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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | A New Anthraquinone from Clinopodium polycephalum Glyceroyl-1,6,8-trihydroxy-3-methyl-9,10-dioxo-2-anthracene Carboxylate显示文摘A new anthraquinone, Glyceroyl-l, 6, 8 -trihydroxy-3 -methyl-9, 10-dioxo-2 -anthracenecarboxylate 1, was isolated from Clinopodium polycephalum. The chemical structure was determined by spectroscopic methods. | Chen, JY Chen, JM Wan, CL Yang, JS Xiao, PG | 1998 | Chinese Chemical Letters1998，9，2： | 5 |
| 3 | Preliminary results of integrated therapy for patients with knee osteoarthritis显示文摘 | Huang MH Yang RC Lee CL | | Arthritis and Rheumatism0，，： | 2 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | The effect of short - term withdrawal from continuous positive airway pressure therapy on sym- pathetic activity and markers of vascular inflammation in subjects with obstructive sleep apneea显示文摘 | Phillips CL Yang Q Williams A | 2007 | J Sleep Res2007，16，2： | 1 |
| 6 | Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma 显示文摘 | Yang MH Chen CL Chau GY | 2009 | Hepatology2009，50，5： | 1 |
| 7 | Mechanism of proximal tubule bicarbonate absorption in NHE3null mice显示文摘 | Wang T Yang CL Abbiati T | 1999 | Am J Physiol1999，277，2： | 1 |
| 8 | Detection of intestinal duplication on Tc-99m pertechnetate imaging显示文摘 | Yang JG Li CL Hao RR | | 0，，03： | 1 |
| 9 | Incidental finding of Tc-99 mMDP bone scintigraphy in a case of X-linked spondyloepiphysealdysplasia tarda显示文摘 | Yang F Xu HQ Li CL Yang JG | 2012 | Clin Nucl Med2012，37，2： | 1 |
| 10 | Distinct evolution and predictive value of hepatitis B virus precore and basal core promoter mutations in interferon-induced hepatitis B e antigen seroconversion 显示文摘 | Yang HC Chen CL Shen YC | 2013 | Hepatology2013，57，3： | 1 |
| 11 | Copper-resistant bacteria enhance plant growth and copper phytoextrac-tion显示文摘 | YANG LX LUO CL CHEN YH | | 0，，6： | 1 |
| 12 | Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1C levels in human pancreatic islets显示文摘 | Yang BT Dayeh TA Kirkpatrick CL | | 0，，： | 1 |
| 13 | Endoscopic removal of a huge duodenal Brunner′s glanf adenoma: a new technique显示文摘 | Huang CH Perng CL Yang YH | 1999 | Gastrointest Endosc1999，50，： | 1 |
| 14 | Express of apoptosis related genes in experiment chronic renal scarring 显示文摘 | Yang B Johnson TS Thomas CL | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 15 | Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport显示文摘 | Zhu X Wang Z | 2005 | J Clin Invest2005，115，： | 1 |
| 16 | Effect of neonatal isolation on outcome following neonatal sei- zures in rats-the role of eorticosterone 显示文摘 | Lai MC Holmes GL Lee KH Yang SN Wang CA Wu CL | 2006 | Epilepsy Res2006，68，2： | 1 |
| 17 | Weight loss,nutritional sta-tus and physical activity in patients with Alzheimer’s disease:Acontrolled study显示文摘 | Wang PN Yang CL Lin KN | 2004 | J Neurol2004，251，3： | 1 |
| 18 | Leptin and cholesterol levels are low in major depressive disorder,but high in schizophrenia显示文摘 | Jow GM Yang TT Chen CL | 2006 | J Affect Disord2006，90，1： | 1 |
| 19 | Simultaneously significant hepatic and mild splenic uptake of Tc-99m MDP resulting from Walden- strom macroglobulinemia显示文摘 | Yang JG Yin CH Li CL | 2009 | Clin Nucl Med2009，34，： | 1 |
| 20 | Insulinpromoter DNA methylation correlates negatively with insulingene expression and positively with HbAlc levels in humanpancreatic islets 显示文摘 | YANG BT DAYEH TA KIRKPATRICK CL | 2011 | Diabetologia2011，54，2： | 1 |
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