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| 1 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 2 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 3 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 4 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 5 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 6 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 7 | Spatio-temporal variation of net anthropogenic nitrogen inputs in the upper Yangtze River basin from 1990 to 2012显示文摘The net anthropogenic nitrogen input(NANI) is an important nutrient source that causes eutrophication in water bodies. Understanding the spatio-temporal variation of NANI is important for regional environment assessment and management.This paper calculated NANI in the upper Yangtze River basin(YRB), upstream of the Three Gorges Dam(TGD), from1990 to 2012, and analyzed its spatio-temporal characteristics. Over the past 23 years of the study, the average annual NANI increased from 3200 kg N km^(-2) to 4931 kg N km^(-2). The major components were fertilizer N application, atmospheric N deposition,and net food and feed N import. In the northwest high mountainous region with a sparse population, the main component was atmospheric N deposition. Fertilizer N application and net food and feed N import were concentrated in the Chengdu Plain because of the high population density and large areas of farmland. This research found that NANI increased with rapid urbanization and increasing population. The Pearson correlation results illustrated that the spatial distributions of NANI and its major components were affected by land cover/use, agricultural GDP and total population. Increasing NANI has been the major cause of the degrading stream water quality over the past 20 years and is becoming a major threat to the water quality of the TGD reservoir. | WANG Ai TANG LiHua YANG DaWen LEI HuiMin | 2016 | Science China Earth Sciences2016，59，11： | 11 |
| 8 | Over-activation of TLR5 signaling by high-dose flagellin induces liver injury in mice显示文摘Flagellin 是涉及天生、适应的免疫的大量房间类型的有势力使活跃之物。因此,它是疫苗的一个好辅助候选人,并且它可能在癌症放射疗法和放射紧急情况的一个缓和者期间对主要尖锐放射症候群作为生物杀虫撒布剂工作。然而,积累证据含有在一些煽动性的疾病的出现的 flagellin 例如尖锐的肺发炎,心血管的倒塌和煽动性的肠疾病。这研究的目的是阐明 flagellin-TLR5 发信号激活是否仅仅或是否在肝的 pathophysiology 起一个作用某另外的 flagellin 活动也经由细菌的感染或在临床的应用期间贡献肝损害。Recombinant flagellin 蛋白质与或没有刺激 TLR5 活动被用来评估 flagellin-TLR5 在肝损害发信号在的角色野类型并且 TLR5 击倒老鼠。粗野损害和 hepatocellular 坏死的大区域在 100 或 200 µ 的 intraperitoneal 管理以后在肝织物 12 h 被观察;在一个剂量依赖者的 g flagellin (警察) 和在野类型的老鼠,然而并非在 TLR5 击倒老鼠的时间依赖者举止。flagellin 的 N 终端或 TLR5 绑定域的删除禁止了导致 flagellin 的煽动性的回答和随后的尖锐的肝函数反常和损坏。这些数据证实 flagellin 是肝损害的一个必要决定因素并且证明由高剂量的 flagellin 发信号的 TLR5 的在激活上在肝引起了尖锐煽动性的回答,嗜中性的累积和氧化应力,它贡献导致 flagellin 的肝损害的前进和严厉。 | Yang Xiao Fang Liu Jingyi Yang Maohua Zhong Ejuan Zhang Yaoming Li Dihan Zhou Yuan Cao Wei Li Jie Yu Yi Yang Huimin Yan | 2015 | Cellular & Molecular Immunology2015，12，6： | 9 |
| 9 | Investigation of the characteristics and deactivation of catalytic active center of Cr-Al_2O_3 catalysts for isobutane dehydrogenation显示文摘Deactivation mechanism of Cr-Al2O3 catalyst and the interaction of Cr-Al in the dehydrogenation of isobutane, as well as the nature of the catalytic active center, were studied using XRD, SEM, XPS, H2-TPR, isobutane-TPR and TPO techniques. The results revealed that the deactivation of Cr-Al2O3 catalyst was mainly caused by carbon deposition on its surface. The Cr3+ion could not be reduced by hydrogen but could be reduced to Cr2+by hydrocarbons and monoxide carbon. The active center for isobutane dehydrogenation could be Cr2+/Cr3+produced from Cr6+by the on line reduction of hydrocarbon and carbon monoxide. The binding energy of Al3+was strongly affected by the state of chromium cations in the catalysts. | Deren Fang Jinbo Zhao Wanjun Li Xu Fang Xin Yang Wanzhong Ren Huimin Zhang | 2015 | Journal of Energy Chemistry2015，24，1： | 8 |
| 10 | Treatment of mine water high in Fe and Mn by modified manganese sand显示文摘The iron and manganese absorption properties of several filter media were studied. Four plain filter media and six surface-modified media were examined. The surface modification was performed using potassium permanganate as a surface treatment. The surface-modified manganese sand was found to be most efficient at removing iron and manganese from water. The metal concentrations in filtered effluent were between 0.01 and 0.04 mg/L, which is far lower than the standard for recycle water. A concen-tration of 5% KMnO4 was found to be most effective as surface modifier. The surface of the manganese sand modified by 5% KMnO4 was examined and found to be covered with a dense membrane of some compound. The membrane had the advantages of uniform texture, large surface area and physical and chemical stability. It was effective at removing iron and manganese from mine water. | HE Xuwen YANG Huimin HE Yong | 2010 | Mining Science and Technology2010，20，4： | 7 |
| 11 | Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries显示文摘Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury. | Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang | 2019 | Bioactive Materials2019，4，1： | 7 |
| 12 | Catalytic effect of alkali carbonates on CO_2 gasification of Pingshuo coal显示文摘Na2CO3,Li2CO3,and K2CO3 were used as additives to Pingshuo(PS) coal that was subsequently gasified under a CO2 stream.The catalytic gasification of coal samples by CO2 in the presence single or mixed alkali carbonates was investigated by thermogravimetric analysis.The experimental results indicate that the catalytic effect of Li2CO3 is significantly larger than that of Na2CO3 or K2CO3.The catalytic effect of the mixed,bi-metal carbonate containing Li2CO3 and Na2CO3,or Li2CO3,and K2CO3,is related to the composition of the catalyst and the proportion of the two components.The bi-metal carbonates having a mole ratio of 9:1(Li:X) has the largest catalytic effect for PS coal gasification.A synergistic effect between Li and K,or Na,carbonate appears at temperatures greater than 1300 K.An un-reacted shrinking core model is suitable for kinetic analysis of catalytic gasification of coal samples in the presence of alkali carbonates.It is inappropriate,however,to evaluate the catalytic effect only by the activation energy obtained from the kinetic calculations. | Meng Lili Wang Meijun Yang Huimin Ying Hongyan Chang Liping | 2011 | Mining Science and Technology2011，21，4： | 7 |
| 13 | Epidemiological Characteristics of Human Brucellosis-China,2016−2019显示文摘Introduction:Brucellosis is an important zoonotic infectious disease with its main mode of transmission from livestock to humans.The study analyzed epidemiological characteristics of human brucellosis from 2016 to 2019 in China,aiming to understand progress of the National Program of Brucellosis Prevention and Control.Methods:The research obtained data on human brucellosis cases reported through China’s National Notifiable Disease Reporting System(NNDRS)from January 1,2016 to December 31,2019 and described brucellosis epidemiological patterns by region,seasonality,age,sex,and occupation.Results:The number of cases reported nationwide in China decreased from 47,139(3.4/100,000)in 2016 to 37,947(2.7/100,000)in 2018,and then increased to 44,036(3.2/100,000)in 2019,with an average annual incidence of 3.0/100,000 during the four study years.Brucellosis in Xinjiang declined from 35.6/100,000 in 2016 to 16.3/100,000 in 2019-an average annual decrease of 22.9%.Brucellosis in Inner Mongolia increased from 23.8/100,000 in 2016 to 54.4/100,000 in 2019-an average increase of 31.8%per year and accounting for 22%of all reported cases.Northern China reported 95.2%of cases during this period and still had an incidence of 7.2/100,000 and 87.0%of counties being affected by brucellosis in 2019.In this region in 2019,males aged 45-64 years old had an incidence of over 15.9/100,000,compared with over 7.0/100,000 among females aged 45-64 years old.Conclusions:Although there was progress in prevention and control of human brucellosis in some provincial-level administrative divisions(PLADs)in 2016 through 2019,progress was limited nationwide and there was an overall resurgence of brucellosis in 2019.The resurgence was primarily in Inner Mongolia.An One Health approach should be strengthened to ensure successful and sustainable brucellosis prevention and control in China. | Zhongfa Tao Qiulan Chen Yishan Chen Yu Li Di Mu Huimin Yang Wenwu Yin | 2021 | China CDC weekly2021，3，6： | 6 |
| 14 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 15 | Nitrogen additions inhibit nitrification in acidic soils in a subtropical pine plantation: effects of soil pH and compositional shifts in microbial groups显示文摘Plantation forests play a pivotal role in carbon sequestration in terrestrial ecosystems, but enhanced nitrogen(N) deposition in these forests may affect plantation productivity by altering soil N cycling. Hence,understanding how simulated N deposition affects the rate and direction of soil N transformation is critically important in predicting responses of plantation productivity in the context of N loading. This study reports the effects of N addition rate(0, 40, and 120 kg N ha^(-1) a^(-1)) and form(NH_4Cl vs. NaNO_3) on net N mineralization and nitrification estimated by in situ soil core incubation and on-soil microbial biomass determined by the phospholipid fatty acid(PLFA) method in a subtropical pine plantation. N additions had no influences on net N mineralization throughout the year. Net nitrification rate was significantly reduced by additions of both NH_4Cl(71.5) and NaNO_3(47.1%) during the active growing season, with the stronger inhibitory effect at high N rates. Soil pH was markedly decreased by 0.16 units by NH_4Cl additions. N inputs significantly decreased the ratio of fungal-to-bacterial PLFAs on average by 0.28(49.1%) in November. Under NH_4Cl additions, nitrification was positively related with fungal biomass and soil pH. Under NaNO_3 additions,nitrification was positively related with all microbial groups except for bacterial biomass. We conclude that simulated N deposition inhibited net nitrification in the acidic soils of a subtropical plantation forest in China,primarily due to accelerated soil acidification and compositional shifts in microbial functional groups. These findings may facilitate a better mechanistic understanding of soil N cycling in the context of N loading. | Liang Kou Xinyu Zhang Huimin Wang Hao Yang Wei Zhao Shenggong Li | 2019 | Journal of Forestry Research2019，30，2： | 5 |
| 16 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 17 | NLRC4 downregulates 的激活对 flagellin 的调停 TLR5 的抗体免疫者回答显示文摘细菌的 flagellin 是一个唯一的联系病原体的分子的模式(PAMP ) ,它能被表面认出局部性的像使用费的受体 5 (TLR5 ) 并且 cytosolic 像点头的受体(NLR ) 蛋白质 4 (NLRC4 ) 受体。由 flagellin 和产生有免疫力的回答戏表明小径的 TLR5 或 NLRC4 的激活在抗菌剂免疫的重要角色。然而,它仍然保持不清楚怎么 flagellin 的双活动激活 TLR5 或 NLRC4 发信号小径安排有免疫力的回答。在这研究,我们估计了缺乏能力对 flagellin 在适应有免疫力的回答上独自或在联合激活 TLR5 和 NLRC4 的 flagellin 和它的异种的效果。是不能的激活 NLRC4 的 Flagellin 比的导致了显著地更高的抗体回答野类型的 flagellin。当巨噬细胞在 vivo 被弄空时,增加的抗体反应能被消除。由 flagellin downregulated 的 NLRC4 的激活对 flagellin 的导致 flagellin 、调停 TLR5 的有免疫力的回答。 | Wei Li Jingyi Yang Ejuan Zhang Maohua Zhong Yang Xiao Jie Yu Dihan Zhou Yuan Cao Yi Yang Yaoming Li Huimin Yan | 2016 | Cellular & Molecular Immunology2016，13，4： | 5 |
| 18 | Annealed microstructure dependent corrosion behavior of Ti-6Al-3Nb-2Zr-1Mo alloy显示文摘Corrosion resistance of titanium(Ti)alloys is closely connected with their microstructure which can be adjusted and controlled via different annealing schemes.Herein,we systematically investigate the specific effects of annealing on the corrosion performance of Ti-6 Al-3 Nb-2 Zr-1 Mo(Ti80)alloy in 3.5 wt.%NaCl and 5 M HCl solutions,respectively,based on open circuit potential(OCP),potentiodynamic polarization,electrochemical impedance spectroscopy(EIS),static immersion tests and surface analysis.Results indicate that increasing annealing tempe rature endows Ti80 alloy with a higher volume fraction ofβphase and finerαphase,which in turn improves its corrosion resistance.Surface characterization demonstrates thatβphase is more resistant to corrosion thanαphase owing to a higher content of Nb,Mo,and Zr in the former;additionally,the decreased thickness of a phase alleviates segregation of elements to further restrain the micro-galvanic couple effects betweenαandβphases.Meanwhile,the influential mechanisms of environmental conditions on corrosion of Ti80 alloy are discussed in detail.As the formation of a highly compact and stable oxide film on surface,annealed Ti80 alloys exhibit a low corrosion current density(10^(-6)A/cm^(2))and high polarization impedance(10^(6)Ω·cm^(2))in 3.5 wt.%NaCl solution.However,they suffer severe corrosion in 5 M HCl solution,resulting from the breakdown of native oxide films(the conversion of TiO_(2)to aqueous Ti^(3+)),active dissolution of substrate Ti to aqueous Ti^(3+)and existence of micro-galvanic couple effects.Those findings could provide new insights to designing Ti alloys with high-corrosion resistance through microstructural optimization. | Baoxian Su Liangshun Luo Binbin Wang Yanqing Su Liang Wang Robert O.Ritchie Enyu Guo Ting Li Huimin Yang Haiguang Huang Jingjie Guo Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，3： | 5 |
| 19 | Preparation of Monodisperse Spherical SiO_2 by Microwave Hydrothermal Method and Kinetics of Dehydrated Hydroxyl显示文摘Monodisperse spherical SiO2 particles were successfully synthesized in 2-propanol-H2O-NH3 system by the microwave hydrothermal method using ammonia as catalyst. To investigate the influences on the size of spherical SiO2 particles, factors such as ammonia concentration, reaction temperature, stirring intensity and reactants mol ratio have been studied. The orthogonal experiments were carried out. The as-prepared SiO2 particles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR) and differential thermal analysis (DTA). The results indicated that the size of SiO2 particles increased greatly with the increase in ammonia concentration, temperature and reactants mol ratio, but increased slightly with the increase in stirring intensity. Monodisperse spherical SiO2 particles were amorphous with perfect sphere and uniform size. Hydroxyl was detected in SiO2. Kinetic parameters were calculated, and finally the reaction rate equation of dehydrated hydroxyl was obtained. | Xiaoyi Shen Yuchun Zhai Yang Sun Huimin Gu | 2010 | Journal of Materials Science & Technology2010，26，8： | 5 |
| 20 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
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