coastal Lagoon with Coral Reefs in Southeastern Hainan Island显示文摘Coastal lagoons with small catchment basins are highly sensitive to natural processes and anthropogenic activities. To figure out the environmental changes of a coastal lagoon and its contribution to carbon burial, two sediment cores were collected in Xincun Lagoon, southeastern Hainan Island and (210) ~Pb activities, grain size parameters, total organic carbon(TOC), total nitrogen(TN), total inorganic carbon(TIC) and stable carbon isotopes(δ^(13)C) were measured. The results show that in 1770–1815, the decreasing water exchange capacity with outer open water, probably caused by the shifting and narrowing of the tidal inlet, not only diminished the currents and fined the sediments in the lagoon, but also reduced the organic matter of marine sources. From 1815 to 1950, the sedimentary environment of Xincun Lagoon was frequently influenced by storm events. These extreme events resulted in the high fluctuation of sediment grain size and sorting, as well as the great variation in contributions of terrestrial(higher plants, soils) and marine sources(phytoplankton, algae, seagrass). The extremely high content of TIC, compared to TOC before 1950 could be attributed to the large-scale coverage of coral reefs. However, with the boost of seawater aquaculture activities after 1970, the health growth of coral species was severely threatened, and corresponding production and inorganic carbon burial flux reduced. The apparent enhanced inorganic carbon burial rate after 1990 might result from the concomitant carbonate debris produced by seawater aquaculture. This result is important for local government long-term coastal management and environmental planning. | ZHOU Liang GAO Shu GAO Jianhua ZHAO Yangyang HAN Zhuochen YANG Yang JIA Peihong | 2017 | Chinese Geographical Science2017，27，3： | 2 |
| 9 | Three-layer phosphorene-metal interfaces显示文摘Phosphorene 最近由于它的高级搬运人活动性和悦耳的直接 bandgap 在电子的 nanoscale 和 optoelectronic 设备作为其他的隧道材料吸引了许多注意。与单层(ML ) 相比 phosphorene,很少层(FL ) phosphorene 更容易准备,在实验是更稳定的,并且被期望在 phosphorene 金属接口形成更小的 Schottky 障碍高度(SBH ) 。用 ab initio ,电子结构计算和量搬运模拟,我们执行界面的性质的系统的研究三层( 3L ) phosphorene 领域效果晶体管(联邦货物税)与几普通金属联系了(艾尔, Ag , Au , Cu , Ti , Cr , Ni ,并且 Pd )第一次。从投射乐队在垂直方向获得的 SBH 3L phosphorene 金属系统组织到左 bilayer (2L ) phosphorenes 是可比较的,那些为 2L phosphorene 联邦货物税从量运输模拟在侧面的方向获得了。当分别地, Ag 和 Cu 被用作电极,p类型 Schottky 与 0.05 的洞 SBH 联系时,为 3L phosphorene 联邦货物税的量运输模拟证明 3L phosphorene 在侧面的方向与 0.16 和 0.28 eV 的电子 SBH 形成n类型 Schottky 接触, 0.11 , 0.20 ,在侧面的方向的 0.30 , 0.30 ,和 0.31 eV 当 Cr , Pd , Ni , Ti ,艾尔,和 Au 分别地被用作电极时。3L phosphorene 联邦货物税的计算极性和 SBH 通常与可得到的实验一致。 | Xiuying Zhang Yuanyuan Pan Meng Ye Ruge Quhe Yangyang Wang Ying Guo Han Zhang Yang Dan Zhigang Song Jingzhen Li Jinbo Yang Wanlin Guo Jing Lu | 2018 | Nano Research2018，11，2： | 2 |
| 10 | miR-4651 inhibits cell proliferation of gingival mesenchymal stem cells by inhibiting HMGA2 under nifedipine treatment显示文摘Drug-induced gingival overgrowth(DIGO) is recognized as a side effect of nifedipine(NIF);however, the underlying molecular mechanisms remain unknown. In this study, we found that overexpressed mi R-4651 inhibits cell proliferation and induces G0/G1-phase arrest in gingival mesenchymal stem cells(GMSCs) with or without NIF treatment. Furthermore, sequential window acquisition of all theoretical mass spectra(SWATH-MS) analysis, bioinformatics analysis, and dual-luciferase report assay results confirmed that high-mobility group AT-hook 2(HMGA2) is the downstream target gene of mi R-4651. Overexpression of HMGA2 enhanced GMSC proliferation and accelerated the cell cycle with or without NIF treatment. The present study demonstrates that mi R-4651 inhibits the proliferation of GMSCs and arrests the cell cycle at the G0/G1 phase by upregulating cyclin D and CDK2 while downregulating cyclin E through inhibition of HMGA2 under NIF stimulation. These findings reveal a novel mechanism regulating DIGO progression and suggest the potential of mi R-4651 and HMGA2 as therapeutic targets. | Xiao Han Ruzhuang Yang Haoqing Yang Yangyang Cao Nannan Han Chen Zhang Ruitang Shi Zhengting Zhang Zhipeng Fan | 2020 | International Journal of Oral Science2020，12，2： | 2 |
| 11 | High-performance sub-10-nm monolayer black phosphorene tunneling transistors显示文摘 | Hong Li Jun Tie Jingzhen Li Meng Ye Han Zhang Xiuying Zhang Yuanyuan Pan Yangyang Wang Ruge Quhe Feng Pan Jing Lu | 2018 | Nano Research2018，11，5： | 2 |
| 12 | Spatial and temporal dynamics of microbial community composition and factors influencing the surface water and sediments of urban rivers显示文摘The temporal and spatial characteristics of urban river bacterial communities help us understand the feedback mechanism of bacteria to changes in the aquatic environment.The Fuhe River plays an important role in determining the water ecological environment of Baiyangdian Lake.16S rRNA gene sequencing was used to study the microbial distribution characteristics in the Fuhe River in different seasons.The results showed that some environmental factors of the surface water(ammonia nitrogen(NH_(3)^(-)N),total nitrogen(TN),and total phosphorus(TP))were different on the spatial and temporal scales.Moreover,there were no seasonal differences in the contents of TN,TP,total organic carbon(TOC),or heavy metals in the sediments.The distributions of Cyanobacteria,Actinomycetes and Firmicutes in the water and Actinomycetes and Planctomycetes in the sediments differed significantly among seasons(P<0.05).There were significant spatial differences in bacteria in the surface water,with the highest abundance of Proteobacteria recorded in the river along with the highest nutrient concentration,while the abundance of Bacteroidetes was higher in the upstream than the downstream.Microbial communities in the water weremost sensitive to temperature(T)and the TP concentration(P<0.01).Moreover,differences in the bacterial community were better explained by the content of heavy metals in the sediments than by the chemical characteristics.A PICRUStmetabolic inference analysis showed that the effect of high summer temperatures on the enzyme action led to an increase in the abundances of the metabolic-related genes of the river microorganisms. | Hongjie Wang Xingchun Liu Yali Wang Shengqi Zhang Guangming Zhang Yangyang Han Mengxiang Li Ling Liu | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 13 | Electrical contacts in monolayer blue phosphorene devices显示文摘半导体的单层(ML ) 蓝色 phosphorene (BlueP ) 与 ML 黑 phosphorene (BP ) 分享类似的稳定性,并且它最近有在 Au 表面上是成年的。潜在的 ML BlueP 设备经常与金属要求直接接触启用搬运人的注射。第一次,用 ab initio,电子结构计算和量搬运模拟我们在与在一只领域效果晶体管(联邦货物税) 跨越一个宽工作函数范围的金属的接触执行 ML BlueP 的界面的性质的系统的研究配置。ML BlueP 由于和五金属的强壮的相互作用经历了 metallization。与 0.42 的一个卡住的因素由于导致金属的差距状态(米格机) 在 ML BlueP 联邦货物税有强壮的费密水平(FLP ) ,卡住。分别地, ML BlueP 与 0.22, 0.22,和 0.80 eV 的电子 Schottky 障碍高度(SBH ) 与 Sc, Ag,和磅电极形成 n 类型 Schottky 接触并且与有 0.61 和 0.79 eV 的洞 SBH 的 Au 和 Pd 电极的 p 类型 Schottky 接触分别地。米格机被在 ML BlueP 和金属电极之间插入 graphene 消除,从强壮的 FLP 由转变伴随了到弱 FLP。我们的学习不仅提供卓见进 ML BlueP 金属接口,而且在 ML BlueP 设备的设计帮助。 | Jingzhen Li Xiaotian Sun Chengyong Xu Xiuying Zhang Yuanyuan Pan Meng Ye Zhigang Song Ruge Quhe Yangyang Wang Han Zhang Ying Guo Jinbo Yang Feng Pan Jing Lu | 2018 | Nano Research2018，11，4： | 2 |
| 14 | miR-34a inhibits the migration and invasion of esophageal squamous cellcarcinoma by targeting Yin Yang-1显示文摘 | Jihua Nie Xin Ge Yangyang Geng Han Cao Wei Zhu Yang Jiao Jinchang Wu Jundong Zhou Jianping Cao | 2015 | Oncology Reports2015，，： | 1 |
| 15 | Simultaneous determination of four Sudan dyes in rat blood by UFLC–MS/MS and its application to a pharmacokinetic study in rats显示文摘A rapid and sensitive method based on ultrafast liquid chromatography–tandem mass spectrometry was developed and validated for simultaneous determination of Sudan I, Sudan II, Sudan III, and Sudan IV levels in rat whole blood. Cleanert C18 mixed-mode polymeric sorbent was used for effective solid-phase extraction cleanup. Separation was carried out on a reversed-phase C18column(100 mm 2.1 mm,1.8 μm) using 0.1%(v/v) formic acid in water/0.1%(v/v) formic acid in acetonitrile as the mobile phase in gradient elution. Quanti fi cation was performed by an electrospray ionization source in the positive multiple reaction monitoring mode using D5-Sudan I as the internal standard. Calibration curves showed good linearity between 0.2 and 20.0 μg/L, with correlation coef fi cients higher than 0.9990. The average recovery rates were between 93.05% and 114.98%. The intra- and inter-day relative standard deviations were within 6.2%. The lower limit of quanti fi cation was 0.2 μg/L. All the analytes were found to be stable in a series of stability studies. The proposed method was successfully applied to a pharmacokinetic study of four Sudan dyes after oral administration to rats. | Hao Zhu Yijun Chen Changshun Huang Yangyang Han Yiwei Zhang Shucan Xie Xiaohong Chen Micong Jin | 2015 | Journal of Pharmaceutical Analysis2015，5，4： | 1 |
| 16 | Dynamic apertures with diffusion-regulatory functionality in soft porous crystals:A key to solving the century puzzle on isotopologues separation显示文摘The separation of water isotopologues has been a“century-old”challenge,also known as“the Holy Grail”in separation science.Heavy water(D2O)is a stable non-radioactive water isotopologue that plays a critical role in scientific research,military,nuclear energy,and medical fields.Heavy water was first reported in 1931 when H.C.Urey discovered D2 and D2O,for which he was awarded the Nobel Prize in Chemistry in 1934.Then in 1933,G.N.Lewis et al.obtained 0.5μL of heavy water at a concentration of around 65.7%when electrolyzing 10 liters of water.In 1935,the world's first heavy water plant was built in Norway,producing 2 tons of heavy water by electrolysis,but the separation factor was merely 1.05,which was extremely energy-consuming.In 1943,the first heavy water plant employing the distillation method was built in the United States. | Yanhong Li Jianze Xiao Yangyang Guo Ning Han Fangli Yuan Yunfa Chen Ming-Shui Yao | 2023 | Nano Research2023，16，2： | 1 |
| 17 | Expression of wheat expansin driven by the RD29 promoter in tobacco confers water-stress tolerance without impacting growth and development显示文摘 | Li Feng Han Yangyang Feng Yanan | 2013 | Journal of Biotechnology2013，163，3： | 1 |
| 18 | Chlorophyll sensitized BiVO4 as photoanode for solar water splitting and CO2 conversion显示文摘Converting solar energy into valuable hydrogen and hydrocarbon fuels through photoelectrocatalytic water splitting and CO_2 reduction is highly promising in addressing the growing demand for renewable and clean energy resources. However, the solar-to-fuel conversion efficiency is still very low due to limited light absorption and rapid bulk recombination of charge carriers. In this work, we present chlorophyll(Chl) and its derivative sodium copper chlorophyllin(ChlCuNa), as dye sensitizers, modified BiVO_4 to improve the photoelectrochemical(PEC) performance. The photocurrent of BiVO_4 is surprisingly decreased after a direct sensitization of Chl while the sensitization of ChlCuNa obviously enhances photocurrent of BiV04 electrodes by improved surface hydrophilicity and extended light absorption.ChlCuNa-sensitized BiV04 achieves an improved H_2 evolution rate of 5.43 μmol h^(-1) cm^(-2) in water splitting and an enhanced HCOOH production rate of 2.15 μmol h^(-1) cm^(-2) in CO_2 PEC reduction, which are1.9 times and 2.4 times higher than pristine BiVO_4, respectively. It is suggested that the derivative ChlCuNa is a more effective sensitizer for solar-to-fuel energy conversion and CO_2 utilization than Chl. | Yiqing Feng Hanyun Cheng Jin Han Xiuzhen Zheng Yangyang Liu Yang Yang Liwu Zhang | 2017 | Chinese Chemical Letters2017，28，12： | 1 |
| 19 | Polysaccharides Purified from Wild Cordyceps Activate FGF2/FGFR1c Signaling显示文摘Land animals as well as all organisms in ocean synthesize sulfated polysaccharides. Fungi split from animals about 1.5 billion years ago. As fungi make the evolutionary journey from ocean to land, the biggest changes in their living environment may be a sharp decrease in salt concentration. It is established that sulfated polysaccharides interact with hundreds of signaling molecules and facilitate many signaling transduction pathways, including fibroblast growth factor(FGF) and FGF receptor signaling pathway. The disappearance of sulfated polysaccharides in fungi and plants on land might indicate that polysaccharides without sulfation might be sufficient in facilitating protein ligand/receptor interactions in low salinity land. Recently, it was reported that plants on land start to synthesize sulfated polysaccharides in high salt environment, suggesting that fungi might be able to do the same when exposed in such environment. Interestingly, Cordyceps, a fungus habituating inside caterpillar body, is the most valued traditional Chinese Medicine. One of the important pharmaceutical active ingredients in Cordyceps is polysaccharides. Therefore, we hypothesize that the salty environment inside caterpillar body might allow the fungi to synthesize sulfated polysaccharides. To test the hypothesis, we isolated polysaccharides from both lava and sporophore of wild Cordyceps and also from Cordyceps militaris cultured without or with added salts. We then measured the polysaccharide activity using a FGF2/FGFR1 c signaling-dependent Ba F3 cell proliferation assay and found that polysaccharides isolated from wild Cordyceps activated FGF2/FGFR signaling, indicating that the polysaccharides synthesized by wild Cordyceps are indeed different from those by the cultured mycelium. | ZENG Yangyang HAN Zhangrun YU Guangli HAO Jiejie ZHANG Lijuan | 2015 | Journal of Ocean University of China2015，14，1： | 1 |
| 20 | Biological traits and life history of Pagiophloeus tsushimanus(Coleoptera:Curculionidae),a weevil pest on camphor trees in China显示文摘Cinnamomum camphora(L.)J.Presl.(Laurales:Lauraceae)is widely cultivated as an important landscape tree species in many urban areas in South China,especially in Shanghai City.Pagiophloeus tsushimanus Morimoto has become a destructive insect pest of C.camphora plantations in Shanghai,but the biological and ecological traits of this pest remain largely unknown.In this study,we investigated the damage and life history and determined the larval instar of P.tsushimanus.The results indicated that P.tsushimanus is a monophagous weevil pest,and C.camphora is the unique host tree species.C.camphora plantations in all administrative districts of Shanghai have been seriously damaged by P.tsushimanus.Adults often aggregate for feeding on the tender bark of twigs and occasionally on newly emerged buds.After experiencing damage,the twigs shrink and crack and the buds will shrink.Adults tend to repeatedly mate and oviposit,and all females lay single eggs at a time.Eggs will be covered with a mixture of secretions and wood chips by female adults.Larvae(1 st-2 nd instar)feed on the phloem,while 3 rd-5 th instar can bore into the phloem and the cambium.Massive tunnels,including three shapes(inverted'L',inverted'T',and inverted'Z'),were observed in the trunk of each tree,and resulted in swelling of the outer bark.P.tsushimanus has one life cycle per year in Shanghai.Both adults and larvae(3 rd-5 th instar)overwinter from early November to early April.Adults overwinter in grooves on the underside of branches or at branch nodes,and larvae overwinter in tunnels.Five larval instars of P.tsushimanus were determined according to Dyar’s and Crosby’s rules.The biological traits and life history of P.tsushimanus have been identified and can provide guidance in terms of pest control and plantation management. | Cong Chen Congcong Zhang Shouyin Li Han Zhu Binqi Fan Yan Wang Peng Su Yangyang Han Dejun Hao | 2021 | Journal of Forestry Research2021，32，5： | 0 |
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