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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | 老年医学与衰弱老年人的医疗服务显示文摘 | Kenneth Rockwood Xiaowei Song Arnold Mitnitski 于普林 石婧(译) 宋晓崴(校) | 2009 | 中华老年医学杂志2009，28，5： | 50 |
| 3 | A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize显示文摘 | Chenxu Liu Xiang Li Dexuan Meng Yu Zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei Li Liang Li Xiaolong Tian Haiming Zhao Weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen | 2017 | Molecular Plant2017，10，3： | 39 |
| 4 | 基于卷积神经网络和集成学习的阿尔茨海默症早期诊断显示文摘阿尔茨海默症(AD)是一种典型的神经退行性疾病,临床上表现为失忆、丧失语言能力、丧失生活自理能力等。迄今为止,AD病因尚不明确且病程不可逆,也没有治愈的方法,因此,AD的早期诊断对于研发新型药物和措施以减缓病情发展具有重要意义。轻度认知障碍(MCI)是一种介于AD和正常老化(HC)之间的状态。研究表明,MCI患者比没有患过MCI的人更有可能发展成AD,因此,对MCI患者的准确筛查成为了AD早期诊断的研究热点之一。随着神经影像技术和深度学习的飞速发展,越来越多的研究者使用深度学习方法对大脑神经影像如磁共振影像(MRI)进行分析,用于AD的早期诊断。于是,本文提出基于卷积神经网络(CNN)和集成学习的多切片集成分类模型用于AD早期诊断。与只用单切片训练获得的CNN分类模型相比,本文采用三个维度上的多个二维切片进行训练而获得的集成分类器模型,能更充分地利用MRI包含的有效信息,从而提高分类的准确率和稳定性。 | 曾安 贾龙飞 潘丹 Song Xiaowei | 2019 | 生物医学工程学杂志2019，36，5： | 18 |
| 5 | miRNAs and lncRNAs in vascular injury and remodeling显示文摘Vascular injury,remodeling,as well as angiogenesis,are the leading causes of coronary or cerebrovascular disease.The blood vessel functional imbalance trends to induce atherosclerosis,hypertension,and pulmonary arterial hypertension.As several genes have been identified to be dynamically regulated during vascular injury and remodeling,it is becoming widely accepted that several types of non-coding RNA,such as microRNAs(miRNAs)and long non-coding RNAs(lncRNAs),are involved in regulating the endothelial cell and vascular smooth muscle cell(VSMC)behaviors.Here,we review the progress of the extant studies on mechanistic,clinical and diagnostic implications of miRNAs and lncRNAs in vascular injury and remodeling,as well as angiogenesis,emphasizing the important roles of miRNAs and lncRNAs in vascular diseases.Furthermore,we introduce the interaction between miRNAs and lncRNAs,and highlight the mechanism through which lncRNAs are regulating the miRNA function.We envisage that continuous in-depth research of non-coding RNAs in vascular disease will have significant implications for the treatment of coronary or cerebrovascular diseases. | SONG XiaoWei SHAN DongKai CHEN Jian JING Qing | 2014 | Science China(Life Sciences)2014，57，8： | 17 |
| 6 | 生成式对抗网络在医学图像处理中的应用显示文摘近年来,研究人员将众多领域方法引入到医学图像处理中。经过不断改进,医学图像处理算法的效果和效率均得到不同程度的提高。目前,生成式对抗网络(GAN)在医学图像处理领域中的应用研究发展迅速。本文主要综述了GAN在医学图像处理中的应用研究情况,介绍了GAN的基本概念,并从医学图像降噪、检测、分割、合成、重建和分类等六个方面对GAN应用研究的最新进展进行了归纳总结,最后对该领域中值得进一步研究的方向进行了展望。 | 潘丹 贾龙飞 曾安 Song Xiaowei | 2018 | 生物医学工程学杂志2018，35，6： | 8 |
| 7 | Characterization of odorous charge and photochemical reactivity of VOC emissions from a full-scale food waste treatment plant in China显示文摘Food waste treatment plants(FWTPs) are usually associated with odorous nuisance and health risks, which are partially caused by volatile organic compound(VOC) emissions. This study investigated the VOC emissions from a selected full-scale FWTP in China. The feedstock used in this plant was mainly collected from local restaurants. For a year, the FWTP was closely monitored on specific days in each season. Four major indoor treatment units of the plant, including the storage room, sorting/crushing room, hydrothermal hydrolysis unit, and aerobic fermentation unit, were chosen as the monitoring locations.The highest mean concentration of total VOC emissions was observed in the aerobic fermentation unit at 21,748.2–31,283.3 μg/m3, followed by the hydrothermal hydrolysis unit at 10,798.1–23,144.4 μg/m3. The detected VOC families included biogenic compounds(oxygenated compounds, hydrocarbons, terpenes, and organosulfur compounds) and abiogenic compounds(aromatic hydrocarbons and halocarbons). Oxygenated compounds,particularly alcohols, were the most abundant compounds in all samples. With the use of odor index analysis and principal components analysis, the hydrothermal hydrolysis and aerobic fermentation units were clearly distinguished from the pre-treatment units, as characterized by their higher contributions to odorous nuisance. Methanthiol was the dominant odorant in the hydrothermal hydrolysis unit, whereas aldehyde was the dominant odorant in the aerobic fermentation unit. Terpenes, specifically limonene, had the highest level of propylene equivalent concentration during the monitoring periods. This concentration can contribute to the increase in the atmospheric reactivity and ozone formation potential in the surrounding air. | Zhe Ni Jianguo Liu Mingying Song Xiaowei Wang Lianhai Ren Xin Kong | 2015 | Journal of Environmental Sciences2015，27，3： | 7 |
| 8 | ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-a-processing alteration显示文摘 | Ming Zhu Xiaonan Zhao Jia Chen Jiajia Xu Guangjing Hu Dongqing Guo Qin Li Xiaowei Zhang Catherine C.Y. Chang Baoliang Song Ying Xiong Tayuan Chang Boliang Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 7 |
| 9 | 加拿大老年医学科医生培训情况显示文摘目的本文结合加拿大医科生的培训情况,介绍加拿大的老年医学培训。在加拿大,老年医学隶属于内科学的范畴,经加拿大皇家医师学会认证,有全国通用的老年医学专业资格证书。要成为老年科医生,在经过了大学本科和医学院培训并从事临床工作的基础上,还需参加2年的老年医学科培训。学习内容主要是有关衰老以及老年人特有的健康问题,包括衰弱、联合用药、认知损害、痴呆和功能损害。在老年医学专业培训的过程中,医生要学习如何对老年人进行综合性评估,并学习如何在住院部、门诊部、疗养所和老年人家中等多种医疗环境中及多学科组成的医疗团队中从事诊治工作。 | Kenneth Rockwood Melissa Andrew Xiaowei Song 于普林 石婧(译) 宋晓崴(校) | 2009 | 中华老年医学杂志2009，28，6： | 6 |
| 10 | 基于卷积循环神经网络的阿尔茨海默症早期诊断显示文摘早期准确诊断能延迟阿尔茨海默症(Alzheimer′s disease,AD)病情的恶化。磁共振成像(MRI)和正电子发射断层扫描(PET)已被证明有助于了解AD相关的解剖和功能性神经变化。近期研究表明,多模态特征的融合可以提高分类性能。本研究提出了一种基于卷积循环神经网络的多模态数据分类新框架,新框架结合了2D卷积神经网络和循环神经网络,以学习3D MRI和3D PET图像切分为2D切片序列之后的切片内、切片间特征,完成AD的早期诊断。本研究方法在AD与NC的分类实验中ACC为93.3%,AUC为98.1%;在MCIc与NC的分类实验准确率为83.8%,AUC为91.9%;MCIc与MCInc的分类实验准确率为79.0%,AUC为88.9%。结果表明该方法具有良好的分类性能。 | 曾安 黄殷 潘丹 SONG Xiaowei | 2020 | 生物医学工程研究2020，39，3： | 6 |
| 11 | 基于sMRI的阿尔茨海默症分类影响因素研究显示文摘本研究提出基于三类解剖特征的SVM建模方法,探索样本、特征及算法选择三个因素,对阿尔茨海默症(AD)及其前驱阶段分类的重要性。该方法以三维重构s MRI后不同大脑区域的灰质体积、皮层表面积及其平均厚度三类特征作为SVM模型的输入参数,并采用十折交叉验证方法对AD患者、轻度认知损害患者和健康者进行分类识别,并与其他文献结果进行比较分析。实验结果表明,为了达到更高的分类准确率,选择合适的样本和特征,比选择算法更重要。此结论为未来AD的计算机辅助诊断研究工作提供了有益的指导。 | 黎建忠 曾安 潘丹 Song Xiaowei 郭慧 王卓薇 | 2018 | 生物医学工程研究2018，37，2： | 5 |
| 12 | Gold nanoparticles doped metal-organic frameworks as near-infrared light-enhanced cascade nanozyme against hypoxic tumors显示文摘We report gold nanoparticles(AuNPs)doped iron-based metal-organic frameworks(GIM)which displays near-infrared light(NIR)-enhanced cascade nanozyme against hypoxic tumors.Due to the strong protein adsorption-induced surface passivation,AuNPs suffer from the loss of glucose oxidase(GOx)activity.However,GIM could protect the GOx-like activity of AuNPs with the satisfactory shield capability.In addition,GIM exhibited excellent photothermal conversion ability and unique NIR light-enhanced GOx-like activity,which could efficiently increase the endogenous H2O2 production.Meanwhile,as the produced H2O2 is converted by GIM into O2 and highly toxic OH.Thus,GIM-catalyzed cascade reactions with NIR light irradiation not only offer the O2 but also promote the reactive oxygen species(ROS)generation at tumor sites.The produced O2 could be further applied to AuNPs catalytic oxidation of glucose and relieve hypoxic condition of tumor microenvironment(TME).As a proof-of-concept study,GIM demonstrates the admirable tumor ablation under NIR irradiation in vivo. | Xinli Liu Yongchun Pan Jingjing Yang Yanfeng Gao Ting Huang Xiaowei Luan Yuzhen Wang Yujun Song | 2020 | Nano Research2020，13，3： | 5 |
| 13 | Microstructural evolution of carbon fiber reinforced SiC-based matrix composites during laser ablation process显示文摘In this work, four different carbon fiber reinforced SiC-based matrix composites(C/SiC) were prepared,and microstructure evolution during laser ablation process was characterized. Laser irradiation provided a special high-temperature environment up to 3500℃. For all four composites, different morphologies can be obtained in the transition region due to the oxidation of different matrices. While only needle-shaped carbon fiber and nanolayered carbon without any matrix remained in the central region, indicating that graphitization process occurred in the center, resulting from the high-temperature and low-oxygen environment in the laser process. Therefore, the laser ablation of C/SiC composites is controlled by chemical and physical erosion, and mainly by the physical erosion in the center. | Xiaolin Dang Xiaowei Yin Xiaomeng Fan Yuzhao Ma Jiangtao Wang Panfei Ju Hongwei Song | 2019 | Journal of Materials Science & Technology2019，35，12： | 4 |
| 14 | Enhancement of transfection efficiency for HeLa cells via incorporating arginine moiety into chitosan显示文摘Arginine-rich peptides have attracted considerable attention due to their distinct internalization mechanism. It was reported that arginine and guanidino moieties were able to translocate through cell membranes and played a critical role in the process of membrane permeation. In this work, arginine was conjugated to the backbone of chitosan to form a novel chitosan derivative, arginine modified chitosan (Arg-CS). Arg-CS/DNA complexes were prepared according to the method of coacervation process. The physicochemical properties of Arg-CS and Arg-CS/DNA complexes were characterized and the transfection activity and efficiency mediated by Arg-CS/DNA complexes were investigated taking HeLa cells as target cells. Arg-CS was characterized by FTIR and 13C NMR. Arg-CS/DNA polye- lectrolyte complexes were investigated by agarose gel retardation, dynamic light scattering (DLS) and atomic force microscopy (AFM). The results revealed that the Arg-CS/DNA complexes started to form at N/P ratio of 2:1, and the size of particles varied from 100 to 180 nm. The cytotoxicity of Arg-CS and their complexes with plasmid DNA were determined by MTT assay for HeLa cells, and the results suggested that Arg-CS/DNA complexes were slightly less toxic than Arg-CS. Moreover, the derivative alone and their complexes showed significantly lower toxicity than PEI and PEI/DNA complexes, respectively. Taking HeLa cells as target cells and using pGL3-control as reporter gene, the luciferase expression mediated by Arg-CS was greatly enhanced to about 100 folds compared with the luciferase expression mediated by chitosan at different pH media. These results suggest that Arg-CS is a promising candi- date as a safe and efficient vector for gene delivery and transfection. | ZHU DunWan ZHANG HaiLing BAI JinGen LIU WenGuang LENG XiGang SONG CunXian YANG Jian LI XiaoWei JIN Xu SONG LiPing LIU LanXia LI XiuLan ZHANG Yang YAO KangDe | 2007 | Chinese Science Bulletin2007，52，23： | 4 |
| 15 | Excess TNF-α in the blood activates monocytes with the potential to directly form cholesteryl ester-laden cells显示文摘肿瘤坏死因素 --(TNF-) 并且 monocytic 房间在动脉粥样硬化的发展起一个关键作用,它是冠的心疾病(CHD ) 的主要原因。在这个工作,我们在血在单核白血球上调查了过量 TNF- 的效果并且发现从 CHD 病人的血单核白血球有潜力直接形成 cholesteryl 酉旨(CE ) 沉重的房间在下面在里面有 oxLDL 的 vitro 孵化。proinflammatory cytokines 的血浆层次例如 TNF- , interleukin 6 (IL-6 ) ,并且 C 反应蛋白质(CRP ) ,在 CHD,病人们是比在控制的那些显著地高级的健康志愿者。然而, TNF- ,然而并非 IL-6 或 CRP 的仅仅血浆水平,断然与血单核白血球的潜力被相关直接形成 CE 沉重的房间。由使用人的血单核白血球和 monocytic THP-1 房间, CE 沉重的房间的形成上的 TNF- 的激活的效果被表明,它能被 anti-TNF- 抗体明确地堵住。而且, TNF- 能由分别地提高功能的粘附分子和 scavenger 受体的表示增加粘附和单核白血球的 oxLDL 举起,这也被揭示。最后,结果在 vivo 并且在 vitro,与一个老鼠模型一起的实验证实在血的过量 TNF- 与潜力激活单核白血球直接形成 CE 沉重的房间。这些数据证明在血的过量 TNF- 是为动脉粥样硬化和 CHD 的开发的主要扳机。 | Ming Zhu Lei Lei Zhenhua Zhu Qin Li Dongqing Guo Jiajia Xu Jia Chen Huifang Sha Xiaowei Zhang Xinying Yang Baoliang Song Boliang Li Yan Yan Ying Xiong | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 4 |
| 16 | Pharmacokinetic study of gallocatechin-7-gallate from Pithecellobium clypearia Benth. in rats显示文摘The pharmacokinetic profile of gallocatechin-7-gallate(J10688)was studied in rats after intravenous administration.Male and female Sprague-Dawley(SD)rats received 1,3,and 10 mg/kg(i.v.)of J10688 and plasma drug concentrations were determined by a high performance liquid chromatography-mass spectrometry(LC–MS)method.The pharmacokinetic software Data Analysis System(Version 3.0)was used to calculate the pharmacokinetic parameters.For different i.v.doses of J10688,the mean peak plasma concentration(C_0)values ranged from 11.26 to 50.82 mg/L,and mean area under the concentration-time curve(AUC_(0–t))values ranged from 1.75 to 11.80(mg h/L).J10688 lacked dosedependent pharmacokinetic properties within doses between 1 and 10 mg/kg,based on the power model.The method developed in this study was sensitive,precise,and stable.The pharmacokinetic properties of J10688 in SD rats were shown to have rapid distribution and clearance values.These pharmacokinetic results may contribute to an improved understanding of the pharmacological actions of J10688. | Chao Li Xiaowei Song Junke Song Xiaocong Pang Zhe Wang Ying Zhao Wenwen Lian Ailin Liu Guanhua Du | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 17 | The frail older adult and the Intensive Care Unit显示文摘 | Kenneth Rockwood Zhenhui Guo Xiaowei Song | 2013 | 中华老年医学杂志2013，32，1： | 3 |
| 18 | Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma显示文摘Hepatocellular 癌(HCC ) 是世界范围的致命的肝恶意。在这研究,我们报导了那个蛋白质磷酸酶镁依赖者(PPM1D ) 1 高度在 HCC 案例(约 59%) 的多数被表示并且显著地把水平与高浆液 -fetoprotein (法新社) 联系了(P = 0.044 ) 。Kaplan- Meier 和考克斯回归数据显示 PPM1D overexpression 是 HCCspecific 全面幸存的一个独立预言者(HR, 2.799;95% CI, 1.346-5.818, P = 0.006 ) 。, Overexpressing PPM1D 支持了房间生存能力和侵略 RNA 调停干扰 PPM1D 击倒有教养的 HCC 房间的禁止的增长,侵略,和移植。另外,由小介入 RNA 的 PPM1D 抑制减少了在 vivo 的 HCC 房间的 tumorigenicity。总的来说,结果建议 PPM1D 为 HCC 是一个潜在的预示的标记和治疗学的目标。 | Zhi Xu Chunxiang Cao Haiyan Xia Shujing Shi Lingzhi Hong Xiaowei Wei Dongying Gu Jianmin Bian Zijun Liu Wenbin Huang Yixin Zhang Song He Nikki Pui-Yue Lee Jinfei Chen | 2016 | Frontiers of Medicine2016，10，1： | 3 |
| 19 | Low-level expression of human ACA T2 gene in monocytic cells is regulated by the C/EBP transcription factors显示文摘 | Dongqing Guo Ming Lu Xihan Hu Jiaiia Xu Guangjing Hu Ming Zhu Xiaowei Zhang Qin Li Catherine C. Y. Chang Tayuan Chang Baoliang Song Ying Xiong Boliang Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 3 |
| 20 | Coevolution of Male and Female Response Preferences to Sexual Signals in Music Frogs显示文摘Male signaling influences both female choice and male-male competition. Although male signaling characteristics and female preferences have been shown to coevolve in many species, few studies have examined whether male signal characteristics and male receiver responses related to male-male competition also coevolve. The present study tested the hypothesis that male and female signal receiver preferences may coevolve in parallel for frogs in the genus Babina by comparing the acoustic structure of male advertisement calls of four closely related and geographically isolated Babina species. Then we assessed the behavioral responses of both male and female B. daunchina(Emei music frog) to male call playbacks from each of the four species. The results support the hypothesis that male and female signal receiver preferences have coevolved in this species. Specifically, both male and female B. daunchina respond strongly to the heterospecific calls of B. hainanensis, suggesting that preexisting biases exist in both females and males. Both male and female individuals showed a slight response to the calls of B. adenopleura while no response was evoked by the calls of B. lini. The manifestation of similar response profiles in male and female B. daunchina to the calls of the four species support the idea that male and female signal receiver preferences evolved in parallel and that the origin of these receiver biases reflects adaptations dependent on the same neural and cognitive systems in both sexes. | Jianguo CUI Jichao WANG Guangzhan FANG Xiaowei SONG Steven E.BRAUTH Yezhong TANG | 2016 | Asian Herpetological Research2016，7，2： | 2 |
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