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| 1 | New incompatible pair of TCM:Epimedii Folium combined with Psoraleae Fructus induces idiosyncratic hepatotoxicity under immunological stress conditions显示文摘Epimedii Folium(EF)combined with Psoraleae Fructus(PF)is a common modern preparation,but liver injury caused by Chinese patent medicine preparations containing EF and PF has been frequently reported in recent years.Zhuangguguanjiewan pills(ZGW),which contain EF and PF,could induce immune idiosyncratic liver injury according to clinical case reports and a nonhepatotoxic dose of lipopolysaccharide(LPS)model.This present study evaluated the liver injury induced by EF or PF alone or in combination and investigated the related mechanism by using the LPS model.Liver function indexes and pathological results showed that either EF or PF alone or in combination led to liver injury in normal rats;however,EF or PF alone could lead to liver injury in LPS-treated rats.Moreover,EF combined with PF could induce a greater degree of injury than that caused by EF or PF alone in LPS-treated rats.Furthermore,EF or PF alone or in combination enhanced the LPS-stimulated inflammatory cytokine production,implying that IL-1β,which is processed and released by activating the NLRP3 inflammasome,is a specific indicator of EF-induced immune idiosyncratic hepatotoxicity.Thus,EF may induce liver injury through enhancing the LPS-mediated proinflammatory cytokine production and activating the NLRP3 inflammasome.In addition,the metabolomics analysis results showed that PF affected more metabolites in glycerophospholipid and sphingolipid metabolic pathways compared with EF in LPS model,suggesting that PF increased the responsiveness of the liver to LPS or other inflammatory mediators via modulation of multiple metabolic pathways.Therefore,EF and PF combination indicates traditional Chinese medicine incompatibility,considering that it induces idiosyncratic hepatotoxicity under immunological stress conditions. | Yuan Gao Zhilei Wang Jinfa Tang Xiaoyi Liu Wei Shi Nan Qin Xiaoyan Wang Yu Pang Ruisheng Li Yaming Zhang Jiabo Wang Ming Niu Zhaofang Bai Xiaohe Xiao | 2020 | Frontiers of Medicine2020，14，1： | 32 |
| 2 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 3 | Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome显示文摘Aberrant activation of NLRP3 inflammasome has been implicated in the pathogenesis of diverse inflammation-related diseases, and pharmacological molecules targeting NLRP3 inflammasome are of considerable value to identifying potential therapeutic interventions. Cardamonin(CDN), the major active ingredient of the traditional Chinese medicinal herb Alpinia katsumadai, has exerted an excellent anti-inflammatory activity, but the mechanism underlying this role is not fully understood. Here, we show that CDN blocks canonical and noncanonical NLRP3 inflammasome activation triggered by multiple stimuli. Moreover, the suppression of CDN on inflammasome activation is specific to NLRP3, not to NLRC4 or AIM2 inflammasome. Besides, the inhibitory effect is not dependent on the expression of NF-κB-mediated inflammasome precursor proteins. We also demonstrate that CDN suppresses the NLRP3 inflammasome through blocking ASC oligomerization and speckle formation in a dose-dependent manner.Importantly, CDN improves the survival of mice suffering from lethal septic shock and attenuates IL-1βproduction induced by LPS in vivo, which is shown to be NLRP3 dependent. In conclusion, our results identify CDN as a broad-spectrum and specific inhibitor of NLRP3 inflammasome and a candidate therapeutic drug for treating NLRP3 inflammasome-driven diseases. | Zhilei Wang Guang Xu Yuan Gao Xiaoyan Zhan Nan Qin Shubin Fu Ruisheng Li Ming Niu Jiabo Wang Youping Liu Xiaohe Xiao Zhaofang Bai | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 19 |
| 4 | Raman tensor of AlN bulk single crystal显示文摘The angle dependence of optical phonon modes of an AlN bulk single crystal from the m-plane(1100) and c-plane(0001) surfaces, respectively, is investigated by polarized Raman spectroscopy in a backscattering configuration at room temperature. Corresponding Raman selection rules are derived according to measured scattering geometries to illustrate the angle dependence. The angle-dependent intensities of phonon modes are discussed and compared to theoretical scattering intensities, yielding the Raman tensor elements of A1(TO), E22, E1(TO), and A1(LO) phonon modes and the relative phase difference between the two complex elements of A1(TO). Furthermore, the Raman tensor of wurtzite AlN is compared with that of wurtzite ZnO reported in previous work, revealing the intrinsic differences of lattice vibration dynamics between AlN and ZnO. | Wei Zheng Ruisheng Zheng Feng Huang Honglei Wu Fadi Li | 2015 | Photonics Research2015，3，2： | 9 |
| 5 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity显示文摘Psoraleae Fructus(PF)is a well-known traditional herbal medicine in China,and it is widely used for osteoporosis,vitiligo,and other diseases in clinical settings.However,liver injury caused by PF and its preparations has been frequently reported in recent years.Our previous studies have demonstrated that PF could cause idiosyncratic drug-induced liver injury(IDILI),but the mechanism underlying its hepatotoxicity remains unclear.This paper reports that bavachin isolated from PF enhances the specific stimuli-induced activation of the NLRP3 inflammasome and leads to hepatotoxicity.Bavachin boosts the secretion of IL-ip and caspase-1 caused by ATP or nigericin but not those induced by poly(I:C),monosodium urate crystal,or intracellular lipopolysaccharide.Bavachin does not affect AIM2 or NLRC4 inflammasome activation.Mechanistically,bavachin specifically increases the production of nigericin-induced mitochondrial reactive oxygen species among the most important upstream events in the activation of the NLRP3 inflammasome.Bavachin increases the levels of aspartate transaminase and alanine aminotransferase in serum and hepatocyte injury accompanied by the secretion of IL-ip via a mouse model of lipopolysaccharide-mediated susceptibility to IDILI.These results suggest that bavachin specifically enhances the ATP-or nigericin-induced activation of the NLRP3 inflammasome.Bavachin also potentially contributes to PF-induced idiosyncratic hepatotoxicity.Moreover,bavachin and PF should be evaded among patients with diseases linked to the ATP-or nigericin-mediated activation of the NLRP3 inflammasome,which may be a dangerous factor for liver injury. | Nan Qin Guang Xu Yan Wang Xiaoyan Zhan Yuan Gao Zhilei Wang Shubin Fu Wei Shi Xiaorong Hou Chunyu Wang Ruisheng Li Yan Liu Jiabo Wang Haiping Zhao Xiaohe Xiao Zhaofang Bai | 2021 | Frontiers of Medicine2021，15，4： | 9 |
| 6 | Power quality enhancement and engineering application with high permeability distributed photovoltaic access to low-voltage distribution networks in Australia显示文摘Considering power quality problems such as overvoltage and three-phase unbalance caused by high permeability distributed photovoltaic access in low-voltage distribution networks,this paper proposes a comprehensive control scheme using a static var.generator(SVG),electric energy storage(EES),a phase switching device(PSD)and an intelligent terminal controller.The control strategies of transformer overload,bus over/under voltage,anticountercurrent,storage battery state of charge(SOC)maintenance,and three-phase unbalance are studied.The engineering application in the Greenvale low-voltage distribution networks in Australia with high permeability distributed photovoltaics is discussed.The results show that the intelligent terminal controller is able to improve the power quality of low-voltage distribution networks through coordination with EES,SVG and PSD. | Ruisheng Li Peter Wong Kun Wang Bin Li Fangfang Yuan | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 2 |
| 7 | Effects of novel Fufang Biejia Ruangan Tablets with sheep placenta as substitute for Hominis Placenta on CCl4-induced liver fibrosis显示文摘Objective:Fufang Biejia Ruangan Tablet(FBRT) is widely used for the treatment of liver fibrosis.However,Hominis Placenta(HP),as an important adjuvant of FBRT,has been restricted for medicinal using due to the limited availability,ethical controversy and safety issues.The present study aimed to investigate the therapeutic effects of novel FBRT(N-FBRT) with sheep placenta(SP) as substitute for HP on liver fibrosis and explore its possible mechanisms.Different dosages of SP in N-FBRT were also evaluated.Methods:Rats were subcutaneously injected with CCl_(4)to induce liver fibrosis and then treated with NFBRT and FBRT.The anti-hepatic fibrosis effect was determined based on biomarkers analysis of liver function and hepatic fibrosis,and the liver pathology was visualized by H&E staining and Masson staining.The oxidative stress and inflammatory cytokines were also detected.Immunohistochemical staining of a-SMA,real time PCR and Western blotting were performed to evaluate hepatic stellate cells(HSCs)activation and TGF-β1/Smad signaling pathway.Results:N-FBRT and FBRT could ameliorate CCl_(4)-induced liver fibrosis and improve liver function,as evidenced by lowering serum biomarkers levels of liver function and hepatic fibrosis,and decreasing hepatic Hyp content and collagen deposition,and improving the hepatic morphology and architecture changes.Moreover,the anti-liver fibrosis effect was better when the dosage of SP used in N-FBRT was 1/2 of HP in FBRT.Administration of N-FBRT markedly alleviated oxidative stress and inflammatory cytokines,and inhibited a-SMA expression.Furthermore,the mRNA expression of Col Ⅰ,Col Ⅲ,a-SMA and TGF-β1,and proteins expression of a-SMA,TGF-β1,Smad2/3 and p-Smad2/3 were significantly down-regulated by N-FBRT treatment.Conclusion:SP can be used as substitute for HP to prepare N-FBRT for the treatment of liver fibrosis and the anti-liver fibrosis effect of N-FBRT is achieved by eliminating oxidative stress and inflammation,and inhibiting HSCs activation and ECM production by blocking TGF-β1/Smad signaling pathway. | Baode Shen Li Deng Yuan Liu Ruisheng Li Chengying Shen Xiao Liu Yinchao Li Hailong Yuan | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 8 | Phytolith carbon sequestration in bamboos of different ecotypes:a case study in China显示文摘Occlusion of carbon(C) within phytoliths(Phyt OC) is becoming one of the most promising terrestrial C sequestration mechanisms. This study explored the production of Phyt OC within 35 bamboo species belonging to three ecotypes using methods of microwave digestion. The aim of this study is to explore the present and potential C sequestration rate within phytoliths of bamboo species from three ecotypes. Phyt OC content in bamboos of three ecotypes ranges from 0.07 % to 0.42 %. The mean Phyt OC production flux decreases as: clustered bamboo(0.050 ±0.016 t CO2ha-1a-1) & mixed bamboo(0.049 ± 0.016 t CO2ha-1a-1) [ scattered bamboo(0.038 ± 0.020 t CO2ha-1a-1). The phytolith carbon sequestration in Chinese bamboo is estimated to be 0.293 ± 0.127 Tg(1 Tg =1012g) CO2a-1; approximately 75 %, 3 %, and 22 % of which is contributed from scattered, mixed and clustered bamboo, respectively. Taking the Phyt OC production flux of 0.18 ± 0.12 t CO2ha-1a-1and current annual area increasing rate of 3 %, global bamboo phytoliths wouldsequester 11.9 ± 7.9 Tg CO2a-1by 2050. Consequently,bamboo forests have significant potential to mitigate the increasing concentration of atmospheric CO2 by maximizing Phyt OC production flux and expanding bamboos. | Beilei Li Zhaoliang Song Hailong Wang Fengshan Guo Renyi Gui Xiaomin Yang Ruisheng Song | 2014 | Chinese Science Bulletin2014，59，34： | 2 |
| 9 | The multiple-kinase inhibitor lenvatinib inhibits the proliferation of acute myeloid leukemia cells显示文摘Background:Current chemotherapy for acute myeloid leukemia(AML)mainly involves cytotoxic agents such as doxorubicin(DNR),mitoxantrone(Mito)or 2‐aminopurine‐6‐thiol(6‐TG).However,because these agents are relatively ineffective,discovering other more effective drugs for AML treatment would be valuable.Methods:The in vitro antitumor effect of lenvatinib on AML cells was examined using the colorimetric MTT assay for assessing cell metabolic activity.AML cells mixed with Poloxamer 407 were injected into nude mice to form subcutaneous tumors.Tumorbearing mice received lenvatinib by oral administration.The antitumor effect of lenvatinib was established by measuring tumor volumes and weights.Results:Lenvatinib inhibited the growth of AML cells in a dose‐dependent manner.We used AML cells to establish subcutaneous tumor tissues by mixing the cell suspension with Poloxamer 407.Poloxamer 407 alone did not influence the subcutaneous growth of AML cells.Treatment of lenvatinib inhibited in vivo tumor growth of AML cells.Conclusion:The multiple‐kinase inhibitor lenvatinib inhibits the in vitro proliferation of AML cells,and restricts the in vivo growth of AML tumors. | Fan Feng Xiaojuan Li Ruisheng Li Boan Li | 2019 | Animal Models and Experimental Medicine2019，2，3： | 2 |
| 10 | Haplotype reconstruction from SNP fragments by minimum error correction显示文摘 | WANG Ruisheng WU Lingyun LI Zhenping | 2005 | Bioinformatics2005，21，10： | 1 |
| 11 | Quan-titative function for community detection显示文摘 | LI Zhengping ZHANG Shihua WANG Ruisheng | 2008 | Physical ReviewE2008，77，03： | 1 |
| 12 | Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies显示文摘Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Methods: In the present work, we prepared a hyaluronic acid‐poloxamer (HA‐POL) hydrogel and tested the therapeutic effect of the hydrogel on skin‐wound healing. Results: The HA‐POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA‐POL hydrogel promoted skin‐wound healing and increased protein accumulation in the wound area. HA‐POL hydrogel allowed greater air permeability than Band‐aid, a typical wound covering. Results from transwell assays showed that the HA‐POL hydrogel effectively isolated skin‐wounds from bacterial invasion. Conclusion: This work demonstrates the advantages of using HA‐POL gel materials in the treatment of cutaneous wounds. | Xiaojuan Li Aimin Li Fan Feng Qiyu Jiang Huiwei Sun Yantao Chai Ruichuang Yang Zhijie Wang Jun Hou Ruisheng Li | 2019 | Animal Models and Experimental Medicine2019，2，2： | 1 |
| 13 | Enhanced Influenza VLP vaccines comprising matrix-2 ectodomain and nucleoprotein epitopes protects mice from lethal challenge显示文摘 | Xiao Gao WenJuan Wang YuFeng Li ShaoGeng Zhang YueQiang Duan Li Xing ZhongPeng Zhao PeiRui Zhang ZhiWei Li RuiSheng Li Xiliang Wang PengHui Yang | 2013 | Antiviral Research2013，，1： | 1 |
| 14 | Haplotype Reconstruction from SNP Fragments by Minimum ErrorCorrection显示文摘 | Wang Ruisheng Wu Lingyun Li Zhenping | 2005 | Bioinformatics2005，21，10： | 1 |
| 15 | Quantitative Function for Community Detection显示文摘 | Li Zhenping Zhang Shihua Wang Ruisheng | 2008 | Physical Review E2008，77，3： | 1 |
| 16 | Quantitative function for community detection显示文摘 | Zhenping Li Shihua Zhang Ruisheng Wang | 2008 | Physical Review E2008，77，36109： | 1 |
| 17 | Fe3O4 nanoparticle-enabled mode-locking in an erbiumdoped fiber laser显示文摘In this paper,we have proposed and demonstrated the generation of passively mode-locked pulses and dissipative soliton resonance in an erbium-doped fiber laser based on Fe3O4 nanoparticles as saturable absorbers.We obtained self-starting mode-locked pulses with fundamental repetition frequency of 7.69 MHz and center wavelength of 1561 nm.The output of a pulsed laser has spectral width of 0.69 nm and pulse duration of 14 ns with rectangular pulse profile at the pump power of 190 mW.As far as we know,this is the first time that Fe3O4 nanoparticles have been developed as low-dimensional materials for passive mode-locking with rectangular pulse.Our experiments have confirmed that Fe3O4 has a wide prospect as a nonlinear photonics device for ultrafast fiber laser applications. | Xiaohui LI Jiajun PENG Ruisheng LIU Jishu LIU Tianci FENG Abdul Qyyum Cunxiao GAO Mingyuan XUE Jian ZHANG | 2020 | Frontiers of Optoelectronics2020，13，2： | 1 |
| 18 | DNA Barcoding:An Effective Tool for Species Identification of Lepidopteran Oak Pests显示文摘[Objective] The paper was to improve the efficiency and accuracy of early forecast of Lepidopteran oak-infesting pests.[Method] DNA barcoding technique was established for quick species identification using mitochondrial cytochrome C oxidase subunit Ⅰ(COⅠ) as the standard gene.This barcoding technique was used to amplify and sequence genomic DNA samples from eggs and pupae of 11 species of Lepidopteran pests collected from oak.[Result] The DNA barcoding standard genes of 594-708 bp were determined from eggs and pupae of Lepidopteran insects.There were differences of 0-2 bases in DNA barcode sequences between conspecific eggs and pupae,with the sequence identity of 99.7%-100%.The average content of A,T,G and C of DNA barcode sequences from Lepidopteran insects were 30.7%,38.5%,14.9% and 15.9%,respectively.The obtained DNA barcode sequences had 91.4%-100% identity and 0-8.6% difference degree with GenBank-deposited DNA barcode sequences from organisms of the genetically-closest relationship.Among them,DNA barcode sequences from egg and pupa samples of 10 Lepidopteran insects(No.1-20) had 99%-100% identity and 0-1.0% difference degree with homologous sequences in GenBank database,while the remaining samples(No.21-22) had high difference degree(8.6%) with homologous sequences.[Conclusion] The established DNA barcoding technique is an effeetive tool for species identification of Lepidopteran pests using genomic DNA from eggs and pupae of Lepidopteran insects. | Yang Ruisheng Zhang Junyi Chen Yubo Wang Yong Jiang Yiren Shi Shenglin Qin Li | 2018 | Animal Husbandry and Feed Science2018，10，2： | 1 |
| 19 | Subwavelength optical localization with toroidal excitations in plasmonic and Mie metamaterials显示文摘Since the performance of electronic circuits is becoming rather limited in face of intensively increasing of amount of information and related operations,alloptical processing offers a promising strategy for future information system.It would benefit a great deal if the all-optical processing could be implemented within the developed electronic chips of nanoscale structures.In that it is highly desirable to break the diffraction limit of light for achieving effective light manipulations with deep subwavelength structures compatible with the state-of-the-art nanofabrication processes.It is of fundamental importance to get subwavelength optical localization,that is,squeeze light wave into subwavelength space for achieving freely manipulating of light fields.This review summarizes the development in realizing subwavelength optical localization by exciting toroidal mode in photonic metamaterials.The toroidal excitations in plasmonic metamaterials and Mie resonant metamaterials,in 3D structures and planar metamaterials,with single or few layers in spectral regime from microwave to optical frequencies are surveyed.Based on the discussion on the configurations of toroidal excitations,the recent development on toroidalrelated optical scattering control actively manipulates the toroidal excitations,and promising applications are further investigated and highlighted. | Ruisheng Yang Jing Xu Nian-Hai Shen Fuli Zhang Quanhong Fu Junjie Li Hongqiang Li Yuancheng Fan | 2021 | InfoMat2021，3，5： | 1 |
| 20 | Quantitative examination of the inhibitory activation of molecular targeting agents in hepatocellular carcinoma patient-derived cell invasion via a novel in vivo tumor model显示文摘Background: The outcomes for patients with advanced hepatocellular carcinoma(HCC) receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib. However, the exact mechanism of resistance to sorafenib remains unclear and it is valuable to establish a novel mouse model to quantitatively analyze the inhibition rates of sorafenib on the invasive growth of HCC cells in the liver.Methods: HCC tissue microblocks derived from patients were cultured and mixed with hydrogel drops. Then, hydrogel drops containing microblocks of HCC tissue were attached onto the surface of the livers of nude mice to form lesions or nodules of HCC. The mice received molecular targeting agents through oral administration. Livers with tumor nodules were harvested for H&E staining(hematoxylin-eosin staining) analysis and H&E staining images were quantitatively analyzed using image J software. The invasive growth of HCC cells into the liver was calculated using the depth of the lesions compared with the total thickness of the liver.Results: Microblocks containing cells derived from HCC patients can form lesions in the liver of nude mice. Oral administration of molecular targeting agents inhibited the invasive growth of HCC cells in the liver of nude mice.Conclusions: The model established in this study involves the invasive growth of HCC cells in the liver of nude mice, and the model allows for the quantitative analysis of the inhibitory effect of molecular targeting agents on the invasion of HCC cells in vivo. | Huiwei Sun Fan Feng Hui Xie Xiaojuan Li Qiyu Jiang Yantao Chai Zhijie Wang Ruichuang Yang Ruisheng Li Jun Hou | 2019 | Animal Models and Experimental Medicine2019，2，4： | 1 |
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