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| 1 | Isolation and Structure Elucidation of Autolytimycin, A New Compound Produced by Streptomyces Autolyticus JX-47显示文摘Autolytimycin 1 was isolated from the culture filtrate of Streptomyces autolyticus JX-47, together with two known compounds, lebstatin 2 and 17-O-demethyl-geldanamycin 3. These compounds showed the activities of anti-HSV-I. The structure of 1 was determined by spectral analysis. | Li, MG Wu, SH Zhao, LX Zhang, Q Li, WJ Cui, XL Xu, LH Wu, DG Jiang, CL | 2001 | Chinese Chemical Letters2001，12，10： | 10 |
| 2 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 3 | Microfluidic actuators based on temperature-responsive hydrogels显示文摘The concept of using stimuli-responsive hydrogels to actuate fluids in microfluidic devices is particularly attractive,but limitations,in terms of spatial resolution,speed,reliability and integration,have hindered its development during the past two decades.By patterning and grafting poly(N-isopropylacrylamide)PNIPAM hydrogel films on plane substrates with a 2μm horizontal resolution and closing the system afterward,we have succeeded in unblocking bottlenecks that thermo-sensitive hydrogel technology has been challenged with until now.In this paper,we demonstrate,for the first time with this technology,devices with up to 7800 actuated micro-cages that sequester and release solutes,along with valves actuated individually with closing and opening switching times of 0.6±0.1 and 0.25±0.15 s,respectively.Two applications of this technology are illustrated in the domain of single cell handling and the nuclear acid amplification test(NAAT)for the Human Synaptojanin 1 gene,which is suspected to be involved in several neurodegenerative diseases such as Parkinson’s disease.The performance of the temperature-responsive hydrogels we demonstrate here suggests that in association with their moderate costs,hydrogels may represent an alternative to the actuation or handling techniques currently used in microfluidics,that are,pressure actuated polydimethylsiloxane(PDMS)valves and droplets. | Loïc D'Eramo Benjamin Chollet Marie Leman Ekkachai Martwong Mengxing Li Hubert Geisler Jules Dupire Margaux Kerdraon Clémence Vergne Fabrice Monti Yvette Tran Patrick Tabeling | 2018 | Microsystems & Nanoengineering2018，4，1： | 3 |
| 4 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 5 | Gliosis and brain remodeling 'after treatment of stroke in rats with marrow stromal cells 显示文摘 | Li Y Chen J Zhang CL | 2005 | Glia2005，49，3： | 1 |
| 6 | Antisense oligonucleotide targeting the transforming growth factor β1 increases expression of specific genes and functions of Leydig cells显示文摘 | Roy CL Leduque P Li JY Seaz JM Langlois D | 1998 | Eur J Biochem1998，257，2： | 1 |
| 7 | Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice显示文摘 | Luo CL Li BX Li QQ | 2011 | Neuroscience2011，184，： | 1 |
| 8 | Characteristics of recurrence af-ter radical esophagectomy with two-field lymph node dissection for thoracic esophageal cancer显示文摘 | Li CL Zhang FL Wang YD | | 0，，01： | 1 |
| 9 | Detection of intestinal duplication on Tc-99m pertechnetate imaging显示文摘 | Yang JG Li CL Hao RR | | 0，，03： | 1 |
| 10 | GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT1A-induced antinociception in the rat 显示文摘 | Huo FQ Qu CL Li YQ | 2008 | Pain2008，139，： | 1 |
| 11 | A new noninvasive method for evaluation of coronary endothelial function in hypertensive patients based on change in diameter of the left main coronary artery induced hy cold pressor test using echocardiography显示文摘 | Deng YB Wang XF Li CL | 2001 | Clin Cardiol2001，24，4： | 1 |
| 12 | Gliosis and Brain Remodeling after Treatment of Stroke in Rats with Marrow Stromal Cells显示文摘 | LI Y CHEN J ZHANG CL | 2005 | Glia (S0894-1491)2005，49，3： | 1 |
| 13 | Incidental finding of Tc-99 mMDP bone scintigraphy in a case of X-linked spondyloepiphysealdysplasia tarda显示文摘 | Yang F Xu HQ Li CL Yang JG | 2012 | Clin Nucl Med2012，37，2： | 1 |
| 14 | The effects of physical activity, body mass index(BMI) and waist circumference( WC ) on glucose intol- erance in older people:a nationwide study from Taiwan 显示文摘 | Li CL Chen SY Lan C | 2011 | Arch Gerontol Geriatr2011，52，1： | 1 |
| 15 | ImmunoCyt and cytokeratin,20 immunocytochemistry as adjunct markers for urine cytologic detection of bladder cancer:a prospective study显示文摘 | Li HX Li M Li CL Ma JH Wang MR Rao J | | 0，，： | 1 |
| 16 | A Novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation显示文摘 | Zhang CL Li AM Zhang XC | 2011 | J Biol Chem2011，286，11： | 1 |
| 17 | Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice显示文摘 | Li Y Lu Z Keoqh CL | 2007 | J Cereb Blood Flow Metab2007，27，： | 1 |
| 18 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 19 | Longitudinal tracking of adolescent smoking,physical activity,and food choice behaviors显示文摘 | Kelder SH Perry CL Klepp LI | 1994 | Am J Public Health1994，84，： | 1 |
| 20 | Effects of withdrawal of Xuezhikang,an extract of cholestin,on lipid profile and Creactive protein:a short-term time course study in patients with coronary artery disease显示文摘 | Hu CL Li YB Tang YH | 2006 | Cardiovasc Drugs Ther2006，20，3： | 1 |
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