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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Induction of robust cellular immunity against HPV6and HPV11in mice by DNA vaccine encoding for E6/E7antigen显示文摘 | Shin TH Pankhong P Yan J | 2012 | Hum Vaccin Immunother2012，8，4： | 1 |
| 3 | Effect of Recombinant Hirudin Variant IIl Emtttsive Microparticles on Thrombosis and the study on its oral absorption mechanism显示文摘 | Liu Y Wan B Yan TH | 2010 | Chinese CJNM2010，8，6： | 1 |
| 4 | Effects of salidroside on hemorheolo- gy and myocardial ischemic reperfusion injury in isolated heart of rats 显示文摘 | Yan TH DU BS Yang W | 2008 | Chin J Nat Med2008，6，3： | 1 |
| 5 | Methylated DNA immuno-precipitation and microarray-based analysis:detection ofDNA methylation in breast cancer cell lines显示文摘 | Weng YI Huang TH Yan PS | 2009 | MethodsMol Biol2009，590，1： | 1 |
| 6 | Safety assessment of Cordyceps guangdongensis 显示文摘 | YAN WJ LI TH LIN QY | 2010 | Food Chem Toxicol2010，48，11： | 1 |
| 7 | Effects of salidroside on hemorheology and myocardial ischemic reperfusion injury in isolated heart of rats 显示文摘 | Yan TH Du BS Yang W | 2008 | Chin J Nat Med2008，6，3： | 1 |
| 8 | LRRK2 kinase activity mediates toxic interac- tions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin 显示文摘 | Yang D Li T Liu Z Arbez N Yan J Moran TH | 2012 | Neurobiol Dis2012，47，3： | 1 |
| 9 | Safety assessment of Cordyceps guangdongensis显示文摘 | YAN WJ LI TH LIN QY | 2010 | Food and Chemical Toxicology2010，48，11： | 1 |
| 10 | Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice显示文摘 | Yang MW Wang TH Yan PP | | 0，，： | 1 |
| 11 | Ocular surface changes in pterygium显示文摘 | Cordelia ML Chan Yan Ping Liu Donald TH Tan | 2002 | Cornea2002，21，1： | 1 |
| 12 | Experimental study of anti -tumor effects of polysaccharides from Angelica sinensis 显示文摘 | Shang P Qian AR Yan g TH | 2003 | World J Gastroen- terol2003，9，9： | 1 |
| 13 | DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumouts 显示文摘 | Felsberg J Yan PS Huang TH | 2006 | Neuropathol Appl Neurobiol2006，32，： | 1 |
| 14 | Safety assessment of cordyceps guangdongensis显示文摘 | Yan WJ Li TH Lin QY | 2010 | Food and Chemical Toxicology2010，48，11： | 1 |
| 15 | Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells显示文摘 | Kim SR Bae YH Bae SK Choi KS Yoon KH Koo TH Jang HO Yan I Kim KW Kwon YG Yoo MA Bae MK | | 0，，05： | 1 |
| 16 | Curcumin improves bone rrdcroarchitecture and enhances mineral density in APP/PSI transgenic mice 显示文摘 | Yang MW Wang TH Yan PP | 2011 | Phytomedicine2011，18，23： | 1 |
| 17 | Induction of robust cellular immunity against HPV6 and HPV11 in mice by DNA vaccine en- coding for E6/E7 antigen 显示文摘 | Shin TH Pankhong P Yan J | 2012 | Hum Yaccin Immunother2012，8，4： | 1 |
| 18 | Safety assessment of Cordyceps guangdongensis显示文摘 | YAN WJ LI TH LIN QY | 2010 | Food Chem Toxico12010，48，11： | 1 |
| 19 | MMP14 regulates cell migrationand invasion through epithelial-mesenchymal transition in naso-pharyngeal carcinoma 显示文摘 | Yan TH Lin ZH Jiang JH | 2015 | Am J Transl Res2015，7，5： | 1 |
| 20 | Genetic factors for differentiated thyroid cancer in French Polynesia:new candidate loci显示文摘Background:Populations of French Polynesia(FP),where France performed atmospheric tests between 1966 and 1974,experience a high incidence of differentiated thyroid cancer(DTC).However,up to now,no sufficiently large study of DTC genetic factors in this population has been performed to reach definitive conclusion.This research aimed to analyze the genetic factors of DTC risk among the native FP populations.Methods:We analyzed more than 300000 single nucleotide polymorphisms(SNPs)genotyped in 283 DTC cases and 418 matched controls born in FP,most being younger than 15 years old at the time of the first nuclear tests.We analyzed the genetic profile of our cohort to identify population subgroups.We then completed a genome-wide analysis study on the whole population.Results:We identified a specific genetic structure in the FP population reflecting admixture from Asian and European populations.We identified three regions associated with increased DTC risk at 6q24.3,10p12.2,and 17q21.32.The lead SNPs at these loci showed respective p-values of 1.66×10^(−7),2.39×10^(−7),and 7.19×10^(−7) and corresponding odds ratios of 2.02,1.89,and 2.37.Conclusion:Our study results suggest a role of the loci 6q24.3,10p12.2 and 17q21.32 in DTC risk.However,a whole genome sequencing approach would be better suited to characterize these factors than genotyping with microarray chip designed for the Caucasian population.Moreover,the functional impact of these three new loci needs to be further explored and validated. | Monia Zidane Marc Haber Thérèse Truong Frédérique Rachédi Catherine Ory Sylvie Chevillard Hélène Blanché Robert Olaso Anne Boland Éric Conte Mojgan Karimi Yan Ren Constance Xhaard Vincent Souchard Jacques Gardon Marc Taquet André Bouville Jean-François Deleuze Vladimir Drozdovitch Florent de Vathaire Jean-Baptiste Cazier | 2023 | Precision Clinical Medicine2023，6，2： | 0 |
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