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| 1 | Processes of initial collision and suturing between India and Asia显示文摘The initial collision between Indian and Asian continents marked the starting point for transformation of land-sea thermal contrast,uplift of the Tibet-Himalaya orogen,and climate change in Asia.In this paper,we review the published literatures from the past 30 years in order to draw consensus on the processes of initial collision and suturing that took place between the Indian and Asian plates.Following a comparison of the different methods that have been used to constrain the initial timing of collision,we propose that the tectono-sedimentary response in the peripheral foreland basin provides the most sensitive index of this event,and that paleomagnetism presents independent evidence as an alternative,reliable,and quantitative research method.In contrast to previous studies that have suggested collision between India and Asia started in Pakistan between ca.55 Ma and50 Ma and progressively closed eastwards,more recent researches have indicated that this major event first occurred in the center of the Yarlung Tsangpo suture zone(YTSZ) between ca.65 Ma and 63 Ma and then spreading both eastwards and westwards.While continental collision is a complicated process,including the processes of deformation,sedimentation,metamorphism,and magmatism,different researchers have tended to define the nature of this event based on their own understanding,an intuitive bias that has meant that its initial timing has remained controversial for decades.Here,we recommend the use of reconstructions of each geological event within the orogenic evolution sequence as this will allow interpretation of collision timing on the basis of multidisciplinary methods. | DING Lin Satybaev MAKSATBEK CAI FuLong WANG HouQi SONG PeiPing JI WeiQiang XU Qiang ZHANG LiYun Qasim MUHAMMAD Baral UPENDRA | 2017 | Science China Earth Sciences2017，60，4： | 23 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 4 | Protonation induced high-T_c phases in iron-based superconductors evidenced by NMR and magnetization measurements显示文摘Chemical substitution during growth is a well-established method to manipulate electronic states of quantum materials, and leads to rich spectra of phase diagrams in cuprate and iron-based superconductors. Here we report a novel and generic strategy to achieve nonvolatile electron doping in series of(i.e.11 and 122 structures) Fe-based superconductors by ionic liquid gating induced protonation at room temperature. Accumulation of protons in bulk compounds induces superconductivity in the parent compounds, and enhances the Tclargely in some superconducting ones. Furthermore, the existence of proton in the lattice enables the first proton nuclear magnetic resonance(NMR) study to probe directly superconductivity. Using Fe S as a model system, our NMR study reveals an emergent high-Tcphase with no coherence peak which is hard to measure by NMR with other isotopes. This novel electric-fieldinduced proton evolution opens up an avenue for manipulation of competing electronic states(e.g.Mott insulators), and may provide an innovative way for a broad perspective of NMR measurements with greatly enhanced detecting resolution. | Yi Cui Gehui Zhang Haobo Li Hai Lin Xiyu Zhu Hai-Hu Wen Guoqing Wang Jinzhao Sun Mingwei Ma Yuan Li Dongliang Gong Tao Xie Yanhong Gu Shiliang Lie Huiqian Luo Pu Yu Weiqiang Yu | 2018 | Science Bulletin2018，63，1： | 7 |
| 5 | Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity显示文摘Dear Editor,Pancreatic cancer (PCa) is a high-grade gastrointestinal malignancy more commonly occurring in elderly populations with lower than 5% overall 5-year survival rate (Hidalgo, 2010). PCa responds poorly to most chemotherapeutic agents, and therefore it is imperative to develop novel therapeutic agents that have anti-cancer activities against PCa. | Juanjuan Feng Mingjin Rao Man Wang Lin Liang Zhi Chen Xiufeng Pang Weiqiang Lu Zhenliang Sun | 2019 | Science China(Life Sciences)2019，62，10： | 6 |
| 6 | Evaluation index system of shared energy storage market towards renewable energy accommodation scenario:A China’s Qinghai province context显示文摘With the ever-increased installed capacity of renewable energy generation units in a power system,the so-called shared energy storage(SES),a novel business model under the umbrella of the shared economy principle,has the potential to play an essential role in the accommodation of renewable energy generation.However,unified evaluation standards and methods,which can help decision-makers analyze the performance of the SES market,are still not available.In this paper,an evaluation index system of the SES market is designed based on the trading rules of China’s Qinghai province and the structure-conduct-performance(SCP)analytical model.Moreover,the definition and characteristics of the indices,which can show the performance of the SES market from different perspectives,are given.Furthermore,the ideal cases are presented as the evaluation benchmark based on the development expectation of the SES market,and the analytic hierarchy process(AHP)and the technique for order preference by similarity to an ideal solution(TOPSIS)are applied to evaluate the SES market comprehensively.Finally,a case study based on actual data of the SES trading pilot project in Qinghai shows that the evaluation index system can reflect the operation status,existing problems and influencing factors of the SES market. | Baomin Fang Weiqiang Qiu Maochun Wang Wei Zhou Zhenzhi Lin Fushuan Wen | 2022 | Global Energy Interconnection2022，5，1： | 5 |
| 7 | A review of the application of nanoparticles in the diagnosis and treatment of chronic kidney disease显示文摘Chronic kidney disease(CKD)poses a great burden to global public health as current therapies are generally ineffective.Early detection and effective therapy are crucial for the future prevention and progression of CKD.Nanoparticles(NPs)vary by particle size,charge,shape and the density of targeting ligands and are associated with enhancement of the pharmacokinetic properties,targetability,or the bioavailability of drugs.Thus,the emergence of NPs in medicine has provided novel solutions to the potential diagnosis and treatment of CKD.This review describes the current experimental research,clinical applications of NPs,the current challenges,and upcoming opportunities in the diagnosis and treatment of CKD. | Yanhong Ma Fanghao Cai Yangyang Li Jianghua Chen Fei Han Weiqiang Lin | 2020 | Bioactive Materials2020，5，3： | 3 |
| 8 | An incentive model between a contractor and multiple subcontractors in a green supply chain based on robust optimization显示文摘In this paper,we consider the incentive mechanism of a construction supply chain which includes a contractor and several subcontractors from both economic and environmental perspectives.Firstly,we describe the structure of the construction supply chain as well as the relationship between the contractor and subcontractors.Then,a bi-level nonlinear model with multiple followers comprising uncertain parameters is developed to balance the benefits of all supply chain members.In this model,the contractor is the leader while the subcontractors are followers.Next,we convert the primal model into a deterministic counterpart robust model,and a heuristic polynomial algorithm is designed to solve the transformed model.Finally,the validity of the model is verified by a numerical example.Our paper provides a method to quantitatively analyze construction projects from the perspective of supply chains while considering economic performance and environmental performance with the existence of uncertainty. | Yaqin Lin Weiqiang Zhang | 2020 | Journal of Management Analytics2020，7，4： | 2 |
| 9 | Reduction in Intrahepatic cccDNA and Integration of HBV in Chronic Hepatitis B Patients with a Functional Cure显示文摘Background and Aims:Functional cure(FC)is characterized by the clearance of the hepatitis B surface antigen from the serum of patients with chronic hepatitis B(CHB).However,the level of intrahepatic covalently closed circular DNA(cccDNA)and hepatitis B virus(HBV)integration remains unclear.We conducted this study to determine them and reveal their value in the treatment of CHB.Methods:There were two sessions to elucidate the changes in intrahepatic cccDNA and HBV integration after antiviral therapy.In the first session,116 patients were enrolled and divided into FC,non-functional cure(NFC),and CHB groups,including 48 patients with functionally cured CHB,27 with CHB without functional cure after antiviral treatment,and 41 with treatment-naïve CHB.Patients were tested for both intrahepatic cccDNA and other viral markers.All patients in the FC group were followed up for at least 24 weeks to observe relapse.In the second session,another ten patients were included for in-depth whole-genome sequencing to analyze HBV integration.Results:Thirteen patients in the FC group were negative for intrahepatic cccDNA.Intrahepatic cccDNA was much higher in the CHB group compared with the FC group.Seven patients had HBsAg seroreversion,including two with virological relapse.Integration of HBV was detected in one(33.3%)functionally cured patients and in seven(100%)with CHB.28.0%of the HBV breakpoints were assigned in the 1,500 nt to 1,900 nt range of the HBV genome.Conclusions:After achieving an FC,the rate of intrahepatic cccDNA and HBV integration was significantly reduced in patients with CHB.For those patients who cleared intrahepatic cccDNA,the chances of developing virological relapse were even lower. | Weiqiang Gan Na Gao Lin Gu Zhishuo Mo Xiuqing Pang Ziying Lei Zhiliang Gao | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 2 |
| 10 | Recent advances in engineered nanomaterials for acute kidney injury theranostics显示文摘Acute kidney injury(AKI),has become the focus of increasing attention due to its high risk of death.The early diagnosis and treatment of AKI significantly reduce the risk of renal tissue damage and kidney dysfunction.However,the efficient early diagnosis and treatment approach for AKI remains a challenge.AKI screening via precise nanomaterial theranostics is a new alternative approach.This study summarizes the recent advances in functional nanomaterials in the early detection and treatment of AKI.The challenges and problems in the use of nanomaterials for AKI in clinical applications are also discussed.It is anticipated that highlighting these new advances will lay the foundation for further translational research on the promising application of nanomaterials for AKI. | Lefeng Wang Yunjing Zhang Yangyang Li Jianghua Chen Weiqiang Lin | 2021 | Nano Research2021，14，4： | 1 |
| 11 | Central extensions and derivations of the Lie algebras of skew derivations for quantum torus显示文摘 | Weiqiang Lin Shaobin Tan | 2005 | Communication in Algebra2005，，33： | 1 |
| 12 | Central Extension, Derivations and Automorphism Grouj? for Lie Algebras Arising from the 2-Dimensional Toms显示文摘 | Min Xue Weiqiang Lin Shaobin Tan | 2006 | Journal of Lie Theory2006，，16： | 1 |
| 13 | Representations of the Lie algebra of derivations for quantum torus 显示文摘 | LIN Weiqiang TAN Shaobin | 2004 | J Algebra2004，275，： | 1 |
| 14 | A phase I trial of flavopiridol in relapsed multiple myeloma显示文摘 | Craig C. Hofmeister Ming Poi Mindy A. Bowers Weiqiang Zhao Mitch A. Phelps Don M. Benson Eric H. Kraut Sherif Farag Yvonne A. Efebera Jennifer Sexton Thomas S. Lin Michael Grever John C. Byrd | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 1 |
| 15 | The classification of Z - graded intermediate serial modules over q- analog Virasoro-like algebra显示文摘 | Wu Yina Lin Weiqiang | 2004 | Algebra Colloquium2004，17，2： | 1 |
| 16 | KPI-based Real-time Situational Awareness for Power Systems with a High Proportion of Renewable Energy Sources显示文摘With the increasing complexity of power systems and the widespread penetration of renewable energy sources(RES),real-time situational awareness for power systems is of great significance for operational scheduling.Considering the impact of RES on power system operations,a situational awareness key performance index(KPI)system for power systems with a high proportion of RES is proposed in this paper,which consists of reserve capacity abundance,ramp resource abundance,center of inertia(COI)frequency deviation,interface power flow margin,synthesized voltage stability,and angle stability margin.Then,the KPIs are synthesized and visualized by the decision tree method and radar chart method,respectively,for monitoring the operation states(i.e,normal,alert,and emergency states)of power systems with a high proportion of RES.Numerical simulations are conducted in a revised New England 16-machine 68-bus power system and an actual CEPRI-RE power system in the northwest region of China with a high proportion of RES.The results show that the proposed KPI-based situational awareness method is able to accurately monitor the real-time state of power systems with a high proportion of RES,and can assist power dispatchers to make effective decisions. | Tianhan Zhang Shengyuan Liu Weiqiang Qiu Zhenzhi Lin Lingzhi Zhu Zhao Dawei Minhui Qian LI Yang | 2022 | CSEE Journal of Power and Energy Systems2022，8，4： | 1 |
| 17 | Graded modules over the q-analog Virasoro-like algebra显示文摘 | Lin Weiqiang Tan Shaobin | 2008 | Journal of AIgebras and Representation Theory2008，，11： | 1 |
| 18 | Air Temperature Estimation with MODIS Data over the Northern Tibetan Plateau显示文摘Time series of MODIS land surface temperature(T_s) and normalized difference vegetation index(NDVI) products,combined with digital elevation model(DEM) and meteorological data from 2001 to 2012,were used to map the spatial distribution of monthly mean air temperature over the Northern Tibetan Plateau(NTP). A time series analysis and a regression analysis of monthly mean land surface temperature(T_s) and air temperature(T_a) were conducted using ordinary linear regression(OLR) and geographical weighted regression(GWR). The analyses showed that GWR,which considers MODIS T_s,NDVI and elevation as independent variables,yielded much better results [R_(Adj)~2> 0.79; root-mean-square error(RMSE) =0.51℃–1.12℃] associated with estimating T_a compared to those from OLR(R_(Adj)~2= 0.40-0.78; RMSE = 1.60℃–4.38℃).In addition,some characteristics of the spatial distribution of monthly T_a and the difference between the surface and air temperature(T_d) are as follows. According to the analysis of the 0℃ and 10℃ isothermals,T_a values over the NTP at elevations of 4000–5000 m were greater than 10℃ in the summer(from May to October),and T_a values at an elevation of3200 m dropped below 0℃ in the winter(from November to April). T_a exhibited an increasing trend from northwest to southeast. Except in the southeastern area of the NTP,T d values in other areas were all larger than 0℃ in the winter. | Fangfang HUANG Weiqiang MA Binbin WANG Zeyong HU Yaoming MA Genhou SUN Zhipeng XIE Yun LIN | 2017 | Advances in Atmospheric Sciences2017，34，5： | 1 |
| 19 | Antibacterial and antiparasitic activities analysis of a hepcidinlike antimicrobial peptide from Larimichthys crocea显示文摘As an economically important marine fish,the large yellow croaker Larimichthys crocea suffered from marine white spot disease caused by the ectoparasite Cryptocaryon irritans in recent years.This disease not only could result in physiological damage,but also lead to secondary bacterial invasion.Reports indicated some AMPs(antimicrobial peptides)were of antiparasitic activity to C.irritans.Hepcidin-like(Lc-HepL)was one of the significant differential expression genes excavated from the transcriptome following a challenge with C.irritans.In this study,we characterized this AMP’s bioactivity based on the levels of mRNA and protein.After challenged by C.irritans,qRT-PCR showed Lc-HepL was significantly upregulated in six tissues,including gill,muscle,liver,head kidney and spleen during theront infection,trophont falling off,and secondary bacterial invasion stages,which implicated a role Lc-HepL played in the immune defense against C.irritans and secondary bacterial infection.Recombinant Lc-HepL(rLc-HepL)was induced and purified successfully.rLc-HepL exhibited antibacterial activity to certain bacteria in a dose-and time-dependent manners.Anti-C.irritans activity was explored for the first time and found it could cause the theronts membrane rupture and contents leakage.These results provided the first evidence that Lc-HepL had strong antiparasitic activity against marine fish ectoparasites C.irritans theronts.Together,data indicated that Lc-HepL might be an important component in the innate immune system against C.irritans and has the potential to be employed in future drug development. | Libing Zheng Yuan Li Jun Wang Ying Pan Jia Chen Weiqiang Zheng Longshan Lin | 2020 | Acta Oceanologica Sinica2020，39，10： | 1 |
| 20 | Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury显示文摘Ferroptosis plays a critical pathophysiological role in several types of acute kidney injury(AKI).The development of nanomaterials targeting iron metabolism and ferroptosis is a promising approach for AKI treatment.Herein,we synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles(GGP NPs)as a potential iron-scavenging agent because of their nearly ionic radius and chemical similarity with iron.The results indicated that GGP NPs accumulated in tubular epithelial cells and showed good biocompatibility.GGP NPs significantly inhibited cisplatin(CP)-induced ferroptosis in HK-2 cells by reducing the accumulation of intracellular free iron and mitochondrial dysfunction,and suppressing the perturbations of ferroptosis processes,including lipid peroxidation,nicotinamide adenine dinucleotide phosphate(NADPH)and glutathione(GSH)levels,glutathione peroxidase 4(GPX4)activity,and ferritinophagy.An in vivo study demonstrated that treatment with GGP NPs significantly ameliorated the renal tubular injury and mitochondrial damage induced by CP treatment or ischemia-reperfusion injury.Our study suggests that GGP NPs may be an effective and promising candidate for AKI treatment and enable potential clinical translation. | Xishao Xie Yunjing Zhang Xinwan Su Junni Wang Xi Yao Dou Lv Qin Zhou Jianhua Mao Jianghua Chen Fei Han Yangyang Li Weiqiang Lin | 2022 | Nano Research2022，15，7： | 0 |
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