|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain显示文摘 | Liu D Smith CL Barone FC | 1999 | Mol Brain Res1999，68，： | 2 |
| 3 | Surface flattening based on energy model 显示文摘 | Charlie CL Wang Shana SF Smith Matthew MF Yuen | 2002 | Computer-Aided Design2002，，11： | 2 |
| 4 | Adherence of neutrophils to canine cardiac myocytes in vitro is dependent on intercellular adhesion molecule-1 显示文摘 | Smith CW Entman ML Lane CL | 1991 | J Clin Invest1991，88，： | 2 |
| 5 | Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis显示文摘 | Smith CL Lamensdorf I | 2001 | J Cell Biol2001，153，： | 1 |
| 6 | Nuclear factor kappa B in the dorsal raphe of macaques:An anatomical link for steroids,cytokines and serotonin显示文摘 | Bethea CL Reddy AP Smith LJ | 2006 | J Psychiatry Neurosci2006，31，2： | 1 |
| 7 | An evaluation of the physicochemical risk for renal stone disease in pregnancy 显示文摘 | Smith CL Kristensen C Davis M | 2001 | Clin Nephrol2001，55，3： | 1 |
| 8 | DNA translocation and loop formation mechanism of chromatin remodeling by SWI/SNF and RSC显示文摘 | Zhang Y Smith CL Saha A | 2006 | Mol Cell2006，24，： | 1 |
| 9 | Using death rounds to improve end-of-life education for internal medicine residents显示文摘 | Smith L Hough CL | 2011 | Journal Palliat Medicine2011，14，1： | 1 |
| 10 | Etiology of supracondylar humerus fracture 显示文摘 | Farnsworth CL Smith PD Mubarak SJ | 1998 | Pediatr Orthop1998，18，： | 1 |
| 11 | The neuroprotective properties of the Ginkgobilobal leaf:a review of the posssibl erelationship to plateletactivating factor(PAF)显示文摘 | Smith PF Madennan K Darlingtan CL | 1996 | J Ethnopharmaeology1996，50，3： | 1 |
| 12 | Relationships of protective factors to stress and symptoms of illness 显示文摘 | DOLBIER CL SMITH SE STEINHARDT MA | 2007 | American Journal of Health Behavior2007，，31： | 1 |
| 13 | Movement of Bax from the cytosol to mitochondria during apoptosis显示文摘 | Wolter KG Hsu YT Smith CL | 1997 | J Cell Biol1997，139，5： | 1 |
| 14 | Design, syn- thesis and biological evaluation of C-42 hydroxyesters of rapamycin: the identification of CCI-779 显示文摘 | Skotnicki JS Leone CL Smith AL | 2001 | Clin Cancer Res2001，7，1： | 1 |
| 15 | Immortalization of primary human smooth muscle cells显示文摘 | Perez-Reyes N Halbert CL Smith PP | | 0，，： | 1 |
| 16 | Cerebrospinal fluid ab- normalities in patients with syphilis: association with clinical and laboratory features 显示文摘 | Marra CM Maxwell CL Smith SL | 2004 | J infect Dis2004，189，3： | 1 |
| 17 | Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates 显示文摘 | Sano T Smith CL Cantor CR | 1992 | Science1992，258，5079： | 1 |
| 18 | Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features显示文摘 | Marrac CM Maxwell CL Smith SL | 2004 | Infect Dis2004，189，3： | 1 |
| 19 | Movement of Bax from the cytosol to mitochondria during apoptosis 显示文摘 | Wolter KG Hsu YT Smith CL | 1997 | J Cell Biol1997，139，5： | 1 |
| 20 | Upper airway collapsibility in children with obstructive sleep apnea syndrome显示文摘 | Marcus CL McColley SA Carroll JL Loughlin GM Smith PL Schwartz AR | 1994 | J Appl Physiol1994，77，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员