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| 1 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 2 | Systematic characterization of transport and thermoelectric properties of a macroscopic graphene fiber显示文摘Graphene,有非凡的电、热、有弹性的性能的二维的材料,是未来技术的一个潜在的候选人。然而, graphene 的优异性质还没为 graphenederived 被认识到宏观的结构象 graphene 纤维那样。在这研究,我们系统地调查了温度(T) 依赖者运输和 graphene 纤维的热电的性质,包括热传导性() ,电的电导率() ,并且 Seebeck 系数(S) 。从 45.8 ~ 149.7 Wd | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Mincheng Yang Xing Zhang Chao Gao | 2016 | Nano Research2016，9，11： | 6 |
| 3 | Chemically doped macroscopic graphene fibers with significantly enhanced thermoelectric properties显示文摘当与突出的热电的性质结合了时,灵活便携电子学为收获系统的未来精力正在答应候选人。Graphene 和它的宏观的集会(例如,基于 graphene 的纤维和电影) 因为他们的非凡的电、机械的性质,因此是众多的研究的题目。然而,这些集会没由于他们的高内在的热传导性为热电的应用程序被认为合适。在这研究,溴做被表明是为显著地提高 graphene 纤维的热电的性质的一个有效方法。做提高声子由于增加的缺点散布并且因此减少热传导性,当电的传导性和 Seebeck 系数被费密增加时,铺平换至较低排挡。作为结果,优点的最大的数字是 2. | Weigang Ma Yingjun Liu Shen Yan Tingting Miao Shaoyi Shi Zhen Xu Xing Zhang Chao Gao | 2018 | Nano Research2018，11，2： | 6 |
| 4 | The in situ observation of modelled sea ice drift characteristics in the Bohai Sea显示文摘Sea ice drift is mainly controlled by ocean currents, local wind, and internal ice stress. Information on sea ice motion, especially in situ synchronous observation of an ice velocity, a current velocity, and a wind speed, is of great significance to identify ice drift characteristics. A sea ice substitute, the so-called 'modelled ice', which is made by polypropylene material with a density similar to Bohai Sea ice, is used to complete a free drift experiment in the open sea. The trajectories of isolated modelled ice, currents and wind in the Bohai Sea during non-frozen and frozen periods are obtained. The results show that the currents play a major role while the wind plays a minor role in the free drift of isolated modelled ice when the wind is mild in the Bohai Sea. The modelled ice drift is significantly affected by the ocean current and wind based on the ice–current–wind relationship established by a multiple linear regression. The modelled ice velocity calculated by the multiple linear regression is close to that of the in situ observation, the magnitude of the error between the calculated and observed ice velocities is less than12.05%, and the velocity direction error is less than 6.21°. Thus, the ice velocity can be estimated based on the observed current velocity and wind speed when the in situ observed ice velocity is missing. And the modelled ice of same thickness with a smaller density is more sensitive to the current velocity and the wind speed changes. In addition, the modelled ice drift characteristics are shown to be close to those of the real sea ice, which indicates that the modelled ice can be used as a good substitute of real ice for in situ observation of the free ice drift in the open sea, which helps solve time availability, safety and logistics problems related to in situ observation on real ice. | Yu Yan Wei Gu Yingjun Xu Qian Li | 2019 | Acta Oceanologica Sinica2019，38，3： | 3 |
| 5 | Mechanistic insights into the adsorption and bioactivity of fibronectin on surfaces with varying chemistries by a combination of experimental strategies and molecular simulations显示文摘Fibronectin(Fn)is significant to the performance of biomaterials,and the chemistry of biomaterial surface play important roles in Fn adsorption and subsequent cell behavior.However,the“molecular scale”mechanism is still unclear.Herein,we combined experimental strategies with molecular simulations to solve this problem.We prepared self-assembled monolayers with varying chemistries,i.e.,SAMs-CH3,SAMs-NH2,SAMs-COOH and SAMs-OH,and characterized Fn adsorption and cell behaviors on them.Next,Monte Carlo method and all-atom molecular dynamics simulations were employed to reveal the orientation/conformation of Fn on surfaces.We found that SAMs-CH3 strongly adsorbed Fn via hydrophobic interactions,but show poor bioactivity as the low exposure of RGD/PHSRN motifs and the deformation of Fn.SAMs-NH2 and SAMs-COOH could adsorb Fn efficiently via vdW interactions,electrostatic interactions,hydrogen bonds and salt bridges.Fn exhibited excellent bioactivity for cell adhesion,proliferation and osteogenic differentiation as high exposure of bioactive motifs on SAMs-NH2,or as the activation of other inferior cell-binding motifs on SAMs-COOH.SAMs-OH showed poor Fn adsorption as the water film.However,the adsorbed Fn displayed non-negligible bioactivity due to high exposure of PHSRN motif and large degree of protein flexibility.We believe that the revealed mechanism presents great potential to rationally design Fn-activating biomaterials. | Lijing Hao Tianjie Li Lin Wang Xuetao Shi Yan Fan Chang Du Yingjun Wang | 2021 | Bioactive Materials2021，6，10： | 3 |
| 6 | Negative association of donor age with CD34+ cell dose in mixture allografts of G-CSF-primed bone marrow and G-CSF-mobilized peripheral blood harvests显示文摘 | Li Yan Chang Yingjun Xu Lanping Zhang Xiaohui Huang Xiaojun | 2014 | Chinese Medical Journal2014，，20： | 2 |
| 7 | 3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration显示文摘Bone bionics and structural engineering have sparked a broad interest in optimizing artificial scaffolds for better bone regeneration.However,the mechanism behind scaffold pore morphology-regulated bone regeneration remains unclear,making the structure design of scaffolds for bone repair challenging.To address this issue,we have carefully assessed diverse cell behaviors of bone mesenchymal stem cells(BMSCs)on theβ-tricalcium phosphate(β-TCP)scaffolds with three representative pore morphologies(i.e.,cross column,diamond,and gyroid pore unit,respectively).Among the scaffolds,BMSCs on theβ-TCP scaffold with diamond pore unit(designated as D-scaffold)demonstrated enhanced cytoskeletal forces,elongated nucleus,faster cell mobility,and better osteogenic differentiation potential(for example,the alkaline phosphatase expression level in D-scaffold were 1.5-2 times higher than other groups).RNA-sequencing analysis and signaling pathway intervention revealed that Ras homolog gene family A(RhoA)/Rho-associated kinase-2(ROCK2)has in-depth participated in the pore morphology-mediated BMSCs behaviors,indicating an important role of mechanical signaling transduction in scaffold-cell interactions.Finally,femoral condyle defect repair results showed that D-scaffold could effectively promote endogenous bone regeneration,of which the osteogenesis rate was 1.2-1.8 times higher than the other groups.Overall,this work provides insights into pore morphology-mediated bone regeneration mechanisms for developing novel bioadaptive scaffold designs. | Qiji Lu Jingjing Diao Yingqu Wang Jianlang Feng Fansen Zeng Yan Yang Yudi Kuang Naru Zhao Yingjun Wang | 2023 | Bioactive Materials2023，，8： | 2 |
| 8 | Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes显示文摘The present study used cultures of primary astrocytes, isolated from neonatal rats, to verify the hypothesis that arsenite-induced neurotoxicity can influence neuronal function by altering glutamate-induced gliotransmitter release. Primary astrocytes were exposed to 0, 2.5, 5, 10, 20 or 30 μM arsenite for 24 hours. Cell viability and morphological observations revealed that 5 μM arsenic exposure could induce cytotoxicity. Cells were then cultured in the presence of 0, 2.5, 5, or 10 μM arsenite for 24 hours and stimulated with 25 μM glutamate for 10 minutes. Results showed that [Ca2+]i in astrocytes exposed to 5 and 10 μM arsenite was significantly increased and levels of D-serine, γ-aminobutyric acid and glycine in cultures exposed to 2.5-10 μM arsenite were also increased. However, glutamate levels in the media were significantly increased only after treatment with 10 μM arsenite. In conclusion, our findings suggest that arsenic exposure may affect glutamate-induced gliotransmitter release from astrocytes and further disturb neuronal function. | Yan Wang Fenghong Zhao Yingjun Liao Yaping Jin Guifan Sun | 2012 | Neural Regeneration Research2012，7，31： | 1 |
| 9 | Transient inhibition of foot-and-mouth disease virus replication by siRNAs silencing VP1 protein coding region显示文摘 | Ke Lv Yingjun Guo Yiliang Zhang Kaiyu Wang Ka Li Yan Zhu Shuhan Sun | 2008 | Research in Veterinary Science2008，，3： | 1 |
| 10 | A future laminted bamboo structure residetial building prototype in China:Life cycle assess- ment of energy use and carbon emission 显示文摘 | Yu Dongwei Tan Hongwei Yan Yingjun | 2011 | Energy and Building''2011，43，10： | 1 |
| 11 | Temperature effect on spinel Li 4 Ti 5 O 12 as anode materials for lithium ion batteries显示文摘 | Zhenwei Zhang Liyun Cao Jianfeng Huang Dunqiang Wang Yan Meng Yingjun Cai | 2013 | Electrochimica Acta2013，，： | 1 |
| 12 | Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells显示文摘Acute graft-versus-host disease(a GVHD)is caused by allo-activated donor T cells infiltrating target organs.As a regulator of immune function,granulocyte colony-stimulating factor(G-CSF)has been demonstrated to relieve the a GVHD reaction.However,the role of G-CSF-primed donor Tcells in specific target organs is still unknown.In this study,we employed a classical MHC-mismatched transplantation mouse model(C57BL/6 into BALB/c)and found that recipient mice transplanted with GCSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group.This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this a GVHD mouse model,especially in the lung and gut.Moreover,we found that Tcells polarized towards Th2 cells and regulatory T cells were increased in specific target organs.In addition,G-CSF treatment inhibited inducible co-stimulator(ICOS)expression and increased the expression of tolerance-related genes in recipient mice.Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated a GVHD,especially for its precise regulation in GVHD target organs. | Yang Zhoui Leqing Cao Huidong Guo Yan Hong Ming Wang Ke Wang Xiaojun Huang Yingjun Chang | 2021 | Science China(Life Sciences)2021，64，7： | 1 |
| 13 | Preliminary study of Shortcut Nitrification and Denitrification Using Immobilized of Mixed Activated Sludge and Denitrifying Sludge显示文摘 | CHEN Yan WANG Yingjun FAN Minghao | 2011 | Procedia Envi- ronmental Sciences2011，，11： | 1 |
| 14 | Rainfall forecast errors in different landfall stages of Super Typhoon Lekima (2019)显示文摘The rainfall forecast performance of the Tropical Cyclone(TC)version Model of Global and Regional Assimilation PrEdiction System(GRAPESTCM)of the China Meteorological Administration for landfalling Super Typhoon Lekima(2019)is studied by using the object-oriented verification method of contiguous rain area(CRA).The major error sources and possible reasons for the rainfall forecast uncertainties in different landfall stages(including near landfall and moving further inland)are compared.Results show that different performance and errors of rainfall forecast exist in the different TC stages.In the near landfall stage the asymmetric rainfall distribution is hard to be simulated,which might be related to the too strong forecasted TC intensity and too weak vertical wind shear accompanied.As Lekima moves further inland,the rain pattern and volume errors gradually increase.The Equitable Threat Score of the 24 h forecasted rainfall over 100 mm declines quickly with the time-length over land.The diagnostic analysis shows that there exists an interaction between the TC and the mid-latitude westerlies,but too weak frontogenesis is simulated.The results of this research indicate that for the current numerical model,the forecast ability of persistent heavy rainfall is very limited,especially when the weakened landing TC moves further inland. | Bin HE Zifeng YU Yan TAN Yan SHEN Yingjun CHEN | 2022 | Frontiers of Earth Science2022，16，1： | 1 |
| 15 | Coordinative regulation of plants growth and development by light and circadian clock显示文摘The circadian clock,known as an endogenous timekeeping system,can integrate various cues to regulate plant physiological functions for adapting to the changing environment and thus ensure optimal plant growth.The synchronization of internal clock with external environmental information needs a process termed entrainment,and light is one of the predominant entraining signals for the plant circadian clock.Photoreceptors can detect and transmit light information to the clock core oscillator through transcriptional or post-transcriptional interactions with core-clock components to sustain circadian rhythms and regulate a myriad of downstream responses,including photomorphogenesis and photoperiodic flowering which are key links in the process of growth and development.Here we summarize the current understanding of the molecular network of the circadian clock and how light information is integrated into the circadian system,especially focus on how the circadian clock and light signals coordinately regulate the common downstream outputs.We discuss the functions of the clock and light signals in regulating photoperiodic flowering among various crop species. | Chen Su Yan Wang Yingjun Yu Yuqing He Lei Wang | 2021 | aBIOTECH2021，2，2： | 1 |
| 16 | Profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria: a retrospective study in China, 2014–2021显示文摘Background: In areas where malaria has been eliminated, delayed care-seeking and diagnosis of imported malaria are constant threats. This study aimed to describe the profile and determinants of delayed care-seeking and diagnosis among patients with imported malaria in China.Methods: This retrospective study assessed surveillance data obtained from 2014 to 2021 in the Chinese provincial-level administrative divisions (PLADs) of Anhui, Henan, Hubei, and Zhejiang, and Guangxi. Epidemiological characteristics were analyzed using descriptive statistics. Furthermore, factors associated with delayed care-seeking and diagnosis among imported malaria cases were identified using multivariate logistic regression.Results: Overall, 11.81% and 30.08% of imported malaria cases had delays in seeking care and diagnosis, respectively. During the study period, there was a decreasing trend in the proportion of imported malaria cases with delayed care-seeking (χ^(2) = 36.099,P < 0.001) and diagnosis (χ^(2) = 11.395,P = 0.001). In multivariate analysis, independent risk factors associated with delayed care-seeking include PLADs (Guangxi as reference), consultations in high-level facilities for the first medical visit, infections with non-Plasmodium falciparum species, and older age. However, PLADs (Guangxi as reference), the purpose of traveling (labour as reference), and infections with non-P. falciparum species increased the risk of delayed diagnosis. Delayed care-seeking (adjusted odds ratio: 1.79,P = 0.001) and diagnosis (adjusted odds ratio: 1.62,P = 0.004) were risk factors for severe disease development.Conclusions: Based on this study’s findings, we strongly advocate for improved access to quality healthcare to reduce the rate of misdiagnosis at the first visit. Infections caused by non-P. falciparum species should be highlighted, and more sensitive and specific point-of-care detection methods for non-P. falciparum species should be developed and implemented. In addition, education programs should be enhanced to reach target populations at risk of malaria infection. All these factors may reduce delayed care-seeking and diagnosis of imported malaria. | Tao Zhang Duoquan Wang Yingjun Qian Wei Ruan Ying Liu Jing Xia Hui Yan Yuan Sui Shenning Lu Xian Xu Jingjing Jiang Xiaofeng Lyu Shuqi Wang Shizhu Li Weidong Li | 2022 | Infectious Diseases of Poverty2022，11，6： | 1 |
| 17 | Synthesis and effect of forming Fe 2 P phase on the physics and electrochemical properties of LiFePO 4 /C materials显示文摘 | Yanbin Xu Yingjun Lu Lan Yan Zhengyin Yang Rudong Yang | 2006 | Journal of Power Sources2006，，1： | 1 |
| 18 | Facile size-controllable aqueous synthesis of water soluble CdTe/Cd(OH)2 core/shell nanoparticles with tunable optical property, high quantum yield and good stability显示文摘 | CAI Zhaoxia CHEN Yingjun YAN Xiuping | 2008 | Chinese Journal of Chemistry2008，26，10： | 1 |
| 19 | Study on Tissue Culture and Rapid Propagation of Tilia amurensis显示文摘To explore the establishment of a tissue culture and rapid propagation system of Tilia amurensis,the effects of basic medium and concentrations and ratios of plant growth regulators on tissue culture and rapid propagation of T.amurensis were studied.The results showed that 1/2 MS medium was the most suitable proliferation medium,and the proliferation coefficient could reach 13.5 after adding 0.05 mg/L 6-BA and 0.03 mg/L IBA;MS medium was the most suitable medium for strong plantlets and rooting,and the best medium for strong plantlets was MS+0.1 mg/L 6-BA+0.1 mg/L IBA+0.03 mg/L GA_(3),with which the average plantlet height reached 5.15 cm;and the best rooting medium was MS+1.0 mg/L6-BA+0.05 mg/L NAA,with which the rooting rate was 93.3%and the number of roots was 5.7 roots. | Yinhua WANG Yuguang KONG Yingjun HE Liping YAN Dejun WU | 2022 | Agricultural Biotechnology2022，11，3： | 0 |
| 20 | Biomimetic hydroxyapatite coating on the 3D-printed bioactive porous composite ceramic scaffolds promoted osteogenic differentiation via PI3K/AKT/mTOR signaling pathways and facilitated bone regeneration in vivo显示文摘The architecture and surface modifications have been regarded as effective methods to enhance the bi-ological response of biomaterials in bone tissue engineering.The porous architecture of the implanta-tion was essential conditions for bone regeneration.Meanwhile,the design of biomimetic hydroxyap-atite(HAp)coating on porous scaffolds was demonstrated to strengthen the bioactivity and stimulate osteogenesis.However,bioactive bio-ceramics such asβ-tricalcium phosphate(β-TCP)and calcium sili-cate(CS)with superior apatite-forming ability were reported to present better osteogenic activity than that of HAp.Hence in this study,3D-printed interconnected porous bioactive ceramicsβ-TCP/CS scaf-fold was fabricated and the biomimetic HAp apatite coating were constructed in situ via hydrothermal reaction,and the effects of HAp apatite layer on the fate of mouse bone mesenchymal stem cells(mBM-SCs)and the potential mechanisms were explored.The results indicated that HAp apatite coating en-hanced cell proliferation,alkaline phosphatase(ALP)activity,and osteogenic gene expression.Further-more,PI3K/AKT/mTOR signaling pathway is proved to have an important impact on cellular functions.The present results demonstrated that the key molecules of phosphatidylinositol 3-kinase(PI3K),protein kinase B(AKT)and mammalian target of rapamycin(mTOR)were activated after the biomimetic hydrox-yapatite coating were constructed on the 3D-printed ceramic scaffolds.Besides,the activated influence on the protein expression of Runx2 and BMP2 could be suppressed after the treatment of inhibitor HY-10358.In vivo studies showed that the constructed HAp coating promoted bone formation and strengthen the bone quality.These results suggest that biomimetic HAp coating constructed on the 3D-printed bioac-tive composite scaffolds could strengthen the bioactivity and the obtained biomimetic multi-structured scaffolds might be a potential alternative bone graft for bone regeneration. | Bizhi Tan Naru Zhao Wei Guo Fangli Huang Hao Hu Yan Chen Jungang Li Zemin Ling Zhiyuan Zou Rongcheng Hu Chun Liu Tiansheng Zheng Gang Wang Xiao Liu Yingjun Wang Xuenong Zou | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
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