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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | Assessment of air quality benefits from national air pollution control policies in China. Part II: Evaluation of air quality predictions and air quality benefits assessment显示文摘 | Litao Wang Carey Jang Yang Zhang Kai Wang Qiang Zhang David Streets Joshua Fu Yu Lei Jeremy Schreifels Kebin He Jiming Hao Yun-Fat Lam Jerry Lin Nicholas Meskhidze Scott Voorhees Dale Evarts Sharon Phillips | 2010 | Atmospheric Environment2010，，28： | 1 |
| 3 | 显示文摘 | Yan Chun Zhang Shouhai Yang Daling | 2007 | Journal of Functional Materials2007，38，7： | 1 |
| 4 | Lidar study of the characteristics of gravity waves in the mesopause region at a southern low-latitude location显示文摘 | Guotao Yang Barclay Clemesha Paulo Batista Dale Simonich | 2008 | Journal of Atmospheric and Solar-Terrestrial Physics2008，，7： | 1 |
| 5 | Self-assessment of excellence: An application of the evidential reasoning approach显示文摘 | Yang J B Dale B G Siow C H R | 2001 | International Journal of Production Research2001，39，16： | 1 |
| 6 | Early weaning reduces small intestinal alkaline phosphatase expression in pigs显示文摘 | Dale L Yang C B Tania A | 2010 | J Nutr2010，140，： | 1 |
| 7 | Preparation and characterization of poly( phthalazinone ether sulfone ketone) hollow fiber ultrafiltration membranes with excellent thermal stability 显示文摘 | Yang Yongqiang Yang Daling Zhang Shouhai | 2006 | Journal of Membrane Science2006，280，： | 1 |
| 8 | Poly(phthalazinone ether sulfone ketone) (PPESK) hollow fiber asymmetric nanofiltration membranes: Preparation, morphologies and properties显示文摘 | Yang Yongqiang Jian Xigao Yang Daling | 2006 | Journal of Membrane Science2006，27，： | 1 |
| 9 | FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion显示文摘Revascularization and angiogenesis,as substrates of sustained collateral circulation,play a crucial role in determining the severity and clinical outcome of acute ischemic stroke(AIS)due to large vessel occlusion(LVO).Developing an adjunct biomarker to help identify and monitor collateral status would aid stroke diagnosis and prognosis.To screen the potential biomarkers,proteomic analysis was performed in this study to identify those distinct plasma protein profiles in AIS due to LVO with different collateral status.Interestingly,we found that levels of Plasma Factor VII Activating Protease(FSAP)significantly increased in those AIS patients with poor collaterals,and were correlated with worse neurological outcome.Furtherly,both in vitro and in vivo models of ischemic stroke were used to explore pathological mechanisms of FSAP in endothelial dysfunction.We demonstrated that the FSAP inhibitor,high-molecular-weight hyaluronan(HMW-HA),enhanced the pro-angiogenic vascular factors,improved the integrity of brain blood barrier,and promoted newly formed cerebral microvessels in the ischemic penumbra,consequently improving neurological function.To elucidate the pathways that might contribute to revascularization during LVO,we applied transcriptomic analysis via unbiased RNA sequencing and showed that Wnt signaling was highly involved in FSAP mediated endothelial dysfunction.Notably,inhibition of Wnt5a largely reversed the protective effects from HMW-HA treatment,implying that FSAP might aggravate endothelial dysfunction and neurological deficits by regulating Wnt5a signaling.Therefore,FSAP may represent a potential biomarker for collateral status after LVO and a promising therapeutic target to be explored in the treatment of stroke. | Dai-Shi Tian Chuan Qin Luo-Qi Zhou Sheng Yang Man Chen Jun Xiao Ke Shang Dale BBosco Long-Jun Wu Wei Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 10 | Cloning of an ovine 11β-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid:tissue and temporal distribution if its messenger ribonucleic acid during fetal and neonatal development显示文摘 | Yang K Smith CL Dales D | 1992 | Endocrinology1992，131，5： | 1 |
| 11 | Preparation and characterization of polypiperazine amide/PPESK hollow fiber composite nanofiltration membrane 显示文摘 | Fajie Yang Shouhai Zhang Daling Yang | 2007 | Journal of Membrane Science2007，，301： | 1 |
| 12 | Serf-assessment of excellence: An application of the evidential reasoning approach显示文摘 | Yang J B Dale B G Siow C H R | 2001 | International Journal of Production Research2001，39，16： | 1 |
| 13 | Studies on solid circulation rate and gas bypassing in spouted fluid-bed with a draft tube显示文摘 | Yang Wenching Dale L Keairns | 1983 | Can J Chem Eng1983，61，6： | 1 |
| 14 | Estrogen dependent expression of heat shock transcription factor: Implications for uterine synthesis of heat shock proteins 显示文摘 | Yang X Dale EC Diaz J | 1995 | J Steroid Biochem Mol Biol1995，52，5： | 1 |
| 15 | Parametric Yield Optimization for MOS Circuit Blocks显示文摘 | Hocevar Dale E Cox Paule F Yang Ping | 1988 | IEEE Trans on CAD1988，7，6： | 1 |
| 16 | Self-assessment of excellence:an application of the evidential reasoning approach显示文摘 | Dale B G Siow C H R | 2001 | International Journal of Production Research2001，39，16： | 1 |
| 17 | Synthesis and characterization of multi-walled carbon nanotubes reinforced polyamide 6 via in situ polymerization显示文摘 | Chungui Zhao Guanjun Hu Ryan Justice Dale W. Schaefer Shimin Zhang Mingshu Yang Charles C. Han | 2005 | Polymer2005，，14： | 1 |
| 18 | Poly (phthalazinone ether sulfone ketone) (PPESK) hollow fibre asymmetric nanofiltration membranes: preparation, morphologies and properties 显示文摘 | Yang Yongqiang Jian Xigao Yang Daling | 2006 | J Membr Sci2006，270，： | 1 |
| 19 | Estimating ground-level PM 2.5 concentrations in the southeastern U.S. using geographically weighted regression显示文摘 | Xuefei Hu Lance A. Waller Mohammad Z. Al-Hamdan William L. Crosson Maurice G. Estes Sue M. Estes Dale A. Quattrochi Jeremy A. Sarnat Yang Liu | 2012 | Environmental Research2012，，： | 1 |
| 20 | Study on solid circulation rate and gas by passing in spouted fluid-bed with a draft tube显示文摘 | YANG Wen-ching DALE L KEAIRNS | 1983 | Can J Chem Eng1983，61，： | 1 |
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