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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes显示文摘 | Li Y Guessous F Zhang Y Dipierro C Kefas B Johnson E Marcinkiewicz L Jiang J Yang Y Schmittgen TD Lopes B Schiff D Purow B Abounader R | 2009 | 中国神经肿瘤杂志2009，7，4： | 56 |
| 3 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 4 | Study on the expression of matrix metalloproteinase-2 mRNA in human gastric cancer显示文摘 | Ji F Wang WL Yang ZL Li YM Huang HD Chen WD | 1999 | World Journal of Gastroenterology1999，5，5： | 19 |
| 5 | Leber's hereditary optic neuropathy is associated with the mitochondrial ND4 G11696A mutation in five Chinese families显示文摘 | Zhou XT Wei QP Yang L Tong Y Zhao FX Lu CJ Qian YP Sun YH Lu F Qu J Guan MX | 2006 | 中国生物学文摘2006，20，4： | 18 |
| 6 | Optimizing Parameters of CSM-CERES-Maize Model to Improve Simulation Performance of Maize Growth and Nitrogen Uptake in Northeast China显示文摘Crop models can be useful tools for optimizing fertilizer management for a targeted crop yield while minimizing nutrient losses.In this paper,the parameters of the decision support system for agrotechnology transfer(DSSAT)-CERES-Maize were optimized using a new method to provide a better simulation of maize(Zea mays L.) growth and N uptake in response to different nitrogen application rates.Field data were collected from a 5 yr field experiment(2006-2010) on a Black soil(Typic hapludoll) in Gongzhuling,Jilin Province,Northeast China.After cultivar calibration,the CERES-Maize model was able to simulate aboveground biomass and crop yield of in the evaluation data set(n-RMSE=5.0-14.6%),but the model still over-estimated aboveground N uptake(i.e.,with E values from-4.4 to-21.3 kg N ha-1).By analyzing DSSAT equation,N stress coefficient for changes in concentration with growth stage(CTCNP2) is related to N uptake.Further sensitivity analysis of the CTCNP2 showed that the DSSAT model simulated maize nitrogen uptake more precisely after the CTCNP2 coefficient was adjusted to the field site condition.The results indicated that in addition to calibrating 6 coefficients of maize cultivars,radiation use efficiency(RUE),growing degree days for emergence(GDDE),N stress coefficient,CTCNP2,and soil fertility factor(SLPF) also need to be calibrated in order to simulate aboveground biomass,yield and N uptake correctly.Independent validation was conducted using 2008-2010 experiments and the good agreement between the simulated and the measured results indicates that the DSSAT CERES-Maize model could be a useful tool for predicting maize production in Northeast China. | LIU Hai-long YANG Jing-yi HE Ping BAI You-lu JIN Ji-yun Craig F Drury ZHU Ye-ping YANGXue-ming LI Wen-juan XIE Jia-gui YANG Jing-min Gerrit Hoogenboom | 2012 | Journal of Integrative Agriculture2012，11，11： | 13 |
| 7 | The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells显示文摘 | Liu X Wu JY Zhou F Sun XL Yao HH Yang Y Ding JH Hu G | 2006 | 中国生物学文摘2006，20，10： | 11 |
| 8 | bFGF and heparin but not laminin are necessary factors in the mediums that affect NSCs differentiation into cholinergic neurons显示文摘 | Ren W Guo Q Yang Y Chen F | 2006 | 中国生物学文摘2006，20，5： | 10 |
| 9 | GURTIN VARIATIONAL PRINCIPLE AND FINITE ELEMENT SIMULATION FOR DYNAMICAL PROBLEMS OF FLUID-SATURATED POROUS MEDIA显示文摘Based on the theory of porous media,a general Gurtin variational principle for theinitial boundary value problem of dynamical response of fluid-saturated elastic porous media isdeveloped by assuming infinitesimal deformation and incompressible constituents of the solid andfluid phase.The finite element formulation based on this variational principle is also derived.Asthe functional of the variational principle is a spatial integral of the convolution formulation,thegeneral finite element discretization in space results in symmetrical differential-integral equationsin the time domain.In some situations,the differential-integral equations can be reduced to sym-metrical differential equations and,as a numerical example,it is employed to analyze the reflectionof one-dimensional longitudinal wave in a fluid-saturated porous solid.The numerical results canprovide further understanding of the wave propagation in porous media. | Yang Xiao Cheng Changjun Department o,f Mechanics, Shanghai Institute of Applied Mathematics and Mechanics,Shanghai University,Shanghai 200436,China) | 2003 | Acta Mechanica Solida Sinica2003，16，1： | 10 |
| 10 | Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture.显示文摘 | Li X Lu F Tian Q Yang Y Wang Q Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 9 |
| 11 | Late Quaternary palaeoenvironmental changes documented by microfaunas and shell stable isotopes in the southern Pearl River Delta plain,South China显示文摘Ahigh resolution study of sediments,microfaunas(ostracods and foraminifers),and stable isotopes of ostracod shells from core PRD05,sampled from the Da’ao plain of the Pearl River Delta,provides new data about palaeoenvironmental changes during the Late Quaternary.The basal fluvial gravelly sediments of the core,representing the lowest deposits of the Quaternary at the core site,were possibly formed prior to the transgression associated with the last interglacial stage.This fluvial setting changed into a marginal marine setting during the last interglacial stage,any record of calcareous fossils were destroyed by subsequent dissolution during the last glacial phase,when the upper part of the deltaic sediments experienced subaerial oxidation,indicated by a mottled clay layer in the core.The postglacial sealevel rise in the South China Sea began at16,700 cal yr B.P.During the first phase of sea-level rise(from ~16,700 to 10,100 cal yr B.P.),a swamp environment developed at the core site.At ~10,100 cal yr B.P.,marine waters intruded onto the Da’ao plain and reached the core site through the Modaomen channel.This timing was earlier than in other parts of the Pearl River Delta.Since then,a semi-enclosed estuarine environment developed and was maintained until ~5560 cal yr B.P.During this transgressive interval,short-term environmental fluctuations can be recognized based on microfauna and shell geochemical data.From ~10,100 to 8630 cal yr B.P.,the sea-level rose,which was followed by a fall from ~8630 to 8520 cal yr B.P.An expanded transgression occurred between ~8520 and 7900 cal yr B.P.The time intervals from ~8520 to 8200 cal yr B.P.and from ~8080 to 7900 cal yr B.P.were marked by peak transgression.From ~7900 to 5560 cal yr B.P.,the core site generally showed a reduced marine influence and enhanced freshwater input.A fluvial environment developed from ~5560 to 3100 cal yr B.P.,and was succeeded by an alluvial plain setting. | Liu Chunlian Franz T. Fürsich Wu Jie Dong Yixin Yang Tingting Yin Jian | 2013 | Journal of Palaeogeography2013，2，4： | 8 |
| 12 | ANOMALOUS BEHAVIOR REVISITED:DYNAMIC RESPONSE OF ELASTIC-PLASTIC STRUCTURES显示文摘Based on the minimum principle of acceleration in the elastic-plastic continua under fi-nite deformation,the dynamic response of an elastic-perfectly plastic pin-ended beam subjected to rect-angular impulse loading is studied with the help of a numerical approach.The calculated results once a-gain show the anomalous behavior of the beam during its response process,which was previously foundin[1].By carefully analyzing the instantaneous distribution of the bending moment,the membraneforce,the curvature and displacement during the response process,it is concluded that the interactiveeffect between the geometry and materials nonlinearities of the structure is the key reason for leading tothe anomalous behavior.This will be helpful for clarifying some misunderstandings in explaining theproblem before. | Xi, F Yang, JL Li, ZL | 1998 | Acta Mechanica Solida Sinica1998，11，4： | 7 |
| 13 | TRPS1是一种高度敏感和特异的乳腺癌标志物,尤其对三阴性乳腺癌显示文摘基于雌激素受体(ER)/孕激素受体(PR)及人类表皮生长因子受体2(HER2)表达,乳腺癌分为ER阳性、PR阳性、HER2阳性(15%)及三阴性(TNBC,15%)。ER阳性及PR阳性分别被称为管腔A型及管腔B型,二者约占乳腺癌的70%。TNBC具有未分化表型,通常与基底样乳腺癌重叠,复发率高,转移早,缺乏乳腺起源的肿瘤标志物。 | Ai D Yao J Yang F 方三高(译) 魏建国(校) | 2021 | 诊断病理学杂志2021，28，5： | 7 |
| 14 | Involvement of cholinergic system in suppression ot formalin-induced inflammatory pain by cobratoxin显示文摘瞄准: 调查 cobratoxin (CTX ) 的止痛效果,长链的 α从泰国眼镜蛇恶意的神经毒素,在导致福尔马林的煽动性的疼痛的一个老鼠模型。 | Gao-na SHI Yan-li LIU Hai-ming LIN Shi-lin YANG Yu-lin Feng Paul F REID Zheng-hong QIN | 2011 | Acta Pharmacologica Sinica2011，32，10： | 6 |
| 15 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 16 | Gut microbiota mediated molecular events and therapy in liver diseases显示文摘Gut microbiota is a community of microorganisms that reside in the gastrointestinaltract. An increasing number of studies has demonstrated that the gutliveraxis plays a critical role in liver homeostasis. Dysbiosis of gut microbiota cancause liver diseases, including nonalcoholic fatty liver disease and alcoholic liverdisease. Preclinical and clinical investigations have substantiated that themetabolites and other molecules derived from gut microbiota and diet interactionfunction as mediators to cause liver fibrosis, cirrhosis, and final cancer. This effecthas been demonstrated to be associated with dysregulation of intrahepaticimmunity and liver metabolism. Targeting these findings have led to thedevelopment of novel preventive and therapeutic strategies. Here, we review thecellular and molecular mechanisms underlying gut microbiota-mediated impacton liver disease. We also summarize the advancement of gut microbiota-basedtherapeutic strategies in the control of liver diseases. | Xiaoqiang Qi Ming Yang Joseph Stenberg Rahul Dey Leslie Fogwe Muhammad Shawkat Alam Eric TKimchi Kevin F Staveley-O'Carroll Guangfu Li | 2020 | World Journal of Gastroenterology2020，26，48： | 5 |
| 17 | Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology显示文摘Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well. | Thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude Joel F Platt Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 5 |
| 18 | A novel membrane-dependent on/off switch mechanism of talin FERM domain at sites of cell adhesion显示文摘heterodimeric 的激活(α /β) 由 cytosolic 蛋白质 talin 的 integrin transmembrane 受体为调整多样的 cell-adhesion-dependent 过程是关键的包括血凝结,改变的组织,和癌症转移。这进程被 talin (talin-FERM ) 的 N 终端 FERM (four-point-one-protein/ezrin/radixin/moesin ) 领域的重合的绑定触发到内部膜表面和 integrin β细胞质的尾巴,但是这些有约束力的事件怎么空间与时间地被调整,仍然保持阴暗。这里,我们报导休眠 talin 的水晶结构,揭示怎么一个 C 终端 talin 杆片断(talin-RS ) 自我面具经由一个大接口的 talin-FERM 上的一个关键 integrin 有约束力的地点。出人意料地,结构也在静电地妨碍 talin-FERM 绑定到膜的 talin-RS 上揭示不同否定地控告的表面。为 talin 的如此的双禁止的拓扑学与生物化学、功能的数据一致,但是与一个以前的模型显著地不同。我们与 phosphotidylinositol-4,5-bisphosphate (PIP2 ) 在丰富之上显示出那 - 已知的 talin 使活跃之物,膜强烈在 talin-FERM 上吸引断然控告的表面并且同时在 talin-RS 上排斥否定地控告的表面。如此的静电的 “ pull-push”过程支持 talin-FERM 的双抑制的消除,它不同于经典 “位的 clash”为常规导致 PIP2 的 FERM 领域激活当模特儿。这些数据因此解开膜依赖者 FERM 领域规定的一种新类型并且说明它怎么调停 talin 开/关换到调整 integrin transmembrane 发信号和房间粘附。 | Xianqiang Song Jun Yang Jamila Hirbawi Sheng Ye H Dhanuja Perera Esen Goksoy Pallavi Dwivedi Edward F Plow Rongguang Zhang Jun Qin | 2012 | Cell Research2012，22，11： | 5 |
| 19 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 20 | Thermal and Transmission Properties of UV Nonlinear Optical Material——ZnCd(SCN)_4 Crystal显示文摘Zinc cadmium thiocyanate(ZCTC), ZnCd(SCN) 4, has been discovered as a UV second order nonlinear optical coordination crystal. Its thermal and transmission properties are reported. The thermal decomposition is characterized by using the X ray powder diffraction (XRPD) and infrared (IR) spectroscopy at room temperature. The absorptions of intrinsic ions and ZCTC in a solution state are discussed as well as transmission properties of the ZCTC crystal. An effective method of reducing the surface reflection loss of ZCTC crystal is introduced. | NING H X, XU D, WANG X Q, CHENG X F, YANG Z H (Institute of Cryst. Mater. and State Key Lab. of Cryst. Mater., Shandong University, Jinan 250100, CHN) | 2002 | Semiconductor Photonics and Technology2002，8，1： | 4 |
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