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| 1 | Zebrafish embryo toxicity of 15 chlorinated, brominated, and iodinated disinfection by-products显示文摘Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products(DBPs), many of which are halogenated and cyto-and genotoxic. Only a handful of assays have been used to compare DBP toxicity,and researchers are unsure which DBP(s) drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell,Chinese hamster ovary cells. Traditionally, most DBP research focuses on the threat to human health, but the effects on aquatic species exposed to DBPs in wastewater effluents remain ill defined. We present the developmental toxicity for 15 DBPs and a chlorinated wastewater to a model aquatic vertebrate, zebrafish. Mono-halogenated DBPs followed the in vivo toxicity rank order: acetamides > acetic acids > acetonitriles ~ nitrosamines, which agrees well with previously published mammalian in vitro data. Di-and tri-halogenated acetonitriles were more toxic than their mono-halogenated analogues, and bromine-and iodine-substituted DBPs tended to be more toxic than chlorinated analogues. No zebrafish development effects were observed after exposure to undiluted or non-concentrated,chlorinated wastewater. We find zebrafish development to be a viable in vivo alternative or confirmatory assay to mammalian in vitro cell assays. | David Hanigan Lisa Truong Michael Simonich Robert Tanguay Paul Westerhoff | 2017 | Journal of Environmental Sciences2017，29，8： | 5 |
| 2 | Removalof fragrance materials during US and European wastewatertreatment显示文摘 | Simonich S L Federle T W Eckhoff W S | 2002 | Environmental Science&Technology2002，36，13： | 1 |
| 3 | Organic Pollutant Accumulation in Vegetation显示文摘 | Simonich S L Hites R A | 1995 | Environmental Science and Technology1995，29，： | 1 |
| 4 | Effect of Dibenzopyrene Measurement on Assessing Air Quality in Beijing Air and Possible Implications for Human Health显示文摘 | Layshock J Simonich S M Anderson K A | 2012 | Journal of Environmental Monitoring2012，，12： | 1 |
| 5 | Vegetation - atmospheric partition- ing of polycyelic aromtic hymns显示文摘 | SIMONICH S L HTTES R A | 1994 | Environmental Science and Technology1994，28，5： | 1 |
| 6 | The annual variation of the high of the atmospheric sodium layer at 23°S,Possible evidence for convective transport显示文摘 | Clemesha B R Simonich D M Takashashi H | 1992 | J Geophys Res1992，97，： | 1 |
| 7 | Importance of vegetation in removing polycyclic aromatic hydrocarbons from the atmosphere显示文摘 | Hites R A | 1994 | Nature1994，370，： | 1 |
| 8 | Global distribution of persistent organochlorine compounds 显示文摘 | Simonich S L Hites R A | 1995 | Science1995，269，5232： | 1 |
| 9 | Lidar observations of atmospheric sodium at an equatorial location显示文摘 | Clemesha B R Simonich D M Batista P P | 1998 | Journal of Atmospheric and Solar-Terrestrial Physics1998，60，： | 1 |
| 10 | Organic pollution accumulation in vegetation 显示文摘 | Simonich S L Hites R A | 1995 | Environmental Science and Technology1995，29，： | 1 |
| 11 | Lidar study of the characteristics of gravity waves in the mesopause region at a southern low-latitude location显示文摘 | Guotao Yang Barclay Clemesha Paulo Batista Dale Simonich | 2008 | Journal of Atmospheric and Solar-Terrestrial Physics2008，，7： | 1 |
| 12 | Vegetation-atmosphere partition-ing of polycyclic aromatic hydrocarbons显示文摘 | Simonich S L Hites R A | 1994 | Environmental Science and Technology1994，28，： | 1 |
| 13 | Arsenic(III,V),indium(III),and gallium(III)toxicity to zebrafish embryos using a high-throughput multiendpoint in vivo developmental and behavioral assay显示文摘 | OLIVARES C I FIELD J A SIMONICH M | 2016 | Chemosphere2016，148，： | 1 |
| 14 | Trace analysis of fragrance materials in wastewater and treated wastewater显示文摘 | Simonich S L Begley W M Debaere G | 2000 | Environ Sci Technol2000，34，6： | 1 |
| 15 | Atmospheric concentrations and air-soil gas exchange of polycyclic aromatic hydrocarbons( PAHs ) in remote, rural village and urban areas of Beijing-Tianjin region, North China显示文摘 | Wang W T Simonich S Girl B | 2011 | Science of the Total Environment2011，409，15： | 1 |
| 16 | Organic pollutant accumulation in vegetation显示文摘 | Simonich S L Hites R A | 1995 | Environmental Science Technology1995，29，29： | 1 |
| 17 | Mutations in LACS2, a Long- Chain Acyl -Coenzyme A Synthetase, Enhance Susceptibility to Avimlent Pseudomonas syringae But Confer Resistance to Botrytis einerea in Arabidopsis显示文摘 | Tang Ding Simonich M T Innes R W | 2007 | Plant Physiol2007，144，： | 1 |
| 18 | Global distribution of persistent organochlorine compounds显示文摘 | Simonich S L Hites R A | 1995 | Science1995，269，： | 1 |
| 19 | Global distribution of persistent organochlo-rine compounds显示文摘 | Simonich S L Hites R A | 1995 | Science1995，269，： | 1 |
| 20 | Removal of fragrance materials during US and European wastewater treatment 显示文摘 | Simonich S Federle T W Eckhoff W S | 2002 | Environ Sci Technol2002，36，： | 1 |
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